Articles tagged with Cohort Studies
Early-life air and noise pollution exposure were associated with increased risk of psychotic experiences, depression, and anxiety from adolescence to young adulthood. Interventions to reduce pollution exposure could potentially improve population mental health.
A matched cohort study found no overall increased risk of early death among women with premenstrual disorders. However, the risk was elevated for young women and deaths by suicide, highlighting the need for careful follow-up and suicide prevention strategies.
A cohort study found that heat waves were associated with increased rates of preterm and early-term deliveries, especially among vulnerable populations. The results suggest that extreme heat events pose a significant threat to perinatal health.
A cohort study suggests that prenatal exposure to endocrine-disrupting chemicals is associated with adverse metabolic health in children, highlighting the need for public health implications. The findings indicate a potential link between chemical mixtures and metabolic syndrome in offspring.
First-seizure clinic (FSC) attendance, particularly early attendance, is associated with reduced rates of subsequent hospital utilization. Adequate resource allocation for FSCs may improve timely and equitable access.
After living kidney donation, donors experience a slower rate of estimated glomerular filtration rate (eGFR) decline compared to non-donors. However, donors are more likely to have an eGFR between 30-60 mL/min/1.73 m2 at least once during follow-up.
A cohort study of Japanese older adults found that upward and downward socioeconomic status transitions were associated with an increased risk of dementia. The study also revealed a link between social mobility and the length of dementia-free periods throughout life.
A longitudinal study found that boys experienced a significant increase in depressive symptoms during the COVID-19 pandemic, emerging later in the first year and then early into the second year. In contrast, girls' symptoms decreased during the school-closure phase but returned to pre-pandemic levels after schools reopened.
A new study from the University of Copenhagen found that long-term exposure to air pollution accelerates cognitive decline and increases risk of dementia. The research, which followed a cohort of nurses for 27 years, also suggests that physical activity may mitigate the adverse effects of air pollution.
A study published in Circulation found that revascularization significantly enhances the health-related quality of life (HRQoL) for patients with chronic limb-threatening ischemia. Patients who underwent endovascular intervention (Endo) showed slight statistical superiority over those who received surgical bypass (Bypass) in some HRQoL...
Clear sociodemographic disparities were identified in patient portal engagement among patients with hypertension treated in primary care. Without targeted interventions, patient portals may exacerbate existing health disparities.
Research suggests that the onset of daylight saving time is associated with increased consumption of processed snack foods and fewer trips to the gym. The study found that people ate more processed snack foods later in the day and on overcast days after the time change.
A new study finds mail-order pharmacy dispensing of mifepristone for medication abortion is effective, acceptable to patients, and feasible. This care model can improve access to medication abortion services and reduce the need for in-person screening.
A cohort study found that high levels of telehealth use were associated with more clinician encounters, ambulatory care-sensitive hospitalizations, and higher healthcare costs. COVID-19 cases still remained high during the study period, suggesting that HSAs with higher telehealth intensity may have better capacity for health services.
Researchers found a significant association between neighborhood deprivation and DNA methylation in brain tissue, which may be linked to immune response. The study identified one CpG site (cg26514961, PLXNC1 gene) significantly associated with neighborhood deprivation after controlling for covariates.
Research from the University of Birmingham found that children who experienced chronic lack of sleep from infancy were more than twice as likely to develop a psychotic disorder in early adulthood. Persistent sleep problems also increased the risk by nearly four times. The study, published in JAMA Psychiatry, suggests that addressing sl...
Researchers found associations between inflammatory and metabolic biomarkers and accelerated aging, with GlycA and GrimAge showing robust correlations. The study provides insight into the relationship between aging and cardiometabolic health, potentially informing vulnerable populations.
Black and Hispanic patients with atrial fibrillation were less likely to initiate direct oral anticoagulants at study onset, but these disparities narrowed over time. The study highlights the need to address unequal access to novel therapies for Black and Hispanic populations.
A cohort study found that individuals with a first colonoscopy with negative findings for colorectal cancer may benefit from longer screening intervals, potentially up to 15 years. This could lead to fewer unnecessary invasive examinations and improved patient outcomes.
A recent study published in BJSM found that increased cardio fitness level can reduce the risk of death from any cause and heart disease by 11-17% and 18%, respectively. Regular aerobic exercise programs can achieve this, leading to a reduced risk of early death and chronic conditions.
