Research that follows groups of people over time. Covers cancer-linked stroke, light exposure and health, neurodegeneration in athletes, and fertility-treatment risk.
A secondary analysis of the Women's Ischemia Syndrome Evaluation (WISE) cohort study found that black and non-black women with obstructive coronary artery disease had similar long-term cardiovascular outcomes. The study suggests that guideline-based treatment, including statins and ACE inhibitors, may reduce racial disparities in cardi...
A new study reveals that prenatal exposure to endocrine-disrupting chemicals is linked to accelerated BMI gain in children from birth to nine years old. The study found that certain mixtures of these chemicals increase the risk of childhood obesity and its related health consequences.
A clinic-based community program improved food security scores, healthy eating behaviors, and depression scores in a vulnerable, food-insecure population. The Geaux Get Healthy Clinical Program provided comprehensive education and access to resources, leveraging community partnerships.
The UK Biobank study found that racial minority status increased dementia risk by 24%, with socio-economic status attenuating this effect. Lifestyle factors such as diet, smoking, physical activity, and sleep were identified as crucial in reducing racial and socio-economic disparities in dementia.
A new study finds that racial and ethnic disparities in chronic pain after acute traumatic injury are driven by differences in the nature of and health care response to acute injuries. Factors associated with disparities include mechanism of injury, severity of injury, pain in the hospital, and length of hospital stay.
A study published in Alzheimer's Research & Therapy suggests a possible association between chronic stress and an increased risk of developing mild cognitive impairment or Alzheimer's disease. The research, conducted on 44,447 individuals between 18-65 years old, found that those with chronic stress or depression had a higher risk of d...
The University of Colorado Anschutz Medical Campus has received a $54 million grant from the National Institutes of Health to advance clinical and translational science. The grant will enable the Colorado Clinical and Translational Sciences Institute (CCTSI) to translate discoveries into better health and patient care across the state.
A recent study found that gene panel sequencing as a first-tier screening test detected 2.7% of infants, with 50.4% diagnosed correctly. This alternative method identified undiagnosed cases in 1 out of every 500 newborns and showed promise for reducing false positives.
A longitudinal study of over 8,100 women reveals seven pathways that illustrate the long-term ripple effects of major life events. The research highlights the fluidity of education in many women's lives and challenges traditional notions of adulthood.
A large-scale international study of childhood cancer survivors found that women who received high-dose doxorubicin chemotherapy without chest radiation have a significantly increased risk of breast cancer before age 40. The researchers are calling for broadening guidelines for breast cancer screening in these patients.
A new Australian study found that implementing simple bone-strengthening strategies throughout the community can lead to a substantial decrease in hip fractures. The study analyzed data from over 3000 individuals aged 60+ and showed a 45% decline in hip fractures despite only a 3% increase in bone mineral density.
Researchers found that Dectin-1 stimulation induced a unique immune signature in HIV-positive older adults, characterized by increased levels of IL-12, TNF-α, and IFN-α. This signature may contribute to the pro-inflammatory environment associated with HIV and aging.
A study published in JAMA Pediatrics found that children who spent more than four hours a day on screens at age one were more likely to experience developmental delays by age four. The research suggests that different domains of development, such as communication and problem-solving skills, may be affected differently by screen time.
A new study by Harvard Pilgrim Health Care Institute found that residence in neighborhoods with higher opportunity or lower vulnerability is associated with a decreased risk of pediatric asthma. The study used a geographically diverse cohort of over 10,000 children and examined associations between neighborhood attributes and asthma in...
Researchers found that urine levels of adenine are predictive and causative biomarkers of looming progressive kidney failure in patients with diabetes. An oral therapeutic drug showed promise in mice by reducing kidney adenine levels and protecting against diabetic kidney disease.
A new study found that catheter ablation significantly lowers the incidence of cardiovascular events and death in very old patients with nonvalvular atrial fibrillation. The researchers compared 208 patients who underwent AF ablation with those who received medical therapy only, finding a lower risk of both cardiovascular events and de...
A study found that adolescents from low-income families gained more weight during the pandemic, with girls experiencing accelerated weight gain. The researchers tracked over 400 low-income Hispanic families and compared their weight gain to a cohort of wealthier families.
Researchers have identified a family of broadly neutralizing antibodies targeting the HIV-1 envelope protein, which may contribute to long-term remission from infection. These antibodies were found to induce the elimination of infected cells and impose a selective pressure on the virus, paving the way for new therapeutic approaches.
A Netherlands cohort study has revealed that healthcare workers who engaged in nose-picking were at a higher risk of contracting SARS-CoV-2 during the pandemic. The study emphasizes the significance of proper hygiene practices among healthcare professionals to prevent COVID-19 transmission.
