Articles tagged with Internal Medicine
A new study found that over half of adult cancer survivors experience significant hearing problems after chemotherapy treatment. The researchers also discovered that platinum and taxane drugs, commonly used to treat the majority of cancers, are linked to high rates of hearing loss and tinnitus.
The American College of Physicians (ACP) has issued a position paper on the ethical use of genetic testing and precision medicine in internal medicine. The guidelines address key issues such as incidental findings, education for physicians and patients, and counseling needs. ACP emphasizes the need for ongoing surveillance and anticoag...
A new clinical model predicts hospital mortality and major adverse kidney events in critically ill patients with acute kidney injury. The proposed model exhibits good performance for outcome prediction, enabling timely interventions to promote kidney recovery.
The study reveals the involvement of serotonin and its receptor HTR2A in NAFLD pathology. Hepatic blockade of autonomic neural signals reduced NAFLD progression by inhibiting 5-HT, HTR2A, and lipogenic gene expression.
A secondary analysis of the CARDIA Lung study found that a substantial proportion of middle-aged adults with normal spirometry findings had emphysema on CT scan. Race-specific interpretations of spirometry may underestimate respiratory symptom burden and risk for death in Black adults, perpetuating structural racial inequities.
A five-month field experiment involving 199 primary care physicians found that comparing performance to peers decreased job satisfaction while increasing burnout. The study also showed that training leaders on how to best support physicians mitigated such negative effects.
Lumasiran, an RNA interference therapeutic, has been shown to reduce oxalate levels in patients with primary hyperoxaluria type 1 (PH1) who have relatively preserved kidney function. In the ILLUMINATE-C study, lumasiran resulted in substantial reductions in plasma oxalate with acceptable safety in patients on hemodialysis.
A study of 3069 ICU patients found racial and ethnic disparities in oxygen supplementation, with Asian, Black, and Hispanic patients receiving less oxygen than white patients. Pulse oximeter performance may be contributing factor to these disparities.
A longitudinal cohort study found significant reductions in liver disease and mortality among people with HCV infection who received treatment. The study's findings suggest that continued testing, treatment, and community-based interventions could lead to the elimination of HCV infection within the next decade.
A new study found that the fourth COVID-19 vaccine reduces the risk of death among elderly individuals in long-term care facilities by 72%. The study, which included approximately 40,000 residents, also showed a significant reduction in hospitalizations and infections.
A long-term study of 3,926 adults with CKD found that higher levels of physical activity reduced the risk of atherosclerotic events, new-onset heart failure, and death. The association was strongest for incident peripheral arterial disease and reinforces current guideline recommendations.
Regularly active adults showed lower all-cause and cause-specific mortality rates compared to physically inactive peers. Weekend warriors who performed recommended levels of weekly physical activity one to two times also had similar mortality rates as regularly active participants.
A cross-sectional study found significant differences between estimated glomerular filtration rate (eGFR) and directly measured GFR (mGFR), highlighting the importance of considering uncertainty in eGFR calculations. Researchers suggest renaming eGFR as a population average GFR to improve accuracy.
Following the leaked SCOTUS draft ruling, internet searches for abortion medication increased by 350,000 during the first week of May. These searches were more prevalent in states with restrictive reproductive rights.
Residents in predominantly Black communities are more likely to live near a hospital with a certified stroke center but face lower chances of receiving optimal treatment. The study also reveals significant disparities in access to stroke centers based on income and geographic location.
The American College of Physicians (ACP) says inadequate access to nutritious food negatively impacts the health of many Americans, exacerbating social factors and leading to various health issues. The ACP recommends strengthening the nation's food insecurity response and empowering physicians to address social drivers of health.
A systematic review of 84 studies found insufficient evidence that multivitamins or supplements can prevent cardiovascular disease and cancer in healthy adults. In contrast, diet and exercise are key to maintaining health. Whole fruits and vegetables contain a mixture of vitamins, phytochemicals, fiber, and other nutrients that act syn...
A study published in Annals of Internal Medicine found that Medicare could save up to $3.6 billion by purchasing generic drugs at the same prices as the Mark Cuban Cost Plus Drug Company. The researchers compared the price of 89 generic drugs sold by MCCPDC to the price Medicare paid in 2020 and estimated potential savings of up to $3....
A new study led by UCSF found that routine screening for and removal of precancerous anal lesions can significantly reduce the risk of anal cancer. The study, known as ANCHOR Study, showed a 57% reduction in anal cancer among people with HIV who underwent treatment for high-grade squamous intraepithelial lesions (HSIL).
Healthcare workers must be vigilant in detecting and managing suspected monkeypox cases while avoiding stigmatization of affected communities. The authors stress the importance of careful infection control practices and community allyship with men who have sex with men to combat the outbreak.
