Articles tagged with Gene Regulation
Researchers developed a new approach called Co-opting Regulation Bypass Repair (CRBR) that can correct genetic diseases caused by single gene mutations. The method uses the CRISPR/Cas9 system and non-homologous end joining to insert a functional copy of the gene, enabling treatment in all adult tissues.
New research from the University of Waterloo reveals shift work disrupts the circadian clock, affecting immune response and increasing risk of infection. The study shows sex differences in immune system reactivity, with males more prone to overactivation and females better prepared to fight off infections.
Scientists at Beam Therapeutics have created a redesigned base editor that successfully repairs the single-base mutation causing sickle-cell disease. The therapy targets an upstream regulatory pathway to express fetal hemoglobin, offering a potential solution for this genetic disorder.
A new study identified 267 genes unique to modern humans that play a crucial role in creativity, self-awareness, cooperativeness, and healthy longevity. These genes are found only in Homo sapiens and not in Neanderthals or chimpanzees.
Researchers from Skoltech identified the role of distant RNA regions in regulating gene expression, revealing their impact on splicing and gene regulation.
Researchers at John Innes Centre discovered two genes, ATH1 and DELLA, controlling plant compactness and elongation. These findings may lead to more precise ways to modify crop shape and height in agriculture.
Researchers use CRISPR-Cas9 to introduce thousands of mutations into C. elegans worms, then analyze the effects on physical traits and functions. They discover a surprise finding that mutations in specific microRNA binding sites can affect gene expression.
Bioengineers have discovered a way to harness multiple forms of regulation in living cells to strictly control gene expression. This breakthrough enables precise regulation of biochemical processes involved in producing chemicals, medicines, and other products, leading to improved biotechnologies.
Researchers found that multiple genes and genetic variants are linked to flight performance in flies, with a central gene called pickpocket 23 regulating interactions. This study highlights the importance of genome-wide association studies in understanding complex traits like flight, which involve numerous genes.
A high-resolution protein architecture of the budding yeast genome was mapped using ChIP-exo, revealing two distinct gene regulatory architectures. The study identifies a surprisingly small number of unique protein assemblages used repeatedly across the yeast genome, expanding the traditional model of gene regulation.
A high-resolution map of protein binding locations in yeast has produced two distinct gene regulatory architectures, challenging traditional models of gene regulation. The study revealed unique protein assemblages and absence of specific regulatory control signals at housekeeping genes.
Researchers discovered that the WOX9 gene can induce more flowers to form in various plant species by changing its regulation, suggesting potential for improving crop yields. Genome editing allowed them to reveal the gene's additional functions without altering its protein product.
A new computational tool called mixscape has been developed to help understand the function and regulation of human genes. Mixscape identified a molecular mechanism for regulating immune checkpoint proteins that govern the immune system's ability to identify and destroy cancer cells.
Researchers at Heidelberg University developed a novel fluorescence marker called RhoBAST to enable super-resolution RNA imaging in live cells. The method reveals details of subcellular structures and molecular interactions involving RNA, improving image resolution.
A new Stanford-led study investigates air pollution's effects at the single cell level and its impact on cardiovascular and immune systems in children. The analysis reveals that brief exposure to fine particulate matter can alter gene regulation, potentially leading to increased risk of disease later in life.
Scientists reveal that the African Coelacanth gained 62 new genes through encounters with other species, which arose from transposons. The genes likely play a role in gene regulation and are tissue-specific, with evidence suggesting they were introduced multiple times throughout evolutionary history.
Researchers found modest differences in gene expression between individuals with a mental disorder and those without, but more pronounced differences in transcript levels. The study identifies specific transcripts associated with each disorder, providing insights into their distinctness and potential treatment responses.
A comprehensive epigenome map has been created, revealing genetic control elements linked to hundreds of human traits. The researchers identified 300 modules controlling specific biological processes and predicted links between control elements and target genes.
Researchers used computer simulations to study evolution and phenotypic switching in organisms, finding that a 'hidden' switch mechanism is used for stability, and can be activated in response to environmental changes. The study suggests that this mechanism helps organisms maintain gene expression levels under stable conditions.
The EGR1 transcription factor inhibits expression of pro-inflammatory genes in macrophages, blunting their activation and the immune response. This discovery sheds light on the fundamental process of macrophage maturation, which is critical for inflammation.
