Articles tagged with Academic Journals
Researchers have discovered several novel downstream p53 targets that could lead to improved cancer therapies. The study highlights the critical role of p53 in preventing cancer and identifies two new genes, ALDH3A1 and NECTIN4, as potential targets for cancer treatment.
Research team develops novel method to exploit frictionless sliding for improved memory performance and energy efficiency. The new technology enables unprecedentedly efficient data read/write operations while consuming significantly less energy.
A rare case of adenomyosis in an 81-year-old postmenopausal woman closely resembles invasive endometrial cancer, emphasizing the challenges of diagnosing this condition. Further studies are needed to refine diagnostic protocols and determine risk factors for postmenopausal patients.
A study found that pro-inflammatory molecules contribute to benign prostatic hyperplasia (BPH) in aging men, especially those with metabolic syndrome. Men with BPH had higher levels of pro-inflammatory markers and lower anti-inflammatory substances, suggesting a link between inflammation and prostate conditions.
ABT-263 eliminates harmful aging cells in the gut, reducing inflammation and lowering cancer risk in a mouse model of GI cancer. The study suggests that removing senescent cells could help prevent radiation-related GI cancer, highlighting the potential of senolytic drugs as a preventive treatment.
A new study from the University of Texas at Arlington found that Americans aged 65 and older who experienced parental divorce as children were more likely to suffer a stroke compared to their peers. The study analyzed data from over 13,000 older Americans and found that about 14% had experienced parental divorce during childhood.
Osteosarcoma cells often have extra copies of the SETDB1 gene, making the cancer more aggressive and harder to treat. Blocking SETDB1 may help the immune system recognize and attack osteosarcoma cells, offering a promising new way to treat this type of bone cancer.
A rare case report highlights the association between systemic mastocytosis and severe osteoporosis in a young adult patient, emphasizing the importance of early diagnosis and consideration of SM as an underlying cause. The study aims to raise awareness about this underrecognized condition and its potential impact on bone health.
The expanded partnership makes it easier for researchers to discover OA funding opportunities through Taylor & Francis OA agreements. Researchers can now explore an additional 178 titles, including unique journal profiles and enhanced discoverability on ResearchGate.
A study by Durham University has shown that E-coli bacteria produce an enzyme breaking down nutrients from dead cells, offering a banquet for neighboring cells. This process demonstrates that death is not the end of programmed biological processes, which can evolve to function after death.
A new study found that babies show positive responses to the smell of foods they were exposed to in the womb after birth. Newborns whose mothers had taken carrot powder capsules reacted favourably to the smell of carrot, while those whose mothers had taken kale powder capsules reacted more positively to the scent of kale.
A recent study published in Nature Reviews examines the complex role of sexual desire in relationships, highlighting its potential to fade over time. The research reveals how desire can be shaped by biological, social, and psychological factors, influencing partnership dynamics and relationship longevity.
A new case report reveals a rare and aggressive form of leukemia developing from donor cells nine years after a stem cell transplant. The disease, driven by genetic mutations in key genes, progresses despite intensive treatment and ultimately proves fatal.
A new genetic mutation, RUFY1-RET fusion, was discovered in a patient with stage IV CD-74-ROS1 fusion NSCLC who developed resistance to lorlatinib. The finding highlights the importance of ongoing genetic testing to guide therapy decisions.
A study found clear differences in brain health between Hispanic and non-Hispanic White older adults, with Hispanic participants scoring lower on tests of memory, attention, and problem-solving despite similar mental health. Researchers emphasize the importance of considering social, economic, and cultural factors when developing progr...
A large study found pregnant women with cervical cancer face higher health risks during pregnancy and childbirth, including premature birth and cesarean sections. However, the babies' health is largely unaffected, with no significant differences in birth defects or stillbirths.
A new Journal of Marketing study reveals that 'buy now, pay later' installment payments can significantly increase customer spending. The research found that by spreading payments into interest-free installments, retailers can boost both the number and average amount spent on purchases.
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
A recent study introduces an innovative method for analyzing body composition, providing accurate assessments of body fat and muscle distribution. The approach utilizes deep, nonlinear methods to enhance estimation accuracy, surpassing previous linear models.
