Articles tagged with Cohort Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a blood test using circulating microparticle proteins to predict placenta accreta spectrum (PAS) cases as early as the second trimester. The study found five unique proteins that can distinguish PAS patients from control patients, enabling safe predication before delivery.
The American College of Physicians recommends bisphosphonates as initial pharmacologic treatment to reduce fracture risk in osteoporosis patients. Long-term use may increase risks, so treatment duration should be limited to 5 years or less.
A new study found that living in neighborhoods with higher opportunity or lower vulnerability can lead to lower mean BMI trajectory and lower risk of obesity in children. The study suggests that investing in neighborhood environments could help mitigate future chronic disease risk, particularly for marginalized communities.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
Researchers investigated the relationship between diet quality and gestational weight gain during pregnancy, ruling out poor diet quality as a major cause. The study found that a high intake of red meat may be associated with an increased risk of gestational weight gain.
Current tobacco and electronic nicotine delivery systems use associated with increased risk of bleeding after brushing or flossing. Longitudinal studies highlight the importance of tobacco cessation counseling in clinical practice.
A retrospective cohort study of 1,404 subjects with type 2 diabetes found that metformin use reduced the risk of delirium by 50% and decreased 3-year mortality rates. The study suggests that metformin may be a potential benefit for patients with diabetes, particularly in reducing age-related disorders such as dementia.
A recent study published in Molecular Psychiatry reveals a genetic link between attention-deficit/hyperactivity disorder (ADHD) and Alzheimer's disease in older adults. Researchers used a polygenic risk score to analyze the relationship between ADHD genetic predisposition and cognitive decline, finding a higher risk of developing Alzhe...
Insulin pump use has grown over two decades but disparities persist among racial, ethnic, and socioeconomic groups. Youth from lower-income backgrounds and minority groups are less likely to use insulin pumps.
Researchers have identified optimal blood tests to detect Alzheimer's disease at its earliest stages. The study found that phospho-tau217 is a reliable marker for monitoring disease progression and selecting individuals for novel trials.
A new study found that increasing protein intake by 25g a day and drinking regular cups of tea or coffee can reduce the risk of hip fracture in women by up to 14% and 4%, respectively. The study, which analyzed data from over 26,000 middle-aged women, also discovered that underweight women may experience greater reductions in risk.
The study analyzed over 180,000 patients, finding that depression, addiction, and stress reaction disorder are the most uncertain diagnoses. Doctors can use this data to predict treatment outcomes and improve care for patients, ultimately leading to better evidence-based follow-up.
A new study from the Mid-Atlantic Permanente Research Institute highlights nationwide health disparities in COVID-19 testing, hospitalization rates, and death. Black and Hispanic men were more likely to be hospitalized and die from COVID-19 compared to their white counterparts.
A study found that South Asian women with genes associated with type 2 diabetes are at a higher risk of developing gestational diabetes during pregnancy. The researchers identified genetic signatures linked with type 2 diabetes risk as strongly and independently associated with gestational diabetes in this population.
Researchers found that shingles increases the long-term risk of stroke and heart attacks by up to 30% in individuals aged 50 and older. The study followed over 200,000 participants for up to 16 years and suggests that vaccination may help reduce this risk.
A study in Japan reveals that universal screening methods for biliary atresia, a rare and severe lung condition in infants, are cost-effective. The research found that stool color card screening and direct bilirubin testing gained significant clinical benefits and saved lives.
A randomized controlled trial found that both total ankle replacement and ankle fusion improve quality of life and have similar clinical scores in patients with end-stage ankle osteoarthritis. However, TAR is associated with greater wound-healing complications and nerve injuries, while AF is linked to more blood clots and nonunion of t...
A new study found racial and ethnic disparities in brain aging among middle-age and older adults. In late life, Latinx and white adults experienced more pronounced brain aging, while Black adults showed accelerated brain aging in midlife.
A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
Researchers have found therapies that can help patients with relapsed multiple myeloma who tried CAR-T therapy, including bispecific antibodies and other types of CAR-T cell therapy. The study analyzed 79 patients and found that stem cell transplants and other drug combinations showed some efficacy in these patients.
A recent study published in Oncotarget reveals that Nectin-4 is widely expressed in head and neck squamous cell carcinoma (HNSCC), with significant correlations to clinico-pathological parameters. Non-smokers and p16-positive HNSCC showed higher expression of Nectin-4, leading to better survival rates for positive tumors.
