Research on antibodies and their uses. Covers engineered antitoxin antibodies, long-lasting immunity, monoclonal therapies, and antiviral T cells.
A new therapy has shown promise in promoting vascular repair following a stroke, leading to improved motor functions and regeneration of damaged blood vessels. Researchers used anti-Nogo-A antibodies in mice and found better recovery and reduced motor function impairment compared to control groups.
Blocking Nogo-A increases newly formed blood vessels and improves motor tasks, neuronal survival, dopamine levels, and nerve fiber density after ischemic stroke. Anti-Nogo-A antibodies may represent a therapeutic strategy for ischemic stroke recovery.
Research found associations between serum antibodies against P. gingivalis and A. actinomycetemcomitans with altered metabolite levels, including lipoprotein particles and fatty acids. These findings suggest exposure to periodontal pathogens may contribute to a proatherogenic state.
Researchers identified factors contributing to placental transfer of antibodies, including a preference for NK-activating antibodies that activate natural killer cells. This knowledge can be used to develop more effective maternal vaccines and deliver them during pregnancy to protect newborns from serious diseases like polio.
Researchers at the University of Oxford have identified protective antibodies against malaria, which may lead to a highly effective vaccine. The study found that specific antibodies can block the malaria parasite's ability to bind to red blood cells.
A genome-wide search has revealed genetic variants linked to varying antibody levels after childhood vaccines, potentially informing personalized vaccine strategies. The study identifies two genetic loci associated with the persistence of vaccine-induced immunity.
A study published in Nature Medicine finds that targeting the stalk of the flu virus provides protection against infection. Researchers analyzed naturally occurring influenza cases and found that individuals with higher levels of stalk antibodies had a reduced risk of getting sick, correlating with a 42% reduction in influenza infection.
Researchers discovered Charcot-Leyden Crystals are abundant in airway mucus, stimulate immune system and promote inflammation, which can be treated with newly developed antibodies. These antibodies can dissolve the crystals to reduce asthma features.
Researchers developed a 3D-printed pipette-tip test that leverages the enzyme-linked immunosorbent assay (ELISA) method. The new technology significantly reduces testing costs and time, allowing for faster diagnosis and potentially making medical testing available in rural or remote areas.
Researchers have discovered a human antibody that recognizes and disrupts a vulnerable region on the hemagglutinin protein of the influenza virus. This breakthrough could lead to the development of effective vaccines against multiple strains of the virus, potentially eliminating the need for annual seasonal flu vaccination.
A study by ISGlobal and colleagues found that the RTS,S vaccine's protective effect increases with the strength of antibodies, not just their quantity. Children tend to have better protection due to higher avidity responses.
Researchers found widespread inconsistencies in antibody use, causing unreliable results and wasting $2 billion per year. They call for industry-wide standards to validate antibodies, especially in human tissue research.
Researchers used VirScan to detect antibodies against viruses in kidney transplant recipients and found results concordant with conventional viral screening. Antibody responses remained largely unchanged one year after transplantation, suggesting a safe and reproducible approach to monitor post-transplant viral infections.
Researchers at Aarhus University and Novo Nordisk have developed a novel method for connecting proteins to DNA structures, enabling the assembly of large multi-antibody-like nanostructures. This innovation has potential applications in enhancing traditional therapies and understanding biological mechanisms.
Researchers have generated two antibodies that potentially could be used in a simple filter paper test to detect Ebola virus. The study, published in the American Journal of Tropical Medicine & Hygiene, marks a breakthrough in diagnosing Ebola and Marburg viruses, which can cause severe bleeding and organ failure with high fatality rates.
A study found that children who developed de novo donor-specific antibodies (dnDSA) after kidney transplant had thicker carotid intima-media layers than those without these antibodies. Being African American was also associated with increased CIMT in transplant recipients.
Researchers developed protein catalyzed capture technology to improve receptor stability and manufacturability for wearable sensor applications. The technology enables real-time monitoring of Soldier health and performance, as well as sensing environmental threats.
Researchers developed a statistical method to quantify changes in environmental systems, finding La Nina winters favor mountain snowpack. Scientists also invented synthetic antibodies that could improve disease detection and toxin identification.
Researchers at the University of Zurich have developed a simple and fast method for radiolabelling antibodies against breast cancer using UV light. The new procedure allows for the production of radioactive drugs and diagnostic agents in under 20 minutes, making it a game-changer for PET imaging and targeted radioimmunotherapy.
Researchers at the NIH have made progress toward developing an EBV vaccine by identifying key antibodies that block infection. The new vaccine candidates elicited potent anti-EBV antibody responses in animals, offering potential protection against EBV-associated cancers and infectious mononucleosis.