Dr. Emre Umucu, a UTEP researcher, has received the Roger G. Barker Distinguished Research Contribution Award from the American Psychological Association. His research focuses on improving health and wellbeing for veterans with chronic conditions through employment, education, and psychology.
A recent study found that patients who left emergency departments before being medically advised had higher rates of readmission, mortality, and increased costs. The COVID-19 pandemic led to a 53.6% increase in such cases, primarily due to concerns about infection, long wait times, and dissatisfaction with care.
Researchers found a genetic change, pR552*, that could give the RB1 gene a new function leading to cancer growth. This challenges the common belief that both copies of the RB1 gene must be damaged for cancer to develop.
A new algorithm proposes measuring quadriceps muscle mass for more accurate sarcopenia diagnosis, potentially leading to earlier detection and better treatment options. Ultrasound imaging is recommended as a cost-effective and practical solution for diagnosing sarcopenia in clinical settings.
A natural compound derived from gut-friendly bacteria significantly slows vitiligo progression and may restore pigmentation in mice. The findings could offer hope to millions affected by the autoimmune disease, which causes visible patches of skin discoloration and carries profound emotional and physical consequences.
Researchers found that pomalidomide enhances key immune cells, such as T cells and natural killer cells, which helps the body recognize and destroy cancer cells. This leads to improved immune profiles in patients with myeloma, resulting in longer progression-free survival periods.
Scholastica's new integration with Crossmark allows journals to link article updates and retractions, ensuring the scholarly record's accuracy. The feature supports Crossref member organizations' efforts to maintain integrity and provide metadata for readers and downstream services.
Researchers explore HER2-low breast cancer, a new clinical subtype that benefits from novel treatments and personalized care. Current testing methods are not always accurate, calling for better detection methods to correctly identify patients who can benefit from these new therapies.
The open-access journal Plant Hormones focuses on fundamental research and reviews in plant hormone biosynthesis, signal transduction, and roles in growth and development. It aims to provide a platform for worldwide academic exchange and knowledge dissemination in the field of botany.
A new study published in Oncotarget discovered an anti-correlation between PD-1 and KLRG1 expression in human tumor infiltrating CD8 T cells. This finding suggests the potential for combination therapy to enhance cancer treatment by targeting both markers simultaneously, which could lead to more significant and long-lasting benefits.
Researchers tracked spur-winged lapwings in urban and rural areas, finding that city-dwellers are more mobile, especially during nesting season. The study also reveals seasonal differences in exploration patterns between males and females, highlighting the complex impact of human presence on bird behavior.
A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.
Researchers applied ACE questionnaires to select Marvel and DC characters, finding that childhood trauma does not determine heroism or villainy. The study suggests that using fictional characters can help address child abuse and trauma in a non-confrontational way.
A new study analyzing US data from over 27,500 participants reveals that retirees show more signs of depression than working individuals, with binge drinking exacerbating the issue. Moderate drinking appears to have fewer depressive symptoms compared to abstaining completely.
A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.
Researchers developed a gene therapy approach to treat chronic hypereosinophilia by delivering an anti-human eosinophil antibody via AAV-based gene therapy. The therapy successfully suppressed blood eosinophil levels in mice, showing promise as a potential treatment for the condition.
A systematic literature search identified high-priority clinical actions for post-acute care, including early education, risk assessment, and mental health screening. Implementing these actions can improve the quality of care for non-hospitalized TBI patients.
The January 2025 themed issue of Speculum reflects on the evolution of medieval studies, highlighting shifts toward global perspectives, feminist scholarship, and decolonization. The issue offers histories of para-academic groups, such as the Society for Medieval Feminist Scholarship, BABEL, and the Material Collective, and critiques t...
Dr. Marco Demaria joins Aging-US as Editor-in-Chief with expertise in cellular senescence and aging research. He aims to develop new therapeutic approaches to mitigate age-related diseases.
A new study by Tel Aviv University reveals Rujm el-Hiri's original alignment does not match celestial observations, casting doubt on its use as an astronomical observatory. The site's current orientation differs from its original position due to thousands of years of geodynamic shifts.
