Articles tagged with Academic Journals
Researchers found significantly higher levels of p16INK4a in young people with sickle cell disease, indicating accelerated cellular aging. This discovery may lead to new treatments targeting cell aging and improved quality of life for SCD patients.
New research from Lancaster University highlights the devastating impact of the UK's unprecedented use of citizenship stripping on British children trapped in dire camps in North-East Syria. The study calls for a children's right approach to repatriation decision-making to ensure safe return and family reunification.
Researchers discovered that Prostaglandin E2 drives skin cells to age and enables some of these cells to become pre-cancerous, leading to increased cancer risk. The study found that blocking PGE2 reduced the chances of aged cells becoming precancerous.
A new research paper published in Oncotarget introduces an innovative AI tool combining CT scans and body composition data to predict severe liver problems in primary sclerosing cholangitis (PSC) patients. The model achieved impressive results, correctly identifying at-risk patients with 97% accuracy.
A new study found that gene therapy delandistrogene moxeparvovec significantly extended the median survival of Duchenne muscular dystrophy (DMD) rats to >25 months. Additionally, the treatment elicited statistically significant improvements in cardiac parameters and mobility.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Mesenchymal stem cells (MSCs) show promise in delivering treatments directly to cancer cells and boosting the immune system's fight against cancer. However, ongoing research highlights challenges related to MSC behavior, including variability in their effects and potential to create conditions that support tumor growth.
Researchers analyzed seismic data from southern Israel and found weak ground motions caused by Hamas forces' unusual vehicle movement. This breakthrough highlights the potential of using seismic data to provide early warnings for future terrorist activities.
This editorial introduces persistence landscapes as a mathematical method to identify and correct biases in medical imaging. Persistence landscapes offer a way to reduce random noise while preserving important details, making it easier for clinicians to focus on meaningful image parts.
A recent study found that combining informative and persuasive cues, especially monetary incentives, boosts opt-ins. However, purely informative messages don't necessarily increase opt-ins. Firms with significant offline presence tend to use more persuasive strategies.
Researchers at the University of Rochester Medical Center have discovered a potential biomarker for psychosis diagnosis by analyzing brain connectivity patterns. The 'somato-visual' biomarker shows promise in predicting psychosis onset and stratifying patients into clinically meaningful subgroups.
Researchers introduce a new tool called 'persistence images' that uncovers hidden biases in medical imaging data, advancing fairness in healthcare AI. The technology helps detect bias, filter out noise, and improve overall accuracy, leading to more reliable diagnoses and better patient outcomes.
A Tel Aviv University study finds that individuals who enhance their appearance are more likely to exhibit prosocial behavior, including donating to charity. The research suggests that feeling attractive can motivate people to engage in good deeds, with a significant impact on social consciousness.
A new paper reveals widespread transnational human rights violations (THRVs) due to repressive states' intensifying tactics. The authors urge the establishment of 'Transnational Rights Protection Offices' to provide support and guidance for individuals affected by these actions.
Maximum Academic Press five journals have demonstrated exceptional quality and scholarly value, leading to their indexing in one of the world's most reputable academic databases. The five ESCI-indexed journals cover various fields such as fruit science, vegetable research, ornamental plants, grass species, and forestry.
Researchers found that middle meningeal artery embolization reduces treatment failure rates in chronic subdural hematoma patients without increasing short-term stroke risk. The study's findings emphasize the need to update treatment protocols in the field, making MMAE a beneficial adjunctive treatment for eligible patients.
The APE Award for Innovation in Scholarly Communication is now open for applications, honoring individuals who bring innovation to the field. Established by Digital Science and the Berlin Institute for Scholarly Publishing, the award includes €1,000 prize money.
Luke McCormack, a Tree Root Biologist at The Morton Arboretum, has been recognized as one of the most cited and influential researchers worldwide. He leads the Root Biology Lab, examining root strategies to help trees cope with waterlogging and drought stress.
Researchers introduce persistence barcodes, a tool that reduces diagnostic bias and uncovers subtle details in medical images. The method preserves key structural details, enabling clearer insights into the data.
The journal welcomes Dr. Ana Novoa Perez, Prof. Tammy Robinson, Prof. Phil Hulme, and Dr. Andrew Liebhold to bring expertise in invasion science, aiming to expand global reach and impact.
This systematic review analyzes 33 biological clocks used for aging and mortality quantification, categorizing them into epigenetic and phenotypic clocks. Epigenetic clocks demonstrate precision in estimating chronological age through DNA methylation, while phenotypic clocks predict mortality using easily measurable clinical variables.
