Articles tagged with Dopamine
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A study in obese mice reveals that physical inactivity is linked to altered dopamine receptors, contradicting the assumption that excess body weight is the primary cause. The research suggests that dopamine signaling defects contribute to reduced movement in obesity.
A new study reveals that brain stimulation can improve timing abilities in mice lacking dopamine, a key player in Parkinson's disease. The breakthrough finding suggests that targeted brain stimulation could be used to treat cognitive problems caused by PD and possibly other conditions.
A novel analysis in mice reveals that dopamine neuron activity plays a key role in judgment of time, slowing down the internal clock. The study found that transient activation or inhibition of dopamine neurons was sufficient to slow down or speed up time estimation.
A team of neuroscientists has identified neural circuitry in a deep region of the mouse brain that modulates judgments of elapsed time. The discovery may help explain why time seems to fly or stretch depending on our emotions and attention.
Dopamine neurons use a mathematical approach to predict errors, responding similarly across individual neurons. This uniformity simplifies information coding, allowing prediction errors to be broadcasted robustly throughout the brain.
Researchers at Iowa State University found a gene mutation linked to an accelerated onset of Parkinson's disease in Caucasians, with those under 50 experiencing symptoms 5 years earlier and a 45% increased risk. The study also highlights the importance of blood cholesterol levels, which are directly related to dopamine production.
Researchers at Lund University have made a significant breakthrough in producing high-quality dopamine neurons using stem cells. The study has identified key markers that correlate with successful transplantation and graft function, enabling a more accurate methods for producing dopamine cells for clinical use.
Researchers at Massachusetts General Hospital discovered that stimulating dopamine neurons in mice receiving general anesthesia triggers signs of arousal, including movement and increased respiratory rate. This finding could lead to the development of new therapies to treat conditions like traumatic brain injury and coma.
Activating dopamine neurons in the ventral tegmental area of the brain causes active emergence from general anesthesia. This could lead to faster recovery times and reduced side effects for patients. The researchers are now conducting further experiments to confirm these findings and develop a new treatment.
Research suggests that mutations in the FTO gene and variants of the dopamine D2 receptor gene increase the risk of developing obesity and diabetes. The study found that individuals with both genetic alterations had a higher percentage of body fat, more abdominal fat, and lower insulin sensitivity.
A study by the University of Edinburgh has found that attention-grabbing experiences activate a specific area of the brain, releasing memory-boosting chemicals. Researchers discovered that mice who had new experiences just before or after learning a new location remembered it better the next day.
A new study in mice finds that dopamine release from the brain's locus coeruleus region can enhance memory retention. The researchers used optogenetics to activate dopamine-carrying neurons and found a direct, long-lasting synaptic strengthening that improved learning and memory.
Researchers have developed a new technique to observe brain activity in real-time, enabling them to study how we learn and develop addictions. The 'CNiFERs' tool measures the release of specific neurotransmitters, revealing the timing of dopamine surges during learning and addiction processes.
A study by Duke University researchers found that manipulating dopamine signaling can control inflammation in the gut, providing a proof of principle for using drugs originally designed to target the nervous system to treat immune system disorders such as rheumatoid arthritis and autoimmune disease.
The Georgia Institute of Technology researchers have created an interactive model of the brain's chemical balance to simulate major systemic changes in schizophrenia sufferers. This tool depicts chemical underpinnings in simple graphics, helping clinicians better understand the disease and test hypotheses virtually.
The article explores the link between reward deficiency syndrome, dopamine dysregulation, and amino-acid therapy. Research suggests that individuals with certain gene variants may benefit from neuronutrient-amino-acid therapy to prevent addictive behaviors.
Researchers found that brain dopamine function returns to normal three months after quitting smoking, indicating chronic smoking may cause smoking-related deficits. This suggests the possibility of treatments targeting dopamine systems in smokers.
Researchers at WashU Medicine discovered a region of the brain involved in decisions made under uncertainty and identified cells that suppress value-coding neurons when making a risky choice. This study could lead to treatments for psychological disorders, such as problem gambling and anxiety disorders.
Researchers found that an FDA-approved cancer drug increased brain dopamine and reduced toxic proteins linked to Parkinson's disease progression. The study showed significant signs of benefit for patients with neurodegenerative diseases, including improved cognitive and motor functions.
Researchers at Northwestern University have identified a new framework for understanding the role of dopamine neurons in movement control and learning/reward. The study found two distinct populations of dopamine neurons, one carrying signals for motor control and movement, and the other transmitting signals about unpredicted reward.
