Articles tagged with Immune Response
A study published in the Journal of Allergy and Clinical Immunology found that exposure to air pollution suppressed immune system regulatory T cells, leading to increased severity of asthma symptoms and lower lung capacity. The research suggests a potential long-term effect of polluted air on children's health.
A new study found that HIV-infected individuals who start antiretroviral therapy (ART) soon after acquiring the virus have stronger immune responses to other pathogens compared to those who start ART later. Early treatment restores resting memory B cells and reduces immature B cells, leading to improved immune system function.
Recent research suggests that some TB vaccines under study may not be effective in older people, as the molecule responsible for immune response activation remains relatively inactive. The study's findings highlight the need for a new approach to vaccine development to ensure protection against tuberculosis for the elderly.
A team from Case Western Reserve University has identified a novel dual recognition mechanism in Mycobacterium tuberculosis that may contribute to immune evasion. The discovery could aid in the design of new vaccines and antibiotics to combat the disease.
The Novartis 2010 Immunology Prizes were awarded to Professor Michael Bevan and Charles Dinarello, and Juerg Tschopp, for their contributions to basic and clinical immunology. The prizes recognize individual achievement and provide financial support for further research.
Researchers discovered the function of PTP-PEST, a protein that stimulates T cells' participation in immune responses, potentially leading to new treatments for autoimmune diseases. The study's results suggest that suppressing PTP-PEST could prevent certain autoimmune diseases and weaken overactive immune responses.
Coral reefs' immune system is linked to their susceptibility to bleaching and disease, with corals using energy for growth and reproduction affecting immune function. Understanding this connection can help scientists predict vulnerability to stress and develop preventive measures.
A study at the University of Pennsylvania School of Veterinary Medicine has identified a key player in animal gut immunity and revealed surprising similarities between fish and humans. The discovery provides new insights into how humans maintain healthy intestines and could lead to improved approaches for keeping fish safe from pathogens.
Researchers developed an alphavirus vector to overcome neutralizing antibodies and Tregs, inducing clinically relevant immune responses in patients with metastatic cancer. Repeated administration led to longer overall patient survival, making the approach a promising therapeutic option.
Researchers have identified three protein fragments in gluten that trigger an immune response in people with coeliac disease, leading to small intestine damage. This discovery could pave the way for a new generation of diagnostic tools, treatments, and prevention strategies.
Researchers found 323 unique genes influenced by smoking, with a strong involvement in processes related to cancer, cell death, and metabolism. The study's results indicate that exposure to cigarette smoke alters gene expression, leading to a sobering scale of influence on human disease risk.
Researchers at Oregon State University discovered that the genetic regulator Ctip2 controls the formation of T cells, a type of white blood cell crucial for immune function. This finding may lead to new immune system-based therapies for diseases like HIV/AIDS and autoimmune disorders.
Researchers used DNA barcoding to reveal that parasites infecting freshwater fish mostly specialize on specific hosts, except for those targeting the eyes which can infect many different species and even frogs. This discovery may have practical benefits for wildlife managers and fish farmers.
Researchers have discovered variations in 10 genes associated with immune response in people with vitiligo, pointing to multiple cellular pathways contributing to the disease. The findings offer potential starting points for developing therapies tailored to individual genetic susceptibilities.
A new animal model demonstrates that early childhood lung infections can lead to asthma development later in life. The study found that an altered immune response in neonatal mice played a key role in the progression of asthma.
Researchers used PET probes to monitor immune cell function in mice with a retrovirus-induced sarcoma. The study found that two different PET probes detect distinct immune cell populations, primarily innate immune cells and active CD8+ T cells.
A recent study has linked leptin action in the brain to sepsis survival. Researchers found that leptin mediates actions in the central nervous system, improving the host response to a standard model of sepsis.
A Princeton University-led team tracked fever and sickness behaviors in song sparrows using radio transmitters, discovering that different populations respond differently to infection. The study's findings may aid in forecasting where diseases will take hold, including West Nile virus.
A study found that song sparrows from California displayed higher body temperatures during the night due to their longer breeding season, allowing them to prioritize their immune response. In contrast, sparrows from Washington had shorter breeding seasons, which may limit their ability to invest in immune reactions.
Scientists use micro-particles to mimic bacterial scents, tracking immune cell responses. Neutrophils migrate towards single chemical-releasing particles within minutes.
