Articles tagged with Academic Journals
This systematic review analyzes 33 biological clocks used for aging and mortality quantification, categorizing them into epigenetic and phenotypic clocks. Epigenetic clocks demonstrate precision in estimating chronological age through DNA methylation, while phenotypic clocks predict mortality using easily measurable clinical variables.
Luke McCormack, a Tree Root Biologist at The Morton Arboretum, has been recognized as one of the most cited and influential researchers worldwide. He leads the Root Biology Lab, examining root strategies to help trees cope with waterlogging and drought stress.
Researchers introduce persistence barcodes, a tool that reduces diagnostic bias and uncovers subtle details in medical images. The method preserves key structural details, enabling clearer insights into the data.
The journal welcomes Dr. Ana Novoa Perez, Prof. Tammy Robinson, Prof. Phil Hulme, and Dr. Andrew Liebhold to bring expertise in invasion science, aiming to expand global reach and impact.
Researchers developed a novel lentivirus-based gene therapy strategy in CD34+ hematopoietic progenitor cells, which showed therapeutic levels of expression of the anti-sickling beta globin protein. Cyclosporin improved transduction efficiency and preserved cell viability.
A new review highlights the differences in brain aging and Alzheimer's disease between humans and non-human primates, revealing that primate brains are more resistant to aging-related damage. The study suggests that tau tangles play a critical role in Alzheimer's progression, challenging the amyloid cascade hypothesis.
A new approach using topological data analysis (TDA) enhances the reliability and reduces bias in AI systems used for medical diagnosis in radiology. TDA captures intricate features and provides a holistic view of medical images, leading to more accurate diagnoses and equitable patient care.
Researchers explore potential synergies between chemotherapy, cannabinoids, and intermittent serum starvation in treating colorectal cancer. Combining these therapies could create a strong synergy by depriving cancer cells of glucose, making them more susceptible to treatment.
Researchers from Indiana University have uncovered how the EphA2 protein receptor contributes to cataract formation. The study found that canonical ligand-dependent EphA2 signaling remains stable in aging lens tissue, while non-canonical signaling increases with age, affecting lens fiber cell maturation.
The review explores the impact of extracellular matrix (ECM) geometry on immune cell behavior and treatment efficacy. Specific ECM configurations, known as Tumor-Associated Collagen Signatures (TACS), create physical barriers that limit immune cell access to tumors.
The Collective Pathway to Open Publishing (CPOP) pilot program aims to support Humanities and Social Sciences (HSS) journals by combining OA agreements with 'read' income. CPOP will make all articles in participating journals open access if thresholds are met, expanding their international reach and impact.
Metformin, a widely prescribed diabetes drug, may increase risks of obesity and diabetes in newborns when given to pregnant women. The study found that the drug accumulated in the fetal kidneys, liver, and other organs, leading to growth restriction, which has been linked to an elevated risk of obesity and insulin resistance in childhood.
A study of nearly 2,000 retailers reveals that they tend to disengage from supplier relationships when a direct channel is introduced. This results in a decrease in the number of SKUs ordered and an increase in wholesale prices, with total order value decreasing by €399.50.
A new study introduces the Meuhedet Electronic Frailty Index (MEFI) to assess frailty in older people and identify those at risk for serious health outcomes. The index classifies individuals as 'fit,' 'mildly frail,' or 'severely frail' and has been shown to predict mortality and hospitalization with high accuracy.
AI models trained on limited data may misdiagnose certain populations, particularly those in underserved communities. Researchers propose six key strategies to develop fair AI models, including using diverse datasets and transparent decision-making processes.
New assessment tools, Well-Being Signs (WBS) and Well-Being Brief (WBB), can guide treatment planning and identify needs beyond healthcare. These measures aim to enhance clinical practice by addressing whole-person outcomes and supporting referrals.
University of Cincinnati researchers highlight the importance of emergency consent in acute stroke trials due to time-sensitive nature and high mortality rate. They argue for more efficient alternatives to traditional informed consent, emphasizing patient autonomy and beneficence.
Researchers analyzed tumor samples from 64 SCLC patients, identifying promising results for biomarkers DLL3 and TTF-1. These biomarkers showed potential as targets for therapies like Tarlatamab and improved survival rates in patients with TTF-1-positive tumors.
A multicenter national clinical trial is being conducted to study whether giving antibiotics at the start of labor induction can decrease C-sections in pregnant women with obesity. The trial aims to enroll nearly 800 women and analyze infection rates, complications, and microbiome changes.
