Articles tagged with Internal Medicine
Researchers have developed a novel strategy to treat, prevent, and possibly reverse liver damages by exploiting small extracellular vesicles derived from interferon-γ pre-conditioned MSCs. The approach has shown promising results in reducing inflammation and fibrosis in a mouse model of cirrhosis.
During the COVID-19 pandemic, there was a significant shift in internal medicine residency and fellowship applications. The study found that the number of applicants and applications submitted per applicant decreased in 2021 compared to previous years.
The new online-only journal aims to share valuable lessons from clinicians' discussions on challenging cases, contributing to medical innovation and improved care. The digital, peer-reviewed journal will publish bi-monthly issues initially and become more frequent over time.
Researchers from NIH propose a new method to estimate vaccine efficacy by following original placebo recipients after vaccination, allowing assessment of durability and potential delayed harm. This approach enables timely access to the vaccine for placebo recipients while maintaining unbiased estimates.
A nationally representative survey found that over 40% of US adults aged 50-80 trust online reviews almost as much as family or friend recommendations when selecting a physician. Factors such as insurance acceptance and race/ethnicity were more influential, with online reviews ranking ninth in importance.
Case report describes two patients who underwent a successful second dose of the Moderna vaccine using a graded dosing protocol after experiencing immediate hypersensitivity reactions. Both patients responded well and developed IgG antibodies, suggesting effective vaccination despite the modified dosing schedule.
Vaccinating healthcare workers reduced positive COVID-19 cases by over 90%, with infection rates lowest among fully vaccinated employees, according to data from UT Southwestern Medical Center. The institution saw a significant reduction in required isolations and quarantines.
A Zika virus candidate, Ad26.ZIKV.001, showed promising safety and immunogenicity in a phase I clinical trial. The vaccine induced persistent neutralizing antibody responses and was found to be safe with mild to moderate reactogenicity. Researchers recommend further development of the vaccine should the need reemerge.
The Advisory Committee on Immunization Practices (ACIP) has released its 2021 Recommended Adult Immunization Schedule, which includes interim recommendations for COVID-19 vaccination. The updated schedule features revised content and harmonized changes with the Child and Adolescent Immunization Schedule.
The American College of Physicians (ACP) has updated its practice points on the use of remdesivir in treating hospitalized COVID-19 patients. The new guidelines aim to target patients who are most likely to benefit from treatment, recommending a duration of treatment based on symptom duration and disease severity. According to the upda...
The American College of Physicians and Annals of Internal Medicine hosted a third virtual COVID-19 vaccine forum, discussing the allocation and distribution of available vaccines. Researchers also published an observational study finding that early therapeutic anticoagulation in critically ill patients with COVID-19 did not affect surv...
A review of 61 studies confirms that at least 1 in 3 people infected with SARS-CoV-2 do not exhibit symptoms, suggesting widespread testing can help identify asymptomatic spreaders. The findings also underscore the importance of determining vaccine effectiveness against asymptomatic infections.
A recent study found that mortality rates decreased among critically ill COVID-19 patients over time. In contrast, experts from NIAID emphasized the importance of using data to encourage vaccine uptake. Meanwhile, a hospital essay describes a Ransomware attack during the pandemic, highlighting the challenges faced by healthcare profess...
The American College of Physicians (ACP) has released a comprehensive framework to address disparities and discrimination in healthcare, proposing policy recommendations to enhance quality and effectiveness for all patients. The framework also discusses specific contributors to health disparities and steps to improve them.
A recent study found that 85.9% of COVID-19 patients with mild cases experienced olfactory dysfunction, lasting an average of 21.6 days. Nearly one-quarter of patients did not recover their sense of smell 60 days after losing it.
Researchers suggest that single-dose vaccines may offer greater population benefit due to the speed-versus-efficacy tradeoff. Alternative dose allocation strategies also improve benefits by vaccinating more people sooner while maintaining scheduling for second doses.
A study from Cedars-Sinai Medical Center found that people who move due to unaffordable housing are at increased risk of failing to receive necessary medical care, leading to long-term health problems. The research highlights the need for preventive action to mitigate the adverse effects of cost-related moves on healthcare access.
A national survey of 4,000 adults found that fewer than 10% have ever discussed firearm safety with a clinician, highlighting the need for improvement in clinical settings. The study also found that when conversations occurred, the most common advice given was to lock all household firearms.
The American College of Physicians (ACP) hosted a virtual COVID-19 Vaccine Forum II to address barriers to optimal vaccine uptake. Panelists emphasized the need for comprehensive public health communications campaigns to refute misinformation and build trust among disproportionately affected minority communities.
