Articles tagged with Metabolic Health
A study of older adults found that decline in body mass index, waist circumference, and high-density lipoprotein (HDL) occurred up to a decade before dementia diagnosis. These cardiometabolic changes may provide insights into the potential for early monitoring and intervention.
A new meta-analysis published in the European Journal of Applied Physiology found that using neuromuscular electrical stimulation (NMES) while doing resistance training increases muscle mass and strength compared to resistance training alone. The analysis reviewed over a dozen studies and showed that longer training periods yielded bet...
A study found that persistent short sleep duration from pregnancy to 2-7 years after delivery is associated with adverse cardiometabolic outcomes. The researchers suggest exploring sleep-targeted interventions for improved cardiometabolic health, particularly among high-risk populations.
Research found that intermittent fasting inhibits hair growth in mice by causing oxidative stress on stem cells. A clinical trial showed a similar effect in humans, with a 18% reduction in hair growth speed.
A new study reveals that alternate-day fasting sensitizes key genes and liver enhancers, leading to enhanced ketogenesis during subsequent fasting bouts. The liver adapts to recurring nutritional challenges through a cellular memory mechanism, highlighting the benefits of intermittent fasting for metabolic health.
Researchers developed a novel 2D framework, the Health State Map (HSM), to assess metabolic health and nutritional capacity. The study found that HSM provided additional information on postprandial homeostatic resilience, which was positively associated with liver function, insulin sensitivity, and physical activity.
A new study found that changes in the gut environment influence the composition and activity of gut bacteria. The study involved swallowing a capsule with pH sensors through breakfast, revealing unique gut environments and travel times among individuals. This may help explain individual differences in digestion, nutrient uptake, and bo...
Long-term hormone therapy in transgender individuals leads to significant changes in body composition and risk factors for cardiovascular disease. Transgender men experience increased muscle volume and abdominal fat, while women's muscle mass decreases, according to a new study published in the Journal of Internal Medicine.
Medically induced weight loss with GLP-1 receptor agonists can lead to substantial muscle loss, compromising physical strength and immune function. The authors emphasize the need for a multimodal approach combining medication with exercise and nutritional interventions to preserve muscle mass.
A new study has identified novel strains of microbes that have adapted to use limited resources in cities, including those found in Hong Kong's subways and skin. These microbes can metabolize manufactured products, posing health risks if they are pathogenic.
A new study found that childhood trauma can have specific consequences for biological health and risk of developing 20 major diseases later in life. The study's findings differ by sex and type of stressor, highlighting the need for a precision medicine approach based on patients' sex and specific stress profile.
Researchers found that early diet and physical activity intervention can profoundly influence metabolism even years after the intervention ends. The study identified 80 metabolites linked to cardiometabolic diseases, with some changes persisting for eight years.
Scientists discovered the highest natural blood sugar levels in mammals, found in a species of bats that can survive on a diet rich in sugars. The study's findings suggest that these bats have evolved unique strategies for glucose regulation, which may hold potential for managing metabolic diseases in humans.
A new five-year grant will explore the mammary gland's influence on metabolic diseases like obesity and type 2 diabetes. The research aims to identify specific hormones produced by the mammary gland, known as mammokines, which may impact obesity and diabetes in mothers and offspring.
Research suggests that metabolically healthy obese individuals have a significantly lower risk of cardiovascular disease and death compared to those with metabolic unhealthy obesity. Fat distribution plays a crucial role in defining metabolic health, according to a recent review article.
A recent study published by American Society for Nutrition found that paternal fish oil supplementation can lead to lower body weight and improved metabolic health in offspring. Researchers gave male mice a high-fat diet with or without added fish oil, then mated them with female mice on a healthy low-fat diet.
The ARMMS-T2D study found that bariatric surgery yields greater long-term improvements in quality-of-life compared to medical management, with sustained weight loss correlating with better health and reduced pain.
Researchers developed a metabolic health score based on clinical parameters and used it to explore its genetic underpinnings in mice, validating findings in human data. The study identified two significant genetic regions linked to metabolic health and pinpointed candidate genes associated with metabolic traits.
The Pennington Biomedical Research Center is conducting a clinical trial to better understand lipedema. Participants will undergo comprehensive assessments and imaging techniques to help advance medical knowledge related to chronic disease. Compensation of up to $475 is offered for participation in the three-month study.
A single episode of intense exercise reduces subsequent physical activity and body temperature in mice, leading to weight gain. The study highlights the importance of considering not only calories burned during exercise but also subsequent activity levels and circadian rhythm for effective weight loss.
