Articles tagged with Cohort Studies
A cohort study of over 9,000 persons found that asymptomatic middle-aged individuals with subclinical coronary atherosclerosis are at an 8-fold increased risk for myocardial infarction. The study highlights the importance of identifying and addressing obstructive coronary artery disease in patients without known cardiovascular disease.
A retrospective cohort study of hospitalized patients with and without substance use disorders during the early phase of the COVID-19 pandemic found no association between SUD and inpatient COVID-19-related mortality. Patients with and without SUD had similar clinical complications, including mechanical ventilation and ICU admission.
A cohort study found that nirmatrelvir treatment within five days of a positive COVID-19 test result was associated with reduced post-COVID-19 condition risk, regardless of vaccination status and prior infection history. The study suggests that nirmatrelvir may reduce the risk of long COVID across the risk spectrum.
A new report reveals that children born into the poorest fifth of families in the UK are 12 times more likely to experience poor health and educational outcomes by age 17. This clustering of adverse outcomes is linked to early childhood disadvantage, with modest reductions seen when lifting families out of poverty.
Researchers found that physical activity can prevent cancer recurrence in stage III colon cancer patients by lowering the recurrence rate within the first year of treatment. This association persisted for approximately three years after surgery, suggesting a long-term survival benefit.
A world-first study from the University of South Australia is providing valuable insights into how young people understand chronic pain, potentially helping thousands of sufferers to better manage their symptoms and long-term wellbeing. Researchers found that young people tend to make sense of chronic pain by explaining it as a softwar...
The European Platform for Neurodegenerative Diseases has launched its Cohort Catalogue, featuring an extensive list of international cohorts across the neurodegeneration disease spectrum. Researchers can search and filter cohorts by metadata characteristics to discover relevant studies and initiate new collaborations.
A study found that prenatal exposure to the anti-nausea drug Bendectin, containing dicyclomine, increased the risk of colorectal cancer in adult offspring. Incidence rates were three times higher among exposed children compared to those not exposed.
A recent large-scale Netherlands cohort study found that growing up in an affluent neighborhood has a more significant positive impact on educational attainment than growing up in a poor one. Exposure to affluence was found to have a greater effect, surpassing the negative effects of poverty.
After six months of disrupted schooling during the COVID-19 pandemic, German students scored substantially lower on intelligence tests compared to earlier cohorts. The gap in test scores persisted even after sixteen months of irregular schooling.
A new study published in The Lancet found that contracting a respiratory infection in early childhood is associated with a higher risk of dying from respiratory disease as an adult. Children who had a lower respiratory tract infection (LRTI) before the age of two were 93% more likely to die prematurely from respiratory disease, account...
A US FDA mandate to limit acetaminophen dosage in pills combining it with opioids significantly reduced hospitalizations and acute liver failure cases. Researchers found a persistent decline in yearly rates of these cases after the mandate was implemented in 2014.
A one-year case-control study found increased rates of adverse outcomes among adults with long COVID compared to those without COVID-19, highlighting the need for continued monitoring, particularly in cardiovascular and pulmonary management. The study's findings underscore the importance of addressing at-risk individuals.
A review of dozens of studies found a positive association between sugary drinks and weight gain in both adults and children, with increasing SSB intake linked to greater weight gain over time. Limiting SSB consumption is an effective way to prevent age-related weight gain.
A growing gap in NIH funding created an elite class of super principal investigators with persistent gaps in gender, ethnicity, and race. Researchers highlighted the critical need for reform to promote equity among NIH investigators.
A recent study found that bacterial co-infection in COVID-19 patients significantly increased the risk of death, intensive care unit admission, and mechanical ventilation. The study reviewed 13,781 COVID-19 inpatient encounters and identified laboratory trends associated with COVID-19 bacterial co-infection.
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
A study found that over 80% of American adults with type 2 diabetes meet the criteria to use GLP-1 RAs or SGLT2is, but only a small percentage are using them. The medications have a substantially higher cost than current first-line treatments, making it difficult for patients to access them.
A new study published by researchers at Charité - Universitätsmedizin Berlin found a significant link between early childhood trauma experienced by mothers and various health problems in their children. The research analyzed data from over 4,300 American mothers and their children, revealing that children of mothers with adverse experi...
Researchers have identified three novel pathogenic variants of the ATR gene as predisposing to male breast cancer. These variants were found in a cohort of individuals with early onset and familial breast cancers, using a combination of exome sequencing and functional investigations. The study suggests that extended genetic analysis ca...