A new study published in PLOS ONE found that chronic pain at age 44 is associated with poor mental health outcomes, joblessness, and general health issues in later decades. The research also suggests a link between chronic pain and COVID-19 infection, highlighting the need for attention to chronic pain as a public health concern.
A major birth cohort study reveals that children exposed to traumatic events, such as witnessing death or serious injury, are almost twice as likely to develop psychiatric disorders. By age 11, over a third of the children had been exposed to trauma, associated with a wide range of mental health problems.
A study in Brazil found that reducing childhood poverty could prevent up to 22.5% of future criminal convictions. The researchers analyzed 22 risk factors and interviewed over 1,900 children twice, finding that poverty was the only modifiable factor significantly associated with crime.
An automated texting program supported primary care patients after hospital discharge, resulting in significant reductions in acute care resource use. The patient-centered approach may serve as a model for improving post-discharge care.
Researchers found that autistic women are more vulnerable to psychiatric conditions and hospitalization than men, with a higher risk of depression, anxiety disorders, and self-harm. The study suggests that healthcare needs to be expanded for young adults, especially autistic women, to detect mental illness in time.
Researchers found that centenarians have a lower epigenetic age than expected, suggesting slowed biological aging. The study used four epigenetic clocks based on small CpG sites to reveal these differences.
A simple symptom-based screening tool, Childhood Asthma Risk Tool (CHART), predicts asthma risk in children as young as two years old. With 91% accuracy, CHART identifies high-risk kids and recommends follow-up actions to prevent hospitalizations.
A US cohort study suggests that maternal acetaminophen use during pregnancy may be associated with increased risk of sleep and attentional problems in offspring at age 3. The study found a potential link between acetaminophen exposure and neurobehavioral issues in children.
A cohort study of nearly 200,000 people found that intentional weight loss reduces the risk of type 2 diabetes for those who are overweight or obese. However, for lean individuals, weight loss attempts are associated with longer-term weight gain and higher risks of type 2 diabetes.
A cohort study found that endoscopists performing colonoscopies in FIT-based screening programs should aim for markedly higher ADRs compared to primary colonoscopy screening. The study suggests that high ADRs are associated with lower colorectal cancer incidence and mortality. Researchers recommend using ADR targets, including differen...
A cohort study of 4,443 patients with first-time strokes found that early recovery curves and long-term decline patterns varied across functional domains. Clinical factors such as age, sex, and stroke type significantly impacted activities of daily living performance at 60 months.
A study found an association between air pollution exposure during pregnancy and the first 5 years of life with altered white matter structural connectivity in children's brains. Exposure to fine particulate matter was also linked to changes in brain volume, particularly in preadolescents.
A Rutgers study analyzing data from 9,174 households found that chronic conditions like asthma and heart disease significantly contribute to medical debt. The study revealed that medical debt affects middle- and higher-income households as well, making it a society-wide issue.
Research at the University of Birmingham suggests that people who experience frequent bad dreams in middle age are more likely to be diagnosed with dementia later in life. The study found that middle-aged individuals with weekly nightmares were four times more likely to experience cognitive decline over a decade.
A new international study found that maternal education levels and household income at birth are significant predictors of childhood overweight and obesity. Social inequalities were evident across seven high-income countries, with lower maternal education associated with higher risk of overweight and obesity.
A new study has found associations between plasma miRNAs and cognitive function among cognitively normal men, including those with higher MMSE scores and slower rates of cognitive decline. These findings suggest that extracellular microRNAs may play a role in the early stages of cognitive decline.
For seven years after bariatric surgery, participants showed clinically important improvements in pain levels, physical function, and work productivity, with some backsliding over time. The study found durable effects on walking speed, fitness, and most metrics of pain, even among older adults.
Researchers at the University of Rochester Medical Center found that children who experience a mild traumatic brain injury are more likely to develop emotional and behavioral problems. The study, which analyzed data from thousands of children, revealed a 15-percent increased risk of these problems in kids with a mild TBI.
A cross-sectional study of over 25,000 adults found that approximately 70% of identified adrenal tumors were nonfunctioning, regardless of participant's age. The prevalence of adrenal tumors increased with age, from 0.2% in young adults to 3.2% in older adults.