Researchers at Colorado State University developed a technology that can detect extremely small amounts of antibodies in a person's blood, allowing for faster diagnosis and treatment. The new sensor can detect as few as 10 antibody molecules within 20 minutes, making it more sensitive than current medical testing methods.
A joint team from Hokkaido University and Keio University has identified a key player in the gut defense mechanism of infants, a protein called Sox8. This discovery could help understand how infants develop their own intestinal immune systems after weaning.
A Stanford University School of Medicine study found that blocking a specific protein's activity improved cognitive behavior in aging mice. The researchers identified a gene called CD22, which is involved in microglial phagocytosis and is upregulated with age.
Scientists have discovered that white blood cells enter the spleen primarily via vessels in the red pulp and migrate to other structures. The Clever-1 molecule controls this process, also regulating antibody-producing white blood cell expression.
Scientists have developed edible antibodies that can survive digestion and reach the gut, offering an alternative to traditional treatments. The technology has potential applications in fighting gut infections, treating inflammatory disorders, and preventing diarrhea in pigs and humans.
A large study published in The New England Journal of Medicine found that treating women with thyroid antibodies and normal thyroid function with Levothyroxine did not improve the chances of live birth. The study showed similar outcomes in both groups, with 56.6% and 58.3% becoming pregnant, respectively.
A large study led by the University of Birmingham found that treating women with normal thyroid function and thyroid peroxidase antibodies with Levothyroxine did not increase live-birth rates. The researchers suggested that previous recommendations to use Levothyroxine in these women may have been based on limited evidence.
Researchers found that IgG antibodies play a crucial role in stabilizing arterial plaques, reducing the risk of rupture and clotting. The study suggests that these antibodies may be a new target for mitigating atherosclerosis and improving cardiovascular health.
A study published in Cell Host & Microbe found that antibodies from previous exposures to flu viruses can enhance the immune system's response to new strains, potentially reducing the need for annual vaccinations. The researchers discovered that more than 70% of persistent antibodies targeted invariant parts of the virus.
A study by researchers at Karolinska Institutet found that very premature babies carry anti-viral antibodies transferred from the mother, suggesting a previously underappreciated source of protection. The analysis also revealed that the protection offered by these antibodies lasts different durations depending on the virus.
Researchers from German Cancer Research Center have successfully reconstructed biomolecules in their mirror-image form. This breakthrough could lead to the creation of mirror-image therapeutic proteins that are protected from biological breakdown and do not provoke immune responses.
Researchers have made a breakthrough in understanding antibody-mediated rejection, a major challenge in organ transplantation. They discovered the critical amino acids and binding site of alloantibodies on HLA molecules, providing new avenues for developing therapies to prevent or treat this type of rejection.
Researchers discover that targeting a specific protein called neuraminidase (NA) in flu vaccines can induce a broader protective response against influenza type B viruses. This finding suggests a potential way to boost the efficacy of current vaccines and develop a universal flu vaccine.
Researchers at the Weizmann Institute of Science discovered that gut immune cells operate under harsh conditions and use a more socialistic principle to select B cells with varying levels of antibody affinity. This unique process may lead to the development of more effective oral vaccines.
Researchers examined antibody isotype and B cell receptor composition in young children, finding associations between environmental exposures and increased somatic hypermutation frequencies. This study sheds light on the complex relationships between environmental factors and immune system development in childhood.
A new machine-learning algorithm uses cholera antibody test results to identify recently infected individuals, making it easier to detect deadly epidemics. The algorithm was tested on a dataset of 1,569 blood samples and showed high accuracy in estimating the time window for cholera infection.
Researchers at NYU Langone Health have found a strong link between systemic lupus erythematosus (SLE) and an abnormal mix of bacteria in the gut. The study showed that patients with SLE had significantly higher levels of Ruminococcus gnavus bacteria in their guts, which triggered immune reactions and disease flares.
The elderly are more susceptible to the flu due to a lack of antibody diversity, which reduces their ability to adapt to new viral strains. Antibodies from elderly individuals target only conserved proteins and structures, making it harder for them to protect against evolving viral strains.
Artist Heather Dewey-Hagborg collaborated with scientists to create a custom virus that increases oxytocin production, associated with feelings of love and empathy. The 'Lovesick' virus is a harmless, non-replicating vector that expresses the hormone oxytocin and a fluorescent protein, allowing cells to glow bright red.
Researchers at Stanford University School of Medicine developed an antibody-based treatment that gently eliminates diseased blood-forming stem cells in the bone marrow. This could circumvent the need for harsh chemotherapy or radiation to prepare people for transplant, expanding the number of patients who can benefit from the procedure.