Researchers found that a combination of symptom and high-level viral rebound after untreated COVID-19 infection is rare, occurring in only 3 percent of study participants. This suggests that accounting for underlying rates of symptom relapse is crucial when evaluating antiviral treatment effects.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.
Researchers found SARS-CoV-2 in 18.2% of tear samples from patients with COVID-19, and in 12.1% of those collected using the Schirmer strip test. The method may predict patient prognosis and provide an alternative to uncomfortable nasopharyngeal swabbing.
A University of Massachusetts Amherst epidemiologist is leading a team to better understand the effects of chronic stress on future health risks. They will examine metabolites in blood samples from a large, racially diverse population to identify potential biomarkers for heart disease, diabetes and cognitive decline.
A recent study published in BMC Medicine found that higher consumption of free sugars is associated with a higher risk of cardiovascular disease. The researchers analyzed data from 110,497 individuals and found that consuming more free sugar, particularly from sugary drinks and sweets, increases the risk of heart disease and stroke. In...
A recent study monitored the Italian province of Pescara for 18 months and found no increased risk of serious diseases among vaccinated individuals. The study revealed that vaccinated persons were more protected against COVID-19 and had lower rates of deaths and disease occurrences compared to non-vaccinated individuals.
A new study suggests that childhood mental health problems resulting from early-life adversity drive poorer cognitive performance in adolescence. Researchers found that addressing mental health difficulties when children are young can alleviate the effects of early-life adversity on later cognition.
Ultrafast MRI provides beneficial information for predicting DCIS upgrade to invasive cancer, including time to enhancement and lesion size. A study found that UF-MRI can accurately predict lesions diagnosed as DCIS at percutaneous biopsy that will be upgraded to invasive cancer at surgery.
A study published in the journal Nutrients found that regular coffee consumption is associated with lower blood pressure levels, both peripheral and central. The researchers analyzed data from a sample of Italian adults and discovered that moderate coffee drinkers had significantly lower systolic and pulse pressures.
Researchers analyzed electronic health record data from over 7.1 million children to identify risk factors associated with a faster decline in kidney function, including disease origin, proteinuria, hypertension, and younger age. The study found that certain attributes are linked to a more rapid decline in kidney function, providing va...
A UK study using data from over 150,000 hospitalized patients found that immunocompromised individuals had a 44% higher risk of death compared to those with normal immune systems. The gap in mortality rates widened for immunocompromised patients over time, highlighting the need for targeted interventions such as antiviral treatments an...
A systematic review and meta-analysis found that MRI-based surveillance after surgical treatment can detect clinically occult local recurrences, potentially improving patient outcomes. The study included 19 studies and showed a significant association between high-intensity surveillance and the detection of local recurrences.
A long-term study by UC Davis MIND Institute researchers identified three distinct paths of intellectual development in autistic children: persistent intellectual disability, an increase in IQ, or average IQ. The study used IQ trajectories to track changes in communication and behavioral development over time.
A cohort study of over 600 persons with non-MRI-conditional implantable cardioverter defibrillators found that these devices continue to appropriately treat detected tachyarrhythmias after MRI scans. The findings suggest that patients with non-MRI-conditional ICDs can safely undergo MRI exams without compromising device function.
A new study published in the Journal of Dental Research has found that heavy smokers with severe periodontitis do not receive any benefits from treatment. The study suggests that smoking cessation is crucial for effective treatment and may even worsen the disease during active treatment. The findings highlight the need to rethink pract...
A nationwide study in Japan found that high-quality primary care attributes, including accessibility and continuity, significantly reduced hospitalizations. Researchers identified a reduction in total hospitalizations among participants with better primary care coordination and comprehensiveness.
A $2.3 million grant from the US Department of Energy funds a 'solar testbed' at I-79 Technology Park in Fairmont, supporting research on battery storage, grid integration, and cybersecurity. The project aims to assess solar panel health and monitor grid interactions with solar power.
A new study published in JAMA Network Open suggests that an early return to school is associated with better outcomes for children who have suffered a concussion. The study found that children who returned to school within two days of their injury had lower symptom burdens and faster recoveries compared to those who stayed home longer.
A recent gene expression study has discovered 45 novel genes associated with body mass index (BMI), shedding light on the biology of obesity and potential treatments. The research, conducted in a diverse multiethnic cohort, highlights the importance of genetic factors in obesity and opens doors to new biomarkers and therapeutic targets.