A study published in PLOS Medicine found that children born via frozen embryo transfer have similar metabolic profiles to those born via fresh embryo transfer. The research compared over 4,000 children aged 2-5 years and found no differences in blood glucose, insulin, or cholesterol levels.
Research from Stockholm University reveals that marsupials possess a not fully evolved form of brown fat, a crucial finding for understanding the origin and regulation of this heat-producing organ. The study suggests that the gene networks required to enable thermogenesis existed before the divergence of marsupials and placental mammals.
A cohort study suggests that prenatal exposure to endocrine-disrupting chemicals is associated with adverse metabolic health in children, highlighting the need for public health implications. The findings indicate a potential link between chemical mixtures and metabolic syndrome in offspring.
Researchers found that a small number of biochemical pathways are responsible for the majority of metabolic changes in autism. These changes may be linked to the cell danger response and can be partially restored with existing pharmaceutical drugs.
Researchers have identified a population of mesothelial-like cells in omental adipose tissue that limit fat cell formation, offering new insights into the mechanisms underlying obesity. These cells secrete Insulin-like Growth Factor Binding Protein 2, which inhibits adipogenesis and regulates metabolic behavior.
A new study from Washington State University found that just a few days on a night shift schedule can disrupt protein rhythms related to blood glucose regulation and energy metabolism. This dysregulation may lead to chronic metabolic conditions such as diabetes and obesity.
Scientists at St. Jude Children's Research Hospital found that improving metabolic health in obese mice before flu vaccination but not after, protects against influenza virus. A healthy diet improved T-cell function and a robust anti-flu response during later exposure.
Researchers discovered that consuming over 22% of daily calories from protein can lead to increased activation of immune cells contributing to atherosclerotic plaque formation. Leucine, an amino acid found in animal-derived foods, plays a disproportionate role in driving pathological pathways linked to atherosclerosis.
Recent research by scientists at Boyce Thompson Institute reveals that a specific fatty acid produced by gut bacteria directly influences fat metabolism in animals. This discovery sheds light on the complex interplay between diet, gut microbiota, and host metabolic health.
Researchers at Pennington Biomedical aim to investigate the effects of intermittent fasting and calorie counting on healthspan. Participants in the DiAL-Health study will be compensated up to $2,500 for their involvement.
Researchers found that switching fruit flies to a low-calorie diet extends their lifespan, even in old age. This study suggests that obese humans may benefit from reducing calorie intake in old age, as it can dramatically change their metabolisms and extend their lives.
A new study by an international team of researchers found that common oral infections and periodontal diseases are associated with inflammatory metabolic profiles. Oral infections were also predicted to cause future adverse changes in metabolic profiles.
A genetic study found that grizzly bears' energy production follows a daily pattern even during hibernation, with a blunted amplitude and shifted peak. This suggests that the circadian rhythm helps bears conserve energy while still maintaining some metabolic function.
A new study suggests that progressive strength training using resistance can protect against the detrimental effects of a high-protein diet. The research found that exercise protected mice from gaining excess fat mass, but did not affect blood sugar control. This paradoxical finding has implications for athletes and individuals with se...
Research suggests that eating habits in winter may be better for metabolic health than in summer, especially in mice exposed to 'winter light'. The study found that these mice had less body weight gain and more rhythmic eating patterns, leading to benefits in metabolic health. Further studies in humans are needed to confirm this finding.
Studies show that people with metabolically healthy obesity (MHO) have a 50% increased risk of coronary heart disease, despite not exhibiting metabolic complications. This raises questions about the validity of the MHO concept.
Neuroscientists at Scripps Research have identified a specific cluster of neurons that work as a 'switch' for cold-related food-seeking behavior in mice. The discovery could lead to potential therapeutics for metabolic health and weight loss by targeting this brain circuitry.
A recent study published in Immunity has found that ketone bodies, produced by the liver during fasting or low glucose levels, power immune cells and improve T cell function. This discovery may pave the way for personalized dietary recommendations to augment treatments for infection, cancer, and other diseases.
A world-first study from the University of South Australia exposes the real weight gains of everyday Australians, finding that weight fluctuates throughout the year. The study highlights the importance of targeting temporal hot spots to curb unhealthy weight fluctuations and prevent unwanted weight gain.
Researchers found a genetic link that explains how certain individuals store fat at the abdomen but remain protected from type 2 diabetes. This discovery could pave the way for personalized medicine, tailoring treatments to individual genetic variations.
A vegetarian diet has been shown to modestly but significantly improve cardiometabolic outcomes in people at high risk of cardiovascular disease. This finding suggests that vegetarian diets could be a useful addition to standard pharmacological therapy for primary prevention.