Researchers have identified a unique genetic 'mimicry switch' that determines whether male and female Elymnias hypermnestra palmflies mimic the same or different species. The study found that sexual dimorphism arose repeatedly in different populations, linked to a gene associated with melanin localization and regulation.
A new deep-learning framework predicts gene regulation at the single-cell level, enabling the study of transcription factor binding. This breakthrough has the potential to advance disease understanding and treatment, particularly in cancer research.
Researchers used CRISPR/Cas9 genome editing to increase formicamycin production in Streptomyces formicae bacteria, which could lead to new antibiotics against MRSA. The over-producing strain can be used to purify enough formicamycins to study their mode of action and development as antibiotics.
Researchers at EPFL and Weizmann Institute of Science study spatial shifts of gene expression within liver lobules in relation to the circadian clock. The study reveals that many liver genes are both zonated and rhythmic, regulating key metabolic functions.
Researchers identify large set of gene regulatory regions in the human brain that have undergone positive selection throughout evolution. These regions are believed to contribute to the development of cognitive abilities.
Researchers at Ben-Gurion University have discovered a new end-to-end cyber-biological attack that can trick scientists into generating dangerous toxins in their labs. The attack uses malware to interfere with biological processes within the victim's lab, exploiting weaknesses in biosecurity screening protocols and cybersecurity controls.
Researchers at the University of Illinois Urbana-Champaign found that gut hormones FGF15/19 turn off fat-producing genes in the liver. The study suggests a new target for therapeutic treatment options to address obesity-related metabolic disorders.
Researchers found triclosan suppressed FGF21 expression and altered genes involved in amino acid and lipid metabolism. Triclosan also accelerated liver disease development in mice with type I diabetes and changed gut microbiota similar to NASH patients.
Scientists at University of Tokyo identify genes that give plant nucleus its shape, also regulate copper tolerance. The discovery reveals fundamental knowledge about genome regulation and points towards future methods for manipulating gene expression.
Researchers at Baylor College of Medicine have made significant discoveries about the 3D structure of mammalian ferroportin, revealing two iron-binding sites and a unique mode of action. This new understanding has potential implications for treating iron overload diseases, such as anemia and cancer.
Researchers at Harvard University have identified a key gene POPOVICH responsible for floral nectar spur development, a crucial innovation in plant evolution. This discovery provides insight into the origin of this trait and its role in promoting biodiversity among flowering plants.
Researchers identified mechanisms in Alzheimer's disease that cause neurons to de-differentiate and lose synaptic connections, resulting in cognitive decline. The study found changes in chromatin structure trigger these effects.
Heidelberg researchers discovered that RNA synthesis and protein translation play crucial roles in shaping organ functions. The study analyzed over 100 billion gene expression fragments, revealing the importance of regulatory mechanisms at both layers of gene expression.
A novel computational method reveals reduced gene coordination in old cells compared to young cells across multiple organisms and cell types. The findings support Vijg's theory that a decline in gene regulation mechanisms contributes to the aging process.
Scientists have discovered a new RNA-centric mechanism that regulates the creation of a crucial cancer microRNA. The findings reveal that environmental stimuli can activate a 'hidden' layer of regulation, enhancing the efficiency of miR-21 processing and potentially leading to disease.
A new gene expression study by McLean Hospital researchers identifies CREB as a molecular switch regulating fear and extinction. Targeting this gene in neurons may provide new insights and treatments for anxiety and post-traumatic stress disorder.
Researchers will investigate chromatin organization within cells and how it changes over time to identify disease targets. The study aims to develop navigable maps of chromatin architecture across multiple cell types, enabling new treatments for a range of diseases.
A recent study by IMDEA Networks Institute revealed that over 150 million websites among a billion tested contain sensitive and tracked content, despite European General Data Protection Regulation (GDPR) rules. The research uses machine learning classifiers to identify sensitive URLs on the web, finding that these pages are being track...
Researchers discovered two genetic mutations in moles that lead to the development of ovarian and testicular tissues, resulting in high levels of testosterone and aggression. The study sheds light on how DNA changes contribute to evolution and the formation of unique sexual features in mammals.
A recent study published in Scientific Reports has found that Y chromosome genes may regulate cellular functions differently than previously thought, potentially explaining why men are more susceptible to certain diseases like Covid-19. The discovery could also provide insights into the underlying mechanisms of male health disparities.
Researchers found epigenetic changes in domesticated chickens that differ from their wild ancestors, the red junglefowl. They identified 'hotspots' in DNA controlling epigenetic changes at hundreds of locations.