Scientists have identified a shared gene module in people with depression and cardiovascular disease, providing new markers for both conditions. The study found that genes involved in inflammation are associated with both diseases, explaining why they often occur together.
A recent study by Harvard Pilgrim Health Care Institute found that bisexual women died 37% sooner and lesbian women 20% sooner than heterosexual women. The study analyzed data from over 100,000 female nurses and highlighted the need for targeted interventions to reduce disparities among sexual minority groups.
A significant disparity in mortality rates was observed between lesbian, bisexual, and heterosexual female nurses, highlighting the need to address modifiable risks and social forces driving these disparities. The study's findings underscore the importance of promoting inclusive workplaces and addressing LGBTQ+ health inequities.
A cohort study found statistical signals for myocarditis and pericarditis after BNT162b2 vaccination in children aged 12-17 years, consistent with previous reports. Seizures after mRNA-1273 vaccinations in younger age groups require a robust epidemiologic investigation to confirm findings.
A large French study found a link between chronic exposure to certain emulsifiers and increased risk of developing type 2 diabetes. The researchers analyzed data from over 104,000 adults and observed an association with several emulsifiers.
A study by Germans Trias i Pujol Research Institute reveals that people living with HIV who contract COVID-19 face a significant increase in cardiovascular disease risk. The researchers identified several factors associated with this increased risk, including age, previous cardiovascular disease, and chronic conditions.
A national cohort study found that neighborhood disadvantage was independently associated with shorter breast cancer–specific survival. The study suggests potential unaccounted-for mechanisms, including both nonbiologic and biologic factors, and highlights the need for further research.
A new study found that maltreated children are three times more likely to be admitted to hospital for alcohol and substance use disorders by the age of 40. The likelihood of hospital admission was higher among those with substantiated notifications for sexual abuse or emotional abuse.
A national cohort study of over 2 million Swedish women found that those experiencing five major adverse pregnancy outcomes had significantly higher mortality rates. The study highlights the importance of early preventive evaluation and long-term follow-up for detection and treatment of chronic disorders associated with premature morta...
A new study from the Keck School of Medicine of USC found that genome-wide association studies' imputation technique works better for European, African American, and Latino groups than others. The researchers evaluated over 100 global populations, finding that imputation is less reliable for those farther away from Europe.
A new AI-based video biomarker is associated with aortic stenosis development and progression, allowing for opportunistic risk stratification across various imaging modalities. The study's findings suggest potential applications on handheld devices for early detection and intervention.
Researchers discovered that known genetic variants account for a large portion of chronic kidney diseases with unknown origin. The study found that 10% of patients had pathogenic variants in CKD-causing genes, and some hereditary renal diseases could be diagnosed and treated early on to slow down disease progression.
A new study from Aarhus University reveals that only 67% of Danes registered with an ectodermal dysplasia diagnosis actually have congenital ectodermal dysplasia. The study identifies key characteristics, including abnormal teeth, skin issues, and nail problems, highlighting the need for collaboration across healthcare disciplines.
Polybrominated diphenyl ether exposure significantly associated with cancer mortality and all-cause mortality. Further studies needed to replicate findings and understand underlying mechanisms.
Studies at the University of Gothenburg found a clear shift in arterial disease risks in diabetes, with decreases in central organ diseases like heart attack and stroke, but increases in peripheral vessel complications. Closer monitoring of long-term blood sugar levels can reduce peripheral arterial disease risk by 30-50%.
A Danish study found that PrEP use was associated with a more than twofold increase in chlamydia, gonorrhea, and syphilis diagnoses. The researchers suggest that changes in sexual risk-taking may lead people to seek PrEP rather than increased risks.
A study published in PLOS ONE found that earlier puberty onset is associated with higher adult cardiometabolic risk and mediates the effects of childhood risk factors. The research suggests targeting puberty onset may improve health outcomes in at-risk girls.
A large cohort study found that longer durations of exclusive breastfeeding were associated with a lower risk of childhood B-cell precursor-acute lymphoblastic leukemia. The study's results suggest potential biologic mechanisms underlying this association and inform the need for further research on preemptive interventions.
A cohort study of 64,000 Americans found that nearly 80% consumed excessive sodium, associated with 10-30% increase in cardiovascular disease mortality. Public health programs targeting reduced sodium intake may be beneficial for this underserved population.
Long-term BMI variability was a significant risk marker for adverse cardiovascular events, independent of mean BMI, across major racial and ethnic groups. The study's findings have implications for the phenotype of high BMI variability and potential preventive measures.
