Articles tagged with Progesterone Signaling
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Researchers discovered a link between neuroactive steroids in pregnant women's blood and the risk of developing postpartum depression. Measuring these molecules via a blood test could enable doctors to provide treatment sooner. The study may lead to a preventive treatment using existing prescription drugs.
New research led by Andrija Sente uncovers the atomic structure of GABA <sub> A </sub> receptors, revealing unique subunit combinations that create previously unrecognized receptor types. These findings highlight the need to account for variations in drug development to avoid unintended binding sites.
A recent study from the Women's Health Initiative found that both obesity and metabolic syndrome increase breast cancer risk, but in distinct ways for different subtypes. The research highlights the importance of controlling waist circumference and metabolic conditions to reduce breast cancer risk.
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
A new review paper suggests ACSL4 status as a biomarker for breast cancer subtype classification and predictor of response to hormone-based therapies. The enzyme may also serve as a target for developing new treatment modalities in quadruple negative breast cancer.
Researchers found that progesterone can protect nerve cells from dying in people with Parkinson's disease. The study suggests that a balanced diet and steroid hormone-based therapeutic approaches could help slow down or stop the progression of neurodegenerative diseases.
Researchers used an ancient fish, elephant sharks, to gain insights into human biology and how a widely used medication works. The findings show that progesterone receptor activation in humans requires a different mix of hormones and steroids than in elephants sharks, with the latter not inhibited by RU486.
A new study found that unbalanced progesterone signals may cause preterm labor or prolonged labor in pregnant women. The researchers used genetically engineered mouse models to alter the ratio of PGR-A and PGR-B signaling in the uterus, identifying key biological pathways influenced by both forms.
A University of South Florida Health study uncovers a novel mechanism by which maternal stress triggers idiopathic preterm birth. Elevated FKBP51 levels and enhanced progesterone receptor binding stimulate labor, while Fkbp5-deficient mice are resistant to preterm birth.
A new study published in the American Journal of Psychiatry suggests that a progesterone receptor modulator may be an effective treatment for premenstrual dysphoric disorder (PMDD). The treatment showed significant improvement in mental symptoms, with half of women experiencing complete relief.
Researchers found that women inheriting a Neandertal gene variant have lower rates of early miscarriages, fewer bleedings during pregnancy, and higher birth rates. The study suggests the variant has a favorable effect on fertility, with increased progesterone receptor production leading to greater sensitivity and protection.
A recent study found that the progesterone receptor gene evolved rapidly in humans, but its function was compromised, potentially leading to complications like preterm birth. The research provides insight into the evolution of human pregnancy and raises more questions about this complex process.
High levels of progesterone enable increased mineralocorticoid receptor expression, leading to blood vessel damage in young females with obesity. The study found that removing or blocking progesterone and aldosterone receptors can prevent blood vessel dysfunction.
A new study finds significant variation in triple-negative breast cancer incidence among black women born in different US regions. U.S.-born and Western-African-born women have the highest rates, while Eastern-African-born women have lower rates compared to both groups.
A study found that genetic variations in the progesterone receptor gene are linked to prematurity risk, with different versions affecting various populations. The research suggests that genes play a role in determining risk, but also highlights the importance of environmental factors.
Researchers are exploring how obesity impacts cardiovascular health in premenopausal women, a population with heightened risk due to estrogen levels and hormone sensitivity. They aim to understand the underlying mechanisms and identify potential treatments to restore protection against cardiovascular disease.
A study of wild female bonobos found that their sexual swellings are unreliable signals of fertility, allowing females to manipulate mate choice. The findings suggest that male bonobos may not be able to successfully compete over females due to the variability in swelling patterns.
Researchers discovered that progesterone receptor dramatically alters how estrogen receptors interact with cell's DNA, leading to inhibition of cellular proliferation and metastasis. Combining tamoxifen with a progestin antagonist showed added benefit in shrinking tumors.
Researchers have identified cellular pathways in skin pigment cells activated by estrogen and progesterone, leading to either skin darkening or lightening. The discovery could lead to the development of new products changing skin tone without harmful chemicals.
A new study found that fracking chemicals can block the activity of key hormone receptors, including glucocorticoid and thyroid hormone receptors. This disruption has been associated with poor health outcomes such as infertility, cancer, and birth defects.
Scientists have found new targets for potential intervention in breast cancer, which could increase effectiveness and reduce undesirable side effects. The study used hydrogen-deuterium exchange mass spectrometry to map the intricate interactions between the progesterone receptor's AF1 and AF2 domains.
High total and saturated fat intake associated with greater risk of ER+PR+ breast cancer and HER2- disease. A high-fat diet increases BC risk, especially receptor-positive disease linked to saturated fat intake.
A study at Columbia University's Mailman School of Public Health found that breastfeeding significantly reduces the risk of ER/PR-negative breast cancer. Women who breastfed their children had no increased risk of this aggressive tumor subtype.
Researchers have found that measuring progesterone receptor expression can improve hormone-receptor-positive breast cancer management. The study identifies a subpopulation of patients with high survival rates when treated with endocrine therapy alone, and could lead to a more personalized medicine approach in breast cancer.
A new study reveals that the chemical mediator for sexual reproduction in rotifers is progesterone, a molecule also found in humans and plays a vital role in regulating reproduction. The research has significant evolutionary implications and sheds light on how environment, metabolism, hormones, and behaviors interact.
Research finds that genetic variation in progesterone receptor affects 17P treatment response, with predictive SNPs identified for African-American and non-African-American women. Progesterone treatment may be less effective in some women due to genetic predisposition.
A study examining caffeine's association with breast cancer risk found that high caffeine intake may increase the risk of hormone-receptor negative and large breast tumors. The study also found a positive association between caffeine consumption and benign breast disease, but not overall breast cancer risk.
Researchers from USC found evidence that progesterone signaling influences ovarian cancer risk, particularly two haplotypes (4-D and 4-E) that increase risk by almost 3.5-fold in women who carry them. The study's findings suggest that subtle changes in the progesterone receptor gene may decrease its efficiency, leading to ovarian cancer.
Researchers at UT Southwestern discovered that administering the drug trichostatin A can effectively delay the start of labor in mice by allowing progesterone to continue functioning. This is significant because mice have a short gestation period, and pre-term birth affects over 460,000 infants annually.
Researchers predict personalized breast cancer treatments using genetic profiles, with potential annual reduction of recurrence risks. Up to 100,000 genes in each cell are being studied for predictive value, leading to a future of tailored therapies.
Researchers discovered a mutation in the mineralocorticoid receptor gene, leading to dangerously high blood pressure in pregnant women. The mutation renders the receptor more sensitive to progesterone, causing excessive salt retention and skyrocketing blood pressure.
A team of Dutch doctors and scientists have found a possible link between testosterone and endometrial cancer, with high local pelvic androgen levels and increased expression of androgen receptors detected in patients. The study suggests that androgens may be a co-factor in the development of endometrial cancer.
Researchers at UCSF have identified a new chemical pathway in the brain involved in regulating mood, which may improve treatment for depression. The study found that popular antidepressants like Prozac and Zoloft increase the synthesis of a key neurosteroid, potentially providing a new target for mood-regulating drugs.
A new study found that steroid receptors are not mere on-off switches but rather complex molecular control panels. This discovery could lead to the development of targeted therapies for various diseases such as breast and prostate cancer, inflammation, osteoporosis, and endometriosis.