Articles tagged with Gene Regulation
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A recent study has investigated the regulation of genes by noncoding DNA, which controls gene expression and determines cellular function. The research found that cell-specific enhancers have relatively small effects on target genes, highlighting the importance of tight regulation under normal conditions.
Researchers have developed a neuron-optimized CRISPR activation system that efficiently regulates genes involved in learning and memory, plasticity, and neuronal development. This breakthrough paves the way for studying genetic influences on brain health and disease using model organisms more closely resembling humans.
Researchers developed a powerful new tool to investigate brain development, memory, and learning, and the role of gene regulation in neuropsychiatric diseases. The tool selectively and robustly turns on genes in neurons, allowing for controlled expression of individual or multiple genes.
A multinational review of peppers/chilis (Capsicum species) explores various aspects, including taxonomy, genetic resources, cytogenetic studies, and capsaicinoid biosynthesis. The crop's global production, cultivation, and economic value are also examined.
Researchers identified six target disease genes at previously known AMD loci and three additional candidate genes, providing insights into the genetic architecture of AMD. The study used RNA sequencing data to expand on the genetic contributions to AMD.
Researchers studied genome sequences of various species to understand the genetic factors behind limb loss in snakes. By analyzing gene regulatory elements, they found that only one gene was lost in snakes, but not its associated regulatory element, suggesting a more complex process.
Researchers at UNC School of Medicine discovered that Lin28a is needed for the development of pathological hypertrophy, a process where the adult heart enlarges in response to cardiac stress. This discovery could lead to more potent therapeutics for heart disease treatment.
Researchers studied mRNA and microRNA interactions in prenatal human brain cells to understand their role in cell type identification. They found that these interactions are highly cell-type specific, which can lead to overexpression of certain genes and uncontrolled cell production.
A gene expression atlas has mapped the variability in genetically identical plants, revealing that around 9% of genes behave unpredictably. This variation helps plants respond to environmental factors like light, temperature, and pathogens, increasing their survival chances.
Researchers at UNIGE discovered the identity of Hydra's inhibitor, protein Sp5, which maintains a single-headed adult body and regulates regenerative response. The mechanism has been conserved throughout evolution, suggesting potential therapeutic applications in human tumors.
A new report highlights the need for effective communication in addressing 'post-normal' science technologies, such as gene drives, which pose a challenge to science journalists. The technology has the potential to reduce malaria deaths but also raises concerns about safety and regulation.
Scientists have identified a novel step in gene expression that controls the expression of genes crucial for breast cancer cell growth and tumour progression. The discovery highlights a specific modification allowing RNA polymerase II to overcome a pausing barrier, enabling the transcription of proliferation genes.
Researchers identified 24 candidate genes associated with monogamy in vertebrates, including heightened expressions of those involved in neural development, synaptic activity, learning, and memory. This suggests a putative gene expression signature common to some vertebrate species.
A new study suggests that Actin, a cytoskeleton protein, plays a crucial role in regulating the genome during neuron formation. The research has potential implications for the development of personalized medicines.
A Texas A&M-led study reveals that transcription factor Foxo1 plays a crucial role in regulating blood glucose levels and may serve as a key therapeutic target for preventing Type 2 diabetes. By understanding the molecular mechanism of Foxo1, researchers aim to develop novel interventions for controlling blood glucose homeostasis.
A team of UD engineers has developed a method to use CRISPR/Cas9 technology for conditional gene regulation, introducing a new functionality to the technology. This allows scientists to precisely target and edit DNA within living cells, which could help correct inherited diseases.
Researchers found that enhancers regulate the SOX9 gene, which is critical for male development. The study reveals that disruptions to these enhancers can lead to disorders of sex development.
Scientists at the Salk Institute discovered a complex gene regulation network that helps plants cope with DNA damage. The research identified approximately 2,400 genes responding to DNA damage, with only 200 directly activated by SOG1, revealing its 'hands-off' overseer role.
Researchers identified the Ikzf2 gene as a key regulator of special cells needed for hearing. Introducing a virus engineered to overexpress helios into inner ear hair cells transformed some mature inner hair cells into outer hair cells, exhibiting critical characteristics. This discovery may lead to therapies for age-related hearing loss.
Researchers found that vertebrate genomes underwent two whole genome duplications, driving the evolution of genetic characteristics. The study, published in Nature, also revealed regulatory mechanisms shared between lancelets and vertebrates, shifting our understanding of gene control along the evolutionary timeline.
