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Why some breast cancer treatments stop working

A new review highlights how breast cancer cells change their communication and growth patterns, helping tumors survive, spread, and resist treatment. The review explores disrupted signaling pathways, including PI3K/Akt/mTOR and RAS/RAF/MEK/ERK, which can promote tumor progression and resistance to treatment.

SAMSUNG T9 Portable SSD 2TB

SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

Organoid fusions as models to study meninges-brain signaling

A new study presents a proof-of-concept leptomeningeal neural organoid (LMNO) fusion model to study meninges-brain signaling. The co-culture system of neural organoids fused with fetal leptomeninges from mice demonstrates stability and interface characteristics.

Montelukast improves retinal health in aging mice

A new study found that treating aged mice with montelukast improved retinal health by reducing inflammation and boosting proteasome activity. This approach may offer a promising new way to slow age-related vision loss and protect eye health in older adults.

Biology Open smashes the peer review mold

Biology Open's Fast & Fair peer review pilot has successfully reduced publication delays by recruiting contracted reviewers who are paid per manuscript. The innovative system, launched in July 2024, ensures high-quality reviews within 7 business days, often faster.

Evaluating DNA impurities in recombinant adeno-associated virus

A new study found that recombinant adeno-associated virus (rAAV) capsids contain single-stranded DNA impurities derived from plasmid and host cell DNA. The researchers suggest that the adverse effects of these impurities may differ from those of double-stranded DNA, highlighting the need for further evaluation.

Apple iPhone 17 Pro

Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.

Influence of age, sex, and mitochondrial haplotype on gut microbiome in rats

This study found that aging impacts the gut microbiome composition and metabolites differently in male and female rats, influenced by biological sex and mitochondrial DNA. The researchers analyzed fecal samples from genetically diverse rats to assess bacterial changes with age, revealing more significant shifts in females.

Meta Quest 3 512GB

Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.

Impact journals to participate at the AACR Annual Meeting 2025

Impact Journals is proud to exhibit at the AACR Annual Meeting 2025, featuring its esteemed journals Aging-US, Oncotarget, Oncoscience, and Genes & Cancer. The meeting highlights significant advancements in cancer research, aligning with Impact Journals' mission to disseminate impactful scientific research.

Mother’s high-fat diet can cause liver stress in fetus, study shows

A new study published in Liver International found that a mother's high-fat diet during pregnancy can lead to liver stress and changes in the fetus's bile acid levels. This may be a key factor in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) later in life.

Three Speculum articles recognized with prizes

Three Speculum articles have been recognized with the MAA Article Prize in Critical Race Studies and the MAA Van Courtlandt Elliott Prize. These awards honor outstanding research on race and medieval law, with one article exploring the intersection of genealogy and politics in late medieval Granada.

Sky & Telescope Pocket Sky Atlas, 2nd Edition

Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.

Celestron NexStar 8SE Computerized Telescope

Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.

EpiAge: A new test to measure biological age using saliva or blood

A new test called EpiAgePublic estimates biological age using only three DNA sites in the ELOVL2 gene, simplifying traditional methods while maintaining accuracy. The study found that EpiAgePublic accurately tracks aging patterns and can identify factors accelerating the aging process.

Novel cigarette pricing policy linked to decrease in sales in California city

A new study found that an Oakland law requiring cigarette prices to increase to a minimum of $8 per pack led to a 15-percent decrease in cigarette sales and a 25-percent decrease in lower-priced cigarettes. The policy may be particularly effective at curbing tobacco initiation among low-income individuals and youth.

Researchers identify new p53 targets to combat cancer growth

Researchers have discovered several novel downstream p53 targets that could lead to improved cancer therapies. The study highlights the critical role of p53 in preventing cancer and identifies two new genes, ALDH3A1 and NECTIN4, as potential targets for cancer treatment.

GQ GMC-500Plus Geiger Counter

GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.

Rare uterine condition mimics cancer in postmenopausal woman

A rare case of adenomyosis in an 81-year-old postmenopausal woman closely resembles invasive endometrial cancer, emphasizing the challenges of diagnosing this condition. Further studies are needed to refine diagnostic protocols and determine risk factors for postmenopausal patients.

Inflammation and metabolic syndrome linked to benign prostatic hyperplasia

A study found that pro-inflammatory molecules contribute to benign prostatic hyperplasia (BPH) in aging men, especially those with metabolic syndrome. Men with BPH had higher levels of pro-inflammatory markers and lower anti-inflammatory substances, suggesting a link between inflammation and prostate conditions.

