Articles tagged with Gene Regulation
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at UC San Diego discovered the critical gene ZNF263, which regulates heparin biosynthesis in human cells. This breakthrough could enable the production of heparin in well-controlled cell culture, providing a safer and more sustainable alternative to current methods.
Researchers Susanne Hellmuth and Olaf Stemmann found that the protein shugoshin regulates separase activity, preventing premature sister chromatid separation. This discovery adds to our understanding of chromosome inheritance and highlights the importance of tight regulation in cell division.
A new transcription factor (FaPRE1) has been identified as a key regulator of strawberry ripening, controlling the expression of genes related to color, aroma, and texture. The gene plays a twofold role in regulating expression, silencing development genes and beginning ripening genes.
A study by University of Helsinki researchers identified a gene variant in the regulatory region of the retina responsible for canine blindness in Miniature Schnauzers. The finding provides valuable insights into retinal biology and offers a new model for understanding related diseases, such as retinitis pigmentosa.
Researchers at IST Austria find that bacteria can copy genes as an adaptive strategy, creating genetic diversity and tuning gene expression levels. This mechanism allows for quick adaptation on ecological timescales, potentially impacting antibiotic resistance.
Researchers developed a new single-cell sequencing technique to study the regulation of gene transcripts. They found that cells use distinct strategies to control transcript copies, involving both transcription and degradation processes.
Conserved epigenetic regulators BAZ2B and EHMT1 identified as novel anti-aging targets in aging research. The study reveals a mechanism for regulating cognitive aging by reducing mitochondrial function.
A massive genome analysis identified 179 genes and regulators as cancer 'drivers', but found that thousands of non-driver mutations, or 'passengers', can also contribute to cancer development and have a significant impact on genomic regions. These findings suggest that passenger variants can both hinder and promote tumor growth.
The study analyzes mechanisms regulating carcinogenesis and tumor progression, opening new perspectives in the fight against human cancer. HERC1 ligase is found to regulate the activation of ERK and p38 kinase through ubiquitination.
A new study from the University of Michigan presents the first genetic evidence of resistance in some bats to white-nose syndrome, a deadly fungal disease that has decimated some North American bat populations. Genetic differences were found in genes associated with regulating arousal from hibernation and breakdown of fats.
Researchers have identified a link between the nervous system and immune system in Parkinson's disease, finding that genes like Parkin and PACRG protect nerve cells from cell death. These proteins regulate a signalling pathway that also plays a role in innate immunity, which prevents bacterial infections.
Scientists have discovered a fundamental process that regulates gene activity by destroying tangled RNAs. This discovery may lead to powerful new medical treatments and shed light on the development of human disorders.
A team of researchers has identified novel mechanisms of disease progression in the non-coding genome that could lead to better diagnostic tests and precision therapies. The study found evidence of new molecular mechanisms that may cause cancer and give rise to more-aggressive tumours.
Researchers have developed a custom artificial neural network that can analyze molecular signals controlling gene function, enabling biologists to understand complex mechanisms of gene regulation. This breakthrough enables the creation of machine learning algorithms that reflect common concepts in biology.
A new algorithm called OnTAD rapidly identifies and elucidates the functions of topologically associating domains (TADs), which are disrupted in diseases like cancer. The tool reveals increased gene expression in hierarchical TADs, associated with active epigenetic states.
Researchers at Johns Hopkins Medicine used targeted gene epigenome editing to reverse a genetic mutation causing WAGR syndrome, a condition leading to intellectual disability and obesity. The study suggests the potential for developing epigenome editing therapies to prevent brain developmental disorders.
New research from the University of Alberta sheds light on iron biology's role in three human diseases: porphyria, Andersen disease, and Wolfram syndrome. The study finds that a protein called aconitase regulates genes in the nucleus to control iron levels.
Uppsala researchers developed a new method to investigate dynamic processes in large genetic libraries using DuMPLING. This approach enables the examination of thousands of living cells in a single microfluidic chip, linking genetic information to complex cell behavior. The study focuses on bacterial cell cycle regulation and aims to i...
Researchers from MIPT explored microRNA interactions with mRNA in two human cell lines, finding that microRNA does not strongly regulate all genes and its regulation potential does not directly depend on its expression level. The study also identified differences between microRNA interactions in the two cell lines.
New research reveals that chromatin dynamics regulate the entire herpes virus genome's expression during infection. The discovery sheds light on the interplay between the virus and host cells, potentially leading to more effective treatments.
