Articles tagged with Metabolic Health
ISB researchers constructed a biological body mass index that offers a more accurate representation of metabolic health. The team found that even with no weight loss, individuals can be getting healthier biologically through positive lifestyle changes.
A new study by Weill Cornell Medicine investigators found four distinct types of beta cells in the pancreas, with cluster 1 beta cells producing more insulin than others and appearing better able to metabolize sugar. The loss of these high-functioning beta cells may contribute to type 2 diabetes development.
UVA researchers discovered a metabolic pathway that can modulate COVID-19 inflammation, lung recovery, and host metabolic health. They suggest a potentially viable therapeutic agent that may be combined with existing anti-viral agents to treat severe COVID-19 in patients with underlying metabolic disease.
Scientists at the University of Utah Health have discovered a complex network of protein-metabolite interactions within cells that enable them to respond to environmental cues and maintain homeostasis. The study, published in Science, highlights the importance of these interactions in regulating metabolic processes and preventing disease.
The prevalence of metabolically healthy obesity (MHO) has been found to increase significantly among U.S. adults over the past two decades, according to a new study published in JAMA Network Open. The research highlights the need for effective strategies to improve metabolic health status and prevent obesity-related complications.
A review of 25 years of AI health tech research found that only 24% of studies include patient-reported outcomes, but there has been an increase in recent years. Experts emphasize the importance of integrating patient voices into AI models to support personalized care and prevent digitalization of healthcare.
A 60-day bed rest study showed that long-term inactivity significantly increases blood sugar levels even with reduced food intake. The study found average blood sugar levels increased by 6% during the day and 10% at night, highlighting the importance of physical activity for metabolic health.
Researchers at the Francis Crick Institute created a comprehensive map of metabolic pathways in mice, then gathered data to put into a model predicting diet effects on liver cancer. The study found specific changes in metabolism associated with unhealthy diets promote cancer cell growth.
A UC Riverside study found that fathers exposed to chemicals in plastics can affect the metabolic health of their offspring for two generations. Paternal DCHP exposure led to high insulin resistance and impaired insulin signaling in F1 offspring, while F2 offspring showed weaker effects.
A school-based gardening, nutrition, and cooking intervention improved glucose control and reduced low-density lipoprotein cholesterol in high-risk youth. Elementary schools can incorporate garden-based interventions to improve metabolic parameters in children.
A randomized controlled trial found that daily almond supplementation increased the beneficial fat molecule 12,13-DiHOME in blood plasma after intense exercise. This increase was associated with reduced muscle damage and fatigue, as well as improved recovery from exercise. The researchers suggest that polyphenols in almond skin may be ...
A new study published in Science found that the recommended eight 8-oz glasses of water per day is too high for human needs. Water turnover, measured objectively using a stable isotope technique, showed higher values in hot and humid environments, athletes, pregnant women, and individuals with high physical activity. The researchers de...
Researchers at Tufts University found a strong correlation between higher Food Compass scores and lower risk of disease and death. Diets with higher scores were associated with improved blood pressure, blood sugar, cholesterol, and hemoglobin A1c levels.
Researchers will use household dust samples to develop a receptor bioactivity component model to predict adipogenic health outcomes. The goal is to improve chemical risk assessment models to account for everyday exposures to hundreds of different chemicals.
A recent mouse study published in Diabetes found that maternal and paternal exercise significantly improved metabolic health in offspring. The study used metabolomics profiling to examine the effects of parental exercise on tissue metabolites, revealing extensive changes in glucose and fatty acid metabolism.
Researchers at the University of Cincinnati found a significant link between poor metabolic health and low breast milk production. Women with conditions like insulin resistance, high blood pressure, and obesity were more likely to experience persistent low milk supply despite best breastfeeding practices.
Researchers at the University of Houston have discovered a way to activate the soleus muscle, which can sustain elevated oxidative metabolism and improve blood glucose regulation for hours. The 'soleus pushup' movement has been shown to increase oxygen consumption and reduce insulin requirements.
A 12-month video-based weight loss programme has shown significant improvements in metabolic health and dietary behaviour among children with obesity. The study, presented at the European Society for Paediatric Endocrinology Meeting, found that participants lost weight and made better food choices.
Studies investigate lifestyle interventions to achieve nutritional ketosis and its impact on chronic illness, sleep, and cardiovascular disease in the military. Researchers aim to understand how ketogenic diet, ketone-based beverages, and their effects on clinical outcomes will benefit soldiers' health.
A study published in Cell Reports found that a rhythmic small intestinal microbiome prevents obesity and type 2 diabetes in mice. The researchers used mouse models to explore how diet and feeding patterns affect the gut microbiome and its impact on host health, particularly with obesity and type 2 diabetes.