Researchers found that heroin use alters the expression of the FYN gene, which regulates Tau production and is associated with neurodegenerative diseases like Alzheimer's. The study suggests that FYN inhibitors may be a promising therapeutic tool for opioid addiction.
Research highlights sex differences in gene expression, finding over a third of genes display sex-biased expression in at least one tissue. Sex-linked disparities contribute to increased cancer rates in males and autoimmune disorders in females.
The GTEx resource provides an important tool to address the relationship between genetic variants and gene regulation, with analysis discovering eQTLs and sQTLs for the vast majority of genes. The study details mechanisms of how genetic effects from coding and non-coding regions affect gene expression and splicing regulation.
Researchers found sex differences in gene expression in almost every type of human tissue, with effects observed in genes related to disease and clinical phenotypes. Sex biases were discovered in genes relevant to drug metabolism and placental development.
A new study from Northwestern Medicine reveals that biological sex has a small but significant impact on gene expression in every type of human tissue. The researchers found over 37% of genes were expressed differently in males and females, with diverse molecular functions involved, including disease-related traits.
The GTEx project has mapped genetic variations that affect gene expression across over four dozen tissues, revealing the importance of cell type in understanding gene regulation. The study cataloged QTLs governing the expression of over 23,000 genes, highlighting the complexity underlying genetic control of gene expression.
Researchers at MDI Biological Laboratory have discovered the role of Klf9 in regulating the physiological response to cortisol, a hormone secreted by the adrenal glands in response to stress. The study sheds light on the mechanisms behind chronic stress-induced inflammation and its contribution to age-related diseases.
Researchers at Skolkovo Institute of Science and Technology have identified new genetic markers for controlling glucosinolate content in rapeseed. This discovery can help crop breeders create oil-rich rapeseed varieties, improving oil quality.
Scientists at Nagoya University discovered two genes, ACE1 and DEC1, that counteract each other to regulate rice plant stem growth. The findings suggest a new approach for genetically modifying rice crops to improve yield and adaptability.
A new study identifies two genes, TMEM106B and RBFOX1, that regulate gene expression in the aging brain and are linked to both Alzheimer's disease and Limbic-predominant Age-related TDP-43 Encephalopathy (LATE). The findings suggest a shared molecular basis for these diseases, which may lead to new treatments and prevention strategies.
A specific gene, NTRK2, is associated with reduced PTSD risk after traumatic experiences, leading to weaker and less severe memories. The study's findings suggest that increased regulation of this gene may reduce memory formation and lower the risk of developing PTSD.
Researchers at Baylor College of Medicine discovered a novel mechanism to regulate ATXN1 levels, reducing protein accumulation and improving SCA1 symptoms. Gene therapy targeting the cerebellum showed promising results by lowering ATXN1 levels and enhancing motor coordination in animal models.
Researchers from the Center for Genomic Regulation discover Phf19 crucial for hematopoietic stem cell differentiation and balanced blood tissue. Without Phf19, mice develop disorders in blood composition compatible with early stages of leukemia.
Researchers at HudsonAlpha Institute for Biotechnology have contributed to the ENCODE Project, a decade-long effort to understand the human genome. By analyzing millions of DNA switches, they identified novel associations between transcription factors, bringing researchers closer to understanding how the human genome functions.
Researchers from UC San Diego School of Medicine contributed to the ENCODE project, describing millions of candidate DNA switches that regulate gene expression. The study reveals novel functions for RNA-binding proteins and identifies genetic elements linked to human disease risk variants.
The ENCODE Project has added millions of candidate DNA switches that appear to regulate gene expression in humans and mice, providing a new registry for assigning biological categories. Researchers used biochemical approaches to explore the entire genome rapidly and comprehensively, identifying regions with potential functional roles.
Researchers at Tokyo University of Science discovered that transcription factor PU.1 plays a crucial role in regulating PD-L2 expression, which has implications for developing new treatments for immune-related disorders and cancer. The study sheds light on the molecular events underlying PD-L2 regulation.
Researchers discovered widespread expression of immune genes in structural cells, which contribute to the response to pathogens. The study highlights that structural cells are not only essential building blocks but also play a key role in defending against infections.
A Northwestern University team uncovered a common mechanism regulating gene expression during development, linking stochasticity to physical constraints. The researchers found that bursts of natural randomness impact protein levels and developmental outcomes.