Articles tagged with Metastasis
Researchers have developed a new cancer treatment that targets and kills bone metastases using engineered stem cells, preserving the bone in the process. This approach could reduce the need for chemotherapy and improve quality of life for patients with bone metastases.
Researchers have discovered how lung cancer cells metastasize by stabilizing protein BACH1, which stimulates glucose metabolism and boosts cancer cell spreading. The studies published in Cell provide a crucial new piece of the oncological puzzle and offer a potential explanation for the Warburg effect.
Scientists discover that UDP-glucose accelerates SNAI1 mRNA decay, impairing lung cancer metastasis. The study also uncovers how UDP-glucose converts to UDP-glucuronic acid, enhancing SNAI1 mRNA stability and promoting tumor cell migration.
Research teams discovered that uridine diphosphate glucose accelerates SNAI1 mRNA decay, impairing lung cancer metastasis. Lower UDP-glucose levels are associated with higher metastasis and recurrence rates in lung cancer.
Researchers developed a microfluidic device to capture circulating cancer cell clusters, providing a new tool for studying metastasis and developing anti-metastatic drug therapies. The device's design enables the collection of viable human cancer cell clusters from patient blood samples, offering a novel approach to combatting cancer.
Researchers at Oregon State University have discovered two compounds, deguelin and rotenone, that can inhibit the metabolism of melanoma cancer cells, effectively starving them of energy. This breakthrough offers a new potential treatment option for drug-resistant metastatic melanoma.
Stanford researchers found that up to 80% of metastatic colorectal cancers have already spread to distant locations by the time the original tumor is clinically detectable. This discovery has implications for patient stratification and earlier detection of cancer.
A new study found that the protein CCN3 is a key factor promoting prostate cancer invasion of bone and predicting poor outcomes. High CCN3 expression correlated with shortened overall survival and bone metastases, while low-expression groups had better survival rates.
The Cytophone system uses laser pulses and focused ultrasound to detect pigmented CTCs in patients with melanoma, identifying 96% of cases within 10 seconds. The technology also destroys detected CTCs and uncovers circulating blood clots, a leading cause of cancer death.
A new pilot study demonstrated the feasibility of using molecular tumor markers to guide chemotherapy selection in patients with metastatic pancreatic cancer. The study reported promising progression-free survival and overall survival rates, with partial responses seen in 28% of patients.
A study by Melanie Rutkowski found that an unhealthy gut microbiome can make breast cancer more invasive and spread quickly. Disrupting the balance of microorganisms in mice resulted in chronic inflammation, priming tumor cells to disseminate and metastasize.
Scientists at VCU Massey Cancer Center identified key biological pathways regulating tumor cell spread to vital organs. They discovered the SRC signaling pathway is highly activated in breast cancer metastases, warranting targeted therapies.
The ECOG-ACRIN Cancer Research Group's phase three trial, E2810, found that pazopanib treatment did not improve disease-free survival in Stage IV patients with no evidence of disease following a surgery to remove the metastases. Average survival for these patients is about two to three years and long-term survival is uncommon.
Researchers at Duke University Medical Center discovered how prostate cancer cells develop to mimic bone-forming cells, enabling proliferation in the bone microenvironment. This understanding could lead to more effective use of radium-233 and development of new therapies to treat or prevent prostate cancer spread to bone.
A new laboratory test could accurately predict which breast cancers are likely to spread and help clinicians select optimal treatments. The test, called Microfluidic Assay for quantification of Cell Invasion (MAqCI), assesses three key features of metastasis in cancer cells.
A new device forces cells through tiny channels, detecting blebbing in cancer cells to identify metastatic prostate cancer. Highly metastatic cells exhibit more blebbing than normal or less-metastatic cells.
Researchers discovered that blocking PHLPP2 enzyme halts prostate cancer growth and metastasis without signs of toxicity in mice or human cells. This finding presents a promising approach for treating prostate cancer and potentially other types of cancers.
Researchers discovered that low levels of syntaphilin at the central core of prostate tumors correlate with increased risk of metastasis. The biomarker may identify patients who require more aggressive management and treatment.
Researchers found that activin B and ALK7 expressed by cancer cells form a barrier that prevents tumor formation and metastasis. The 'barrier' triggers apoptosis in cancer cells, but can be evaded by downregulating activin B or ALK7.
Researchers develop nanobodies that home in on ECM proteins surrounding cancer cells, allowing for early detection and treatment of tumors. The technique has shown promise in imaging and delivering therapeutic treatments to tumors.
