Researchers at University of Wisconsin-Madison develop a systematic study for sustainable production of malonic acid via oxidation of 3-hydroxypropionic acid with a Pd/Carbon catalyst. The kinetic model validated the network, displaying excellent agreement and providing insight into conditions that maximize MA production.
Scientists developed a cost-effective method to produce 3-Hydroxypropanoic acid (3-HP), an industrial chemical used in disposable diapers, microplastics, and acrylic paint. The new process using engineered microbes to ferment plant sugars into 3-HP has been validated for commercial potential.
Phenolic acids have been identified as a promising therapeutic frontier for vascular cognitive impairment, exhibiting potent antioxidant, anti-inflammatory, and neuroprotective effects.
Researchers discovered that gut bacteria can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling. These microbially modified bile acids antagonize the androgen receptor, driving anti-tumor immunity in mice with bladder cancer.
A new study maps how specific lactic acid bacteria can reduce off-flavours and degrade anti-nutrients in plant-based dairy alternatives. Fermentation with these bacterial strains increases nutrient bioavailability and enhances product nutritional profiles.
Researchers developed an electrochemical approach to convert harmful nitric oxide emissions into high-purity nitric acid, reducing industrial nitrogen waste and promoting sustainable pollution mitigation. The process operates at near-ambient conditions with minimal infrastructure, offering economic and environmental benefits.
Researchers at Osaka Metropolitan University developed an engineered yeast that can produce record-high yields of D-lactic acid from methanol, a key compound used in biodegradable plastics and pharmaceuticals. The optimized yeast strain achieves a 1.5-fold boost in production compared to other methanol-based methods.
A new study published in Liver International found that a mother's high-fat diet during pregnancy can lead to liver stress and changes in the fetus's bile acid levels. This may be a key factor in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) later in life.
Researchers found that semisynthetic bile acid NorUDCA inhibits pro-inflammatory T helper 17 cells and promotes anti-inflammatory regulatory T cells in the intestine. This could lead to new therapies for inflammatory bowel diseases such as ulcerative colitis or Crohn's disease.
The article discusses the need for bioanalytical assays to measure immune responses to oligonucleotide therapeutic drugs, especially when they include carriers or conjugates. Highly specific antibodies may enhance the development and production of ONTs, expanding studies on their safety and efficacy.
Researchers developed a conjugated phthalocyanine framework with enhanced electron-withdrawal properties and flexibility, leading to improved capacities, rate capabilities, and cyclic stability in high-voltage lithium metal batteries. The framework also showed longer operating life and higher capacity retention.
Kyushu University researchers create a microwave flow reaction device that converts complex polysaccharides into simple monosaccharides, producing glucose. The device utilizes a continuous-flow hydrolysis process, where cellobiose is passed through a sulfonated carbon catalyst heated using microwaves.
A team of researchers from DTU has successfully produced vitamin B2 using a novel, cost-effective, and climate-friendly method involving food-approved lactic acid bacteria. The production process requires only basic fermentation tools and can be integrated into traditional foods, enhancing public health and reducing environmental impact.
Researchers at Nagoya University have developed a novel fuel cell electrolyte concept using phosphonic acid polymers with hydrocarbon spacers. The new membrane exhibits improved water insolubility, chemical stability and conductivity under high-temperature and low-humidity conditions.
A systematic review of 45 studies found inconsistent descriptions of psychotherapy sessions, making it difficult to replicate studies and compromise patient well-being. Researchers call for improved reporting standards to enhance the replicability, safety, and potential effectiveness of these therapies.
Hokkaido University researchers have developed a novel method to activate alkanes, making it easier to convert these building blocks into valuable compounds. The new technique utilizes confined chiral Brønsted acids, improving efficiency and selectivity in producing desired products.
The team created a new method by adding two different enzymes to the existing reaction, increasing conversion rates from 46% in 7 hours to 80% in 5 hours. This approach also improved fumaric acid production efficiency from 10% to 16%.
A five-year randomized control trial found that diets high in fruits and vegetables lower blood pressure, reduce cardiovascular risk, and improve kidney health. The study also suggests that incorporating fruits and vegetables into treatment plans can be more effective than traditional medication approaches.
Researchers achieved a new method for synthesizing α-substituted carbonyl compounds using a palladium-catalyzed anti-Michael addition reaction. The method produces high-yield products and can be applied to various nucleophiles, including indoles and aromatic compounds.
A wearable health monitor developed by Washington State University researchers can accurately measure levels of important biochemicals in sweat during physical exercise. The device has the potential to track health conditions and diagnose common diseases, including diabetes, gout, kidney disease, and heart disease.