A European study led by Umea University Professor Lars Nyberg found a positive link between the dopamine D2 receptor and long-term episodic memory, which often declines with age. The research suggests that impairment of the dopamine system may play a crucial role in understanding age-related cognitive decline.
A preliminary clinical trial suggests that n-acetylcysteine improves dopamine levels and cognitive function in patients with Parkinson's disease. The study used brain imaging studies to track changes in dopamine levels and found significant improvements in both measures.
Researchers at UCLA discovered that people with Parkinson's disease have impaired decision-making, particularly when sensory information is weak. This finding suggests that the neurological factors underlying Parkinson's may be more complex than previously thought and could lead to earlier detection strategies.
A new study published in Diabetes suggests that age and dopamine receptors may play a role in the preference for sweet foods in people with normal weight, but not in those with obesity. The researchers found that insulin resistance could contribute to the altered brain response in obese individuals.
Researchers found dopamine signaling in the cerebral cortex predicts changes in brain network communication during working memory. This study may lead to better treatments for schizophrenia and other psychiatric disorders by optimizing dopamine signaling.
A new study of over 25,000 people found that declining levels of dopamine in the brain may be responsible for older people's reduced willingness to take risks for potential rewards. Older adults were less likely to choose risky gambles to win points, but not to avoid losing points.
Researchers found that kidney-specific deletion of the D2 dopamine receptor increased inflammation and hypertension, while restoration of DRD2 expression decreased these effects. The study suggests that targeting DRD2 may be a useful approach for treating renal injury.
Researchers studied Parkinson's-affected cells before symptoms appear, finding declines in dopamine neuron function and electrical activity. The study aims to understand the root cause of the disease and develop a therapy to arrest its progression.
Princeton University researchers used advanced techniques to record dopamine neuron activity in the striatum, finding that these neurons not only encode reward but also directly control movements. This discovery challenges current understanding of dopamine's role in movement-related disorders like Parkinson's disease.
A new study from Karolinska Institutet reveals a feedback regulatory system through which dopamine controls its own activity, regulating prolactin levels and potentially mitigating sexual side effects of antipsychotic drugs.
A study by Columbia University Irving Medical Center found that heavy cannabis users have lower dopamine release in the brain's striatum, a region involved in working memory and attention. This effect is similar to other addictive substances and may impair learning and behavior.
A rat study found that adolescent amphetamine abuse leads to long-lasting changes in brain function, affecting dopamine signaling and prefrontal cortex development. These changes persist into adulthood, contributing to behavioral consequences like addiction and relapse.
Researchers found that neural circuits in the striatum, a subcortical part of the forebrain, are involved in both pleasure and caloric value perception. The brain prioritizes energy storage over palatability, suggesting a link between sweetness and calorie craving.
Baylor College of Medicine researchers have developed a new mathematical tool that combines biochemistry and computational analysis to identify specific structural changes in the dopamine 2 receptor, which helps maintain its structure and function throughout an evolutionary time scale. This discovery opens the possibility for better dr...
A study on Bengalese finches found that dopamine levels in a specific region of the brain are crucial for correcting vocal errors. The research suggests that dopamine plays a vital role in sensory-motor learning, which underlies skills such as speaking and singing.
Research reveals that dopamine regulates both rewarding and aversive behaviors in mice, enabling them to learn and remember to avoid negative situations. The study's findings have implications for understanding post-traumatic stress syndrome.
Researchers used fluorescent false neurotransmitter 200 to observe synaptic activity in mice, revealing that only a small number of synapses may be active at any given time. This discovery could help understand how brain signals are transmitted and potentially shed light on brain disorders such as Parkinson's disease.
Researchers at Nagoya University have uncovered a dopamine signaling pathway that controls cocaine reward in mice. The study found that activation of the Rap1 pathway increases neuronal excitability and sensitivity to cocaine reward.
Researchers found that when people see something associated with a past reward, their brain releases dopamine even if they're not expecting it. This could explain why breaking bad habits or sticking to resolutions is hard. The study's results suggest potential benefits for addicts and dieters.
The study reveals the mechanics of dopamine transport into and out of neurons, shedding light on its role in various brain-related functions. The findings have significant implications for understanding and treating diseases related to dopamine imbalance, such as Parkinson's disease and schizophrenia.