A new nomogram developed by researchers can accurately predict the likelihood of occult lymph node metastases in esophageal cancer. This tool may help clinicians identify high-risk patients who would benefit from neoadjuvant therapy, leading to more informed treatment discussions and potentially improved patient outcomes.
Researchers have identified four hallmarks of cancer metastasis: motility, modulation of the microenvironment, plasticity, and ability to colonize. This understanding could lead to the development of new therapeutic interventions for this complex process, which is responsible for up to 90% of cancer deaths.
Research analyzed rates of brain metastases in elderly patients with breast cancer, lung cancer, and melanoma. The study found that these cancers carry a significant risk of developing brain metastases later in life, with varying rates among primary cancer types.
Researchers investigated risk factors for melanoma dissemination and the impact of time on distant relapse. The findings provide valuable information for improving melanoma treatment outcomes.
Two new urine tests have shown promise in accurately detecting bladder cancer, determining its severity, and detecting recurrence. The tests use a gene variant called V1, which is elevated in bladder cancer, and have been found to be 90% effective at detecting the disease.
Researchers at Cornell University discovered a link between diabetes and increased risk of metastatic cancer, attributed to the glycation of collagen matrices. Elevated blood sugar levels lead to structural changes in collagen fibers, facilitating cancer cell movement through the body.
Researchers studied Rho GTPases and IQGAPs proteins to understand cancer metastasis. The study revealed the interaction between these proteins activates mechanisms triggering metastasis in cells.
Studies presented at ESMO Breast Cancer Congress 2019 found that young women with breast cancer tend to have more aggressive tumour subtypes, including triple negative and HER2 positive types. However, proper treatment according to guidelines resulted in good survival rates and local recurrence outcomes.
A team of scientists has uncovered the unique set of genes that keep some cancer cells dormant, which may reveal new therapeutic targets for multiple myeloma and other cancers. The study found that dormant cancer cells have a similar transcriptome signature to immune cells but are only 'switched on' when located next to osteoblasts.
A study found cervical cancer tumors without human papillomavirus (HPV) are rare but have a worse prognosis, diagnosed at advanced stages with higher metastasis rates.
Researchers found E-selectin in bone vascular environment supports early growth of cancer cells, promoting metastasis. Using sugar-mimetic compound Uproleselan, they show reduced bone metastasis and survival advantage in mice with human breast cancer cells.
A study found that capsaicin, a compound in chili peppers, inhibits invasion and metastasis of lung cancer cells, slowing disease progression. The researchers also identified the protein Src as a key player in suppressing lung cancer metastasis.
Metastatic cancer survivors face unprecedented challenges, including psychosocial burdens, financial strain, and emotional struggles. Experts like Terry Langbaum and Thomas Smith advocate for studying this population and improving care management to ease their journey.
A University of Colorado Cancer Center study identifies a compound that inhibits the action of the SIX1/EYA transcriptional complex, which is involved in cancer metastasis. The compound dramatically suppresses breast cancer-associated metastasis in mouse models.
A new animal study suggests that exposure to dim light at night may contribute to the spread of breast cancer to bones. Researchers created a mouse model of bone metastatic breast cancer and found that mice exposed to a light/dim light cycle had larger tumors and increased bone damage compared to those in a standard light/dark cycle.
A new study suggests that consuming thermally abused cooking oil may trigger genetic changes that promote the progression of late-stage breast cancer. Mice fed thermally abused oil developed more tumors and aggressive growth than those fed fresh soybean oil, highlighting a potential link between diet and cancer recurrence.
Researchers identified a common oncogene, KRAS, as a key player in immune checkpoint blockade therapy resistance in metastatic colorectal cancer. Restoring IRF2 expression or inhibiting MDSCs through CXCL3-CXCR2 signaling increased CRC sensitivity to ICB therapy.
The NRG-RTOG 0214 trial found that prophylactic cranial irradiation improved disease-free survival, decreased brain metastasis rates, but did not improve overall survival in patients with locally advanced non-small cell lung cancer. This suggests PCI may prolong OS in a subgroup without primary tumor surgery.
Breast cancer researchers found that stress hormones increase glucocorticoid receptor activity in metastatic cells, leading to tumor heterogeneity and reduced chemotherapy effectiveness. Synthetic derivatives of stress hormones also decrease chemotherapy efficacy.
A recent study has found that Focal Adhesion Kinase (FAK) acts as a sensor to mechanical forces generated by the cytoskeleton, activating biochemical signals regulating cell migration. This discovery provides new insights into how cancer cells invade and metastasize, potentially leading to therapies targeting this mechanism.