Researchers at Tokyo University of Science have developed an enzyme that converts ferulic acid from plant waste into vanillin, a classic flavor compound. The engineered enzyme exhibits high conversion activity and affinities, making it suitable for large-scale commercial production.
A novel multifunctional catalyst has been developed to convert methane into valuable hydrocarbons, reducing greenhouse gas emissions and energy consumption. The catalyst's spatial distribution of Cu and acid sites determines the final products, with uniform distribution leading to stable and efficient methanol production.
Researchers identified a genetic link between higher levels of arachidonic acid and lower risk of bipolar disorder. Arachidonic acid, found in meat, seafood, and human milk, may hold potential for lifestyle or dietary interventions to prevent or treat the condition.
Researchers investigated the role of EDTA stabilizer and microchannel flow technology to improve safety in green adipic acid synthesis. The study found that EDTA mitigates thermal runaway risks by reducing maximum temperatures, and microchannel reactors can efficiently synthesize adipic acid with high yields.
Researchers discovered that 19 amino acids essential to life on Earth can persist for up to four weeks in concentrated sulfuric acid, which is similar to the concentrations found in Venus' clouds. This finding suggests that the clouds of Venus could support complex chemicals needed for life.
Researchers review microbial processes for sustainable lignin valorization, producing dicarboxylic acids, phenolic acids, and complex natural products. Engineered microbes enhance lignin transformation efficiency, offering a promising alternative to traditional chemical synthesis methods.
The study reveals a vast array of secondary bile acids produced by microbes in the gut, expanding our understanding of their functions and impact on human health. These molecules play important roles in digestion, immune system regulation, and metabolic processes, offering new insights into diseases related to bile acids.
Researchers at the University of Toronto found that the liver generates palmitic acid and sends it to the developing brain when dietary levels are low. The study highlights the importance of palmitic acid for brain health, particularly during development.
Researchers have identified a previously unknown endogenous acid sensor in plant cells that responds to changes in pH levels. The acid sensor triggers the release of calcium ions from an endoplasmic reticulum, which activates cellular responses to external stimuli such as infections or drought.
A team of experts has developed a way to convert polyethylene waste into ethylene and propionic acid through atomically dispersed metal catalysts. This method uses renewable solar energy to produce valuable chemicals with high selectivity, alleviating the need for complex separation processes.
Researchers have created a reliable and efficient method to add fluorine to molecules, increasing pharmaceutical drug efficiency. The iron and sulfur-based reaction enables the release of fluorine from carboxylic acids and its incorporation into alkenes, common building blocks for drugs.
Scientists identify pyroglutamination, a spontaneous chemical change, in peptide synthesis, leading to an amyloidal structure and potential implications for neurodegenerative diseases like Alzheimer's and Parkinson's. The process favors aggregation of molecules, forming plaques that interrupt neuronal flow.
Researchers at CABBI developed an economical method for producing succinic acid, a key chemical in food, agricultural, and pharmaceutical products, using acid-tolerant yeast. The new pipeline eliminates costly downstream processing steps, significantly reducing costs and emissions.
Researchers develop novel photoresist system with modified tannic acid to form metal patterns, offering applications in devices assembly. The method avoids poor stability and dispersion of metal nanoparticles, making it a promising approach for micro-nano metal pattern formation.
Researchers developed a novel solid-state mechanochemical reaction to synthesize FCMs from PTFE and graphite, producing materials with enhanced storage capacity and electrochemical stability. The new method bypasses toxic reagents and offers a safer alternative for practical applications.
Researchers from Kumamoto University developed a zero-waste process to synthesize hydrogels containing tannic acid and ultra-high molecular weight polyethylene oxide, resulting in highly stretchable and self-healing materials. These supramolecular materials exhibit excellent mechanical properties and potential eco-friendly applications.
Researchers discovered NSMF protein's role in alleviating DNA replication stress by displacing weakly bound RPA proteins and promoting phosphorylation. This mechanism accelerates relief of replication stress, offering a new direction for treating various diseases, including cancer and age-related conditions.
A team of researchers at UNIST has developed solid electrolyte materials utilizing metal-organic frameworks (MOFs) to improve the efficiency of hydrogen fuel cells. The new materials demonstrate high hydrogen ion conductivity and durability, holding promise for advancing sustainable energy solutions.
A newly discovered fungus has been found to transform the toxic compound patulin into less harmful byproducts, offering potential solutions for controlling its presence in food products. The fungus, identified as Acremonium sp., was shown to degrade patulin into desoxypatulinic acid and other compounds, which are significantly less toxic.
Scientists at Nanyang Technological University have developed a sustainable method to produce lactic acid using discarded jackfruit seeds. The new process is cheaper and more efficient, reducing waste and environmental impact while addressing rising production costs.
