Add BrightSurf on Google Email

Trial results support benefits of minimally invasive therapy (middle meningeal artery embolization) in treating chronic subdural hematoma

Researchers found that middle meningeal artery embolization reduces treatment failure rates in chronic subdural hematoma patients without increasing short-term stroke risk. The study's findings emphasize the need to update treatment protocols in the field, making MMAE a beneficial adjunctive treatment for eligible patients.

SourceSociety of NeuroInterventional Surgery·JournalNew England Journal of Medicine·DateNov 21, 2024

Phenotypic and epigenetic clocks for aging and mortality

This systematic review analyzes 33 biological clocks used for aging and mortality quantification, categorizing them into epigenetic and phenotypic clocks. Epigenetic clocks demonstrate precision in estimating chronological age through DNA methylation, while phenotypic clocks predict mortality using easily measurable clinical variables.

SourceImpact Journals LLC·JournalAging-US·TypeSystematic review·DateNov 20, 2024

Study advances understanding of metformin effects on fetus

Metformin, a widely prescribed diabetes drug, may increase risks of obesity and diabetes in newborns when given to pregnant women. The study found that the drug accumulated in the fetal kidneys, liver, and other organs, leading to growth restriction, which has been linked to an elevated risk of obesity and insulin resistance in childhood.

SourceUniversity of Oklahoma·JournalAmerican Journal of Obstetrics and Gynecology·TypeExperimental study·DateNov 12, 2024

Navigating bias in AI-driven cancer detection

AI models trained on limited data may misdiagnose certain populations, particularly those in underserved communities. Researchers propose six key strategies to develop fair AI models, including using diverse datasets and transparent decision-making processes.

SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateNov 11, 2024

The changing 'history' of a global ice sheet

A computer modeling study found that glacial isostatic adjustment caused downward movements in the eastern US, while upward movements occurred in eastern Canada, contributing to relative sea-level rise. The research will help generate maps for aquifer management and inform decisions on sea-level rise impacts.

SourceVirginia Tech·JournalJournal of Geophysical Research Solid Earth·DateNov 4, 2024

Houston Methodist researchers shed light on increased rates of severe human infections caused by Streptococcus subspecies

Researchers at Houston Methodist have identified a new strain of bacteria, Streptococcus dysgalactiae subspecies equisimilis (SDSE), linked to increasingly severe human infections. The study used integrative analysis to investigate the genome, transcriptome, and virulence of SDSE strains, shedding light on their molecular pathogenesis.

SourceHouston Methodist·JournalmBio·TypeExperimental study·DateNov 1, 2024

Cardiovascular risk biomarkers in inflammaging

Researchers propose a comprehensive biomarker-based approach to assess cardiovascular risk by combining markers of chronic inflammation with cardiac health indicators. This approach reveals the significant impact of aging-related inflammation, or 'inflammaging,' on heart health and opens new avenues for targeted interventions.

SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateOct 29, 2024

New model to study macrophage aging mechanisms

Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.

SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateOct 24, 2024

How blood cancer cells rewire to evade drug treatment

Researchers found that blood cancer cells rewired their gene regulatory networks to evade drug treatment in Acute Myeloid Leukemia (AML), disrupting normal differentiation and growth. The study identified key findings, including changes in open chromatin regions and the loss of binding of RUNX1 and AP-1 transcription factors.

SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateOct 23, 2024

Growing influence of the financial sector in serious illness care in the US

A new article in Journal of Palliative Medicine highlights the growing role of for-profit entities in home health and hospice care, which can compromise care quality and patient welfare. The authors emphasize the need for research and regulatory responses to address these trends and ensure better care for seriously ill older adults.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalJournal of Palliative Medicine·TypeCommentary/editorial·DateOct 16, 2024

Patients say access to health care is about more than just travel time and being seen quickly

A first-of-its-kind study assesses how closely patients' perceptions of network adequacy align with those of insurers. The survey found strong support for definitions related to timely access, specialty care, and mental health care, as well as broader concepts like public transportation access and cultural competency.

SourceTexas A&M University·JournalThe American Journal of Managed Care·DateOct 14, 2024

TP53 mutated AML: Transplant or No Transplant

TP53 mutations are commonly associated with therapy-related AML and complex cytogenetics. Researchers found improved long-term outcomes when allo-HCT was performed during Complete Remission 1 (CR1), despite limited effective therapies for TP53-mutated AML.

SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateOct 11, 2024

One out of every four employees of commercial organizations has withheld inventions from their employer

A new study by Tel Aviv University reveals that 27% of respondents withhold inventions due to reasons such as emotional attachment, fear of credit, or lack of trust in management. The study aims to shed light on this phenomenon and develop effective management tools to increase employees' willingness to disclose their inventions.

SourceTel-Aviv University·JournalAcademy of Management Perspectives·DateSep 29, 2024

WVU researchers say colleges barred from throwing money at student-athletes are offering them multimillion-dollar coaches instead

Researchers found that colleges offer multimillion-dollar coaches instead of throwing money at student-athletes, leading to an arms race in athletics. The study revealed a significant correlation between head coach salaries and team recruitment success, with higher salaries associated with better teams and more victories.

SourceWest Virginia University·JournalApplied Economics·DateSep 23, 2024

Incidence of neuroleptic malignant syndrome during antipsychotic treatment in children and youth

A new study found that patients with 4 or 5 identified risk factors, including age 18-24 years and schizophrenia spectrum disorders, had over 100 times the incidence of Neuroleptic Malignant Syndrome. The data provide a basis for early identification and monitoring of children and youth at elevated risk.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalJournal of Child and Adolescent Psychopharmacology·TypeData/statistical analysis·DateSep 18, 2024

Activity monitoring and lifespan: a longitudinal study

Researchers from the University of California, Davis, present a comprehensive framework for analyzing longitudinal activity and behavior. By employing advanced statistical techniques, they explore the relationship between activity and age-at-death in Mediterranean fruit flies, shedding light on potential links to human lifespan.

SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateSep 18, 2024

Publication demonstrates appeal of menthol cigarettes to young people

A University of Oklahoma researcher found that menthol cigarettes are more addictive and appealing than non-menthol cigarettes, especially among racial and ethnic minorities and the LGBTQ population. Participants were willing to work harder for puffs of menthol cigarettes, indicating a heightened risk of nicotine dependence.

SourceUniversity of Oklahoma·JournalNicotine & Tobacco Research·TypeObservational study·DateSep 18, 2024

Designing a normative neuroimaging library to support diagnosis of traumatic brain injury

A new library of healthy participants' neuroimaging data has been created to aid in the diagnosis and treatment of traumatic brain injury (TBI). The Normative Neuroimaging Library consists of data from approximately 1900 individuals, providing a comprehensive dataset for clinicians and researchers.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalJournal of Neurotrauma·TypeData/statistical analysis·DateSep 6, 2024

New tool detects fake, AI-produced scientific articles

A machine-learning algorithm called xFakeSci has been developed to detect AI-generated scientific articles, with a success rate of nearly 94%. The tool analyzes word patterns and bigrams to distinguish between real and fake papers, highlighting the need for comprehensive detection methods as AIs become increasingly sophisticated.

SourceBinghamton University·JournalScientific Reports·TypeComputational simulation/modeling·DateSep 3, 2024