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Using fMRI, new vision study finds promising model for restoring cone function

Researchers used fMRI to assess brain responses to lights stimulating only cone cells in dogs with different types of retinal diseases. The study found that gene augmentation therapy restored response in cortex to black and white stimulation, making this disease a promising one for photoreceptor cell replacement treatment.

SourceUniversity of Pennsylvania·JournalTranslational Vision Science & Technology·TypeExperimental study·DateJan 26, 2024

Researchers identify new coding mechanism that transfers information from perception to memory

A new study has identified a neural coding mechanism that allows for the transfer of information between perceptual and memory regions of the brain. This discovery challenges traditional understanding of brain organization and suggests that memory areas encode visual information in a 'photographic negative' format.

SourceDartmouth College·JournalNature Neuroscience·TypeImaging analysis·DateJan 2, 2024

Slimming significantly alters your microbiome and brain activity

A study of 25 obese Chinese individuals reveals that intermittent energy restriction (IER) alters the gut microbiome and brain activity, leading to significant weight loss and reductions in obesity-related comorbidities. The changes are coupled over time, suggesting a complex relationship between the gut microbiome and brain.

SourceFrontiers·JournalFrontiers in Cellular and Infection Microbiology·TypeExperimental study·DateDec 20, 2023

Innovative design achieves tenfold better resolution for functional MRI brain imaging

The ultra-high resolution NexGen 7T scanner allows neuroscientists to see functional MRI features 0.4 millimeters across, enabling the study of brain circuitry underlying different diseases with higher spatial resolution. This will help track signals propagating through the brain and reveal underlying causes of developmental disorders.

SourceUniversity of California - Berkeley·JournalNature Methods·DateNov 27, 2023

Researchers identify brain network that is uniquely activated through injection vs. oral drug use

A study published in Nature Communications reveals that the 'salience network' in the brain is uniquely activated by intravenous drug use, which may be associated with higher addiction rates and faster relief from withdrawal. This finding could lead to the development of new therapies for substance use disorders.

SourceNIH/National Institute on Drug Abuse·JournalNature Communications·DateNov 8, 2023

Does cannabis use affect empathy?

Regular cannabis users show a greater understanding of others' emotions, while their brains exhibit stronger connections between regions related to emotional sensing. This study suggests potential therapeutic applications for conditions involving social interaction deficits.

SourceWiley·JournalJournal of Neuroscience Research·DateNov 8, 2023

fMRI study finds correlated shifts in brain connectivity associated with overthinking in adolescents

A recent study from Ohio State University Wexner Medical Center and colleagues found that Rumination-focused Cognitive Behavioral Therapy (RF-CBT) can reduce rumination in adolescents. The study also showed correlated shifts in brain connectivity, suggesting that RF-CBT can help young people break the painful mental loops that contribu...

SourceOhio State University Wexner Medical Center·JournalBiological Psychiatry Global Open Science·TypeRandomized controlled/clinical trial·DateOct 27, 2023

Brain connectivity is disrupted in schizophrenia

Researchers found that hierarchical cortical organization is impaired in people with schizophrenia, leading to disruptions in processing stimuli from the external world. This disruption affects secondary processing of sensorimotor-visual gradients, explaining behavioral and clinical symptoms of the disease.

SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateOct 17, 2023

Researchers unravel cross-species pain-preferential neural pathway

A study published in Nature Human Behaviour has uncovered a neural pathway preferentially involved in pain perception across species. The researchers identified the central role of the medial-dorsal thalamic nucleus in pain perception, which exhibited a more pronounced activation in response to painful stimuli.

SourceChinese Academy of Sciences Headquarters·JournalNature Human Behaviour·TypeObservational study·DateOct 11, 2023

New neural insights into processing uncertainty in obsessive-compulsive disorder

A new study uses brain imaging to explore the neural underpinnings of uncertainty processing in OCD, finding that patients struggle with certainty and decision-making, particularly when outcomes are more certain. This understanding may offer new hope for developing therapies targeting uncertainty processing in OCD.

SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateSep 12, 2023

HSE researchers question the correctness of experiments denying free will

Researchers from HSE University challenged the famous Libet studies on free will, revealing a lack of correlation between brain activity and decision-making. The study used advanced EEG techniques to investigate the timing of intention awareness and final decision, finding that the latter could be influenced by experimental procedures.

Study shows differences in how patients with heroin use disorder process drug and reward cues

Researchers found that individuals with heroin use disorder exhibited a bias towards processing drug cues, while healthy controls showed the opposite pattern. This suggests that efforts to downregulate responses to drug cues may come at the cost of amplifying responses to natural rewards.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalAmerican Journal of Psychiatry·TypeExperimental study·DateJul 18, 2023

A neurobehavioral signature of risk for mania

Researchers identified three neurobehavioral profiles that distinguish individuals with elevated mania vulnerability based on reward sensitivity and sleep-circadian characteristics. These profiles can help detect mania risk and provide targets for early interventions.

SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateJul 11, 2023

Brain imaging-based biomarker of depression identified

Researchers used brain imaging to identify multiple subtypes of depression, finding distinct deviation patterns in functional connectivity among brain regions. This study provides leads for developing better treatments and personalized therapeutic interventions.

SourceElsevier·JournalBiological Psychiatry·TypeObservational study·DateJun 27, 2023

When pigeons dream

Birds experience flight-like sensations in their dreams during REM sleep, suggesting emotional content, while cerebral spinal fluid flow is disrupted. The study reveals similarities between bird and human sleep patterns, highlighting the importance of sleep for brain health and cognition.

SourceRuhr-University Bochum·JournalNature Communications·TypeExperimental study·DateJun 6, 2023

Networks in the dog brain

A recent study on canine brain networks has provided insights into the evolution of human brain function, revealing that the cingulate cortex played a central role in mammalian brain development. The research used fMRI to analyze brain activity in dogs and identified functional networks that differ from those in humans.

SourceEötvös Loránd University·JournalBrain Structure and Function·DateMay 26, 2023

Emotion-focused therapy for bipolar disorder targets the amygdala

A new study found that emotion-focused therapy increased activation and connectivity of the amygdala in patients with bipolar disorder, leading to improved emotion processing. In contrast, cognitive-behavioral therapy showed increased activation of brain regions related to social function but not altered amygdala activity.

SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeRandomized controlled/clinical trial·DateApr 17, 2023

In bilingual readers, the visual cortex processes Latin and Chinese characters differently

A study found that bilingual readers process Latin and Chinese characters in different ways due to the formation of specialized cortical areas within the Visual Word Form Area (VWFA). In English-Chinese bilinguals, areas were only stimulated by recognition of Chinese logograms, while English-French bilinguals showed equal activation fo...

SourceInstitut du Cerveau (Paris Brain Institute)·JournalScience Advances·TypeImaging analysis·DateApr 5, 2023

This is your brain on everyday life

Researchers used functional MRI scanners to monitor brains of subjects watching real-life videos, finding that different parts of the brain work together to understand and remember situations. The study suggests the brain creates mental sketches of people that can be transposed from one location to another.

SourceWashington University in St. Louis·JournalNature Communications·TypeExperimental study·DateMar 31, 2023

Fluid flow in the brain can be manipulated by sensory stimulation

A new study by Boston University researchers reveals that visual stimulation can induce large-scale changes in cerebrospinal fluid flow during wakefulness. The findings have implications for treating conditions like Alzheimer's disease, which are associated with declines in fluid flow.

SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateMar 30, 2023

Characterizing abnormal neural networks in dogs with anxiety

Researchers found that dogs with anxiety have altered brain connectivity, particularly between the amygdala and hippocampus. The study used fMRI to characterize abnormal neural networks in anxious dogs, providing insight into anxiety disorders in both animals and humans.

SourcePLOS·JournalPLOS ONE·TypeObservational study·DateMar 15, 2023

Learning behavior differs between OCD and problem gambling

Research reveals that individuals with OCD exhibit lower-than-normal learning rates when rewards are less than expected, while those with problem gambling display boosted learning from high rewards and blunted learning from low rewards. This study highlights the benefits of using neurocomputational approaches to understand psychiatric ...

SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateMar 14, 2023

Novel optical and fMRI platform identifies brain regions that control large-scale brain network

Researchers have developed a novel experimental platform that combines optical and fMRI techniques to study large-scale brain networks. The platform identified the anterior insular cortex as a key player in controlling the Default Mode Brain Network, which is active during daydreaming, memory retrieval, and envisioning the future.

SourceUniversity of North Carolina Health Care·JournalScience Advances·TypeExperimental study·DateFeb 15, 2023

Study suggests the brain works like a resonance chamber

A recent study published in Nature Communications suggests that the brain functions like a resonance chamber, with distant areas exhibiting correlated activation patterns. The researchers used ultrafast MRI to detect these patterns in rats and found that they are driven by resonant waves, explaining correlations observed in slow imaging.

SourceChampalimaud Centre for the Unknown·JournalNature Communications·TypeExperimental study·DateFeb 6, 2023

Accepting anxiety for peace of mind

A mindfulness-based intervention program significantly decreased subjective anxiety and improved emotional regulation in AN patients. The study found changes in brain regions involved in anxiety, emotion arousal, and self-referential processing.

SourceKyoto University·JournalBJPsych Open·TypeExperimental study·DateFeb 3, 2023

How we navigate through crowds

Scientists from the University of Vienna found that grid cells in the brain play a crucial role in detecting movements of people around us. This mechanism may help explain disorientation in dementia patients. The study suggests that grid cells create a mental map of our surroundings, including the movements of others.

SourceUniversity of Vienna·JournalNature Communications·DateFeb 1, 2023

Study offers neurological explanation for how brains bias partisans against new information

A recent study published in Science Advances found that individuals with similar ideologies have more similar neural fingerprints of political words and process new information in a polarized way. The researchers used a range of methods, including fMRI and representation similarity analysis, to explore how the brains of people who iden...

SourceBrown University·JournalScience Advances·TypeObservational study·DateFeb 1, 2023

Kessler Foundation team to study impact of strategy-based cognitive training on new learning and memory in individuals with multiple sclerosis

Researchers at Kessler Foundation are conducting a double-blind randomized clinical trial to evaluate the impact of their strategy-based cognitive training program on new learning and memory in individuals with multiple sclerosis. The study aims to assess the efficacy of this protocol, which is based on the KF-STEM protocol.

SourceKessler Foundation·JournalContemporary Clinical Trials Communications·TypeRandomized controlled/clinical trial·DateFeb 1, 2023

Traffic pollution impairs brain function

A new study by University of British Columbia researchers found that brief exposure to diesel exhaust causes decreased brain connectivity and may impair cognitive performance. The study's findings suggest a link between air pollution and altered brain network connectivity in humans.

SourceUniversity of British Columbia·JournalEnvironmental Health·TypeRandomized controlled/clinical trial·DateJan 24, 2023

The science of self-esteem: Past experience can predict teenage girls' self-worth, sense of belonging

A study led by Haley Skymba and Karen Rudolph found that teenage girls' past experiences with peer adversity directly impact how they perceive their own self-worth and belonging. The researchers designed a study to observe trends in a cohort of 89 girls, averaging 16 years old, and discovered patterns that demonstrate the connection be...

SourceBeckman Institute for Advanced Science and Technology·JournalJournal of Research on Adolescence·TypeRandomized controlled/clinical trial·DateJan 9, 2023

Researchers gain a better understanding of how the most commonly used ADHD medication works

A new study has shed light on how the most commonly used ADHD medication, methylphenidate, works in the brain. The research found that methylphenidate increases dopamine levels in the nucleus accumbens and improves coordinated brain network activity, resulting in more stable sustained attention in children with ADHD.

SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeObservational study·DateDec 8, 2022

Socialness is in the eye of the beholder

A new Dartmouth study uses a subjective approach to investigate how people perceive social interactions. The results show that the brain responds more strongly to information interpreted as social versus non-social, highlighting humans' tendency to see social connections.

SourceDartmouth College·JournalJNeurosci·TypeExperimental study·DateDec 7, 2022