Researchers developed a novel lentivirus-based gene therapy strategy in CD34+ hematopoietic progenitor cells, which showed therapeutic levels of expression of the anti-sickling beta globin protein. Cyclosporin improved transduction efficiency and preserved cell viability.
A new review highlights the differences in brain aging and Alzheimer's disease between humans and non-human primates, revealing that primate brains are more resistant to aging-related damage. The study suggests that tau tangles play a critical role in Alzheimer's progression, challenging the amyloid cascade hypothesis.
A new approach using topological data analysis (TDA) enhances the reliability and reduces bias in AI systems used for medical diagnosis in radiology. TDA captures intricate features and provides a holistic view of medical images, leading to more accurate diagnoses and equitable patient care.
Researchers explore potential synergies between chemotherapy, cannabinoids, and intermittent serum starvation in treating colorectal cancer. Combining these therapies could create a strong synergy by depriving cancer cells of glucose, making them more susceptible to treatment.
Researchers from Indiana University have uncovered how the EphA2 protein receptor contributes to cataract formation. The study found that canonical ligand-dependent EphA2 signaling remains stable in aging lens tissue, while non-canonical signaling increases with age, affecting lens fiber cell maturation.
Metformin, a widely prescribed diabetes drug, may increase risks of obesity and diabetes in newborns when given to pregnant women. The study found that the drug accumulated in the fetal kidneys, liver, and other organs, leading to growth restriction, which has been linked to an elevated risk of obesity and insulin resistance in childhood.
A study of nearly 2,000 retailers reveals that they tend to disengage from supplier relationships when a direct channel is introduced. This results in a decrease in the number of SKUs ordered and an increase in wholesale prices, with total order value decreasing by €399.50.
A new study introduces the Meuhedet Electronic Frailty Index (MEFI) to assess frailty in older people and identify those at risk for serious health outcomes. The index classifies individuals as 'fit,' 'mildly frail,' or 'severely frail' and has been shown to predict mortality and hospitalization with high accuracy.
The review explores the impact of extracellular matrix (ECM) geometry on immune cell behavior and treatment efficacy. Specific ECM configurations, known as Tumor-Associated Collagen Signatures (TACS), create physical barriers that limit immune cell access to tumors.
The Collective Pathway to Open Publishing (CPOP) pilot program aims to support Humanities and Social Sciences (HSS) journals by combining OA agreements with 'read' income. CPOP will make all articles in participating journals open access if thresholds are met, expanding their international reach and impact.
New assessment tools, Well-Being Signs (WBS) and Well-Being Brief (WBB), can guide treatment planning and identify needs beyond healthcare. These measures aim to enhance clinical practice by addressing whole-person outcomes and supporting referrals.
AI models trained on limited data may misdiagnose certain populations, particularly those in underserved communities. Researchers propose six key strategies to develop fair AI models, including using diverse datasets and transparent decision-making processes.
University of Cincinnati researchers highlight the importance of emergency consent in acute stroke trials due to time-sensitive nature and high mortality rate. They argue for more efficient alternatives to traditional informed consent, emphasizing patient autonomy and beneficence.
A multicenter national clinical trial is being conducted to study whether giving antibiotics at the start of labor induction can decrease C-sections in pregnant women with obesity. The trial aims to enroll nearly 800 women and analyze infection rates, complications, and microbiome changes.
Researchers analyzed tumor samples from 64 SCLC patients, identifying promising results for biomarkers DLL3 and TTF-1. These biomarkers showed potential as targets for therapies like Tarlatamab and improved survival rates in patients with TTF-1-positive tumors.
Researchers discovered Werner syndrome gene WRN plays a crucial role in maintaining constitutive heterochromatin structure, essential for DNA stability. Loss of WRN function disrupts protein interactions, potentially accelerating aging due to cellular disorganization.
Taylor & Francis joins DAISY Consortium’s Inclusive Publishing Partner program to advance accessibility in publishing. The company is committed to producing content accessible to all, regardless of reading requirements.
Researchers have derived a new formula to estimate the maximum occurrence rate of Earth-like habitats (EHs) in the galaxy, concluding that these habitats are relatively rare. The investigation suggests that the probability of extraterrestrial intelligence is significantly rarer still.
A computer modeling study found that glacial isostatic adjustment caused downward movements in the eastern US, while upward movements occurred in eastern Canada, contributing to relative sea-level rise. The research will help generate maps for aquifer management and inform decisions on sea-level rise impacts.