A study by Tufts researchers found that only 6.8% of US adults had optimal levels of blood pressure, blood sugar, cholesterol, adiposity, and cardiovascular disease in 2017-2018. The prevalence of these conditions worsened significantly between 1999 and 2018, with large disparities across sex, age, race, ethnicity, and education levels.
A recent study examined changes in Korean adults' diet quality and cardiometabolic risk factors from 2007 to 2018. The research found declining trends in diet quality and increasing risks of obesity, hypertension, and type 2 diabetes.
A study of middle-aged women approaching menopause found increased body fat, particularly in the waist area, but those with healthier lifestyles had lower fat mass. The research suggests that maintaining physical activity and a balanced diet during this life stage may help protect against health risks associated with increased adiposity.
A new weight-loss intervention has been developed to target the instinctive desire to eat, particularly in individuals who struggle with resisting food cues. The Regulation of Cues program trains individuals to use natural hunger cues, reinforces tolerance of cravings, and inhibits urges to eat palatable foods when not physically hungry.
Women's metabolism alters during menopause due to changes in sex hormone levels. Metabolite profiles show increased lipid and cholesterol levels, especially triglycerides and LDL particles, which can lead to atherosclerosis.
A new study from Pennington Biomedical Research Center found that FGF21 is critical for extending lifespan and improving metabolic health in mice fed a low-protein diet. Without FGF21, mice fail to adapt to the diet and exhibit detrimental effects on health.
A recent study found that obesity, impaired blood glucose metabolism, and high blood pressure significantly increase the risk of dying from COVID-19 in young and middle-aged people. Researchers analyzed data from the European case registry LEOSS and found that patients with all three conditions had a similar increased risk of death as ...
Researchers found that grandmaternal exercise improved glucose tolerance and decreased fat mass in adult male and female grand offspring. The study suggests that exercise during pregnancy may have long-lasting effects on metabolic health, potentially reducing the worldwide incidence of obesity and type 2 diabetes.
A study from the University of Pittsburgh found that methionine restriction can slow down the growth of difficult-to-treat brain tumors in children, known as diffuse midline gliomas. The researchers discovered that these tumors are uniquely dependent on methionine, an amino acid, and that depleting it can repress cancer cell growth.
A new study demonstrated that maternal exercise during pregnancy improves the metabolic health of offspring, even when the mother is obese or on a high-fat diet. The findings suggest that physical exercise by the mother induces the placenta to secrete SOD3, resulting in a lowered risk of diabetes for the offspring.
A study published in the Journal of Cachexia, Sarcopenia and Muscle found that BAM15 improves health outcomes for aged mice with obesity by preventing muscle loss and increasing energy expenditure. The compound helped mice lose fat, gain strength and increase physical activity.
Researchers at Edith Cowan University found that a 7-week healthy cooking course improved participants' general health, mental health, and self-perceived mental well-being. Cooking confidence also increased significantly, particularly among women, who reported improved mental health benefits despite no changes in diet quality.
A randomized study of 379 women with obesity and unexplained infertility found that intensive lifestyle changes that shed pounds led to no better chances of pregnancy than simply increasing physical activity without weight loss. The study also showed significant health benefits from weight loss, including a decrease in metabolic syndrome.
A rigorous randomized controlled trial found that adding a 300-calorie serving of French fries to one's diet daily for a month did not result in differential weight gain or biomarker changes compared to an isocaloric daily serving of almonds. The study measured body composition, blood sugar, and insulin levels, finding no clinically si...
A study led by LSU researchers has found that a natural plant extract called Artemisia scoparia can increase the lifespan of roundworms by 40% and improve their metabolic health. The extract, which is native to Asia, was fed to worms in various doses and showed significant effects on fat regulation and stress resistance.
A study found that bright light during daylight hours and dim light in the evening improves glucose metabolism, thermoregulation, and energy expenditure. In contrast, a dim day with bright evening led to reduced postprandial glucose levels despite unchanged insulin levels.
Researchers found that flavanols activate brown adipose tissue, causing it to burn calories and produce heat. Long-term consumption of flavanols increased the levels of heat-related proteins in mice, suggesting a potential therapeutic effect against obesity-related diseases.
A study found that obesity is associated with severe COVID-19 outcomes, including hospital admission or death. Additionally, accelerated immunosenescence may be a key mechanism explaining the relationship between obesity and T2DM in severe COVID-19. Vaccination effectiveness may also be impacted by metabolic disorders.
A study conducted at the University of Jyväskylä found that physically active lifestyle mitigates unfavourable changes in metabolic health during menopause. Menopausal transition is associated with increased abdominal fat mass, blood pressure, and blood glucose levels.
A new study published in Medicine & Science in Sports & Exercise found that exercising intensely at the start of a fast can maximize health benefits by speeding up the transition to ketosis. Participants who exercised reached ketosis on average three and a half hours earlier, producing 43% more B-hydroxybutyrate.