A recent study found that combining mandatory mask-wearing policies with extensive social distancing can prevent most COVID-19 cases on college campuses, with routine testing also showing high effectiveness. However, the cost of testing may be a barrier for some colleges and universities.
A new study by Michigan Medicine researchers found that pulse oximeter readings may be less accurate in Black patients than in White patients, leading to potential mismanagement of treatment. The findings suggest that device makers may need to make changes to ensure accurate readings for all patients.
A systematic review published in Annals of Internal Medicine confirms health disparities in COVID-19 outcomes among Black and Hispanic populations, attributing the disparity to increased risk of exposure and transmission. The study highlights the need for targeted efforts to reduce exposure to the virus in vulnerable populations.
A systematic review of COVID-19 data in the US reveals disproportionately higher rates of infection and mortality among African American/Black and Hispanic populations. The authors call for urgent interventions to mitigate these disparities. Read the full text to learn more about the findings.
The study found that adults in states voting for Hillary Clinton experienced 54.6 million more days of poor mental health, compared to Trump-voting states, with increases observed in older adults, women, and white individuals. Depression rates also rose in Clinton-voting states after the election.
An agent-based computer model shows that delayed implementation of social distancing measures and low adherence can increase COVID-19 cases in urban areas. Maintaining personal behaviors like face mask use after easing social distancing measures also has a significant impact.
Industry, government, and academic researchers propose general clinical endpoints to facilitate evaluation of COVID-19 vaccine candidates. These endpoints include asymptomatic infection as a study endpoint.
Two new UT Southwestern studies report that only half of practicing physicians are registered to vote, with time being the most common barrier faced by resident physicians. The researchers say finding ways to increase voter participation among doctors is critical as the nation tackles healthcare issues.
The American College of Physicians (ACP) and Annals of Internal Medicine hosted a virtual forum on October 16, assembling leading health experts to discuss timely information related to COVID-19 vaccines. Panelists offered current evidence-based insights into vaccine science, approval processes, and clinical recommendations.
Researchers found that 12.1% of cases received out-of-network claims, often due to out-of-network anesthesiologists and pathologists. The study suggests partnering with in-network providers and considering cost-saving strategies to spare patients surprise bills.
A study by University of Chicago Medicine found that medical scribes can increase physician productivity by up to 20%, allowing for more time to focus on patients. The initial cost of employing a scribe can be recovered in less than a year, after which profits follow.
A randomized controlled trial found that early referral to physical therapy significantly improved function and reduced symptoms of back pain with sciatica compared to usual care. Patients who received physical therapy immediately after their primary care visit reported less disability than those who took the wait-and-see approach.
The National Institutes of Health COVID-19 Treatment Guidelines Panel has expressed uncertainty about the efficacy and safety of convalescent plasma for treating COVID-19. The panel's analysis, published in Annals of Internal Medicine, highlights the need for more data before making recommendations on the treatment.
Researchers found that glucocorticoid therapy, even at low doses (5mg/day or less), significantly increases the risk of serious infections in rheumatoid arthritis (RA) patients. The study used claims data from over 200,000 patients with RA to show a 30% increase in infection risk among those on low-dose glucocorticoids.
Researchers found that COVID-19 is mainly transmitted through respiratory droplets or aerosols, not surfaces. Social distance and proper ventilation are crucial in reducing transmission risk. Novel community isolation quarantine facilities can effectively manage COVID-19 without serious adverse outcomes.
A new study reveals the disproportionate impact of COVID-19 on working-age adults in the US, particularly those from low-income backgrounds, racial/ethnic minorities, and those with less education. The analysis found that these individuals had high rates of uninsurance and food insecurity, which can exacerbate health harm.
Researchers found that prophylactic treatment with direct-acting antivirals prevented chronic hepatitis C virus infection in patients receiving kidneys from HCV-positive deceased donors. The approach has potential to shorten waiting times on the organ waitlist.
A large population-based study found that acute cardiovascular events are common among adults hospitalized with influenza, with older age and underlying cardiovascular disease significantly increasing the risk. Vaccination is crucial for these patients, particularly those with cardiovascular risk factors, to prevent such complications.
A new article by Dr. Ahmad Mourad explores how 'remote misses' in COVID-19 can create a false sense of invulnerability and security, potentially leading to increased risk. This phenomenon is linked to population-wide traumatic experiences and adaptive behavior.
A survey study evaluated the curriculum on health disparities and perceptions of training among internal medicine residents. The findings suggest that program directors and residents have differing perspectives on the adequacy of training, highlighting a need for improvement.