Researchers found that delivering at 39 weeks provides the optimal balance between stillbirth risk and infant health issues, making it an ideal time frame for safest births. The study used a large-scale data set to provide evidence-driven recommendations for delivery timing among women with chronic hypertension.
A scoping review of community health indices has identified a broad range of indicators covering health outcomes and vulnerabilities. These indices offer potential for multi-factorial assessments to inform regional and local policy strategies, aiming to reduce social inequities and improve community health.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
Researchers compared urine NAA levels in patients with mild and typical Canavan disease, finding lower levels in those with the milder form. This discovery has potential for a rapid and cost-effective way to screen for CD incidence and severity.
CEOs innovate based on stock recommendations and analyst feedback, which can foster explorative activities like R&D. However, many sacrifice long-term sustainability for immediate returns, incentivized by their compensation packages.
New research from Lancaster University highlights the devastating impact of the UK's unprecedented use of citizenship stripping on British children trapped in dire camps in North-East Syria. The study calls for a children's right approach to repatriation decision-making to ensure safe return and family reunification.
Researchers have developed a new generation of cell-penetrating antibodies that can target cancer cells and deliver therapeutic molecules directly into tumor cells. The 3E10 antibody shows great promise for treating cancers with defective DNA repair pathways.
Researchers found significantly higher levels of p16INK4a in young people with sickle cell disease, indicating accelerated cellular aging. This discovery may lead to new treatments targeting cell aging and improved quality of life for SCD patients.
Researchers discovered that Prostaglandin E2 drives skin cells to age and enables some of these cells to become pre-cancerous, leading to increased cancer risk. The study found that blocking PGE2 reduced the chances of aged cells becoming precancerous.
A new research paper published in Oncotarget introduces an innovative AI tool combining CT scans and body composition data to predict severe liver problems in primary sclerosing cholangitis (PSC) patients. The model achieved impressive results, correctly identifying at-risk patients with 97% accuracy.
A new study found that gene therapy delandistrogene moxeparvovec significantly extended the median survival of Duchenne muscular dystrophy (DMD) rats to >25 months. Additionally, the treatment elicited statistically significant improvements in cardiac parameters and mobility.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Mesenchymal stem cells (MSCs) show promise in delivering treatments directly to cancer cells and boosting the immune system's fight against cancer. However, ongoing research highlights challenges related to MSC behavior, including variability in their effects and potential to create conditions that support tumor growth.
Researchers analyzed seismic data from southern Israel and found weak ground motions caused by Hamas forces' unusual vehicle movement. This breakthrough highlights the potential of using seismic data to provide early warnings for future terrorist activities.
This editorial introduces persistence landscapes as a mathematical method to identify and correct biases in medical imaging. Persistence landscapes offer a way to reduce random noise while preserving important details, making it easier for clinicians to focus on meaningful image parts.
A recent study found that combining informative and persuasive cues, especially monetary incentives, boosts opt-ins. However, purely informative messages don't necessarily increase opt-ins. Firms with significant offline presence tend to use more persuasive strategies.
A new paper reveals widespread transnational human rights violations (THRVs) due to repressive states' intensifying tactics. The authors urge the establishment of 'Transnational Rights Protection Offices' to provide support and guidance for individuals affected by these actions.
Researchers at the University of Rochester Medical Center have discovered a potential biomarker for psychosis diagnosis by analyzing brain connectivity patterns. The 'somato-visual' biomarker shows promise in predicting psychosis onset and stratifying patients into clinically meaningful subgroups.
Researchers introduce a new tool called 'persistence images' that uncovers hidden biases in medical imaging data, advancing fairness in healthcare AI. The technology helps detect bias, filter out noise, and improve overall accuracy, leading to more reliable diagnoses and better patient outcomes.
A Tel Aviv University study finds that individuals who enhance their appearance are more likely to exhibit prosocial behavior, including donating to charity. The research suggests that feeling attractive can motivate people to engage in good deeds, with a significant impact on social consciousness.
Researchers found that middle meningeal artery embolization reduces treatment failure rates in chronic subdural hematoma patients without increasing short-term stroke risk. The study's findings emphasize the need to update treatment protocols in the field, making MMAE a beneficial adjunctive treatment for eligible patients.