Articles tagged with Dopamine
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A Wayne State University professor has received a nearly $1.7 million grant from the National Institutes of Health to investigate proteasome and parkin as potential pharmaceutical drug targets for treating methamphetamine-abuse related neurotoxicity.
Researchers at Douglas Mental Health University Institute have discovered that dopamine is present in the hippocampus and plays a key role in this region. This finding opens up new avenues for understanding psychiatric diseases such as schizophrenia and may lead to the development of new therapeutic approaches to improve symptoms.
Researchers have discovered that FDA-approved anti-psychotic drugs possess tumor-killing activity against glioblastoma. The finding is based on shRNA technology that identifies genes required for glioblastoma growth and reveals surprising links to dopamine regulation, a crucial component in treating Parkinson's disease and schizophrenia.
A new study will explore the connection between dopamine, a 'feel-good' brain chemical, and hearing loss. The research aims to develop better therapies for people with communication disorders, including those with Parkinson's disease. The $1.6 million grant will fund a team led by Christine Portfors at Washington State University.
Researchers at Duke University found that long-term spinal cord stimulation improved symptoms of Parkinson's-like disease in rats, protecting critical neurons and promoting better survival. The treatment may offer a new option for managing the condition.
Researchers discovered that dopamine-restoring drugs can improve visual function in animal models of diabetes. The study found that L-DOPA and dopamine receptor agonists improved acuity and contrast sensitivity, offering new avenues for treating diabetic retinopathy.
ProSavin, a novel gene therapy, has shown promise in reducing motor symptoms of Parkinson's disease by delivering dopamine-making genes directly into the brain. Significant improvements in motor scores were seen in all patients after treatment.
Researchers at the University at Buffalo used optogenetics to stimulate dopamine neurons, reducing binge drinking behavior in rats. The technique has potential applications for treating alcoholism, mental illnesses, and neurological diseases.
Researchers at Wake Forest Baptist Medical Center are using optogenetics to study the neurochemical basis of addiction. The technology allows them to control specific populations of brain cells using light, providing new direction on patterns of dopamine cell activation that may be most effective to target alcohol drinking.
A team of Montréal researchers discovered that the protein PC7 plays a critical role in the brain by affecting cognitive performance such as anxiety, learning, and emotional memory. The study found that mice lacking PC7 had impaired episodic and emotional memories, while exhibiting increased levels of dopamine in the brain.
Researchers at the University of Missouri have discovered that resveratrol may also block the effects of methamphetamine. The study found that resveratrol significantly diminished methamphetamine's ability to increase dopamine levels in the brain.
Researchers found no effect of low-dose dopamine or low-dose nesiritide on cumulative urine volume, kidney function, weight change, or clinical outcomes compared to placebo. The study's findings do not support the use of these drugs as a renal adjuvant therapy.
Researchers found that a volatile organic compound emitted by fungi, 1-octen-3-ol, attacks genes responsible for dopamine transport and packaging, leading to Parkinson's-like symptoms in fruit flies. The study suggests a potential link between fungal exposure and the degeneration of dopamine-producing neurons.
Researchers developed a simple dot test called the Triplets Learning Task (TLT) to assess dopamine loss in Parkinson's disease. The test shows promise as a non-invasive way to evaluate dopamine deficiency and may lead to new ways to improve treatment for PD patients.
Researchers at OHSU's Vollum Institute published two papers on neurotransmission in Nature, revealing a detailed view of the structural biology of the dopamine transporter. This breakthrough could lead to the development of better antidepressants with few or no side effects.
Scientists at ETH Zurich have created a genetic module that can be controlled via dopamine, which activates the production of an antihypertensive agent. The researchers found that contact with a female mouse triggered feelings of happiness in male mice, correcting hypertension and lowering blood pressure to normal levels.
Researchers found a molecular mechanism linking mechanical ventilation to hippocampal damage and mental impairment in ICU patients. The study suggests that elevated dopamine levels may contribute to the development of neurobehavioral disorders in patients exposed to mechanical ventilation.
A new study found that artificial sweeteners are less effective at reducing calorie intake because they don't provide the same energy reward as sugars. The brain prefers sugars over artificial sweeteners due to the release of dopamine, a chemical necessary for reward signalling.
Researchers at the University of Texas Health Science Center at San Antonio suggest that cell transplants could be a promising treatment for schizophrenia. By transplanting interneurons into the brain, they were able to restore normal function in rats with impaired dopamine systems, which are involved in cognition, movement, and emotions.