A federally funded study led by University of Cincinnati clinical psychologist Sarah Whitton aims to identify mental health risks and protective factors for sexual minority women. The FAB400 cohort, a racially diverse group of nearly 400 women aged 21-26, will participate in an additional six waves of data collection over 2.5 years.
Researchers developed a step-by-step approach for creating joint displays of integrated data collection, facilitating comprehensive connections between qualitative and quantitative data. This method tackles the challenge of integrating qualitative and quantitative information in clinical studies, enabling robust mixed methods analysis.
A large international database analysis found nearly a quarter of esophageal adenocarcinoma patients had normal endoscopies but were still diagnosed within a year. The study suggests using high-quality equipment, rigorous sampling protocols, and future research on biomarker panels to improve screening effectiveness.
A recent study from Leipzig University found no significant link between oropharyngeal cancer and high-risk sexual behavior. The research, which analyzed data from over 300 patients with head and neck cancer, suggests that HPV infection is a key risk factor for the disease.
A comprehensive Chinese National Cohort study found a significant association between high ozone exposure and increased mortality risk. The study revealed a J-shaped pattern of O3-mortality relationship, indicating a potential threshold of O3 concentration.
A new study analyzed data on women born between 1916 and 1975, revealing increases in primary involuntary childlessness and secondary infertility. Meanwhile, the success rate of assisted reproductive technology (ART) increased over time, with significant contributions to population growth.
A cohort study found that U.S. veterans with atherosclerotic cardiovascular disease residing in historically redlined neighborhoods still experience higher prevalence of traditional cardiovascular risk factors and adverse cardiovascular events. Redlining's adverse association persists even decades after its discontinuation.
A study published in the Journal of the American College of Cardiology found that alerting volunteers can increase bystander CPR and AED use, leading to improved survival rates. The volunteer system increased rates of CPR and defibrillation in out-of-hospital cardiac arrests, giving victims a higher chance of receiving early care.
Researchers found that acute kidney injury does not predict worsening of kidney function trajectory in patients with CKD, suggesting that pre-existing kidney disease may be a major contributor. The study recommends focusing on flattening the eGFR slope and treating proteinuria to slow CKD progression.
A new study reveals that biscuspid aortic valve is caused by mutations in the MINDBOMB1 gene, with significant implications for developing alternative treatments to surgery. The research combines genome sequencing and gene editing techniques to analyze the mechanisms of this congenital defect.
OU researchers discovered a correlation between cerebral blood flow regulation and prognosis following cardiac arrest. The study found that detecting this regulatory mechanism can improve management and optimize post-resuscitation care for individual patients.
A new technique using DNA barcoding can identify the plant matter in human feces, improving clinical trials, nutrition studies and historical research. The method detected specific plant species and their relative amounts consumed, varying according to diet, age, and household income.
A recent study published in Nature Neuroscience clarifies the connection between autism and the microbiome, identifying autism-specific metabolic pathways associated with particular human gut microbes. The analysis, which harmonized dozens of previously published datasets, reveals a common microbial signature distinguishing autistic fr...
A multi-nation cohort analysis found that mothers with higher BMIs have shorter breastfeeding durations due to inflammation and cesarean section deliveries. The study identified dietary and systemic inflammation as modifiable factors associated with longer lactation duration in people with high BMI.
A study of 200 people aged 50-70 found that higher carotene levels in the blood were associated with lower atherosclerosis and reduced cardiovascular disease risk. A diet rich in fruits and vegetables, particularly those high in carotenes, may help lower the risk of heart disease.
A new study by CNIC researchers reveals that low-grade systemic inflammation triggered by subclinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals. The study found a strong association between atherosclerosis progression and accelerated biological age, with potential reversibility through lifestyl...
A 37-year study in Finland found that evening types have a slightly increased risk of dying compared to morning types, primarily linked to smoking and drinking habits. The study tracked nearly 23,000 twins and found that lifestyle factors, such as alcohol consumption and smoking status, play a significant role in mortality rates.
A retrospective cohort study reveals that racial disparities in tooth decay among children are significantly influenced by insurance type and dental procedure types. The study's findings suggest targeted strategies can be developed to reduce oral health disparities.
Researchers found a link between short telomeres in ATII cells and lung fibrosis in post-COVID-19 patients. The study revealed loss of ATII cellularity and shorter telomeres concomitant with increased fibrotic lung parenchyma remodeling.
A University of Massachusetts Amherst researcher has updated the Pregnancy Physical Activity Questionnaire (PPAQ), a widely used tool for measuring prenatal physical activity. The new PPAQ is considered reliable and valid, providing estimates of physical activity and sedentary behavior in pregnant women.
A recent study found that mothers who attended prenatal checkups had a lower risk of low birth weight. The study identified factors such as marital status, mental and physical health, and employment status as key contributors to attendance rates.
