Articles tagged with Cohort Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A retrospective cohort study of U.S. veterans found that adding a GLP1 receptor agonist to diabetes treatment reduced the risk of major adverse cardiovascular events and heart failure hospitalization by about 20% compared to DPP4 inhibitors. The study's findings will aid clinicians in choosing a diabetes drug regimen for older patients.
The study found that current 75- and 80-year-olds experience fewer depressive symptoms than those who lived in the 1990s, attributed to improved health and education. However, satisfaction with life was not significantly different between cohorts.
A large study found that people with dementia are at higher risk of self-harm within the first 12 months after diagnosis. The researchers emphasize the importance of providing psychosocial and mental health supports to patients upon diagnosis, particularly men, who are more likely to develop dementia after self-harm.
A new study suggests that increased exposure to air pollution may be associated with first hospital admissions for acute kidney injury. The research found a link between PM2.5, NO2, and O3 exposure and an increased risk of AKI, even at low annual exposures.
A cohort study of 196 people treated with tecovirimat found that HIV status did not impact treatment outcomes. Only 22% of participants experienced nonsevere adverse effects, and 4 serious adverse events occurred, with 3 being persons with HIV. The findings contradict previous uncertainty about HIV's role in mpox acquisition.
A study found that young women are more likely to experience adverse outcomes and rehospitalization after a heart attack, with non-cardiac hospitalizations showing the most significant disparity. Researchers highlight the need for public awareness and sex-specific post-heart attack care.
A University of Houston team has discovered new biomarkers for early detection of bladder cancer, including D-dimer and IL-8, which may identify disease progression. The study's findings could lead to a simple urine test as the new standard for bladder cancer diagnosis.
The University of Central Florida has developed the Virtual Experience Research Accelerator (VERA), a large-scale system for extended reality human subjects research. This project aims to facilitate human subjects research and improve extended reality technologies, making them more inclusive for underrepresented groups.
A 25-year longitudinal cohort study revealed that youths involved with the juvenile justice system have a significantly increased risk of firearm mortality, with rates varying by sex, race, and ethnicity. Sixteen years after detention, nearly one-quarter of Black and Hispanic males had been injured or killed by firearms.
A new study reveals that first-generation college graduates often originate from more affluent families with greater resources. This challenges the notion of a meritocracy, where success is solely based on individual effort. The research highlights the significant advantage these students have due to their family's socioeconomic status.
Research by Professor Mila Vulchanova reveals associations between language development and cognitive skills in children. Non-verbal tests show that severity of language difficulties can be predicted based on cognitive markers, supporting the importance of measuring both verbal and non-verbal skills.
A retrospective study found that elevated CA 19-9 and CEA levels were associated with worsened outcomes in duodenal adenocarcinoma patients. The study, which included 68 patients, suggests that these tumor markers may show promise as prognostic tools for this rare malignancy.
A national cohort study found that early dexamethasone administration reduced odds of mortality in hospitalized COVID-19 patients needing supplemental oxygen or mechanical ventilation. The treatment was not associated with improved outcomes for those without such needs.
A new 'enhanced primary care' model has been found to be effective in reducing blood pressure and hemoglobin A1c levels among patients with severe mental illness. The study, conducted at UNC WakeBrook, showed significant improvements in screening for people with severe mental illness compared to usual primary care.
Researchers found that using monoclonal antibodies within two days of a COVID-19 diagnosis reduced the risk of hospitalization or death by 39% compared to those who did not receive treatment. This finding suggests that early treatment with monoclonal antibodies significantly reduced the severity of COVID-19.
A major international study published in Nature Genetics has provided new insights into the genetics of preterm birth and pregnancy length. The research reveals a mutually antagonistic effect between the woman's and unborn child's genes, favoring earlier labor for the mother's survival and extending pregnancy for the child's weight gain.
A study of over 65,000 Japanese infants found that those exposed to indoor pets during fetal development or early infancy had fewer food allergies. Children exposed to indoor dogs and cats were significantly less likely to experience specific allergies, while hamster exposure unexpectedly increased the incidence of nut allergies.
A cohort study of over 9,000 persons found that asymptomatic middle-aged individuals with subclinical coronary atherosclerosis are at an 8-fold increased risk for myocardial infarction. The study highlights the importance of identifying and addressing obstructive coronary artery disease in patients without known cardiovascular disease.
A retrospective cohort study of hospitalized patients with and without substance use disorders during the early phase of the COVID-19 pandemic found no association between SUD and inpatient COVID-19-related mortality. Patients with and without SUD had similar clinical complications, including mechanical ventilation and ICU admission.