A new model system developed by Salk researchers completes the bridge between cellular and human studies of schizophrenia, enabling faster development of therapeutics. The model uses non-invasive scalp EEGs to detect brain activity, providing insights into sensory integration and neurotransmitter function.
Researchers found that individuals at high risk for alcoholism experience a greater dopamine response when drinking, which may contribute to increased desire for rewards and counteract the sedative effects of alcohol. This study provides insight into the causes of addiction and could mark an important step toward developing treatment o...
Research suggests that brain dopamine responses to alcohol ingestion may serve as a neurobiological marker of vulnerability to AUDs. Individuals at high risk showed increased brain dopamine, while those at low risk showed decreased dopamine levels. This finding could help identify individuals at higher risk for developing AUDs.
A new study from MIT suggests that dopamine signaling plays a crucial role in maintaining focus on long-term goals. The research reveals that the level of dopamine increases steadily throughout each trial, peaking as the animal approaches its goal, reflecting its distance from the reward.
Researchers have found that dopamine neurons are sensitive to reward but not punishment, suggesting a separate dimension for aversiveness. This discovery implies the existence of four neurotransmitters representing two dimensions of value.
Researchers are developing a brain implant that senses dopamine levels and suppresses reward signals to treat and possibly cure drug abuse. The device will be tested on anesthetized laboratory rats next month.
Researchers found lower dopamine levels in long-term cannabis users compared to non-users, suggesting a possible link between cannabis use and motivation issues. The study also suggests that cannabis use may be the cause of altered dopamine systems, which could explain increased risk of mental illnesses like schizophrenia.
Researchers found that electrical signals in the retina spiked high in response to chocolate, similar to those seen with methylphenidate, indicating increased dopamine release. This technique could be useful for studying food addiction and obesity prevention if validated through additional studies.
The new technique allows scientists to study protein function in individual cell types in a living organism, providing deeper insights into protein function. The approach uses nonsense-mediated decay (NMD) to restrict knockdown to a single cell type, giving complete control of gene expression.
Researchers found that insulin-resistant individuals exhibit lower natural dopamine release in response to glucose ingestion compared to healthy controls. The study suggests a possible link between abnormal eating behaviors and the onset of type 2 diabetes.
A recent fish study has identified a key hormone that enables zebrafish to replace damaged motor neurons, which could aid research into neurodegenerative diseases like ALS. This discovery also sheds light on the development of motor neurons in human embryonic stem cells.
Adults with ADHD who received methylphenidate treatment for 12 months showed a 24% increase in dopamine transporter density. This finding may affect how well these individuals respond to the medication, suggesting that elevated dopamine transporter levels are a consequence of chronic treatment rather than a marker for the disorder.
Researchers at Weill Cornell Medical College have developed an anti-cocaine vaccine that prevents the drug from reaching the brain and producing a high. The vaccine works by generating antibodies against cocaine, rendering it ineffective, and has shown promising results in non-human primates.
A novel gene therapy approach using nanoparticles to deliver GDNF may halt Parkinson's disease progression and reverse symptoms. This non-invasive method bypasses the blood-brain barrier, enabling continuous production of GDNF in brain cells.
A study by Indiana University researchers found that tasting beer without alcohol stimulates dopamine release in the brain, associated with drinking and other drug abuse. Participants with a family history of alcoholism showed increased responses, suggesting an inherited risk factor for alcoholism.
A Parkinson's drug has been shown to reverse age-related impairments in decision making in some older people. The study found that treating older adults with a dopamine-boosting drug improved their ability to learn from rewards and make better decisions, comparable to those in their twenties.
Researchers discovered that a reward linked to an image can activate the visual cortex in rhesus monkeys, indicating that rewards influence visual processing. The study used fMRI scans and found that dopamine signaling plays a key role in this process.
Researchers identified specific steps in the sequence of neural events underlying stress-related drug relapse and showed that blocking kappa opioid receptors can prevent relapse. The study suggests a new approach to treating addiction recovery by targeting stress-induced brain mechanisms.
Socially isolated rats are more susceptible to addiction to amphetamine and alcohol due to enhanced reward sensitivity. They exhibit quicker preference formation for environmental cues associated with the rewarding substance, making extinction harder to achieve.
Researchers found that isolating mice with a genetic predisposition to mental illness caused abnormal behaviors, including hyperactivity and depression-like symptoms. Administering a cortisol-blocking compound restored normal behavior, highlighting the role of stress hormones in the development of severe mental illness.
Research at Tel Aviv University finds that Parkinson's patients taking dopamine-enhancing medications are developing artistic talents, including painting, sculpting, and writing. The study suggests a link between dopamine levels and creativity, with some patients exhibiting increased impulsivity and lower inhibitions.