UTSA associate professor Carlos Paladini receives a $1.8 million grant to investigate dopamine bursts and astrocytes in the brain, with potential applications for treating clinical depression, drug addiction, schizophrenia, and Parkinson's disease.
Researchers at the University of British Columbia found that adding flashing lights and music to a 'rat casino' model led to problem gambling behavior in rats. Blocking a specific dopamine receptor corrected this behavior, suggesting a common biological cause for risky decision-making across vices.
A TSRI study reveals that a specific endocannabinoid called 2-arachidonoylglycerol (2-AG) acts as a molecular switch to increase motivation to consume nicotine. By blocking its production, compounds like 1,2,3-triazole urea inhibitors may restore the brain's balance and reduce nicotine's effects.
Researchers found that a specific COMT gene variant is associated with higher cortisol levels in stressed Japanese macaques, leading to more aggressive behavior. This study provides insight into the genetic basis of stress hormone production in non-human primates and its potential connections to human behavior.
Researchers at Rockefeller University discover how dopamine alters connections between neurons in fly brain to change odor responses. This study parallels the action of dopamine in human brain, suggesting a coordinated mechanism for flexible behavior.
Researchers at the University at Buffalo have developed a method to convert skin cells into functional dopamine neurons by manipulating the expression of p53 and Tet1 enzymes. This breakthrough enables the efficient generation of patient-specific neurons that can be transplanted into the brain to repair faulty dopamine neurons.
Researchers mapped brain circuits that cause hyperactive dopamine release in response to cocaine. The study found a key relay between the extended amygdala and ventral subiculum drives persistent dopamine hyperactivity.
Scientists measured dopamine signals in Parkinson's patients during brain surgery, revealing rapid dopamine release encodes information crucial for human choice. The findings have widespread implications for neurological and psychiatric disorders, including depression and addiction.
Scientists from Scripps Research Institute have found that the interaction between a pair of brain proteins has a substantial effect on memory formation. The study reveals that when these two receptors interact, the ghrelin receptor changes the structure of the dopamine receptor and alters its signaling pathway.
A study published in Cell Metabolism found that weight loss surgery curbs sweet tooth behavior by reducing dopamine release in the brain. The research suggests that positive outcomes are more likely if sugary foods seem less rewarding after surgery.
Researchers studying a mutant worm found that the absence of a gene altered dopamine signaling, leading to changes in how nerve cells respond to stimuli. This discovery may open new treatment avenues for diseases such as Parkinson's and schizophrenia.
Researchers found that insulin stimulates the release of dopamine in the brain, leading to a feeling of pleasure. The study also suggests that people may choose high-carb or low-fat meals based on their insulin levels, potentially affecting weight and type II diabetes.
Researchers at Karolinska Institutet have found that OSU6162 can reduce craving for alcohol in people with alcohol dependence, normalizing dopamine levels in brain reward system. Thorough clinical studies are needed to confirm efficacy.
Scientists at NCBS identify new roles for calcium refill mechanisms in regulating dopamine levels in the brain. Inhibiting these mechanisms disrupts dopamine synthesis and transport, affecting gene expression.
Research reveals dopamine transmission via D1 receptors is essential for information flow through the basal ganglia to control movements. Lack of D1 receptor-mediated dopamine transmission disrupts 'direct pathway' and results in slowness of movements in Parkinson's disease.
Researchers at Columbia University Irving Medical Center discovered that long-term use of L-DOPA leads to dyskinesia due to striatonigral neurons becoming less responsive to GABA. This suggests that modulating these neurons could prevent or delay dyskinesia.
A study published in Current Biology reveals that lycaenid butterfly larvae can control the behavior of ants by supplying them with nectar rich in sugars and amino acids. This manipulation reduces locomotor activity and increases aggression in the ants, suggesting a selfish strategy to maintain mutualism.
Researchers found that external brain stimulation, specifically transcranial direct current stimulation (tDCS), can compensate for the loss of dopamine in people with Parkinson's disease by decreasing the effort the brain has to put into getting its motor neurons to fire. This correction improves some patients' motor symptoms.
A new study has found that the satiety hormone leptin plays a crucial role in the 'runner's high' feeling, with mice running longer distances on a wheel due to reduced leptin signaling. The research also suggests that people with lower fat-adjusted leptin levels may be more inclined to exercise.
A University of Bristol study has identified the mechanisms behind disruption in brain communication channels linked to schizophrenia symptoms. The research reveals that over-activation of dopamine receptors can suppress NMDA receptor function, leading to a marked disruption of communication between key brain regions.