Researchers at Houston Methodist have identified a new strain of bacteria, Streptococcus dysgalactiae subspecies equisimilis (SDSE), linked to increasingly severe human infections. The study used integrative analysis to investigate the genome, transcriptome, and virulence of SDSE strains, shedding light on their molecular pathogenesis.
Researchers synthesizing AI with biomarker analysis aim to detect early signs of aging and enable targeted interventions to delay disease. This approach has the potential to slow, prevent or reverse certain effects of aging.
A study led by WVU epidemiologist Bethany Barone Gibbs found that alternating sitting and standing at work reduces sedentary behavior but has no effect on lowering blood pressure. Prolonged static standing may even have negative effects on cardiovascular health due to a physiological mechanism called the muscle pump.
Researchers propose a comprehensive biomarker-based approach to assess cardiovascular risk by combining markers of chronic inflammation with cardiac health indicators. This approach reveals the significant impact of aging-related inflammation, or 'inflammaging,' on heart health and opens new avenues for targeted interventions.
A remarkable clinical and metabolic response is reported in a metastatic BRAF V600E-mutated glomangiosarcoma treated with encorafenib and binimetinib. The combination of BRAF and MEK inhibitors achieves a long-lasting complete morpho-metabolic response in the patient.
Researchers used ex vivo lentiviral gene therapy to treat MPS IVA in mice, achieving partial correction of bone pathology and complete correction of heart pathology. The study suggests potential for novel therapies to treat patients with MPS IVA.
Medically induced weight loss with GLP-1 receptor agonists can lead to substantial muscle loss, compromising physical strength and immune function. The authors emphasize the need for a multimodal approach combining medication with exercise and nutritional interventions to preserve muscle mass.
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
Jan-Benedict E.M. Steenkamp, a renowned marketing expert, has been selected as the next Editor-in-Chief of the Journal of Marketing, effective July 1, 2025. With his extensive research experience and leadership skills, Steenkamp aims to expand the journal's tradition of high-quality research.
Researchers found that blood cancer cells rewired their gene regulatory networks to evade drug treatment in Acute Myeloid Leukemia (AML), disrupting normal differentiation and growth. The study identified key findings, including changes in open chromatin regions and the loss of binding of RUNX1 and AP-1 transcription factors.
Researchers used a mouse model to assess the impact of senolytic agents dasatinib and quercetin on pelvic organ prolapse. The study found that D+Q injections did not result in significant differences in prolapse development but reduced cellular senescence markers.
Researchers humanize the lupus-derived autoantibody 3E10, preserving its therapeutic efficacy, to create novel cell-penetrating antibodies targeting tumors and RAD51. Humanized variants exhibit faster cell uptake and superior in vivo tumor targeting.
Researchers reported a complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer patient with brain metastases. The patient achieved overall survival of 87 months and progression-free survival of 73 months after treatment sequencing.
A new study found that fibroblast growth factor 21 (FGF21) is an independent predictor of all-cause mortality in older adults. The Polsenior2 study revealed that middle and high FGF21 levels were associated with increased mortality risk, particularly when adjusted for age, co-morbidities, and blood parameters.
Research highlights molecular chaperones' role in maintaining tumor suppressor stability and functional integrity. This understanding is crucial for developing targeted therapies for multiple cancers.
A new article in Journal of Palliative Medicine highlights the growing role of for-profit entities in home health and hospice care, which can compromise care quality and patient welfare. The authors emphasize the need for research and regulatory responses to address these trends and ensure better care for seriously ill older adults.
A first-of-its-kind study assesses how closely patients' perceptions of network adequacy align with those of insurers. The survey found strong support for definitions related to timely access, specialty care, and mental health care, as well as broader concepts like public transportation access and cultural competency.
TP53 mutations are commonly associated with therapy-related AML and complex cytogenetics. Researchers found improved long-term outcomes when allo-HCT was performed during Complete Remission 1 (CR1), despite limited effective therapies for TP53-mutated AML.
A study found that more than half of the top US physicians who reviewed research for major medical journals received industry payments, with most being for research purposes. The payments may have implications for conflicts of interest and research outcomes, highlighting a need for transparency in the medical publishing system.
Researchers identify modifiable determinants of cerebral blood flow (CBF) and arterial transit time (ATT) in older adults. A higher BMI was associated with lower CBF and longer ATT, while cardiorespiratory fitness linked to longer ATT in specific brain regions.