Fish oil supplements often make health claims without sufficient trial data, leading to potential variability in safety and efficacy due to differing doses of eicosapentaenoic acid and docosahexaenoic acid. The study highlights the need for more rigorous regulation of these products.
Researchers at Tokyo University of Science successfully synthesized tanzawaic acid B in large amounts, paving the way for new antibiotic development. The breakthrough method could lead to creation of various compounds for pharmaceuticals, including new antibiotic candidates.
Researchers from Tokyo Institute of Technology have developed a novel synthesis method for imine-based COFs, eliminating the need for long reaction times, high temperatures, and Lewis acid catalysts. The method uses an electrogenerated acid as a catalyst, enabling direct fixation of COF films onto electrodes.
Scientists at Chalmers University of Technology have created a new method for removing mercury from concentrated sulphuric acid, reducing levels by more than 90%. This innovation could lead to reduced mercury emissions and the production of high-purity, non-toxic products in industries such as mining and metal refining.
A new study published in JAMA found that bempedoic acid can reduce major adverse cardiovascular events in high-risk primary prevention patients who cannot tolerate recommended doses of statins. The treatment has the potential to improve outcomes for these patients, providing a new option for primary prevention.
A team of researchers from QIBEBT has developed a method to produce high-quality lactic acid from lignocellulosic biomass, reducing the need for intermediate sterilization and nutrient supplementation. This breakthrough has significant implications for industrial-scale production of biodegradable materials.
Scientists investigate how salt uptake affects polyester microdroplets' surface potential, turbidity, size, and internal water distribution. The results suggest that microdroplets can selectively partition salt cations, leading to differential coalescence.
Researchers from GIST have developed a hydrotropic-supporting electrolyte to enhance the solubility of organic redox molecules in aqueous systems. This improvement enables the creation of high-energy-density electrochemical capacitors with potential applications in redox flow batteries.
Researchers develop a new method for fixing carbon dioxide using formic acid, which can replace conventional chemical manufacturing processes with carbon-neutral biological methods. The process produces formaldehyde, a non-toxic substance that can be fed into metabolic pathways to create valuable substances.
Dr. Vesna Najdanovic from Aston University won a $25,000 grant to develop greener analytical methods using ethyl lactate as a solvent for liquid chromatography. This environmentally friendly alternative reduces carbon footprint and pollution in the pharmaceutical industry.
A study found that adding rosmarinic acid to sunscreen increases sun protection factor by over 41% and reduces the need for synthetic chemicals. The natural antioxidant also provides anti-aging benefits, making it a potential multifunctional compound for improved skin health.
Researchers found a 40% reduction in ammonia emissions and a two-thirds decrease in methane emissions by acidifying slurry with sulfuric acid. The method also improves fertilization and could be optimized to achieve even higher reductions.
Researchers from Tokyo Metropolitan University have developed a new catalyst that converts plastic and biomass into organosilane compounds. The hybrid gold nanoparticle catalyst on zirconium oxide support enables mild conditions for the reaction, reducing environmental burden.
Researchers at Tohoku University found that astrocytes exhibit a stronger acid response during REM sleep in epileptic mice, which may drive specific information processing and generating plasticity. This discovery could lead to the development of a biomarker for epilepsy severity and potentially inform therapeutic strategies.
Scientists at Paderborn University have developed a new catalyst, known as Lewis superacid, to break strong chemical bonds and speed up reactions. This breakthrough enables the conversion of non-biodegradable greenhouse gases into sustainable chemicals.
Researchers at Tohoku University developed a novel one-pot reaction to form amide bonds with high yields and minimal equipment requirements. The DMAPO/Boc2O-mediated system produces amides from less reactive nitrogen-containing heterocyclic compounds and carboxylic acids.
Studies elucidate key aspects of traditional Chinese compounds and modern cancer therapeutics, highlighting the efficacy of R. serra in treating colitis and identifying active components of Gan Cao in treating pneumonia. A new radiolabeled antibody-based probe for detecting PD-L1 expression in cancers also provides a novel approach to ...
A Penn State-led research team has invented a new class of ion-exchange membrane wafer assemblies that significantly improves electrodeionization's ability to capture p-coumaric acid from liquid mixtures. The new design reduces the amount of membrane needed, resulting in cost savings and increased efficiency.
Researchers at Hokkaido University have developed a new method using cooperating catalysts to perform challenging dearomative carboxylation reactions. This process enables the production of α-amino acids, which are potentially useful for drug development, and offers greater freedom in designing and synthesizing molecules with carboxyl ...
A team of researchers developed an efficient strategy to recycle lead from discarded car batteries, creating a new market for recycled lead in high-tech equipment. The resulting photodetectors show excellent stability and fast response speeds, with potential applications in optical communication, chemical analysis, and imaging.