Researchers discovered Werner syndrome gene WRN plays a crucial role in maintaining constitutive heterochromatin structure, essential for DNA stability. Loss of WRN function disrupts protein interactions, potentially accelerating aging due to cellular disorganization.
Taylor & Francis joins DAISY Consortium’s Inclusive Publishing Partner program to advance accessibility in publishing. The company is committed to producing content accessible to all, regardless of reading requirements.
A computer modeling study found that glacial isostatic adjustment caused downward movements in the eastern US, while upward movements occurred in eastern Canada, contributing to relative sea-level rise. The research will help generate maps for aquifer management and inform decisions on sea-level rise impacts.
Researchers have derived a new formula to estimate the maximum occurrence rate of Earth-like habitats (EHs) in the galaxy, concluding that these habitats are relatively rare. The investigation suggests that the probability of extraterrestrial intelligence is significantly rarer still.
Researchers at Houston Methodist have identified a new strain of bacteria, Streptococcus dysgalactiae subspecies equisimilis (SDSE), linked to increasingly severe human infections. The study used integrative analysis to investigate the genome, transcriptome, and virulence of SDSE strains, shedding light on their molecular pathogenesis.
Researchers synthesizing AI with biomarker analysis aim to detect early signs of aging and enable targeted interventions to delay disease. This approach has the potential to slow, prevent or reverse certain effects of aging.
A study led by WVU epidemiologist Bethany Barone Gibbs found that alternating sitting and standing at work reduces sedentary behavior but has no effect on lowering blood pressure. Prolonged static standing may even have negative effects on cardiovascular health due to a physiological mechanism called the muscle pump.
Researchers propose a comprehensive biomarker-based approach to assess cardiovascular risk by combining markers of chronic inflammation with cardiac health indicators. This approach reveals the significant impact of aging-related inflammation, or 'inflammaging,' on heart health and opens new avenues for targeted interventions.
A remarkable clinical and metabolic response is reported in a metastatic BRAF V600E-mutated glomangiosarcoma treated with encorafenib and binimetinib. The combination of BRAF and MEK inhibitors achieves a long-lasting complete morpho-metabolic response in the patient.
Medically induced weight loss with GLP-1 receptor agonists can lead to substantial muscle loss, compromising physical strength and immune function. The authors emphasize the need for a multimodal approach combining medication with exercise and nutritional interventions to preserve muscle mass.
Researchers used ex vivo lentiviral gene therapy to treat MPS IVA in mice, achieving partial correction of bone pathology and complete correction of heart pathology. The study suggests potential for novel therapies to treat patients with MPS IVA.
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
Researchers found that blood cancer cells rewired their gene regulatory networks to evade drug treatment in Acute Myeloid Leukemia (AML), disrupting normal differentiation and growth. The study identified key findings, including changes in open chromatin regions and the loss of binding of RUNX1 and AP-1 transcription factors.
Jan-Benedict E.M. Steenkamp, a renowned marketing expert, has been selected as the next Editor-in-Chief of the Journal of Marketing, effective July 1, 2025. With his extensive research experience and leadership skills, Steenkamp aims to expand the journal's tradition of high-quality research.
Researchers used a mouse model to assess the impact of senolytic agents dasatinib and quercetin on pelvic organ prolapse. The study found that D+Q injections did not result in significant differences in prolapse development but reduced cellular senescence markers.
Researchers humanize the lupus-derived autoantibody 3E10, preserving its therapeutic efficacy, to create novel cell-penetrating antibodies targeting tumors and RAD51. Humanized variants exhibit faster cell uptake and superior in vivo tumor targeting.
Researchers reported a complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer patient with brain metastases. The patient achieved overall survival of 87 months and progression-free survival of 73 months after treatment sequencing.
A new study found that fibroblast growth factor 21 (FGF21) is an independent predictor of all-cause mortality in older adults. The Polsenior2 study revealed that middle and high FGF21 levels were associated with increased mortality risk, particularly when adjusted for age, co-morbidities, and blood parameters.
A new article in Journal of Palliative Medicine highlights the growing role of for-profit entities in home health and hospice care, which can compromise care quality and patient welfare. The authors emphasize the need for research and regulatory responses to address these trends and ensure better care for seriously ill older adults.
Research highlights molecular chaperones' role in maintaining tumor suppressor stability and functional integrity. This understanding is crucial for developing targeted therapies for multiple cancers.
A first-of-its-kind study assesses how closely patients' perceptions of network adequacy align with those of insurers. The survey found strong support for definitions related to timely access, specialty care, and mental health care, as well as broader concepts like public transportation access and cultural competency.