PET/CT scans can monitor immunotherapy treatment for metastatic melanoma and predict outcome, allowing personalized therapy adjustments. The study demonstrates that FDG PET/CT can accurately assess tumor response to checkpoint inhibitor therapy with ipilimumab.
A new study by Prof. Sarah-Maria Fendt and her PhD student Ilaria Elia found that breast cancer cells require pyruvate to reshape the lung environment and create a pro-tumor niche. In contrast, normal bone cells rely on glutamine for this process.
Researchers found that estrogen affects astrocytes, which produce growth factors promoting brain metastasis. Anti-estrogen therapy may prevent brain metastasis in women with triple-negative breast cancer.
Researchers at Ben-Gurion University and Texas Southwestern Medical Center developed AI-powered technology to identify melanoma cells with metastatic potential. The technology uses quantitative live cell histology to record video of cells and analyze their appearance and behavioral patterns.
Ralf Janknecht's research on the molecule DNPH1, overproduced in breast cancer, suggests it could serve as a new drug target for reducing cancer metastasis. The removal of DNPH1 from mouse models resulted in fewer tumors and a tenfold reduction in metastasis.
A new reversible antiplatelet therapy has been developed to reduce blood clots and prevent cancer metastasis. The therapy uses decoy platelets that can bind to cancer cells without activating the normal clotting process, offering a promising new approach to treating diseases.
Researchers developed a reversible antiplatelet therapy using deactivated platelets that can reduce the risk of blood clots and prevent cancer metastasis. By adding fresh platelets, the inhibition of normal platelet activity is rapidly reversed, allowing patients to quickly regain their ability to form blood clots.
Researchers created platelet decoys that prevent blood clots and combat cancer spread, offering a promising new therapy. The fast-reversible approach could one day treat life-threatening bleeding in emergencies or surgical settings.
Researchers discovered that cancer cells growing in lymph nodes prefer to use fatty acids rather than glucose as an energy source. The metabolic adaptation was found to be triggered by the activation of yes-associated protein (YAP), which stimulates fatty acid oxidation in metastatic tumor cells.
Researchers at the University of Basel found that neutrophils help tumor cells form metastases by escorting circulating tumor cells. This alliance enhances their ability to seed metastasis, and blocking it could lead to new anti-metastatic drugs.
Patients treated at minority-serving hospitals have only about two-thirds the odds of receiving palliative care compared to those receiving care at typical hospitals. The study found that racial and ethnic minorities are less likely to receive end-of-life palliative care than their counterparts, regardless of race or ethnicity.
Researchers found a causal connection between MDMX overexpression and triple-negative breast cancer metastasis. The study suggests targeting the MDMX protein could prevent cancer spread, offering potential for new treatments.
Research finds that plerixafor reduces fibrosis and improves response to immunotherapy in mouse models of metastatic breast cancer. Fibrosis blocks effectiveness of immunotherapies, but CXCR4 inhibition enhances immune cell infiltration and decreases formation of spontaneous metastases.
Researchers found that cancer cells switch to brute force and build a protrusion when MMP enzymes aren't available. This allows them to penetrate the basement membrane and invade other organs. The study identified a mitochondrial gene target that could be used to develop new treatments.
Jun Ho Lee, a doctoral student at UNIST, received the grand prize of $10,000 from Merck's 2018 Life Science Awards in Tumor Biology. His research on TonEBP expression in hepatocellular carcinoma has shown promise in predicting patient prognosis and preventing cancer recurrence.
A new PET probe targets melanin pigment in skin cancer lesions to improve detection of primary and metastatic melanoma. The probe shows promising results in clinical trials, outperforming existing methods like 18F-FDG PET/CT scans.
A study found that breast cancers diagnosed in young women within 10 years of giving birth are more likely to metastasize than those diagnosed less recently or not at all. The risk is highest among women up to 10 years postpartum and is most pronounced in stage I or II breast cancer.
A dual COX-2/sEH inhibitor may offer a novel alternative to protect against debris-mediated inflammatory responses, which can lead to tumor survival and growth. The study used mouse models of ovarian cancer to demonstrate the anti-inflammatory compound's effectiveness in suppressing cancer growth.
Researchers at the University of Basel have developed a novel differentiation therapy that converts breast cancer cells into fat cells, impeding the formation of metastases in mice. The therapy combines two active substances, Rosiglitazone and Trametinib, to suppress tumor growth and spread.
Researchers have discovered molecular mechanisms that enable the transmission of a deadly facial tumor among Tasmanian devils. The study found that ERBB receptors and STAT3 proteins play a key role in the transmissibility of the disease, which has killed 90% of the wild population.