A new HIV vaccine strategy, called 'mosaic vaccines,' has shown promise in expanding immune responses in rhesus monkeys. The approach uses computational methods to create small sets of highly variable artificial viral proteins that stimulate a strong immune response against the diverse forms of HIV.
A new protocol for fluorescence in situ hybridization allows phylogenetic identification of microorganisms in environmental samples. Meanwhile, a dual-color ELISPOT assay enables simultaneous detection of IL-2 and IFN-γ secreting T cells, promising to monitor immune responses to certain infectious agents.
Researchers have found that CD20 protein is essential for generating optimal B cell immune responses, particularly to T-independent antigens. The discovery was made by analyzing a patient with a mutation in the CD20 gene, who had impaired B cell responses and recurrent infections.
Scripps Research scientists have determined the structure of the Ebola virus's critical protein VP35, which blocks the human immune system. The discovery may lead to new drug therapies and vaccines for Ebola infection.
Lung interstitial macrophages (IMs) produce IL-10, which inhibits LPS-induced DC activation and prevents Th2 responses. Mice with depleted IMs develop severe asthmatic reactions to innocuous airborne allergens.
Research suggests that NSAIDs can prevent the early appearance of neuronal cell cycle events in a mouse model of Alzheimer's disease. However, treatment with NSAIDs does not reverse existing neuronal CCEs. Additionally, interstitial macrophages may play a role in preventing asthma by inhibiting LPS-induced immune responses.
A study published in JCI Journals reveals that PKC-theta protein is required for graft-versus-host disease (GVHD) but not for GVL responses or protection against infectious agents. This finding provides a potential new approach to prevent GVHD while preserving beneficial immune responses.
A study published in Virology demonstrates that the ancient pathogen cowpox still has much to teach us about developing novel vaccines. Researchers identified 9 new protective components of the virus, which offered superior protection in a mouse model compared to existing vaccines.
Aging immune systems in elderly cancer patients are less efficient and require customized treatments. Researchers aim to understand intrinsic defects in the old immune system to stimulate antitumor responses.
Researchers at McGill University Health Centre discovered a key molecule, GP63 protease, that neutralizes macrophages' defences and hinders the body's innate inflammatory immune response. The study provides a promising approach to treating leishmania as well as other infectious diseases.
Preliminary analysis of blood samples from trial participants suggests that the 2009 H1N1 influenza vaccine generates an immune response that is expected to be protective against the virus in most children between 10-17 years old. Younger children had a less robust early response to the vaccine.
Scientists at the University of Michigan have developed a potential vaccine to prevent urinary tract infections, which affect 53% of women and 14% of men. The vaccine targets iron receptors on bacteria that cause infection, inducing an immune response in mucosal tissue.
Alcohol consumption during pregnancy can lead to a range of adverse outcomes, including learning disabilities and increased susceptibility to diseases. The destruction of beta-endorphin neurons in the hypothalamus region can result in permanent impairment of stress and immune system functions throughout life.
A recent study in mice suggests that the mother's immune response interferes with the fetus's ability to tolerate transplanted donor cells. Researchers found that mouse pups nursed by their biological mothers lost transplanted cells, while those nursed by foster mothers retained them.
Researchers developed a blood mRNA expression signature that accurately identified influenza infection and distinguished between viral and bacterial infections. This breakthrough may lead to the creation of a blood test for diagnosing respiratory infections and predicting treatment outcomes.
Researchers at Children's Hospital of Philadelphia have identified an immune mechanism responsible for graft failure in a mouse model of IUHCT. Maternal alloantibodies, produced in response to IUHCT, trigger a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation. This finding opens the...
Researchers found that fetal immune cells eliminate transplanted allogeneic blood cells, but only triggered by maternal breast milk antibodies. This limits engraftment following in utero hematopoietic cell transplantation.
Researchers at University of California - Davis Health report that amyloid plaques and bacterial biofilm elicit the same immune response in human cells, leading to chronic inflammation that damages neurons. The study identifies a protein called TLR-2 as controlling this response.
A Stanford study found that caloric restriction may not be beneficial for infected fruit flies, contradicting previous findings. The research suggests that diet-restricted animals may fare poorly when infected with certain pathogens.
Researchers discovered that GBS fools the immune system by reducing production of antibiotic molecules, allowing the bacteria to survive and proliferate. This understanding may lead to new targets for medical therapy to boost the immune system and clear GBS infection in critically ill newborns.