Among a U.S. national cohort of internal medicine residents, 1 in 4 women and 1 in 31 men reported experiencing sexual harassment. Despite understanding the reporting process, few residents formally reported incidents, resulting in low satisfaction rates with outcomes.
Scientists have identified a new class of 'bivalent' antibodies that can bind to two viral targets at once, neutralizing multiple Omicron variants. These potent antibodies retain efficacy against early SARS-CoV-2 variants and several later Omicron sub-lineages.
A University of Kansas study found that SMART Recovery holds promise in addressing specific concerns of the LGBTQ population, but improvement is still needed. Participants appreciated being part of an LGBTQ-specific group, but faced challenges such as emotion regulation, coping with stigma, and recalling cognitive tools.
A recent study by North Carolina State University found that adult children in separated families receive substantially less emotional, material, and instrumental support from their parents. This often results in disadvantages for these children due to limited access to resources. The study also highlights the importance of providing a...
Researchers developed a blood test using circulating microparticle proteins to predict placenta accreta spectrum (PAS) cases as early as the second trimester. The study found five unique proteins that can distinguish PAS patients from control patients, enabling safe predication before delivery.
The American College of Physicians recommends bisphosphonates as initial pharmacologic treatment to reduce fracture risk in osteoporosis patients. Long-term use may increase risks, so treatment duration should be limited to 5 years or less.
A new study found that living in neighborhoods with higher opportunity or lower vulnerability can lead to lower mean BMI trajectory and lower risk of obesity in children. The study suggests that investing in neighborhood environments could help mitigate future chronic disease risk, particularly for marginalized communities.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
Researchers investigated the relationship between diet quality and gestational weight gain during pregnancy, ruling out poor diet quality as a major cause. The study found that a high intake of red meat may be associated with an increased risk of gestational weight gain.
Current tobacco and electronic nicotine delivery systems use associated with increased risk of bleeding after brushing or flossing. Longitudinal studies highlight the importance of tobacco cessation counseling in clinical practice.
A retrospective cohort study of 1,404 subjects with type 2 diabetes found that metformin use reduced the risk of delirium by 50% and decreased 3-year mortality rates. The study suggests that metformin may be a potential benefit for patients with diabetes, particularly in reducing age-related disorders such as dementia.
A recent study published in Molecular Psychiatry reveals a genetic link between attention-deficit/hyperactivity disorder (ADHD) and Alzheimer's disease in older adults. Researchers used a polygenic risk score to analyze the relationship between ADHD genetic predisposition and cognitive decline, finding a higher risk of developing Alzhe...
Insulin pump use has grown over two decades but disparities persist among racial, ethnic, and socioeconomic groups. Youth from lower-income backgrounds and minority groups are less likely to use insulin pumps.
Researchers have identified optimal blood tests to detect Alzheimer's disease at its earliest stages. The study found that phospho-tau217 is a reliable marker for monitoring disease progression and selecting individuals for novel trials.
A new study found that increasing protein intake by 25g a day and drinking regular cups of tea or coffee can reduce the risk of hip fracture in women by up to 14% and 4%, respectively. The study, which analyzed data from over 26,000 middle-aged women, also discovered that underweight women may experience greater reductions in risk.
The study analyzed over 180,000 patients, finding that depression, addiction, and stress reaction disorder are the most uncertain diagnoses. Doctors can use this data to predict treatment outcomes and improve care for patients, ultimately leading to better evidence-based follow-up.
A new study from the Mid-Atlantic Permanente Research Institute highlights nationwide health disparities in COVID-19 testing, hospitalization rates, and death. Black and Hispanic men were more likely to be hospitalized and die from COVID-19 compared to their white counterparts.
A study found that South Asian women with genes associated with type 2 diabetes are at a higher risk of developing gestational diabetes during pregnancy. The researchers identified genetic signatures linked with type 2 diabetes risk as strongly and independently associated with gestational diabetes in this population.
Researchers found that shingles increases the long-term risk of stroke and heart attacks by up to 30% in individuals aged 50 and older. The study followed over 200,000 participants for up to 16 years and suggests that vaccination may help reduce this risk.
A study in Japan reveals that universal screening methods for biliary atresia, a rare and severe lung condition in infants, are cost-effective. The research found that stool color card screening and direct bilirubin testing gained significant clinical benefits and saved lives.
A randomized controlled trial found that both total ankle replacement and ankle fusion improve quality of life and have similar clinical scores in patients with end-stage ankle osteoarthritis. However, TAR is associated with greater wound-healing complications and nerve injuries, while AF is linked to more blood clots and nonunion of t...