Researchers at Bar-Ilan University developed a computational tool to analyze genetic variations in immune system genes, revealing a rich pattern of deletions and duplications. This discovery sheds light on the critical importance of these genomic regions for understanding the immune system and predicting diseases.
A study by La Jolla Institute for Immunology finds that recurrent group A strep tonsillitis is caused by a combination of genetic and immunological factors, including an insufficient antibody response against SpeA. This understanding may lead to the development of a vaccine to protect against strep throat.
Researchers developed an antibody to target TDP-43 protein aggregates in mouse brains, resulting in significant improvements in cognitive and motor performance. The breakthrough paves the way for immunotherapy development for ALS and frontotemporal dementias.
Researchers at the National Institutes of Health have discovered that antibodies targeting the hemagglutinin protein on influenza viruses also inhibit the neuraminidase enzyme. This inhibition enhances antibody neutralization and activation of innate immune cells with anti-viral activity. The study suggests a promising approach for uni...
Researchers at LSTM and Imperial College London have designed drugs that target the receptors of human cells to combat flu pandemics. The engineered biologicals block interactions between influenza viruses and human cells, offering a potential solution to deadly strains.
Researchers highlight diagnostic pitfalls in Zika and Chikungunya virus detection, particularly for Zika, where false positives can have fatal consequences. Combined testing methods offer higher reliability, with sensitivity improved through the use of Immunoglobulin A (IgA) as a marker.
Scientists have developed a precise measuring tool using DNA origami to optimize antibody effectiveness, with distances of approximately 16 nanometres providing the strongest bond. This technology can help better understand the immune response and design more effective antibodies for vaccines and immunotherapy.
Scientists have identified natural antibodies within protein corona that trigger immune system response to nanoparticles. Depleting these antibodies reduces complement system activation, enabling safe delivery of cancer-fighting drugs and imaging agents.
A new study of twins found that genetic factors significantly impact the body's immune defense networks. The researchers analyzed blood samples from 1835 twins and thousands of siblings to understand how effectively their bodies deploy disease-fighting molecules.
Researchers at the University of Nebraska-Lincoln have identified a potential Zika vaccine that induces strong T-cell responses and substantial protection without producing antibodies. This breakthrough could be a 'huge leap' for immunology, potentially overcoming the obstacle of antibody-dependent enhancement (ADE) of disease.
Researchers have developed monoclonal antibodies effective against several synthetic opioids, including fentanyl and carfentanil. The vaccine could help combat opioid addiction and reduce overdose deaths by blocking the analgesic effects of these potent drugs.
Researchers have developed a new technique using antibodies cloned from patients who recovered from Candida infections, showing potential in treating and diagnosing these life-threatening fungal infections. The discovery could lead to the development of novel antifungal drugs through mycoBiologics, a spinout company.
The ESMO Immuno-Oncology Congress highlighted promising new technologies for cancer treatment, including multiplex immunohistochemistry and bispecific antibodies. Chimeric antigen receptor T-cell therapy and neoantigen therapeutics also showed promise in treating a greater proportion of patients with cancer.
Researchers at VCU are testing a vaccine that blocks heroin and fentanyl effects in patients with opioid use disorder. The vaccine prompts the immune system to generate anti-opioid antibodies, preventing drug molecules from crossing the blood brain barrier.
Scientists at Harvard University and Brigham and Women's Hospital developed a new immunoassay technique that measures extremely low concentrations of small molecules using single-molecule detection. The method was tested on two important human body molecules, cortisol and PGE2, achieving up to 50 times greater sensitivity than conventi...
Researchers have generated six Zika virus antibodies that could be used to diagnose and potentially treat the mosquito-borne disease. The neutralizing property of these antibodies prevents the virus from infecting cells, rendering it harmless.
Researchers at German Primate Center found that MERS virus mutations make it more resistant to the human immune system. This could lead to a rise in severe cases and potentially trigger a pandemic.
A new study found that maternal Zika immunity can increase the severity of dengue disease in mouse pups, which has significant implications for vaccine development. The study suggests that a pan-flavivirus vaccine could be an effective way to elicit maximal protection against both diseases.
Researchers at Scripps Research have discovered a potential new approach to prevent influenza virus infections by tethering four antibodies together, showing cross-reactivity against all types of influenza. The therapeutic candidate has been shown to offer protection against multiple strains of the virus in mice.
A novel immunotherapy combining Hu5F9-G4 and rituximab has shown safety and promise in a phase-1 clinical trial for non-Hodgkin's lymphoma. Half of the 22 patients enrolled experienced a positive response, with eight going into complete remission.