Research on antibodies and their uses. Covers engineered antitoxin antibodies, long-lasting immunity, monoclonal therapies, and antiviral T cells.
Researchers discovered that jawless and jawed vertebrates share similar immune receptor gene structures despite independent evolution. The findings provide insight into the evolution of the adaptive immune system and its importance for human health.
Researchers found IgE-producing plasma cells abundant in the stomach and duodenum of patients with peanut allergy, highlighting a potential mechanism for severe allergies. The study suggests that targeted prevention of class switch recombination in the gut may be a promising treatment approach for severe peanut allergy.
Research found fever, cold-like symptoms, and miscarriage threats during pregnancy are associated with congenital CMV infection in newborns. Blood tests may not be effective in predicting the likelihood of congenital CMV infection, highlighting the need for clinical factors to identify at-risk pregnancies.
Researchers have described the overall structure of IgE antibodies, a key molecule in allergic diseases. The study provides insights into basic mechanisms of allergic reactions and may lead to more effective treatments.
Scientists from UNIGE and HUG identify monogenic diabetes in 42% of pediatric patients, enabling tailored treatments. The study highlights the need for precision medicine to address chronic hyperglycemia, suggesting a systematic diagnosis approach to minimize long-term complications.
Researchers identify precise receptor chain involved in atopic dermatitis, a condition marked by chronic inflammation and itchy patches of skin. A novel antibody targeting this receptor may serve as a potential therapeutic treatment for the disease.
A new study found that biomarker MOG antibodies can accurately diagnose life-threatening autoimmune conditions in children, leading to complete or near-complete recovery after appropriate treatment. The study involved 535 children with central nervous system demyelinating disorders and encephalitis.
A new study published in The Journal of Allergy and Clinical Immunology found that semaphorin protein contributes to allergic reactions and development of nasal polyps in patients with eosinophilic chronic rhinosinusitis. Elevated levels of semaphorin protein were associated with disease severity.
Researchers developed an antibody cocktail that protects nonhuman primates against the related Sudan ebolavirus through in vitro and rodent studies. The treatment showed effectiveness in protecting against the virus, which has caused eight outbreaks and 412 deaths since 1976.
Researchers have developed mosquitoes that can halt the transmission of the dengue virus, targeting four known types of the disease. The engineered mosquitoes use a human antibody to hinder virus replication and prevent transmission to humans.
A new Penn Medicine study developed an mRNA vaccine that successfully protected young mice against influenza and other pathogens in the presence of maternal antibodies. The vaccine worked by continuously producing antigens, eliciting a prolonged immune response.
A new study has established a framework for measuring protein glycosylation, a process critical to the development of safe and effective antibody-based drugs. By pooling data from various labs, researchers have created consensus estimates of glycan composition, shedding light on the variability in measurement techniques.
Researchers have discovered a novel combination of antibodies that significantly enhances the effectiveness of cancer immunotherapy, particularly in 'cold' tumors. The combination stabilizes tumor blood vessels and strengthens the immune system, leading to improved tumor tissue destruction.
A new study has identified key mutations that affect Factor H binding protein (FHbp) on the surface of the meningococcus bacterium, which could lead to improved vaccines. The findings have major implications for current meningococcal group B vaccines, Trumenba and Bexsero.
A team of researchers at the University of Rome Tor Vergata has developed a novel approach to build and dismantle DNA nanostructures using antibodies. They engineered DNA bricks with recognition tags that assemble in the presence of specific antibodies, enabling the creation of intelligent nanostructures with potential applications in ...
Researchers from the La Jolla Institute for Immunology identified a new role for HMCES in alternative end-joining, a secondary strategy used by mammalian cells to rejoin severe cuts across both strands of DNA. This discovery suggests that HMCES is versatile enough to accomplish entirely different tasks in response to DNA damage.
Researchers found that a plant-based compound called halofuginone improves the immune response to a potential dengue vaccine in mice, producing twice as many antibodies and binding more strongly. The compound mimics amino acid starvation, activating a pathway that results in better antibodies.
Researchers developed a rapid diagnostic method for detecting celiac disease antibodies, offering a promising solution to overcome the vast underdiagnosis of this condition. The new method, called RFS, can provide results in less than half an hour, significantly reducing the time and complexity of current testing procedures.
Researchers at Karolinska Institutet developed a new method to separate between two types of herpes virus 6A and 6B, found that MS-patients carry the virus 6A to a greater extent than healthy individuals, and that HHV-6A may be contributing factor to multiple sclerosis development
Researchers discovered that malaria infection triggers the production of highly potent antibodies through strong inflammatory signals, which could be harnessed for new vaccines and therapies against hepatitis C and HIV. The immune system's response to malaria is distinct from chronic viral infections and autoimmune diseases.