A new analysis of nearly 6,000 people found that childhood cognitive ability is associated with better scores on measures of wealth in adulthood, but the relationship varies for different financial measures. The study also discovered an inverted U-shape relationship between cognitive ability and debt levels.
Researchers from Mount Sinai Health System presented new findings on the impact of customized lighting on inpatient sleep, a machine-learned combination of ventilatory, hypoxic, and arousal burdens, and the effects of obstructive sleep apnea and insomnia on cognitive impairment. The studies aim to improve sleep timing and duration, dia...
A new study by Carnegie Mellon University researchers finds that crime risk assessment tools, such as machine learning models, are prone to cohort bias when ignoring social change dynamics. This bias can generate inequality in the criminal justice system, distinct from racial bias.
Researchers identified 37 symptoms across multiple pathophysiological domains that are more common in SARS-CoV-2 infected participants at six months post-infection. A preliminary rule for identifying postacute sequelae of SARS-CoV-2 infection (Long COVID) was derived from a composite symptom score and requires further refinement.
A study of 4.6 million adults in Catalonia found an association between long-term exposure to PM2.5, nitrogen dioxide, and black carbon with a higher risk of severe COVID-19 hospitalization and death. The research suggests that reducing air pollution levels may improve population health.
A Danish nationwide cohort study found that COVID-19 patients, especially those over 70, had a significantly higher risk of developing new-onset mental disorders compared to the general population. Hospitalized COVID-19 patients showed increased mental disorder risk similar to non-COVID-19 hospitalizations.
A team of researchers developed a deep-learning model called WearNet that uses Fitbit data to detect depression and anxiety. The study found that WearNet performed better than state-of-the-art machine learning models in detecting these conditions, producing individual-level predictions.
Survivors of firearm injury experience chronic PTSD symptoms and poor health-related quality of life, emphasizing the need for comprehensive care. Screening for chronic kidney disease could be cost-effective for US adults starting at age 35.
A study of 1,050 pregnant women found frequent detection of HPV, with infrequent perinatal transmission. The authors note challenges in distinguishing contamination from true infection, particularly in placentas.
A national cohort study found that multiple sclerosis (MS) distribution has become more diverse, with white individuals having the highest prevalence, followed by Black and Hispanic populations. The study's results highlight the need for tailored healthcare approaches for diverse patient groups.
A retrospective cohort study of U.S. veterans found that adding a GLP1 receptor agonist to diabetes treatment reduced the risk of major adverse cardiovascular events and heart failure hospitalization by about 20% compared to DPP4 inhibitors. The study's findings will aid clinicians in choosing a diabetes drug regimen for older patients.
Researchers found that solriamfetol, armodafinil–modafinil, and pitolisant reduce excessive daytime sleepiness in patients with obstructive sleep apnea already using conventional therapy. However, patients may be more likely to discontinue the use of these medications due to adverse events including headache, anxiety, and insomnia.
The study found that current 75- and 80-year-olds experience fewer depressive symptoms than those who lived in the 1990s, attributed to improved health and education. However, satisfaction with life was not significantly different between cohorts.
A large study found that people with dementia are at higher risk of self-harm within the first 12 months after diagnosis. The researchers emphasize the importance of providing psychosocial and mental health supports to patients upon diagnosis, particularly men, who are more likely to develop dementia after self-harm.
A study found that young women are more likely to experience adverse outcomes and rehospitalization after a heart attack, with non-cardiac hospitalizations showing the most significant disparity. Researchers highlight the need for public awareness and sex-specific post-heart attack care.
A new study suggests that increased exposure to air pollution may be associated with first hospital admissions for acute kidney injury. The research found a link between PM2.5, NO2, and O3 exposure and an increased risk of AKI, even at low annual exposures.
A cohort study of 196 people treated with tecovirimat found that HIV status did not impact treatment outcomes. Only 22% of participants experienced nonsevere adverse effects, and 4 serious adverse events occurred, with 3 being persons with HIV. The findings contradict previous uncertainty about HIV's role in mpox acquisition.
A University of Houston team has discovered new biomarkers for early detection of bladder cancer, including D-dimer and IL-8, which may identify disease progression. The study's findings could lead to a simple urine test as the new standard for bladder cancer diagnosis.
The University of Central Florida has developed the Virtual Experience Research Accelerator (VERA), a large-scale system for extended reality human subjects research. This project aims to facilitate human subjects research and improve extended reality technologies, making them more inclusive for underrepresented groups.
A new study reveals that first-generation college graduates often originate from more affluent families with greater resources. This challenges the notion of a meritocracy, where success is solely based on individual effort. The research highlights the significant advantage these students have due to their family's socioeconomic status.