Research published in Experimental Physiology reveals smoking during pregnancy increases the likelihood of a baby becoming obese. Higher levels of chemerin, a protein associated with obesity, were found in infants whose mothers smoked during pregnancy. Reduced DNA methylation was also linked to increased expression of this protein.
The study analyzes genome data from multiple species, including humans, mice, and zebrafish, to understand the evolutionary transition from invertebrates to vertebrates. The research identifies key differences in gene regulation between vertebrates and invertebrates, highlighting complex gene regulation and specialization.
A new study reveals LZTR1 as a key regulator of RAS protein signaling, which is central to growth and oncogenesis. The findings provide a molecular explanation for various pathological conditions, including cancers and developmental disorders.
Researchers found a clear connection between gene expression and behavior in little male fish building patterns to attract mates. The study also suggests that the genes behind this behavior have human cousins implicated in autism spectrum disorder.
Researchers found thousands of genetic variants linked to both pit and castle building behaviors, suggesting complex patterns of genetic variation and regulation. The study provides evolutionary insights into the development of these natural behaviors in cichlid fishes.
A new study has discovered a single protein called Dazl that regulates a network of genes essential for developing sperm to replicate and survive. This finding could lay the groundwork for future research into therapies for infertile men, offering insights into molecular events that ensure survival of germ cells.
Researchers report genome assemblies of Eurasian trembling aspen and North American quaking aspen, highlighting the influence of gene network connectivity on genetic diversity. The study suggests that genetic variation is shaped by gene expression levels and regulation in these species.
A new screening method, 'rec-YnH', has been developed to detect direct biomolecule interactions, enabling researchers to understand complex cellular processes. This affordable and accessible technique can be used by standard biomedical laboratories to study protein-protein and protein-RNA interactions.
Researchers at CRG describe how specific proteins guide Tet2 enzyme to DNA regions needed for cell fate specification. This novel mechanism reveals a new way transcription factors interact with the genome.
A study found that a fragment of an ancient retrovirus, HK2, is more frequently integrated in the genes of people who contracted HIV through IV drug use. This suggests that HK2 may contribute to dopaminergic manipulation and be an underappreciated pathogenic burden.
Researchers found a new mechanism by which small snoRNAs regulate the splicing process of host genes, ensuring proper protein production. This breakthrough discovery opens a new avenue of research into gene expression and has implications for understanding diseases like cancer.
Repeated binge drinking alters gene expression in the brain, affecting hormone signaling and immune function in females, while nerve signaling is impacted in males. This study highlights the importance of tailoring treatments for male and female patients with alcohol use disorder.
Researchers have identified the genetic mechanisms underlying preterm labor by studying the Nodal gene. Variations of the gene and inflammation are associated with an increased risk of premature delivery.
Research by University of Manchester scientists found that genes regulating lungs and liver function change with the day-night cycle, impacting steroid side effects. Removing a specific molecule, Reverbα, altered gene expression and showed protective effects against fatty liver buildup.
Researchers identified two essential genes involved in regulating REM sleep duration in mice. The knockout of these genes resulted in drastically decreased REM sleep and altered sleep patterns. This study provides insights into the molecular mechanisms underlying REM sleep, a crucial aspect of maintaining mental and physical health.
Researchers found that Evf2 RNA regulates key genes during embryonic brain development, affecting GABA neurotransmitters and leading to seizures or neurological disorders. The discovery could help identify therapeutic targets to prevent neurological diseases.
Researchers discovered that gene regulation is largely digital and stochastic, with genes being on or off for a fraction of time. This finding adds complexity to human diseases, such as neuropsychiatric disorders, and may help better understand dosage-sensitive genes contributing to these conditions.
A direct link has been discovered between protein aggregation in nerve cells and the regulation of gene expression in Huntington's disease. The study found that impaired autophagy leads to accumulation of misfolded proteins, including AGO2, which disrupts cell function and signal pathways.
The International Wheat Genome Sequencing Consortium has published the reference genome of bread wheat, enabling breeders to identify genes and regulatory elements underlying complex traits. This achievement will boost wheat improvement, similar to maize and rice after their reference sequences were produced.
The complete wheat genome is now sequenced, enabling researchers to identify genes controlling traits such as drought resistance and breed plants with higher nutritional quality. This breakthrough accelerates innovation in breeding resilient and disease-resistant crops to meet global demand for wheat.
Kansas State University scientists have cracked the wheat code, unlocking a detailed description of the bread wheat genome. The high-quality reference genome sequence will help produce wheat varieties with higher yields, enhanced nutritional quality, and improved sustainability to meet future demands of a growing global population.