A Dutch study reveals that 55% of ICU survivors experience significant health-related quality of life impairment one year after admission. The study also found that these patients have high healthcare utilisation and struggle to return to work.
A large French study found a potential direct association between higher artificial sweetener consumption and increased cardiovascular disease risk. The researchers suggest that these food additives should not be considered a healthy alternative to sugar.
Researchers identified an immune biomarker in newborns that can predict the onset and severity of pediatric atopic eczema. The Barrier dysfunction in Atopic newBorns (BABY) study found elevated levels of TARC at 2 months to be more than twice as likely to develop eczema by age 2.
A new study found that young Swiss military personnel with confirmed Covid-19 infections experienced symptoms like fatigue, reduced sense of smell, and psychological problems for up to 180 days. Long-term effects included increased BMI, high cholesterol, and lower physical stamina, suggesting a higher risk of metabolic disorders and ca...
A new study from the National Institutes of Health RECOVER initiative found that post-acute COVID-19 in children is less common than in adults, but more frequent than hospitalization rates for acute COVID-19. Children with medical complexity and those younger than five years old are at higher risk of long COVID-19.
A study led by University College London found that poor heart health at age 36 predicts a higher brain age later in life, with men having older brains than women of the same age. The research used machine learning to estimate brain age from MRI scans and found an association between brain age and increased brain shrinkage over time.
Researchers analyzed genetic data from nearly 43,000 people with autism and identified a novel group of inherited genes of moderate effect. The study shows that these genes contribute to autism through inherited variants and are associated with other neurodevelopmental disorders.
A new study published in PLOS ONE explores the relationship between preterm birth and educational attainment in U.K. children. The research found that children born before 32 weeks had higher rates of poor school attainment, but only those born very preterm remained at risk by the end of secondary school.
A Rutgers study found that early-term births (37–38 weeks) have significantly higher symptoms of hyperactivity, ADHD, and cognitive problems or inattention compared to full-term births. Teachers' reports provided valuable input for the diagnosis of ADHD, highlighting the need for regular screenings.
A new study published in JAMA Network Open found that children conceived through IVF have small differences in growth and weight compared to naturally conceived peers. The study of over 6000 children showed that these differences were negligible by late adolescence and unlikely to have health implications.
A recent UK-based study has revealed that vegetarian women have a 33% higher risk of hip fracture compared to regular meat-eaters. The research found that vegetarians had lower intakes of protein, calcium, and other micronutrients, which are crucial for bone and muscle health.
A study by Tel Aviv University researchers found a unique oral microbiotic signature in the saliva of veteran soldiers with PTSD, which may help diagnose post-traumatic stress disorder objectively. The study also showed that people with PTSD exhibit the same picture of bacteria in their saliva as those who have experienced combat stres...
Researchers from Keck School of Medicine found a strong association between PFOS exposure and liver cancer risk, with the strongest link seen in the top 10% of PFOS exposure. The study suggests that PFOS may disrupt normal liver function, leading to non-alcoholic fatty liver disease and increased risk of liver cancer.
A cohort study found that reinfection rates are low after successful hepatitis C virus (HCV) treatment in people who inject drugs, suggesting a benefit of treatment in this population. The risk for reinfection was highest among those with ongoing injecting drug use and needle sharing.
A nationwide study is investigating the effects of COVID-19 on patients in the US, with a focus on understanding and preventing lingering symptoms. The four-year study, RECOVER Initiative, will enroll up to 20,000 participants and explore factors that put individuals at risk for long-COVID.
Researchers found that higher suPAR levels were associated with increased risk of blood clot formation in COVID-19 patients. Combining suPAR and D-dimer may improve predicting who is at high or low risk of blood clots, enabling targeted therapies to prevent critical outcomes.
A retrospective study found that patients with multiple architectural distortions on digital breast tomosynthesis were more likely to have high-risk pathology, but not significantly different frequencies of malignancy. Biopsy of all areas may be warranted for these patients.
A new study found that Black patients are six times more likely to have advanced vision loss after a glaucoma diagnosis, highlighting the need for early eye screening in this population. The research analyzed nearly 210,000 participants and used artificial intelligence to identify visual field loss patterns.
A new study found that girls who spend more time on household chores in childhood are more likely to have limited future employment opportunities. The research suggests that unequal shares of household care work contribute to the gender pay gap, constraining girls' access to better-paid and higher-quality jobs.