Researchers at the University of Sheffield have identified an antibody that can potentially become a new treatment for pulmonary arterial hypertension. Treatment with this specific antibody was found to reverse the process behind PAH development, showing promise for clinical development.
A team of researchers identified protective antibodies against severe malaria in children, paving the way for a potential vaccine. The discovery uses genomic sequencing and machine learning to pinpoint specific proteins and antibodies that provide immunity.
A new antibody treatment has shown promising results in a small pilot study, allowing participants with severe peanut allergies to eat a modest amount of peanut protein within 15 days. The treatment's effects lasted for up to 45 days, providing a potential breakthrough for food allergy treatments.
Researchers have identified key antibodies that can protect against severe forms of malaria, providing hope for the development of an effective vaccine. The study's findings, published in Cell Host & Microbe, show promise for new approaches to combatting the disease.
Researchers at Wyss Institute develop 'eRapid' technology enabling low-cost, handheld electrochemical devices to detect a range of biomarkers with high sensitivity and selectivity. The platform overcomes biofouling problem with simple yet robust design, allowing mass-production of biochemical sensors at low cost.
Scientists designed a novel approach to create stable and predictable antibody drug conjugates (ADCs) using computational docking molecular simulations. The new therapy, called MAGNET-ADC, can deliver cancer drugs specifically to tumor tissue with reduced toxicity.
Researchers at Boston Medical Center identified specific virus characteristics that can help predict the efficacy of HIV-1 treatments using antibody-based treatments. These findings will enable physicians to make better-informed decisions on treatment plans for patients with HIV-1, ultimately treating the virus to slow it down earlier.
A study published in Pediatric Allergy and Immunology found that 17% of children with food allergies are also allergic to sesame. The researchers developed a mathematical model to predict sesame allergy in children with food allergies, which could help clinicians identify this common allergy.
Researchers at Cornell University have developed a technique using fluorescent probes to study the performance of molecules inside living cells. The probes can accurately measure the rate at which linkers release drugs in cells, enabling pharmaceutical companies to make informed decisions about drug delivery systems.
A recent study published in Science reveals that measles virus infection can eliminate up to 73% of a child's protective antibodies, rendering them defenseless against other viruses. The discovery underscores the importance of widespread vaccination and highlights the potential consequences of measles infection on the immune system.
In unvaccinated children, measles infection can cause a significant weakening of the immune system, leading to impaired immunity against viruses and bacteria for months or even years. This phenomenon, known as 'immune amnesia,' was observed in two separate studies published in Science Immunology and Science.
Researchers found filovirus antibodies in 5.9% of human samples and up to 13.3% of bat species, including those with Ebola virus, Bundibugyo virus, Sudan virus, Marburg virus, and Mengla virus antibodies. The study highlights the need for surveillance at the human-animal interface.
Researchers at Scripps Research have found an antibody that protects against a wide range of influenza viruses by targeting the neuraminidase protein. The discovery could lead to the development of a universal flu vaccine that offers broad protection against human, swine, and avian strains.
A newly discovered antibody protects mice against a wide range of lethal influenza viruses, representing human, swine, and avian strains. The antibody could serve as a template to design a universal flu vaccine and treat severe cases of flu.
Scientists demonstrate flaws in protein detection tools and outline a solution to improve antibody validation. The study highlights the need for accurate standard processes to test antibody quality.
Scientists have decoded the immune response to the Ebola vaccine, revealing a broad range of antibodies against the virus. The research, led by Prof. Klein, found that different sites on the envelope protein of the virus were recognized and many antibodies exhibited high neutralising activity.
A UK-wide collaboration has identified a genetic variant carried by 40% of the population that explains why some patients develop antibodies against anti-TNF drugs and lose response. This discovery could lead to individualized treatment strategies for patients with Crohn's disease.
Researchers at the Hubrecht Institute have created a new method called GateID that allows for the purification of cell types to high purity without using antibodies or genetic reporters. This enables the detailed study of individual cell types, such as stem cells and tumor cells, which are crucial for understanding their properties and...
Researchers found that blocking interleukin-11 protein with therapeutic antibodies can reverse lung fibrosis in a mouse model. This discovery holds promise for treating idiopathic pulmonary fibrosis (IPF), a life-threatening lung disease. Clinical trials are expected to begin by 2021.
Researchers have developed a laser incubator for blood that can slash incubation time to just 40 seconds, improving pre-transfusion testing and saving lives. This technology has the potential to prevent fatal blood transfusions in critically ill patients and detect antibodies in pregnant women.