A study by the University of Vigo found that 56.1% of female students are binge drinkers, compared to 41.3% of males. Female students also exhibit a higher risk of developing unhealthy attitudes towards food and exercise.
New research sheds light on the complexities of learning problems in neurofibromatosis 1 patients. The study found that both increased RAS function and reduced dopamine levels contribute to cognitive dysfunction in individuals with NF1. Developing personalized therapies is now a priority.
Scientists have discovered that a specific region of the brain, the ventral tegmental area, plays a key role in both inducing and relieving depression-like symptoms. By controlling this region with light stimulation, researchers were able to reverse depressed states in mice, providing new hope for future treatments.
Researchers used optogenetics to control brain activity in mice, tracing stress resilience to neurons in the reward circuit. Instantly triggering or reversing depression-like states was possible with flashes of an LED light.
A study by Imperial College London and Brunel University researchers found that stroke patients with spatial neglect performed better when offered a financial reward. The findings suggest new behavioral therapies for stroke patients and highlight a brain system that can be targeted by drugs.
Researchers found that L-DOPA can compensate for lost dopamine in motor pathways, improving symptoms. However, it also increased dopamine in reward pathways, which may have unanticipated effects on emotion and attention.
Researchers from the University of Copenhagen have created a model showing how ADHD medication influences the brain's reward system. The study found that dopamine signaling pathways are sensitive to drugs like Ritalin, leading to paradoxical effects at different dosages.
Scientists at Lund University are using optogenetics to investigate the behavior of transplanted brain cells in a model of Parkinson's disease. The study aims to determine whether light can be used to reinforce dopamine production and improve the effectiveness of nerve cell transplantation.
Researchers have created a new family of compounds that could slow Parkinson's disease progression by shutting down the Cav1.3 channel, which allows calcium to flood into dopamine neurons. The compounds were developed by Northwestern University scientists and show promise in animal trials without obvious side effects.
Researchers found dopamine neurons release GABA, a neurotransmitter that lowers neuronal activity, which could explain why restoring only dopamine leads to waning improvements in Parkinson's patients. This discovery highlights the complex interplay between dopamine and GABA in brain disorders like depression and addiction.
A Wayne State University researcher has developed a new method for analyzing brain chemicals using carbon fiber microelectrodes. The technique, which meets four key criteria of size, speed, selectivity and sensitivity, enables researchers to measure serotonin levels in mice with antidepressants within five minutes.
Researchers have discovered potential new targets for treating depression by modulating dopamine cells and the innate immune system in mice. Increasing activity of dopamine neurons produced depressed behavior, while inhibiting them eased symptoms.
A new model explains dopamine's direct and indirect role in modulating the immune system. Recent research has opened up possibilities for treating diseases such as Parkinson's and Alzheimer's disease, schizophrenia, multiple sclerosis, or autoimmune disorders.
Children spend an average of five screens at home by age 10 and six hours a day watching screens by adolescence. Prolonged screen time is linked to increased risks of heart disease, diabetes, obesity, attention span reduction, and psychosocial problems like Facebook depression and impaired empathy.
Scientists discovered that resveratrol, a natural compound found in red wine, may help improve mobility and prevent life-threatening falls among older people. The study showed that resveratrol decreased motor deficiencies in aging mice, leading to increased quality of life and reduced hospitalization risk.
A recent study published by researchers at UCSF found that increasing dopamine levels in the frontal cortex significantly decreased impulsivity in healthy adults. The study used a medication approved for Parkinson's disease to raise dopamine levels and measured its effect on decision-making tasks.
Scientists from the Max Planck Institute identified four different types of dopamine-releasing nerve cells involved in forming positive and negative memories in fruit flies. These nerve cells use dopamine to communicate with other neurons, and their activation can signal aversive or rewarding stimuli.
Researchers used deep brain stimulation to treat binge eating in mice and found a significant reduction in consumption of high-fat food. The study suggests that deep brain stimulation may be an effective therapy for obesity by modulating activity of neurons expressing the type 2 dopamine receptor.
Researchers discovered that dopamine inhibits melatonin production by forming 'heteromers' with norepinephrine receptors, regulating the body's circadian rhythm. This discovery could lead to new treatments for circadian rhythm disturbances and sleep disorders affecting 40% of the world's population.
A study using molecular imaging found a link between low dopamine levels and aggressive behavior in competitive situations. Participants with lower dopamine synthesis capacity were more likely to act out with aggression when provoked.