Articles tagged with Antibodies
A new COVID-19 vaccine has demonstrated safety and a rapid immune response in a phase 1 clinical trial involving 108 healthy adults. The Ad5-nCoV vaccine produced virus-specific antibodies and T cells in 14 days, with the majority of recipients showing either a positive T cell response or had detectable neutralising antibodies against ...
Researchers at Hokkaido University developed a new method to detect anti-avian influenza virus antibody, which could be used to detect antibodies against SARS-CoV-2. The technology uses a portable fluorescence polarization analyzer that can examine multiple samples and detect the antibody in just 20 minutes.
Prellis Bio successfully generated 300 human IgG antibodies against SARS-CoV2, leveraging its Externalized Human Immune System technology. This achievement demonstrates the potential of the technology for rapid antibody production, reducing time to one month compared to traditional methods.
Serological tests provide snapshot of infection history and immunity in populations. However, they are insufficient for issuing 'immune passports' due to limited specificity, and may lead to biases in testing practices.
Antibody tests are good enough to monitor COVID-19 spread and guide policy decisions, but understanding test characteristics is crucial for accurate results. By fine-tuning existing tests, policymakers can make informed decisions about interventions and population protection.
Serological assays detect SARS-CoV-2-specific antibodies in recovered individuals' blood, informing prevalence and immunity questions. Studies must better address the limitations of these tools to inform accurate decisions about deploying the workforce.
Researchers at Indiana University School of Medicine tracked COVID-19 spread in a pediatric dialysis unit using antibody testing on patients, staff, and healthcare workers. The study found a high occurrence of COVID-19 antibodies among individuals interacting in the unit, suggesting that more healthcare workers may be antibody-positive.
Researchers at EPFL have developed an algorithm to design artificial proteins that precisely guide the body's immune system to produce specific antibodies. The proteins were tested in animal models, triggering a strong immune response against respiratory syncytial virus (RSV), a leading cause of serious lung infections.
Researchers stress importance of detecting neutralizing antibodies in recovered patients. Studies on animal models inform vaccine design to prevent severe disease and death. Professor Subbarao draws parallels between SARS and COVID-19 viruses.
A newly developed inactivated SARS-CoV-2 vaccine candidate protected macaques from infection and neutralized multiple virus strains without ADE risk. Clinical trials with the PiCoVacc are expected to begin later this year.
Cima Universidad de Navarra researchers have developed a novel method for detecting COVID-19, achieving over 95% sensitivity in asymptomatic cases. The platform uses a ribonucleic acid (RNA) extraction method that allows for large-scale processing of samples, enabling efficient testing of populations.
Researchers identified a significant fraction of antibodies expressed by B cell plasmablasts circulating after DENV infection, particularly in individuals experiencing their first infection. This finding holds promise for developing new diagnostic tools and a safe, efficacious dengue vaccine.
Researchers at Washington State University have identified a key protein in Borrelia burgdorferi that shields the immune system from fighting Lyme disease. By understanding this 'VlsE' protein, they hope to develop effective vaccines against the disease.
Researchers linked two llama antibodies to create a new antibody that binds tightly to the SARS-CoV-2 spike protein, blocking viruses from infecting cells. The team aims to conduct preclinical studies and eventually test the treatment in humans to develop a potential COVID-19 therapy.
A fast and sensitive antibody test for SARS-CoV-2 has been developed by researchers at the American Chemical Society. The test can accurately diagnose COVID-19 cases and monitor patient recovery in just 10 minutes.
Researchers have developed synthetic antibodies using bacterial superglue that can neutralize potentially lethal viruses like bunyaviruses. The antibodies were combined to form complexes that efficiently protected mice from the viruses.
A RIKEN research team developed a new 3D staining technique that can visualize whole organs and bodies. The technique allows for detailed anatomical analysis and whole-organ comparisons between species at the cellular level.
A new diagnostic strategy has been developed by Brazilian researchers to detect biomarkers of early-stage multiple sclerosis. The method uses a nanobiosensor that can accurately identify specific antibodies in cerebrospinal fluid and blood serum, allowing for early diagnosis and treatment.
Researchers have identified a promising new strategy for combating malaria by targeting the parasite's 'kill switch' with PfGARP antibodies. The approach, which involves generating anti-PfGARP antibodies or directly infusing them into individuals, has shown promise in nonhuman primates and holds hope for preventing severe malaria.
Scientists at Queen Mary University of London have discovered a link between a specific immune system protein and obsessive compulsive disorder (OCD). Treating mice with an antibody that neutralised the protein reduced anxiety levels, suggesting a potential new treatment for human patients.