Scientists uncover genetic differences in gene expression that underlie species-specific songs, revealing a key role for brain-derived neurotrophic factor (BDNF) in song learning. The study sheds new light on the evolution of animal behaviors.
Researchers found that gene activity in brain regions called song nuclei is associated with species-specific patterns of singing in songbirds. The study identified a signaling molecule called BDNF as a mediator of changes in trans-regulated genes, which disrupted the structures of learned songs in adult zebra finches.
Researchers identified genomic elements regulating optix gene expression in Heliconius butterflies, found to be necessary for normal pattern development. These elements evolved in parallel in distantly related species with similar patterns, highlighting the complexity of butterfly wing patterning.
A study has identified a new mechanism by which pancreatic beta-cells respond to inflammatory environments, leading to the onset of Type 1 Diabetes. Researchers mapped approximately 3,600 non-coding DNA regions that activate in response to inflammation.
A study identified two types of genetic variants in the PM20D1 gene that regulate its expression in adipocytes, with one variant acting as an on/off switch and another similar to a dimmer switch; these variations are associated with obesity risk.
Researchers discovered a brain circuit linking cigarette smoking to type 2 diabetes, showing that nicotine consumption leads to reduced insulin release and higher blood sugar levels. The study found that variations in the Tcf7l2 gene may influence both tobacco addiction and diabetes development.
Researchers analyzed human and chimpanzee cerebral organoids to understand dynamic gene expression and regulation in early brain development. They identified human-specific gene expression patterns and developmental differences in the adult prefrontal cortex.
Researchers at MDI Biological Laboratory have identified post-transcriptional regulation mechanisms governing longevity, which will aid in screening for new therapies. The study uses C. elegans worms and dietary restriction to understand the genetic complexity of aging.
Researchers at the University of Bergen identified new genetic signals regulating infant growth, which may help combat growth-related diseases like obesity and malnutrition. The study found that different BMI-signals exist for children and adults, with varying genetic influences during childhood.
Researchers discovered that gene expression regulators work together to raise an individual's risk of developing schizophrenia. The study found that modeled gene expression changes matched those found in patients' brains, highlighting the importance of considering complex genetic interactions in psychiatric disorders.
Scientists identified over 11,000 families of grouped genes in genomes of different species, with a third being part of conserved clusters. The study found that natural selection favors gene organization, making it easier to regulate genes, and that horizontal transfer may be less common than previously thought.
Researchers at Duke-NUS Medical School have identified a network of RNA-binding proteins that play a key role in the formation of disease-causing fibrous tissue in the heart. Inhibiting specific proteins may help prevent or treat cardiac fibrosis, which underlies many heart diseases.
Researchers investigate Mediator complex's function in transcription, shedding light on its conserved role across evolution. The study reveals the complex's involvement in developmental regulation and provides insights into gene expression.
Researchers developed single-nucleus methyl-3C sequencing (sn-m3C-seq) to analyze chromosome structure and epigenetic features in single human brain cells. This approach enables the simultaneous study of two levels of gene regulation, which may help clarify how genetic variations contribute to human disease.
Researchers have created the first high-resolution atlas of malaria parasite gene expression, revealing new insights into gene function and regulation. The Malaria Cell Atlas provides potential targets for future treatments and a better understanding of the spread of drug resistance.
A recent study found that genetic mutations affecting RNA regulation play a crucial role in autism spectrum disorder and stroke. Analyzing noncoding DNA, researchers discovered new insights into the mechanisms underlying these complex conditions.
Research found that ATG7 is related to the onset of frontotemporal dementia and Lou Gehrig's disease. The study showed that activating autophagy through ATG7 can improve neurodegenerative symptoms in fruit flies, suggesting a potential treatment for neuro-degenerative diseases.
Researchers found KLF4 protein stability is critical for stem cells to specialize and become specific cell types. By preventing this breakdown, stem cells can differentiate into organs.
The EU General Data Protection Regulation (GDPR) complicates data sharing in research, with participants' consent withdrawal rights and limited data retention posing challenges. Researchers advocate for GDPR-compliant repositories and adaptable funding policies to ensure safe data sharing.
A Princeton University-led team used AI to decode the functional impact of non-coding DNA mutations in people with autism. The researchers analyzed 1,790 family genomes and found thousands of potential genetic contributors. This breakthrough method is applicable to discovering genetic contributions to any disease.
Researchers found an interaction between BRD4 and the enzyme MTHFD1 from folate metabolism, which links gene regulation to transcriptional control. This discovery promises new approaches in cancer combination therapy for aggressive tumors.