A recent study led by Dr. Itamar Harel reveals that manipulating AMP biosynthesis can extend lifespan and promote metabolic health in vertebrates. The research used the turquoise killifish as a model organism and found remarkable effects on energy metabolism, including a fasting-like profile and enhanced resistance to high-fat diets.
Research reveals that women with PCOS experience significant body image concerns, including greater self-classification as overweight and lower body satisfaction scores. This correlation may increase the risk of developing eating disorders like anorexia or bulimia.
A new study suggests that eating more calories earlier in the day may improve metabolic health by reducing blood sugar fluctuations and inflammation. The study found that participants who followed an early time-restricted feeding pattern experienced a decrease in time above normal blood glucose levels, thereby improving metabolic health.
A recent study published in GeroScience found that a moderate-protein diet (25% and 35%) improved metabolic health in both young and middle-aged mice. The researchers also observed reduced blood glucose concentrations and lipid levels in liver and plasma. A balanced diet with moderate protein intake may promote metabolic health in huma...
Research reveals both metabolically healthy and unhealthy obesity types linked to increased risk of various obesity-related cancers, with stronger association in metabolically unhealthy obesity. Metabolically unhealthy women face higher risks for endometrial, liver, and kidney cancers.
Recent cluster analyses identify novel risk stratification concepts to better implement precision medicine in clinical practice. Metabolically unhealthy individuals, regardless of weight, face a higher CVD risk compared to obese, metabolically healthy peers.
A new study published in JMIR Diabetes found that Fitterfly's diabetes digital therapeutics program improved glycemic control and weight management in participants with type 2 diabetes. The 90-day program led to significant reductions in hemoglobin A1c levels and body weight.
Researchers at Anglia Ruskin University found that a portable breath test can detect changes in metabolism in response to diet. The study used the Lumen device to monitor metabolic fuel use at home and showed that it could detect acute changes in carbohydrate use, but was not sensitive on a day-to-day basis.
ISB researchers constructed a biological body mass index that offers a more accurate representation of metabolic health. The team found that even with no weight loss, individuals can be getting healthier biologically through positive lifestyle changes.
A new study by Weill Cornell Medicine investigators found four distinct types of beta cells in the pancreas, with cluster 1 beta cells producing more insulin than others and appearing better able to metabolize sugar. The loss of these high-functioning beta cells may contribute to type 2 diabetes development.
UVA researchers discovered a metabolic pathway that can modulate COVID-19 inflammation, lung recovery, and host metabolic health. They suggest a potentially viable therapeutic agent that may be combined with existing anti-viral agents to treat severe COVID-19 in patients with underlying metabolic disease.
Scientists at the University of Utah Health have discovered a complex network of protein-metabolite interactions within cells that enable them to respond to environmental cues and maintain homeostasis. The study, published in Science, highlights the importance of these interactions in regulating metabolic processes and preventing disease.
The prevalence of metabolically healthy obesity (MHO) has been found to increase significantly among U.S. adults over the past two decades, according to a new study published in JAMA Network Open. The research highlights the need for effective strategies to improve metabolic health status and prevent obesity-related complications.
A review of 25 years of AI health tech research found that only 24% of studies include patient-reported outcomes, but there has been an increase in recent years. Experts emphasize the importance of integrating patient voices into AI models to support personalized care and prevent digitalization of healthcare.
A 60-day bed rest study showed that long-term inactivity significantly increases blood sugar levels even with reduced food intake. The study found average blood sugar levels increased by 6% during the day and 10% at night, highlighting the importance of physical activity for metabolic health.
Researchers at the Francis Crick Institute created a comprehensive map of metabolic pathways in mice, then gathered data to put into a model predicting diet effects on liver cancer. The study found specific changes in metabolism associated with unhealthy diets promote cancer cell growth.
A UC Riverside study found that fathers exposed to chemicals in plastics can affect the metabolic health of their offspring for two generations. Paternal DCHP exposure led to high insulin resistance and impaired insulin signaling in F1 offspring, while F2 offspring showed weaker effects.
A school-based gardening, nutrition, and cooking intervention improved glucose control and reduced low-density lipoprotein cholesterol in high-risk youth. Elementary schools can incorporate garden-based interventions to improve metabolic parameters in children.
A randomized controlled trial found that daily almond supplementation increased the beneficial fat molecule 12,13-DiHOME in blood plasma after intense exercise. This increase was associated with reduced muscle damage and fatigue, as well as improved recovery from exercise. The researchers suggest that polyphenols in almond skin may be ...