TP53 mutations are commonly associated with therapy-related AML and complex cytogenetics. Researchers found improved long-term outcomes when allo-HCT was performed during Complete Remission 1 (CR1), despite limited effective therapies for TP53-mutated AML.
A study found that more than half of the top US physicians who reviewed research for major medical journals received industry payments, with most being for research purposes. The payments may have implications for conflicts of interest and research outcomes, highlighting a need for transparency in the medical publishing system.
Researchers identify modifiable determinants of cerebral blood flow (CBF) and arterial transit time (ATT) in older adults. A higher BMI was associated with lower CBF and longer ATT, while cardiorespiratory fitness linked to longer ATT in specific brain regions.
The latest APA journal issues explore schizophrenia spectrum disorders, PTSD treatment, and college mental health. Research highlights include new approaches to psychosis treatment and findings on mental health in higher education.
The expert panel discussion sheds light on the best practices for injecting hyaluronic acid (HA) fillers in the infraorbital hollows. Top surgeons share their preferred fillers and techniques, providing valuable insights for treating undereye dark circles.
A new study by Tel Aviv University reveals that 27% of respondents withhold inventions due to reasons such as emotional attachment, fear of credit, or lack of trust in management. The study aims to shed light on this phenomenon and develop effective management tools to increase employees' willingness to disclose their inventions.
Early-stage HR+ breast cancer survivors experience weight gain, particularly those with healthy BMI or overweight at diagnosis. Black women have higher rates of obesity and related comorbidities compared to White women, leading to a 40% higher breast cancer mortality rate.
Researchers found that colleges offer multimillion-dollar coaches instead of throwing money at student-athletes, leading to an arms race in athletics. The study revealed a significant correlation between head coach salaries and team recruitment success, with higher salaries associated with better teams and more victories.
A University of Oklahoma researcher found that menthol cigarettes are more addictive and appealing than non-menthol cigarettes, especially among racial and ethnic minorities and the LGBTQ population. Participants were willing to work harder for puffs of menthol cigarettes, indicating a heightened risk of nicotine dependence.
A new study found that patients with 4 or 5 identified risk factors, including age 18-24 years and schizophrenia spectrum disorders, had over 100 times the incidence of Neuroleptic Malignant Syndrome. The data provide a basis for early identification and monitoring of children and youth at elevated risk.
Researchers from the University of California, Davis, present a comprehensive framework for analyzing longitudinal activity and behavior. By employing advanced statistical techniques, they explore the relationship between activity and age-at-death in Mediterranean fruit flies, shedding light on potential links to human lifespan.
A noninvasive ultrasound technology called Break Wave lithotripsy (BWL) was found to be highly effective in treating urinary stones, with an 88% fragmentation rate. Patients were able to undergo treatment without anesthesia and had a high success rate of being completely stone-free after follow-up CT scans.
A study published in the journal Brain shows that increases in protein levels with new Alzheimer's drugs can explain the slowing of cognitive impairment at least as well as the reduction in amyloid plaques. The researchers found that higher levels of a critical brain protein correlate equally well with cognitive benefits.
A new study from the University of Notre Dame finds that Big Tech privacy policies can decrease consumer engagement and satisfaction with ads, leading to reduced performance and revenue. The study explores how data minimization and other policies affect ad variety and consumer behavior.
A new library of healthy participants' neuroimaging data has been created to aid in the diagnosis and treatment of traumatic brain injury (TBI). The Normative Neuroimaging Library consists of data from approximately 1900 individuals, providing a comprehensive dataset for clinicians and researchers.
A machine-learning algorithm called xFakeSci has been developed to detect AI-generated scientific articles, with a success rate of nearly 94%. The tool analyzes word patterns and bigrams to distinguish between real and fake papers, highlighting the need for comprehensive detection methods as AIs become increasingly sophisticated.
New research from Bayes Business School finds that launching new technologies requires strategic timing to succeed. The study identifies four timing situations that can confront marketing managers, offering a framework to develop a launch strategy leading to success.
Experts propose a series of scientific principles and experimental approaches to assess potential carcinogenicity of gene therapies. Data transparency is crucial, with publicly accessible data from viral integrations site studies and clinical settings.
Researchers have developed a cost-effective and easily reproducible point-of-care testing device that can accurately measure cortisol levels in the blood. The device uses iridium oxide nanoparticles to improve stability, sensitivity, and selectivity, allowing for commercial use.
Researchers have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease. The treatment approach may represent a potential long-term universal treatment for MSUD.