A cohort study found that nirmatrelvir treatment within five days of a positive COVID-19 test result was associated with reduced post-COVID-19 condition risk, regardless of vaccination status and prior infection history. The study suggests that nirmatrelvir may reduce the risk of long COVID across the risk spectrum.
A new report reveals that children born into the poorest fifth of families in the UK are 12 times more likely to experience poor health and educational outcomes by age 17. This clustering of adverse outcomes is linked to early childhood disadvantage, with modest reductions seen when lifting families out of poverty.
Researchers found that physical activity can prevent cancer recurrence in stage III colon cancer patients by lowering the recurrence rate within the first year of treatment. This association persisted for approximately three years after surgery, suggesting a long-term survival benefit.
A world-first study from the University of South Australia is providing valuable insights into how young people understand chronic pain, potentially helping thousands of sufferers to better manage their symptoms and long-term wellbeing. Researchers found that young people tend to make sense of chronic pain by explaining it as a softwar...
The European Platform for Neurodegenerative Diseases has launched its Cohort Catalogue, featuring an extensive list of international cohorts across the neurodegeneration disease spectrum. Researchers can search and filter cohorts by metadata characteristics to discover relevant studies and initiate new collaborations.
A study found that prenatal exposure to the anti-nausea drug Bendectin, containing dicyclomine, increased the risk of colorectal cancer in adult offspring. Incidence rates were three times higher among exposed children compared to those not exposed.
A recent large-scale Netherlands cohort study found that growing up in an affluent neighborhood has a more significant positive impact on educational attainment than growing up in a poor one. Exposure to affluence was found to have a greater effect, surpassing the negative effects of poverty.
After six months of disrupted schooling during the COVID-19 pandemic, German students scored substantially lower on intelligence tests compared to earlier cohorts. The gap in test scores persisted even after sixteen months of irregular schooling.
A US FDA mandate to limit acetaminophen dosage in pills combining it with opioids significantly reduced hospitalizations and acute liver failure cases. Researchers found a persistent decline in yearly rates of these cases after the mandate was implemented in 2014.
A new study published in The Lancet found that contracting a respiratory infection in early childhood is associated with a higher risk of dying from respiratory disease as an adult. Children who had a lower respiratory tract infection (LRTI) before the age of two were 93% more likely to die prematurely from respiratory disease, account...
A one-year case-control study found increased rates of adverse outcomes among adults with long COVID compared to those without COVID-19, highlighting the need for continued monitoring, particularly in cardiovascular and pulmonary management. The study's findings underscore the importance of addressing at-risk individuals.
A review of dozens of studies found a positive association between sugary drinks and weight gain in both adults and children, with increasing SSB intake linked to greater weight gain over time. Limiting SSB consumption is an effective way to prevent age-related weight gain.
A growing gap in NIH funding created an elite class of super principal investigators with persistent gaps in gender, ethnicity, and race. Researchers highlighted the critical need for reform to promote equity among NIH investigators.
A recent study found that bacterial co-infection in COVID-19 patients significantly increased the risk of death, intensive care unit admission, and mechanical ventilation. The study reviewed 13,781 COVID-19 inpatient encounters and identified laboratory trends associated with COVID-19 bacterial co-infection.
A study found that over 80% of American adults with type 2 diabetes meet the criteria to use GLP-1 RAs or SGLT2is, but only a small percentage are using them. The medications have a substantially higher cost than current first-line treatments, making it difficult for patients to access them.
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
A new study published by researchers at Charité - Universitätsmedizin Berlin found a significant link between early childhood trauma experienced by mothers and various health problems in their children. The research analyzed data from over 4,300 American mothers and their children, revealing that children of mothers with adverse experi...
Researchers have identified three novel pathogenic variants of the ATR gene as predisposing to male breast cancer. These variants were found in a cohort of individuals with early onset and familial breast cancers, using a combination of exome sequencing and functional investigations. The study suggests that extended genetic analysis ca...
Researchers found that a combination of symptom and high-level viral rebound after untreated COVID-19 infection is rare, occurring in only 3 percent of study participants. This suggests that accounting for underlying rates of symptom relapse is crucial when evaluating antiviral treatment effects.
Researchers found SARS-CoV-2 in 18.2% of tear samples from patients with COVID-19, and in 12.1% of those collected using the Schirmer strip test. The method may predict patient prognosis and provide an alternative to uncomfortable nasopharyngeal swabbing.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.
A recent study published in BMC Medicine found that higher consumption of free sugars is associated with a higher risk of cardiovascular disease. The researchers analyzed data from 110,497 individuals and found that consuming more free sugar, particularly from sugary drinks and sweets, increases the risk of heart disease and stroke. In...