A new study published in Annals of Internal Medicine found that a substantial number of overdose deaths were misclassified as sudden cardiac deaths, leading to grossly underestimated national estimates of the opioid overdose burden. Meanwhile, another study provides real-world recommendations for overcoming telemedicine challenges with...
A new analysis of the CANTOS trial found that patients receiving canakinumab had significantly lower rates of total hip or total knee replacements over an average follow-up of 3.7 years. The study's findings are important as no treatments currently exist to prevent or slow osteoarthritis progression.
A comprehensive review of vaccine data over 20 years found vaccines to be remarkably safe, with most safety issues identified through existing postmarketing surveillance programs. The study confirms the effectiveness of the vaccine approval system and postmarketing surveillance in ensuring public health benefits while minimizing risks.
A surgeon demonstrated telesurgery using robotic technology and a 5G network, performing remote operations on a cadaver patient from 15 km away. This was the first public demonstration of remote surgery over 5G. Researchers also explored albumin-creatinine ratio for CKD screening, staging, and prognosis.
A commentary from Beth Israel Deaconess Medical Center reviews basic respiratory physiology and highlights the clinician's role in educating the public against relying on speech as a sign of adequate respiration. Data from studies of war and torture victims show that suffocation is a strong predictor of posttraumatic stress disorder.
Authors describe timely and targeted actions to prevent mental health crisis in overextended and stressed essential workers, citing Lorna Breen's tragic loss as a catalyst. The article emphasizes the need for clinicians to prioritize their well-being during the pandemic.
Researchers in Ontario, Canada, found that physical distancing measures can prevent COVID-19 resurgence. A systematic review on hydroxychloroquine and chloroquine for treating COVID-19 showed conflicting evidence on their effectiveness.
The COVID-19 pandemic has exacerbated mental health issues among healthcare workers, particularly those at higher risk for chronic stress. A recent commentary recommends that healthcare professionals prioritize their own mental well-being by seeking support from colleagues and resources.
A single negative high-quality screening colonoscopy was associated with reduced colorectal cancer incidence and mortality. The study found a 90% reduction in CRC mortality over 17.4 years, suggesting that the current 10-year screening interval could safely be extended.
Researchers from McMaster University discuss cloth masks and ventilation techniques in reducing COVID-19 transmission. They conclude that noninvasive ventilation may reduce mortality but increase risk for healthcare workers.
Researchers found that a short-term diet high in fruits and vegetables significantly lowers markers for subclinical cardiac damage and strain in adults without preexisting cardiovascular disease. The DASH trial data suggests that increased consumption of potassium, magnesium, and fiber may partly explain the observed effects.
Healthcare workers face significant burdens from coronavirus infections, with increased risk associated with certain exposures. The journal Annals of Internal Medicine is publishing rapid reviews and living systematic reviews to keep up with emerging evidence during the pandemic.
A new commentary published in Annals of Internal Medicine emphasizes the importance of environmental cleaning during the pandemic. Environmental services personnel play a crucial role in preventing the spread of COVID-19, and their work is essential for patient safety.
A new UCLA study reveals that most laypersons misunderstand the concept of 'futile treatment,' a crucial discussion for families making end-of-life decisions. The research highlights the need for increased public engagement on this issue, particularly in resource-scarce healthcare systems like during the COVID-19 pandemic.
Researchers from the National Institute for Infectious Diseases in Italy have reported an early detection of infectious SARS-CoV-2 in ocular fluids from a patient with COVID-19. The study found prolonged viral RNA detection, highlighting the need for continued vigilance in monitoring the pandemic.
A recent study surveyed 630 adults aged 23 to 88 years living with 1 or more chronic conditions. The findings highlight the need for improved COVID-19 awareness, knowledge, and behaviors in this vulnerable population.
A new measure of patient frailty could improve accuracy, fairness, and equity in Medicare value-based payment models. Researchers found that incorporating this measure into cost prediction improved performance, especially among frail patients.
A survey of resident physicians found that most felt uncomfortable managing obesity despite its increasing prevalence. The study highlights the need for improved education in obesity management to improve patient care.
The COVID-19 pandemic has significantly impacted cancer care delivery, leading to concerns about treatment delays and reduced access to care. To address these challenges, experts recommend adopting flexible approaches that prioritize patient needs and minimize disruptions.
Dr. Emelia J. Benjamin, a renowned researcher and educator, has been recognized with the Alliance for Academic Internal Medicine Diversity Award for her tireless efforts to promote ethnic, racial, and gender diversity within Boston University School of Medicine and Boston Medical Center.
A cross-sectional survey in the US and UK found that the general public has varying levels of knowledge about COVID-19, with some misunderstanding key concepts. The study suggests that targeted education efforts could improve public understanding and adherence to prevention measures.