A new study in Nature explores the role of chromatin loops in V(D)J recombination, a gene assembly process that generates diverse antibodies. The research reveals how cells exploit loop formation to mix and match genetic code, leading to the creation of new antibodies.
Researchers have developed a technique to make sheep produce new antibodies by injecting DNA building blocks, offering a cheaper and more efficient approach than industrial production. This breakthrough brings the study of antibody gene therapy closer to clinical use.
Researchers at U of T have developed growth factor-mimicking antibodies that can induce tissue repair in the body. The antibodies, called FLAgs, mimic key proteins called Wnt that normally instruct stem cells to form tissue.
Researchers have identified key immunological changes in people who develop a meat allergy triggered by tick bites, which can lead to mild hives or life-threatening anaphylaxis. The study provides important insights into why otherwise healthy individuals can suddenly become allergic to mammalian meat.
New research suggests that the risk of developing microcephaly due to Zika virus infection depends on the types of antibodies produced by pregnant mothers. Antibodies from mothers of babies with microcephaly are more effective at neutralizing the virus, but also show enhanced ability to boost viral entry into human cells.
Researchers found that antibodies generated against the Zika virus itself may contribute to birth defects in some pregnancies. The study suggests that a safe vaccine would need to induce protective antibodies while avoiding those that increase the risk of microcephaly.
A study led by ISGlobal found that vaccination with RTS,S increases levels of antibodies recognizing 'P. falciparum' antigens not included in the vaccine, potentially leading to natural immunity. This effect was observed mainly in regions with low to moderate transmission levels.
Consuming more gluten during early childhood is associated with higher risk of celiac disease and autoimmunity among genetically predisposed children. The study found a significant increase in risk for every 1-gram per day increase in gluten consumption.
A new study finds that enterovirus antibodies were detected in the cerebrospinal fluid of most patients with acute flaccid myelitis, suggesting a possible link between the two conditions. The research provides further evidence that enterovirus infection may be a factor in AFM.
Researchers at KU Leuven have developed a non-invasive biomarker for detecting kidney transplant rejection symptoms after a transplant due to antibody-mediated rejection. The new blood test can identify patients with rejection symptoms earlier and more accurately than current methods, which often rely on invasive biopsies.
A new combination treatment regimen enhances the immune system's ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to attract natural killer immune cells to cancer cells, resulting in increased killing of acute lymphoblastic leukemia cells by up to 35%.
A novel microfluidics-based system detects clinically significant IL-6 levels for sepsis diagnosis in about 25 minutes using less than a finger prick of blood. This device provides a more sensitive and efficient alternative to traditional assays.
Mount Sinai researchers have developed a novel vaccine consisting of DNA and recombinant proteins, which was tested in monkeys and induced antibodies similar to those associated with protection from HIV. The vaccine targets the V1V2 loop of the gp120 envelope protein and showed strong protective effects against HIV infection.
Scientists have developed a novel nanoparticle formulation targeting PD-L1 with high specificity, allowing for improved infiltration of T cells into tumors and increased sensitivity to checkpoint blockade. This approach achieved an 80% mouse survival rate over 70 days, outperforming traditional antibody therapies.
Scientists developed a tumor-activatable antibody nanoparticle to overcome immunological tolerance in tumors. The nanoparticle releases PD-L1, triggering tumor antigen release and CTL infiltration, leading to efficient antitumor immunity and long-term immune memory effects.
A recent study has discovered that IgG antibodies can contribute to drug-induced anaphylactic shock by activating neutrophils, leading to high doses of vasodilating mediators. This finding explains up to 10-20% of previously unexplained cases and may help improve diagnosis and treatment for patients with this condition.
A new antibody treatment for high-frequency migraines has been found to be ineffective in reducing headache frequency among patients. Only six out of 28 patients reported a reduction of at least 25 percent in headache days, with none achieving a 50 percent reduction.
Researchers have identified a new pathological mechanism responsible for 10-20% of unexplained anaphylactic cases involving IgG antibodies that activate neutrophils, releasing harmful vasodilating mediators. This discovery may help improve diagnosis and treatment for patients with anaphylactic shock.
Scientists have discovered a newly found function of the US11 protein that impairs antibody immunity, allowing human cytomegalovirus (HCMV) to evade white blood cells and potentially leading to birth defects and immune system dysfunction. This breakthrough has significant therapeutic prospects for treating autoimmune diseases like lupus.
Scientists have identified a novel pathway allowing subcutaneously administered antibodies to bypass the immune system's traditional route. This breakthrough discovery enables targeted delivery of antibodies to the draining lymph node, potentially revolutionizing treatments for inflammatory diseases and cancers.