A team of international scientists has shown that skeletal muscle cells from people with type 2 diabetes have a different circadian rhythm, leading to altered mitochondrial metabolism. The study suggests that considering cellular rhythms when prescribing treatments for type 2 diabetes could optimize their effectiveness.
A review of 25 studies on intermittent fasting found that all forms produced mild to moderate weight loss, similar to traditional calorie-restrictive diets. Intermittent fasting regimens also showed benefits in decreasing blood pressure and insulin resistance, and improving appetite regulation.
A new study from Institute for Systems Biology (ISB) reveals that the genetic capacity of the gut microbiome is strongly associated with weight loss success or failure. Microbiomes of those who lost weight had higher bacterial growth rates and were enriched in genes that divert dietary nutrients toward bacterial cell growth. In contras...
The energy balance model fails to explain the biological causes of weight gain, whereas the carbohydrate-insulin model identifies excessive consumption of rapidly digestible carbohydrates as a key contributor to obesity. This perspective argues for a shift in focus from calorie restriction to dietary pattern change.
A Finnish study discovered a positive association between standing and improved insulin sensitivity in adults with increased risk of type 2 diabetes and cardiovascular diseases. The researchers found that increasing daily standing time can help prevent chronic diseases, even if physical activity recommendations are not met.
A recent study published in Scientific Reports found that individuals with inflexible metabolisms exhibit higher carbohydrate oxidation rates at night, indicating a reduced ability to burn fat during sleep. This discovery has the potential for practical use in disease prevention and early intervention.
A new study reveals that metabolism increases rapidly during infancy, peaking at around one year old. After a gradual decline until the 20s, metabolism levels off and then slows down again after age 60, with older adults requiring fewer calories. The findings suggest that muscle loss and cellular changes contribute to this decline.
A study by Van Andel Institute scientists found that surplus sugar causes mitochondria to become less efficient, reducing their energy output. A low-sugar ketogenic diet reversed this effect, supporting healthy mitochondrial integrity and function.
A randomized controlled study suggests that probiotic supplements can help obese children lose body weight and reduce their risk of future metabolic conditions. The findings support the potential benefits of microbiome-based treatments for tackling childhood obesity.
A recent study found that the prevalence of metabolic health among American adults is very low, even among those with normal weight. The researchers estimated that only about 12% of Americans meet the criteria for optimal metabolic health using more rigorous guidelines.
A recent study found that only 12.2% of American adults meet the recommended targets for cardiovascular risk factors management, leaving millions vulnerable to developing Type 2 diabetes and heart disease. Factors such as physical activity, education, and weight status are associated with metabolic health.
A water T2 biomarker discovered by Texas Tech University Health Sciences Center El Paso researcher David P. Cistola can detect individuals at risk of developing Type 2 diabetes, allowing for potential disease prevention through lifestyle modifications or therapies.
A new study published in the journal Diabetes found that fathers' exercise habits can improve their offspring's glucose metabolism and reduce body weight, even if they were born to parents who consumed a high-fat diet. The research also suggests that small RNA changes in the father's sperm may play a role in transmitting beneficial met...
Researchers at Joslin Diabetes Center found that paternal exercise improves glucose metabolism, reduces body weight, and decreases fat mass in offspring. Exercise also alters genetic expression in sperm, potentially transmitting beneficial effects to next-generation offspring.
A study by the University of Nottingham discovered that a lack of protein in a father's diet can negatively impact his offspring's long-term health. The research found that low-protein diets affect sperm quality, leading to increased obesity, type 2 diabetes, and reduced metabolic gene expression in offspring.
Women with metabolically 'healthy' obesity still face a higher risk of cardiovascular disease, even if they are not experiencing other metabolic issues. A large cohort study found that this group has a 39% increased risk of cardiovascular events compared to normal weight women without metabolic abnormalities.
New research suggests that a diet low in branched-chain amino acids (BCAAs) may improve metabolic health and promote leanness. The study found that obese mice on a specialized diet experienced improved glucose metabolism and energy expenditure despite not reducing overall calorie intake.
Researchers found that mice lacking fatty acid-binding proteins exhibit substantial protection against obesity and metabolic diseases as they age. However, this effect did not lengthen lifespan. The study suggests that targeting lipid chaperones may be a way to mimic the benefits of calorie restriction.
Researchers found that low leg fat mass is a crucial factor in lean individuals at increased risk of cardiometabolic diseases, similar to lipodystrophy phenotypes. The study suggests personalized prevention and treatment strategies for metabolically unhealthy lean people.
A new study published at the European Congress on Obesity found that regular physical activity and avoiding inactivity significantly reduce the build-up of dangerous liver fat. The researchers discovered that moving about more throughout the day, such as breaking up long periods of sitting, is a key factor in maintaining metabolic health.