Articles tagged with Myocardial Ischemia
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A novel drug target, CD300a, has been identified to suppress immune cell activation and prevent chronic heart and kidney failure after acute tissue injury. The treatment preserves cardiac function and reduces renal fibrosis in mice with genetic deficiency of CD300a.
Patients with atrial fibrillation who live in neighborhoods with poor access to full-service grocery stores face sharply higher odds of stroke and death. Food desert residence is linked to a 2.21-times higher risk of ischemic stroke and a 3.84-times higher risk of death over five years.
Researchers at Sutter Health tested the performance of the American Heart Association's PREVENT equations in diverse Asian and Hispanic subgroups, showing accurate prediction of cardiovascular disease, atherosclerotic CVD, and heart failure events. The study findings aim to improve cardiovascular healthcare for all populations.
A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
Researchers at Uppsala University found that macrophages in injured muscle tissues transform into cells resembling mural cells, promoting restoration of blood flow and healing. This finding highlights the potential for immunotherapies to enhance vascular integrity and tissue repair.
A randomized clinical trial of 1,680 patients with acute ischemic stroke due to large-vessel occlusion found no significant improvement in disability with adjunctive methylprednisolone. The study suggests that methylprednisolone may not be effective as an adjunct therapy after endovascular thrombectomy for this patient population.
The Chinese expert consensus on CMVD diagnosis and treatment emphasizes standardized methods, six areas for classification, and recommendations for non-invasive diagnostic techniques. The consensus also highlights the need for further research into the pathogenesis of CMVD and its impact on cardiovascular events.
A new classification system for heart attacks based on heart muscle damage is released, offering a more differentiated definition and improving understanding of acute atherothrombotic MI. This system has the potential to stratify risk more accurately and lay the groundwork for development of injury-stage-specific therapies.
A new machine learning model developed by University of Pittsburgh researchers uses electrocardiogram (ECG) readings to diagnose and classify heart attacks faster and more accurately than current approaches. The model improves risk assessment, helping patients receive appropriate care without delay.
A new study reveals delayed diagnosis of HoFH leads to premature cardiovascular disease, highlighting the need for increased lipid screening and aggressive treatment. Despite available therapies, most patients require further lipid-lowering treatments.
A recent analysis found a dramatic decline in stroke mortality between 1975 and 2019, but the trend is reversing due to an aging population. Despite this, researchers warn that total stroke fatalities will rise as millennials age, highlighting the need for novel strategies to combat the trend.
A new PET imaging method is more effective than angiograms in determining the need for coronary stents or bypass surgery, according to UTHealth Houston researchers. The study confirms that PET threshold of severity at which stents and bypass surgery improve survival compared to medical treatment alone.
The study found that patients with severe stress-induced myocardial ischemia are likely to benefit from heart bypass surgery or angioplasty, while those with mild or no ischemia are not. Early revascularization was associated with a more than 30 percent reduction in mortality compared to patients treated with medication.
Researchers found smokers have significantly lower A1AT levels, which may reduce cardiac tissue protection during a heart attack. No difference was detected in hypertensive and non-hypertensive individuals.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
A study by the Istituto Neurologico Mediterraneo Neuromed I.R.C.C.S. found that consuming ultra-processed foods significantly increases the risk of a second heart attack or fatal stroke in people with cardiovascular diseases, even if they follow the Mediterranean diet.
Recent research highlights the importance of treating epicardial coronary artery abnormalities that do not result in myocardial ischemia. Aggressive risk factor modification and drug use are recommended for individuals with such conditions.
Researchers found that a specific esmolol-epinephrine ratio can provide cardioprotection while maintaining hemodynamic activity during myocardial ischemia and reperfusion injury. This combination therapy may be beneficial in treating patients with cardiogenic shock or cardiac arrest.
A recent study by researchers at Kumamoto University found that ketone bodies are used at a rate of around 35% in the heart under normal conditions. However, this utilization rate decreases substantially when blood flow to the heart is reduced, highlighting the dynamic nature of energy source switching in the heart.
Researchers discovered that midazolam, a commonly used anesthetic, alters cardiac circadian biology and increases susceptibility to myocardial ischemia. Targeting the circadian rhythm protein Period 2 (PER2) with nobiletin, a flavonoid found in citrus peels, provides significant cardioprotection against MI in a mouse model.
Researchers found that escitalopram reduced mental stress-induced myocardial ischemia by 2.62 times, improving cardiovascular function and reducing platelet serotonin receptor transporters. The study suggests that SSRIs or similar treatments could play a role in managing coronary heart disease.
Researchers developed a method to induce transient ischemia during non-surgical interventional cardiac procedures, boosting adenovector gene transfection by over 100 fold. Cardium Therapeutics' Generx product candidate is being tested in a 100-patient Phase 3 trial for patients with myocardial ischemia and stable angina.
Researchers developed a molecular imaging technique that can detect reduced blood flow in diabetic hearts, potentially saving lives. The study found that this method is safe and beneficial for predicting cardiac events in diabetic patients suspected of having ischemic heart disease.
A study found that bone marrow cell injection significantly improved myocardial perfusion and left ventricular function in patients with chronic ischemia. The treatment also showed greater improvement in exercise capacity and quality-of-life scores, suggesting potential benefits for patients with ischemic heart disease.
Researchers found that spasm of the esophageal smooth muscle may trigger myocardial ischemia, leading to chest pain. The combination of these tests is significant for differential diagnosis, especially with foregut symptoms, and is cost-effective for patients from developing countries.
Researchers are exploring new biomarkers to detect myocardial infarction, which could lead to faster diagnosis and improved treatment outcomes. Currently, cardiac troponin is the gold standard for diagnosing myocardial necrosis, but its limitations include delayed detection and low sensitivity to ischemia.
A recent study found that Asian Americans are seven times more likely to develop silent myocardial ischemia, a condition where plaque buildup restricts blood flow to the heart. Patients may experience fatigue, shortness of breath or palpitations instead of chest pain, emphasizing the need for awareness and early screenings.
A study found that nearly 56% of diabetic patients have stress-induced ischemic defects revealed by SPECT myocardial perfusion imaging, regardless of age or sex. These defects were more prevalent in asymptomatic patients than those with a history of chest pain.
A study found that cardiac stress tests can identify patients at risk of restenosis after stent implantation, with those showing defects experiencing a higher rate of recurrence. The tests also confirmed the efficacy of angioplasty with stent implantation compared to balloon angioplasty.