Scientists have created a comprehensive atlas of the mouse genome's regulatory landscape, revealing how DNA elements regulate cell type identity and identifying potential links to human diseases. The study cataloged over 400,000 regulatory elements and assigned most patterns to specific cell types.
A team of researchers from CSIRO Australia has identified a new gene called C6 that regulates the body's immune response to infection and disease. The discovery could lead to targeted therapies for various diseases, including cancer, diabetes, and inflammatory disorders.
INTS13 is a master regulator of gene expression during monocytic differentiation, promoting lineage-specific genes and cell fate determination in hematopoiesis. Depletion of INTS13 disrupts monocytic/macrophagic gene activation, highlighting its indispensable role in monocytic maturation.
A recent NIH-funded pilot study found that men and women infected with gonorrhea have distinct gene expression profiles during active infection, with increased antibiotic resistance detected more frequently in males. The research highlights the need for gender-specific strategies to combat this increasingly resistant bacterial pathogen.
Researchers developed a new model for comparative genomic analysis, revealing differences in gene regulation between primate species. The Phylogenetic Hidden Markov Gaussian Processes model provides insights into what makes a human a human and has implications for understanding evolution and certain diseases.
A study by Philipp Maass and Anja Weise found that chromosomes 12 and 17 frequently interact with each other across different individuals, resulting in recurrent patterns. This interaction is linked to a human genetic condition, brachydactyly, where the deletion of a specific gene alters chromosomal arrangements and disturbs interactions.
A single episode of binge drinking can alter a key gene that regulates sleep, leading to increased non-rapid eye movement sleep and reduced sleep in subsequent periods. This finding may shed light on the link between sleep disturbances and alcoholism in humans.
A new mechanism has been identified that triggers multiple sclerosis disease through epigenetic regulation, with a protective variant reducing the risk. The study found that people with the major risk variant HLA-DRB1*15:01 have increased expression of the HLA-DRB1 gene, increasing the risk for MS.
A study by the University of Helsinki found that IVF can alter embryonic growth, particularly in relation to genetic variation. Children born from frozen embryo transfer had significantly higher birth weights than those born from fresh embryo transfer.
Researchers have identified a critical non-coding DNA element regulating the Sox9 gene, crucial for male sex development. Deleting this enhancer results in sex reversal in mice, shedding light on the genetic mechanisms underlying sex determination and potentially improving diagnosis for patients with differences in sex development.
A study has identified genetic variants associated with an increased risk of developing pediatric nephrotic syndrome, a debilitating kidney disease in children. The findings could lead to new diagnostics and treatments.
Researchers identified plasma lipid species as signatures of healthy or unhealthy metabolic states, including fatty liver disease. They also pinpointed genetic regulators of lipid species and their physiological functions using systems genetics approaches.
A team led by Prof. Stein Aerts uncovers how access to relevant DNA regions is orchestrated in epithelial cells, shedding light on biological mechanisms of gene regulation and potential new avenues for cellular reprogramming. Grainyhead, a pioneer factor, acts as a key that can be used to access specific DNA regions.
Researchers found that mechanical cues contribute to the regulation of gene expression during early development. External pressure can activate or restore the expression of a crucial developmental regulator gene, brachyury. This mechanism is conserved across species, including zebrafish and fruitflies.
Researchers use CRISPR-Cas9 to precisely alter hundreds of genes or features in yeast cells with 80-100% efficiency, identifying gene alterations that trigger or prevent specific behaviors. The approach allows for rapid profiling and identification of key genes and DNA sequence variations associated with traits and diseases.
Rothamsted Research will conduct a field trial of genome-edited (GE) Camelina, a genetically modified crop that accumulates omega-3 fatty acids, alongside a traditional GM version. The trials aim to investigate the efficiency of genetic engineering in developing plants with desired traits, such as improved nutrition and sustainability.
A new drug has been found to reduce symptoms and activate dormant neurons in preclinical models of Rett syndrome, a genetic disorder causing intellectual disability. The treatment, SB216763, also shows promise in improving quality of life by lengthening lifespan and reducing tremors and breathing difficulties.
Researchers at Stowers Institute for Medical Research discovered a global regulatory element within the Hoxb cluster that controls its expression in blood-forming stem cells. This mechanism helps maintain normal hematopoiesis and prevents acute myeloid leukemia by regulating Hoxb cluster genes in a methylation-dependent manner.
A study published in PNAS found that genes regulating immune system and metabolic processes fail to adapt to new sleep patterns caused by night shifts. Eight healthy volunteers were subjected to a five-day schedule simulating night shift work, showing that almost 25% of rhythmic genes lost their biological rhythm.