A new diagnostic method for allergic rhinitis has been developed using nasal smears, providing a gentle alternative to blood tests. The method detected identical allergic sensitization patterns in both blood and nasal secretions for a wide range of airborne allergens.
Researchers have developed an antibody treatment that improves survival in rodent models of sepsis by targeting a protein called tetranectin. The therapy boosts survival even when started late after sepsis onset, suggesting its potential for treating severe bacterial infections and secondary sepsis in COVID-19 patients.
Scientists at the University of Leeds and AstraZeneca developed a technique to screen antibody fragment susceptibility to aggregation caused by structure disruption much earlier in drug discovery. This approach increases the chances of success by selecting protein sequences that can withstand industrial-scale manufacturing stresses.
The study found significant increases in antinuclear antibody prevalence in the US population, particularly among males and adolescents. The researchers suggest changes in lifestyle or environment may be involved in these increases.
A study conducted in northwestern São Paulo found that nearly a third of the population under 40 lacked immunity against measles, with only 1% over 50 showing similar results. Vaccination remains essential in preventing transmission and controlling outbreaks.
A new vaccine candidate, PittCoVacc, has generated a surge of antibodies against SARS-CoV-2 within two weeks of injection. The vaccine follows a more established approach, using lab-made viral protein pieces to build immunity, and is delivered through a novel microneedle array that can be manufactured at scale.
Scientists at Berkeley Lab have discovered a natural mosquito-killing compound that could lead to safer and more effective anti-mosquito products. Researchers have also made progress on developing fast-charging batteries and created a new library of artificial antibodies with molecular precision.
The study reveals that jawless and jawed vertebrates share similar adaptive immune systems, despite independent evolution for over 500 million years. The researchers used CRISPR/Cas9 to disable a gene in lampreys, showing that they rely on a shared tool-kit to create antibodies.
Researchers discovered that jawless and jawed vertebrates share similar immune receptor gene structures despite independent evolution. The findings provide insight into the evolution of the adaptive immune system and its importance for human health.
Researchers found IgE-producing plasma cells abundant in the stomach and duodenum of patients with peanut allergy, highlighting a potential mechanism for severe allergies. The study suggests that targeted prevention of class switch recombination in the gut may be a promising treatment approach for severe peanut allergy.
Research found fever, cold-like symptoms, and miscarriage threats during pregnancy are associated with congenital CMV infection in newborns. Blood tests may not be effective in predicting the likelihood of congenital CMV infection, highlighting the need for clinical factors to identify at-risk pregnancies.
Researchers have described the overall structure of IgE antibodies, a key molecule in allergic diseases. The study provides insights into basic mechanisms of allergic reactions and may lead to more effective treatments.
Scientists from UNIGE and HUG identify monogenic diabetes in 42% of pediatric patients, enabling tailored treatments. The study highlights the need for precision medicine to address chronic hyperglycemia, suggesting a systematic diagnosis approach to minimize long-term complications.
Researchers identify precise receptor chain involved in atopic dermatitis, a condition marked by chronic inflammation and itchy patches of skin. A novel antibody targeting this receptor may serve as a potential therapeutic treatment for the disease.
A new study found that biomarker MOG antibodies can accurately diagnose life-threatening autoimmune conditions in children, leading to complete or near-complete recovery after appropriate treatment. The study involved 535 children with central nervous system demyelinating disorders and encephalitis.
A new study published in The Journal of Allergy and Clinical Immunology found that semaphorin protein contributes to allergic reactions and development of nasal polyps in patients with eosinophilic chronic rhinosinusitis. Elevated levels of semaphorin protein were associated with disease severity.
Researchers developed an antibody cocktail that protects nonhuman primates against the related Sudan ebolavirus through in vitro and rodent studies. The treatment showed effectiveness in protecting against the virus, which has caused eight outbreaks and 412 deaths since 1976.
Researchers have developed mosquitoes that can halt the transmission of the dengue virus, targeting four known types of the disease. The engineered mosquitoes use a human antibody to hinder virus replication and prevent transmission to humans.
A new Penn Medicine study developed an mRNA vaccine that successfully protected young mice against influenza and other pathogens in the presence of maternal antibodies. The vaccine worked by continuously producing antigens, eliciting a prolonged immune response.
A new study has established a framework for measuring protein glycosylation, a process critical to the development of safe and effective antibody-based drugs. By pooling data from various labs, researchers have created consensus estimates of glycan composition, shedding light on the variability in measurement techniques.
Researchers have discovered a novel combination of antibodies that significantly enhances the effectiveness of cancer immunotherapy, particularly in 'cold' tumors. The combination stabilizes tumor blood vessels and strengthens the immune system, leading to improved tumor tissue destruction.