Researchers analyzed data from 433,000 veterans to assess vaccine side effects over 38 weeks. The study found no significant differences in adverse event risk between the two vaccines.
A nationwide study in Sweden found that receiving red blood cells from female donors does not increase the risk of death in transfused patients. The study controlled for lower haemoglobin levels in women's blood and found no difference in survival rates between male and female donors.
A study found that internal medicine interns spend only about 10 minutes per hour, or less than 1%, of their shift time with patients. The use of a real-time locating system to track the residents' movement improved the efficiency and accuracy of this assessment.
A secondary analysis of the MOVe-OUT trial found molnupiravir-treated participants had a decreased need for respiratory interventions and fewer COVID-19-related acute care visits. Additionally, they showed faster normalization of biomarkers and were discharged earlier than placebo-treated patients.
African Americans with chronic obstructive pulmonary disease (COPD) are more likely to experience flare-ups due to inadequate sleep, which may boost their risk by up to 95%. The study, published on June 6, 2022, suggests that poor sleep quality may partially explain why African American patients tend to fare worse than white patients. ...
A review of 25 trials found that synthetic cannabis products with high THC-to-CBD ratios improved chronic pain, but were associated with higher risks of adverse events. In contrast, products with comparable THC-to-CBD ratios showed few benefits in overall functioning.
Patients with primary glomerular diseases have a significantly higher risk of cardiovascular events, including coronary artery disease and stroke. The study found that inclusion of kidney-specific risk factors improved the prediction of cardiovascular events.
A cohort study found that moderate coffee consumption, especially unsweetened coffee, is associated with a lower risk of death. The results suggest that adults who drink 1.5 to 3.5 cups of coffee per day may be less likely to die during a 7-year follow-up period compared to non-coffee drinkers.
A review of 38 randomized controlled trials found that counseling patients about contraceptive use and providing contraceptives increases use without increasing STI risk or reducing condom use. The interventions also decrease unintended pregnancy in trials designed to evaluate this outcome.
A large-scale analysis of daytime surgeries performed by surgeons who operated the previous night found no correlation with increased risk of in-hospital mortality or major complications. The study, involving nearly 500,000 operations, suggests that surgeons can perform safely and effectively even after a night shift.
A study by researchers at UCSF found that e-cigarette use costs the US $15 billion annually in healthcare expenditures, with each user paying around $2,000 extra per year compared to non-users. The study, published in Tobacco Control, highlights the growing concern over health care costs associated with e-cigarette use.
A protocol-based potassium supplementation strategy resulted in a longer time to the first peritonitis episode and a lower hazard ratio of peritonitis compared to reactive supplementation. This approach also improved PD-related outcomes by significantly reducing the risk of peritonitis.
A new analysis of nationally representative data reveals a significant increase in the impact of HPV vaccination efforts, leading to decreased prevalence of cancer-causing HPV infections among both vaccinated and unvaccinated females. The study found that vaccination has directly protected individuals and generated herd effects, reduci...
A new UCLA-led study finds that affirmative action bans in states led to a decline of 37% in the proportion of underrepresented students in public medical schools. This decrease had a devastating impact on the diversity of the physician workforce, which is crucial for providing equitable healthcare services.
State bans on affirmative action policies are associated with lower enrollment of underrepresented minority students in public medical schools. The study found a 5.5 percentage point decrease in enrollment of underrepresented students relative to control schools.
A new study validates the Canadian Syncope Risk Score as a reliable tool to identify patients at low risk for serious outcomes after 30 days, potentially reducing hospitalization rates. The score showed better performance than another validated score, but its clinical utility remains uncertain and warrants further research.
A nonrandomized controlled trial of 501 patients found that awake prone positioning was linked to better oxygenation and reduced mortality rates among those with COVID-19. The study suggests that this positioning technique may be a valuable adjunct to other treatments for patients with severe respiratory symptoms.
Dr. Anil N. Makam, Assistant Professor of Medicine at UCSF, received the fifth Arti Hurria Memorial Award for Emerging Investigators in Internal Medicine Who are Focused on the Care of Older Adults. His research focuses on long-term acute care hospitals and evidence-based medicine.
Patients with mild to moderate kidney disease and kidney transplant recipients had a higher risk of cancer. They also faced a higher risk of dying from cancer, particularly from cancers such as bladder, kidney, and multiple myeloma, compared to those with normal kidney function.
A team from Goethe University has identified the spatial structure of the mannitol-synthesizing enzyme MtlD in Acinetobacter baumannii, which is crucial for its survival. This discovery could lead to the development of customized substances to inhibit the enzyme and combat this hospital pathogen.