A University of Massachusetts Amherst epidemiologist is leading a team to better understand the effects of chronic stress on future health risks. They will examine metabolites in blood samples from a large, racially diverse population to identify potential biomarkers for heart disease, diabetes and cognitive decline.
A recent study monitored the Italian province of Pescara for 18 months and found no increased risk of serious diseases among vaccinated individuals. The study revealed that vaccinated persons were more protected against COVID-19 and had lower rates of deaths and disease occurrences compared to non-vaccinated individuals.
Ultrafast MRI provides beneficial information for predicting DCIS upgrade to invasive cancer, including time to enhancement and lesion size. A study found that UF-MRI can accurately predict lesions diagnosed as DCIS at percutaneous biopsy that will be upgraded to invasive cancer at surgery.
A new study suggests that childhood mental health problems resulting from early-life adversity drive poorer cognitive performance in adolescence. Researchers found that addressing mental health difficulties when children are young can alleviate the effects of early-life adversity on later cognition.
A study published in the journal Nutrients found that regular coffee consumption is associated with lower blood pressure levels, both peripheral and central. The researchers analyzed data from a sample of Italian adults and discovered that moderate coffee drinkers had significantly lower systolic and pulse pressures.
Researchers analyzed electronic health record data from over 7.1 million children to identify risk factors associated with a faster decline in kidney function, including disease origin, proteinuria, hypertension, and younger age. The study found that certain attributes are linked to a more rapid decline in kidney function, providing va...
A systematic review and meta-analysis found that MRI-based surveillance after surgical treatment can detect clinically occult local recurrences, potentially improving patient outcomes. The study included 19 studies and showed a significant association between high-intensity surveillance and the detection of local recurrences.
A UK study using data from over 150,000 hospitalized patients found that immunocompromised individuals had a 44% higher risk of death compared to those with normal immune systems. The gap in mortality rates widened for immunocompromised patients over time, highlighting the need for targeted interventions such as antiviral treatments an...
A long-term study by UC Davis MIND Institute researchers identified three distinct paths of intellectual development in autistic children: persistent intellectual disability, an increase in IQ, or average IQ. The study used IQ trajectories to track changes in communication and behavioral development over time.
A cohort study of over 600 persons with non-MRI-conditional implantable cardioverter defibrillators found that these devices continue to appropriately treat detected tachyarrhythmias after MRI scans. The findings suggest that patients with non-MRI-conditional ICDs can safely undergo MRI exams without compromising device function.
A new study published in the Journal of Dental Research has found that heavy smokers with severe periodontitis do not receive any benefits from treatment. The study suggests that smoking cessation is crucial for effective treatment and may even worsen the disease during active treatment. The findings highlight the need to rethink pract...
A $2.3 million grant from the US Department of Energy funds a 'solar testbed' at I-79 Technology Park in Fairmont, supporting research on battery storage, grid integration, and cybersecurity. The project aims to assess solar panel health and monitor grid interactions with solar power.
A nationwide study in Japan found that high-quality primary care attributes, including accessibility and continuity, significantly reduced hospitalizations. Researchers identified a reduction in total hospitalizations among participants with better primary care coordination and comprehensiveness.
A new study published in JAMA Network Open suggests that an early return to school is associated with better outcomes for children who have suffered a concussion. The study found that children who returned to school within two days of their injury had lower symptom burdens and faster recoveries compared to those who stayed home longer.
A recent gene expression study has discovered 45 novel genes associated with body mass index (BMI), shedding light on the biology of obesity and potential treatments. The research, conducted in a diverse multiethnic cohort, highlights the importance of genetic factors in obesity and opens doors to new biomarkers and therapeutic targets.
Scientists have identified a new class of 'bivalent' antibodies that can bind to two viral targets at once, neutralizing multiple Omicron variants. These potent antibodies retain efficacy against early SARS-CoV-2 variants and several later Omicron sub-lineages.
A University of Kansas study found that SMART Recovery holds promise in addressing specific concerns of the LGBTQ population, but improvement is still needed. Participants appreciated being part of an LGBTQ-specific group, but faced challenges such as emotion regulation, coping with stigma, and recalling cognitive tools.
Among a U.S. national cohort of internal medicine residents, 1 in 4 women and 1 in 31 men reported experiencing sexual harassment. Despite understanding the reporting process, few residents formally reported incidents, resulting in low satisfaction rates with outcomes.
A recent study by North Carolina State University found that adult children in separated families receive substantially less emotional, material, and instrumental support from their parents. This often results in disadvantages for these children due to limited access to resources. The study also highlights the importance of providing a...