A new study has identified key mutations that affect Factor H binding protein (FHbp) on the surface of the meningococcus bacterium, which could lead to improved vaccines. The findings have major implications for current meningococcal group B vaccines, Trumenba and Bexsero.
A team of researchers at the University of Rome Tor Vergata has developed a novel approach to build and dismantle DNA nanostructures using antibodies. They engineered DNA bricks with recognition tags that assemble in the presence of specific antibodies, enabling the creation of intelligent nanostructures with potential applications in ...
Researchers from the La Jolla Institute for Immunology identified a new role for HMCES in alternative end-joining, a secondary strategy used by mammalian cells to rejoin severe cuts across both strands of DNA. This discovery suggests that HMCES is versatile enough to accomplish entirely different tasks in response to DNA damage.
Researchers found that a plant-based compound called halofuginone improves the immune response to a potential dengue vaccine in mice, producing twice as many antibodies and binding more strongly. The compound mimics amino acid starvation, activating a pathway that results in better antibodies.
Researchers developed a rapid diagnostic method for detecting celiac disease antibodies, offering a promising solution to overcome the vast underdiagnosis of this condition. The new method, called RFS, can provide results in less than half an hour, significantly reducing the time and complexity of current testing procedures.
Researchers at Karolinska Institutet developed a new method to separate between two types of herpes virus 6A and 6B, found that MS-patients carry the virus 6A to a greater extent than healthy individuals, and that HHV-6A may be contributing factor to multiple sclerosis development
Researchers discovered that malaria infection triggers the production of highly potent antibodies through strong inflammatory signals, which could be harnessed for new vaccines and therapies against hepatitis C and HIV. The immune system's response to malaria is distinct from chronic viral infections and autoimmune diseases.
Researchers at the University of Sheffield have identified an antibody that can potentially become a new treatment for pulmonary arterial hypertension. Treatment with this specific antibody was found to reverse the process behind PAH development, showing promise for clinical development.
A team of researchers identified protective antibodies against severe malaria in children, paving the way for a potential vaccine. The discovery uses genomic sequencing and machine learning to pinpoint specific proteins and antibodies that provide immunity.
A new antibody treatment has shown promising results in a small pilot study, allowing participants with severe peanut allergies to eat a modest amount of peanut protein within 15 days. The treatment's effects lasted for up to 45 days, providing a potential breakthrough for food allergy treatments.
Researchers have identified key antibodies that can protect against severe forms of malaria, providing hope for the development of an effective vaccine. The study's findings, published in Cell Host & Microbe, show promise for new approaches to combatting the disease.
Researchers at Wyss Institute develop 'eRapid' technology enabling low-cost, handheld electrochemical devices to detect a range of biomarkers with high sensitivity and selectivity. The platform overcomes biofouling problem with simple yet robust design, allowing mass-production of biochemical sensors at low cost.
Scientists designed a novel approach to create stable and predictable antibody drug conjugates (ADCs) using computational docking molecular simulations. The new therapy, called MAGNET-ADC, can deliver cancer drugs specifically to tumor tissue with reduced toxicity.
Researchers at Boston Medical Center identified specific virus characteristics that can help predict the efficacy of HIV-1 treatments using antibody-based treatments. These findings will enable physicians to make better-informed decisions on treatment plans for patients with HIV-1, ultimately treating the virus to slow it down earlier.
A study published in Pediatric Allergy and Immunology found that 17% of children with food allergies are also allergic to sesame. The researchers developed a mathematical model to predict sesame allergy in children with food allergies, which could help clinicians identify this common allergy.
Researchers at Cornell University have developed a technique using fluorescent probes to study the performance of molecules inside living cells. The probes can accurately measure the rate at which linkers release drugs in cells, enabling pharmaceutical companies to make informed decisions about drug delivery systems.
A recent study published in Science reveals that measles virus infection can eliminate up to 73% of a child's protective antibodies, rendering them defenseless against other viruses. The discovery underscores the importance of widespread vaccination and highlights the potential consequences of measles infection on the immune system.
In unvaccinated children, measles infection can cause a significant weakening of the immune system, leading to impaired immunity against viruses and bacteria for months or even years. This phenomenon, known as 'immune amnesia,' was observed in two separate studies published in Science Immunology and Science.
Researchers found filovirus antibodies in 5.9% of human samples and up to 13.3% of bat species, including those with Ebola virus, Bundibugyo virus, Sudan virus, Marburg virus, and Mengla virus antibodies. The study highlights the need for surveillance at the human-animal interface.