A study has found that a mutation in the NOD2 gene may predispose individuals to Crohn's disease by impairing the immune system's ability to recognize and fight off mycobacteria. The research, published in the Journal of Experimental Medicine, highlights the potential for new therapeutic approaches to combat the disease.
Nearly half of the world's population is at risk of malarial infection, causing over 250 million clinical episodes and one million deaths each year. Researchers identified key challenges in developing a protective malaria vaccine, including identifying which proteins provoke a strong immune response.
Researchers have identified a mechanism by which influenza virus makes individuals more susceptible to secondary bacterial pneumonia. Type I IFNs, key mediators of the antiviral immune response, impair the ability to mount an adequate immune response to subsequent pneumonia-causing bacterial infection.
Researchers at the University of Maryland School of Medicine found that Abatacept reduces severe illness and death in mice exposed to Influenza A virus by tempering the immune response. The treatment approach also improves survival rates for mice infected with a lethal dose of influenza virus.
A novel vaccine strategy using VLPs could provide a more robust immune response and shorter development time compared to traditional vaccines. Researchers have already made VLP vaccines that show complete protection against H5N1 and 1918 influenza viruses.
Lice parasites have been found to modulate the immune system of wild wood mice, suggesting a potential link between parasite exposure and reduced autoimmune disease risk. This research implies that modern humans, lacking natural parasite exposure, may develop less regulated immune systems leading to increased disease susceptibility.
Researchers identify previously unrecognized defense mechanisms that improve treatment of viral skin infections. They found that immune cells in the skin, such as dendritic cells and memory T cells, can trigger a strong response to infections, providing efficient and long-lasting immunity.
A new study from the University of Missouri found that newborns' immune systems require time to mature before responding effectively to vaccines. This slow maturation can lead to an overabundance of Th-2 cells, which can cause allergic reactions and make infants more susceptible to infections.
Scientists have identified a new role for lung epithelial cells in detecting airborne antigens and triggering allergic responses. The discovery suggests that targeting Toll-like receptors may lead to novel treatments for asthma and other allergic diseases.
Research found that parasitic infection reduces immunity to future cholera infections and compromises vaccine effectiveness. Helminth-infected patients had lower IgA antibodies, indicating a weakened immune system.
Studies reveal that PICK1 protein plays a crucial role in acrosome formation, and its deficiency leads to low sperm count and abnormal sperm movement in male mice. This discovery may shed new light on the human disorder of globozoospermia, which affects male fertility.
Scientists engineer a covalent immunization approach that provides immediate protection against diseases, overcoming traditional vaccine drawbacks such as lag time. The method uses adapter molecules to trigger universal immune reactions, potentially revolutionizing disease prevention.
Researchers discovered that mosquitoes use RNA interference to combat dengue virus, allowing the virus to multiply and be transmitted to humans. Genetic manipulation of this response could help stop dengue virus transmission by Aedes aegypti.
Researchers discovered clofazimine's potential to treat autoimmune diseases by inhibiting the Kv1.3 potassium channel. The findings suggest a new approach to treating conditions like multiple sclerosis, psoriasis, and type 1 diabetes.
Researchers at the University of Pennsylvania School of Veterinary Medicine have imaged the body's immune response to a parasitic infection in the brain for the first time. The findings provide unexpected insights into how immune cells are regulated in the brain and have implications for treating inflammatory conditions.
Researchers at UCSF have identified a woman's immune system anomaly that may lead to breakthrough therapies for autoimmune diseases like rheumatoid arthritis and colitis. The discovery of antibodies blocking T-cell movement could result in more targeted treatments with lower risks of infections or tumors.
Researchers study how Toxoplasma gondii infects mice and finds that infected cells fuse with endoplasmic reticulum to present parasitic peptides. This process, called cross-presentation, helps the parasite evade immune detection.
Researchers found that CD4+ T cells play a significant role in Parkinson's disease progression. Infiltration of these immune cells in the brain contributes to neurodegeneration. Targeting the immune system might offer a new therapeutic approach.
Researchers successfully blocked PD-1, boosting anti-viral killer cells and antibody response, reducing plasma viral load and prolonging survival of SIV-infected rhesus macaque monkeys. The therapy showed improved function of T cells in the blood and gut, increasing antibody production against SIV.
Researchers identified a key role for dendritic cells in responding to Leishmania parasites, which cause illness in developing nations and have been detected in US soldiers. The study provides insights into the early stages of the immune response and has implications for vaccine development.