Researchers from the University of Minnesota Medical School discovered that large loops form between DNA sequences where a key protein Pax3 binds, and these loops are essential for the development of skeletal muscle. The study shows how 3D genome organization regulates cell differentiation in skeletal muscle formation.
Researchers discovered that ribosomes in human cells destroy healthy mRNAs, affecting protein production and regulating gene expression. This discovery may lead to a better understanding of gene misregulation in human diseases.
The German Research Foundation (DFG) has approved a new Research Training Group focusing on the evolution of complex genetic regulation systems. The GenEvo group will bring together researchers from evolutionary and molecular biology to analyze regulatory processes and their selection under evolutionary pressures.
A Rutgers discovery identified a siesta-suppressing gene in fruit flies that helps creatures balance the benefits of napping against getting important activities done during the day. The 'daywake' gene regulates behavioral flexibility, allowing flies to seek food or mates when temperatures are cool.
Researchers have identified over 100 new genes that could contribute to the development of cleft lip and palate (CL/P), a condition affecting 1 in 700 live-born babies. The study suggests that genetic variants near these genes are regulated by 'enhancers' in the genome, which play a crucial role in maintaining proper cell identity.
Rhythmic food intake drives liver gene expression independently of the molecular clock, regulating metabolic pathways and potentially leading to health issues like aging and obesity. The study's findings have implications for understanding circadian biology and the impact of timing on health.
Researchers have developed a new label-free imaging technique that reveals the dynamic movement of chromatin in eukaryotic cells just before cell death. The study found that cells experience a 'burst' of activity, known as cellular paroxysm, which is thought to play a role in the earliest stages of cell death.
A team of biologists has discovered new rules governing cell decision-making in genetics, revealing how genes are activated under specific conditions. The study found that a protein called Zelda strengthens Dorsal activity, allowing cells to make decisions about gene activation based on their environment.
Researchers found that Hirschsprung disease shares common genetic mechanisms with complex disorders like schizophrenia and autism. The study identified key genes, cellular mechanisms, and molecular targets for personalized treatment.
A Belgian team developed a new bioinformatics method called cisTopic to analyze gene regulation in cells. The method discovers common topics of gene control across cells, revealing unique gene activity patterns. This enables researchers to understand cellular diversity and its implications for diseases.
A new research unit at Charité - Universitätsmedizin Berlin aims to improve the identification and diagnosis of rare genetic diseases by analyzing non-coding DNA sequences. The researchers will develop software for whole-genome data analysis, enhancing our understanding of gene regulation and transcription.
Researchers discovered a new candidate gene, unpaired 1, that contributes to lifespan regulation in Drosophila melanogaster. Overexpression of this gene increased lifespan in nervous tissue and fat body, but decreased lifespan in intestine.
A team of scientists led by Paula McSteen identified a new gene called barren stalk2 (ba2) that affects the development of axillary meristems in corn plants. The ba2 gene interacts with another gene, barren stalk1 (ba1), to regulate ear formation.
Researchers have made significant breakthroughs in understanding snake genomes, including the evolution of venom genes, dosage compensation mechanisms, and sex determination systems. The study provides a comprehensive genomic context for these complex biological processes, offering new insights into the unique adaptations of snakes.
Researchers developed an artificial chemical DNA switch that can be turned on and off using light, offering a novel approach to epigenetics. The method uses chemical reactions in the major groove of DNA to influence gene switching, potentially leading to targeted regulation of gene expression.
Experts argue that new regulations challenging women with differences of sex development are based on limited scientific data and may set an unscientific precedent. Blood testosterone levels vary naturally in men and women, making it difficult to determine direct associations between testosterone levels and sports performance.
Researchers from the Center for Genomic Regulation have discovered a direct link between nutrient metabolism and gene regulation in embryonic stem cells. The AHCY protein is found to be a key activator of genes involved in controlling stem cell proliferation, with implications for understanding embryonic growth and infertility.
Research led by Queen Mary University of London finds that pesticides affect genes in bumblebees, leading to changes in gene activity levels. The study highlights the need for improved regulation on neonicotinoid pesticides to protect pollinator health and ecosystem stability.
A study published in EMBO Journal has discovered the key aspect of regulating telomeres, which are protective caps at the end of chromosomes. The research team found that the protein complex CST is responsible for maintaining telomeres, and a chemical modification regulates its S component, allowing telomere duplication and elongation.