A recent UCLA study found that the injury rate for e-scooter riders in Los Angeles is higher than the national rates for motorcycle, bicycle, car, and pedestrian injuries. The study estimates 115 injuries per 1 million e-scooter rides, highlighting a growing risk as e-scooters proliferate globally.
A California study found that adults living with handgun owners had twice the homicide rates compared to those without, with most victims being women. Survivors of nonfatal gunshot injuries also experienced significant healthcare costs and worsening mental health.
A large cohort study found that babies born to men who took metformin during sperm development were at increased risk for genital defects in boys. Diabetes control affects sperm quality, so men should discuss alternative treatments with their doctors before conception. The findings suggest a need for further study on treatment of prosp...
Dialysis facilities referred more incident patients, transplant centers evaluated more, but fewer were placed on the waitlist following KAS implementation. This led to a decline in overall waitlisting nationwide.
A study of insurance claims data found that state laws governing opioid prescribing had a negligible effect on opioid prescribing trends. The authors suggest that shifting clinical guidelines, professional norms, or other factors may be driving the decline in opioid prescribing. In contrast, a post-hoc analysis of an ASPREE trial found...
A new study led by UC San Francisco reveals that 87% of seniors with dementia would stop at least one medication if their doctor said it was possible. Polypharmacy contributes to challenges with adherence and adverse interactions, but most patients are willing to reduce their medications.
A modeling study suggests that breast cancer overdiagnosis may occur in about 15% of screen-detected cases, rather than the estimated 30%. This could spare around 25,000 women unnecessary treatment. Researchers used data from the Breast Cancer Surveillance Consortium to estimate the rate of overdiagnosis.
A cost-effectiveness analysis found that adherence promotion programs like MAPS reduce costs and improve outcomes for adolescent kidney transplant recipients. Strategies with similar costs to MAPS can still be cost-effective if they decrease rejection episodes by a small amount.
A new study has found that tubal ligation is no more effective than an intrauterine device (IUD) in preventing pregnancies. The six-year analysis of Medi-Cal claims data showed that hormonal IUDs were more effective, while copper IUDs were as effective as tubal ligation in preventing pregnancies.
Young adults are disproportionately excluded from kidney transplantation, with only 1.8% of Black and 4.4% of Hispanic patients receiving the treatment compared to 10.9% of White patients within this age group. The study highlights the need for targeted interventions to address these disparities.
A study found that COVID-19 patients from high-vulnerability neighborhoods presented with more severe illness and required intensive care, but did not experience higher mortality rates. Researchers suggest policies targeting socially vulnerable neighborhoods to improve access to testing, treatment, and vaccination.
A study of 2,800 adults aged 75+ found that severe financial strain increased the risk of death in the six months following a heart attack. The research highlights the importance of addressing financial stress for older adults with cardiovascular disease.
A new study shows that ZIP code social vulnerability index is linked to COVID-19 severity, with more disadvantaged areas experiencing higher symptom rates. However, differences disappear when patients are discharged from hospitals, suggesting equal access to care plays a crucial role in reducing initial disparities.
A 5-day course of oral ivermectin failed to reduce the risk of severe disease in high-risk patients with COVID-19. The study, published in JAMA Internal Medicine, suggests ivermectin may not be an effective treatment for COVID-19.
A study examined the association between county-level prescription rates of hydroxychloroquine and ivermectin and voting patterns in the 2020 US presidential election. The analysis found a statistically significant correlation between higher prescription rates and Republican vote shares.
A retrospective cohort study of patients with atrial fibrillation and diabetes found that non-vitamin K antagonist oral anticoagulants (NOAC) were associated with a lower risk of diabetes complications and mortality than warfarin. The study suggests that NOAC may be a better therapeutic choice for this patient population.
Patients with severe coronary artery calcium have a significantly increased risk of major adverse cardiovascular events during thoracic radiation therapy for non-small cell lung cancer. The study found that patients with severe coronary artery calcium had a 21.4 times increased risk compared to those with no coronary artery calcium.
Dr. Edward Y. Lee, MD, MPH, receives the highest distinction from North America's first radiological society for his contributions to pediatric thoracic imaging and education. The ARRS Gold Medal honors his tireless efforts to advance radiology globally.
A study of continuous monthly mortality data found that excess deaths associated with COVID-19 reached greater peaks than most other periods of excess deaths since 1918. The relative excess of deaths in 2020 was 12.5% in Switzerland, 8.5% in Sweden, and 17.3% in Spain.
Researchers found a markedly increased risk of carditis associated with BNT162b2 vaccination, particularly in adolescents after the second dose. The study's findings highlight the need for refined vaccination strategies to balance risk and benefits across different sub-populations.