Senolytic ABT-263 reduces radiation-induced gastrointestinal cancer

ABT-263 eliminates harmful aging cells in the gut, reducing inflammation and lowering cancer risk in a mouse model of GI cancer. The study suggests that removing senescent cells could help prevent radiation-related GI cancer, highlighting the potential of senolytic drugs as a preventive treatment.

Researchers uncover surprising link to stroke risk

A new study from the University of Texas at Arlington found that Americans aged 65 and older who experienced parental divorce as children were more likely to suffer a stroke compared to their peers. The study analyzed data from over 13,000 older Americans and found that about 14% had experienced parental divorce during childhood.

Sony Alpha a7 IV (Body Only)

Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.

Severe osteoporosis as a manifestation of systemic mastocytosis

A rare case report highlights the association between systemic mastocytosis and severe osteoporosis in a young adult patient, emphasizing the importance of early diagnosis and consideration of SM as an underlying cause. The study aims to raise awareness about this underrecognized condition and its potential impact on bone health.

GoPro HERO13 Black

GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.

Babies respond positively to smell of foods experienced in the womb

A new study found that babies show positive responses to the smell of foods they were exposed to in the womb after birth. Newborns whose mothers had taken carrot powder capsules reacted favourably to the smell of carrot, while those whose mothers had taken kale powder capsules reacted more positively to the scent of kale.

Sexual desire — the force that connects yet also divides

A recent study published in Nature Reviews examines the complex role of sexual desire in relationships, highlighting its potential to fade over time. The research reveals how desire can be shaped by biological, social, and psychological factors, influencing partnership dynamics and relationship longevity.

Rigol DP832 Triple-Output Bench Power Supply

Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.

Cervical cancer: Maternal, delivery & neonatal outcomes study

A large study found pregnant women with cervical cancer face higher health risks during pregnancy and childbirth, including premature birth and cesarean sections. However, the babies' health is largely unaffected, with no significant differences in birth defects or stillbirths.

Neurocognitive disparities in aging: Exploring ethnicity & mental health

A study found clear differences in brain health between Hispanic and non-Hispanic White older adults, with Hispanic participants scoring lower on tests of memory, attention, and problem-solving despite similar mental health. Researchers emphasize the importance of considering social, economic, and cultural factors when developing progr...

Apple iPad Pro 11-inch (M4)

Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.

ABT-263 treatment rejuvenates aged skin and enhances wound healing

Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.

Creality K1 Max 3D Printer

Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.

ISarcoPRM algorithm: advancing global sarcopenia diagnosis

A new algorithm proposes measuring quadriceps muscle mass for more accurate sarcopenia diagnosis, potentially leading to earlier detection and better treatment options. Ultrasound imaging is recommended as a cost-effective and practical solution for diagnosing sarcopenia in clinical settings.

Microbial therapy offers new hope for vitiligo patients

A natural compound derived from gut-friendly bacteria significantly slows vitiligo progression and may restore pigmentation in mice. The findings could offer hope to millions affected by the autoimmune disease, which causes visible patches of skin discoloration and carries profound emotional and physical consequences.

How pomalidomide boosts the immune system to fight multiple myeloma

Researchers found that pomalidomide enhances key immune cells, such as T cells and natural killer cells, which helps the body recognize and destroy cancer cells. This leads to improved immune profiles in patients with myeloma, resulting in longer progression-free survival periods.

Apple AirPods Pro (2nd Generation, USB-C)

Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.

Anti-correlation between KLRG1 and PD-1 in tumor CD8 T cells

A new study published in Oncotarget discovered an anti-correlation between PD-1 and KLRG1 expression in human tumor infiltrating CD8 T cells. This finding suggests the potential for combination therapy to enhance cancer treatment by targeting both markers simultaneously, which could lead to more significant and long-lasting benefits.

Apple Watch Series 11 (GPS, 46mm)

Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.

Nikon Monarch 5 8x42 Binoculars

Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.

Risk of thyroid cancer among GLP1-RA users

A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.

Gene therapy to treat chronic hypereosinophilia

Researchers developed a gene therapy approach to treat chronic hypereosinophilia by delivering an anti-human eosinophil antibody via AAV-based gene therapy. The therapy successfully suppressed blood eosinophil levels in mice, showing promise as a potential treatment for the condition.

AmScope B120C-5M Compound Microscope

AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.