A landmark study stratifies people with type 2 diabetes using routine variables to visualize metabolic diversity. The algorithm identifies different subtypes of the disease, which can help in targeted prevention and treatment.
Researchers identified six novel protein biomarkers associated with incident coronary heart disease in individuals with and without type 2 diabetes. The study found that these biomarkers may offer potential new approaches to prevention and treatment of CHD.
Researchers developed chronological age prediction models by analyzing gene expression changes in the prefrontal cortex, identifying genes associated with aging and potential mechanisms. The models showed high correlation with age and demonstrated female and male-specific differences.
Researchers found associations between prenatal vitamin and metal exposures and epigenetic aging biomarkers in early life. A one standard deviation increase in essential metals was associated with lower Horvath EAA at birth, while arsenic was linked to greater EAA at birth and in childhood.
The latest American Psychiatric Association journals feature new treatments across the lifespan for anxiety, depression, and substance use disorder. The March issue of The American Journal of Psychiatry highlights several studies with these findings.
A large-scale study has found a significant link between smoking and DNA methylation, with two new epigenetic markers identified that differ by race or ethnicity. The research could lead to better ways to predict smoking-related disease risk and improve early detection and treatment.
A nationwide cohort study found that 25% of pregnant women don't eat fish during pregnancy and only 16% take omega-3 supplements. The study suggests that supplement use is less common among those who consume less fish, increasing their risk for insufficient intake.
A new study found that frequent cannabis use is associated with a higher risk of heart attack and stroke, even after controlling for tobacco use and other cardiovascular risk factors. The study analyzed data from over 430,000 adults in the US and found that smoking cannabis was significantly linked to cardiovascular risks.
An international team of scientists developed AI technology to analyze limited data on rare diseases. The method uses multi-layer networks to explore relationships between genes in patients, revealing genetic causes and severity. This breakthrough opens new avenues for treating rare diseases, including myasthenic-congenital syndromes.
A USC study found that diets high in solid fats and refined grains may increase the likelihood of developing preeclampsia, while a diet rich in vegetables, oils, and fruit may reduce the risk. Low-income Hispanic women are disproportionately affected by this health disparity.
A team of researchers from Aarhus University has developed a simple measurement of protein in the urine that can predict which individuals are at high risk of rapid progression of chronic kidney disease. The study found that patients with newly diagnosed mild to moderate chronic kidney disease within three years have a 15% risk of rapi...
A study of 2,180 participants found that early childhood neighborhood poverty is significantly associated with death from unintentional injury, suicide, and homicide in early adulthood. Economic policies are needed to address health equity and premature mortality.
A new study found that severe maternal grief, particularly the loss of a partner or child, is associated with an increased risk of heart failure in children up to middle age. The research suggests that prenatal stress may lead to adverse changes in mental and physical health, impacting fetal heart development.
Researchers identified NTRK gene fusion in 1.5% of Finnish papillary thyroid cancer patients, with notable co-occurring genetic alterations and favorable treatment outcomes. The study highlights the potential for biobank samples linked to electronic health records to describe patient characteristics and outcomes.
A recent study published in Nature found that smoking has a lasting effect on the immune system, with certain defense mechanisms persisting for up to 10-15 years after quitting. The research used a large cohort of healthy volunteers and identified three key factors: smoking, latent cytomegalovirus infection, and body mass index.
A new study found that 17% of young mothers in Wales experienced at least one child being taken into care between 2014 and 2021. The study also revealed that many care-experienced mothers experience early motherhood and placement instability, leading to concerns about family separation.
A study of 202,000 veterans found that outpatient healthcare use increased significantly in the month following COVID-19 infection before attenuating but remaining greater than uninfected cohorts through 12 months. This suggests ongoing effects of COVID-19 on healthcare utilization.
Two studies found people living with HIV in Catalonia have lower complete COVID-19 vaccination rates than those without HIV. However, they received more booster doses. Factors contributing to these disparities include previous SARS-CoV-2 diagnosis, socioeconomic situation and migration status.
Researchers have uncovered the molecular and ultrastructural features of BCAS1+ cells in diffuse gliomas, highlighting their proliferative capacity and distribution. The study provides a comprehensive characterization of the BCAS1+ cell population within diffuse gliomas, shedding light on its role in tumor malignancy.
A study of over 80,000 children found that high fish and vegetable intakes early in life are associated with a lower risk of inflammatory bowel disease. High sugar beverage intake, on the other hand, was linked to a higher risk.