Articles tagged with Academic Journals
A new gene editing technique, P3a mutagenesis, achieves near 100% success in creating precise DNA mutations. This method simplifies protein engineering, accelerating biomedical research and reducing costs.
A new case report describes the successful treatment of a 37-year-old woman with HER2-positive breast cancer that had spread to the membranes surrounding the brain and spinal cord. Trastuzumab deruxtecan, an antibody-drug conjugate, improved the patient's neurological symptoms and reduced cancer growth.
A new study found that faster biological aging measured by DNA-based epigenetic clocks is associated with greater cognitive decline and higher risk of mild cognitive impairment in Hispanic/Latino adults. The study highlights the potential of epigenetic clocks to track changes in brain health over time.
A new study found that alpha-synuclein triggers early gene expression changes in a Parkinson's disease model, revealing brain region-specific and systemic transcriptomic alterations. These changes may contribute to disease development and serve as potential biomarkers.
A rare case of a mucinous vulvar cyst was reported, which resembled a benign lipoma and caused lower abdominal and back pain. The cyst was surgically removed and confirmed to be non-malignant. The case underscores the importance of careful clinical examination in reproductive-age women presenting with vulvar masses.
The 2026 APE Award for Innovation in Scholarly Communication is now open for applications. The award celebrates innovators who bring new ways of thinking and collaborative approaches to improve scholarly communication. Past recipients include Dr Daniel Hook, CEO of Digital Science.
Researchers found that TRF1 protein loss led to leaner mice with altered metabolic profiles, including lower LDL cholesterol levels and improved blood sugar regulation. These benefits occurred without any detectable shortening of telomeres.
The Journal of the Optical Society of America B will make its content freely available worldwide if institutional subscribers meet a target. This move aims to balance author fees with community-driven open access options.
A new analysis by Taylor & Francis and DataSeer found that over half of researchers included a Data Availability Statement in their journal articles, while a third openly shared their data. The study suggests that factors beyond policy mandates are driving the adoption of open research practices.
Researchers found that PAI-1 levels increase with age in both sexes, but only female mice lacking the gene experienced significant protection against age-related muscle and bone loss. Female mice maintained stronger grip strength and greater muscle mass, while showing less cortical bone loss.
A rare case of pancreatic Hodgkin lymphoma was reported, emphasizing the need for tissue diagnosis before definitive treatment. The patient's symptoms and imaging findings initially raised concern for pancreatic adenocarcinoma, but a biopsy revealed nodular sclerosis subtype of Hodgkin lymphoma.
Brian Denton, professor at the University of Michigan, and Les Servi, a six-year member of INFORMS Board of Directors, have been awarded the 2025 George E. Kimball Medal for their exemplary service across various leadership roles. The award recognizes their transformative contributions to operations research and management sciences.
Longevity clinics have emerged globally, offering advanced diagnostic services and customized lifestyle interventions to extend healthspan. However, concerns arise from lack of scientific validation, high costs, and limited access to populations most at risk for premature aging.
The new tool helps identify gaps in open research information and provides supporting evidence for movements like the Barcelona Declaration. Crossref's Participation Reports now offer expanded features, covering over 175 million records representing a significant share of global research production.
Researchers discovered that folate receptor beta is widely expressed in various pediatric and adolescent solid tumors, making it a promising target for improving tumor surgery accuracy. Pafolacianine, a next-generation dye targeting folate receptors, shows promise as a tumor-agnostic imaging strategy for pediatric cancer surgery.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
Researchers found that overactive Runx1 gene accelerates age-related degeneration of intervertebral discs, causing premature cellular aging and unhealthy tissue changes. Targeting Runx1 may be a promising strategy to prevent or slow disc aging.
Epithelioid hemangioendothelioma is a rare and potentially malignant vascular tumor that can be mistaken for benign conditions. A new case report highlights the diagnostic challenges raised by rare tumors and emphasizes the need for vigilant evaluation of slow-growing swellings.
Researchers found that a supplement containing high-molecular-weight hyaluronan preserves muscle mass and exercise capacity in aging mice. The study suggests that targeting the glycocalyx may be a viable therapeutic strategy to treat age-related physical dysfunction.
Researchers have developed a novel treatment approach using amplitude-modulated radiofrequency electromagnetic fields to slow glioblastoma cell growth and target tumor stem cells. The therapy shows promise in both laboratory experiments and clinical trials with two patients, demonstrating potential for treating brain cancer.
A recent study published in Oncoscience found that lifestyle choices and hormonal imbalances significantly impact male fertility in Indian men. The research discovered a strong association between poor habits such as tobacco and alcohol use, heat exposure, and body weight with lower semen quality and higher DNA damage.
This study found that aged rats living in socially enriched environments retained better memory and cognitive flexibility than those housed alone. Socially housed rats showed increased activity in the hippocampus and reduced overactivity in the anterior cingulate cortex, suggesting a more balanced and efficient neural response.
ACTM-838, a novel bacterial immunotherapy, enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity. The therapy shows durable anti-tumor efficacy and synergizes with anti-PD1 drugs, improving outcomes in treatment-resistant tumor models.
A new study found that miR-145-5p and miRNA-27b-3p interfere with fat cell formation in children with Hutchinson-Gilford progeria syndrome, a rare and fatal premature aging disorder. These microRNAs silence genes required for fat cell growth and function, suggesting they could be a promising therapeutic strategy to restore fat tissue.
The journal will benefit from improved publishing infrastructure and increased visibility for its published research. Phytologia Balcanica is an international journal in plant sciences, publishing original scientific articles across various fields.
A new study calls for standardized, transparent, and reproducible methods to evaluate frailty in preclinical aging studies. The researchers analyzed 18 rodent studies and found substantial variation in how frailty is defined and measured.
Researchers found that a combination of oxytocin and an Alk5 inhibitor significantly extended the lifespan and healthspan of frail, elderly male mice, but not female mice. This dual-drug approach reduced chronic inflammation and tissue damage, leading to improved physical endurance and memory in males.
A new tool called the QQM Checklist has been developed to address gaps in existing methods for evaluating quantitative, qualitative, and mixed-methods studies. The checklist is a concise, versatile tool that enhances rigor in assessing diverse study types and supports more transparent, evidence-based decisions.
Pensoft Publishers has forged a new scholarly partnership with the Vietnam Academy of Science and Technology, aiming to enhance research accessibility and innovation globally. The collaboration will utilize ARPHA's publishing platform for Vietnam's scientific journals, books, and research outputs.
A 71-year-old man was diagnosed with advanced colorectal cancer after suffering from multiple unexplained strokes and blood clots. The cancer remained undetected until widespread clot complications appeared, highlighting the need for comprehensive oncologic evaluation in patients with unexplained hypercoagulable states.
A new study found no clear clinical evidence that rapamycin can extend healthspan or delay aging in healthy adults, despite promising results in animal studies. The review suggests that off-label use of rapamycin should be approached with caution due to limited evidence and potential side effects.
Researchers found that cells exiting the cell cycle show stronger signs of senescence and are more sensitive to senolytic drugs. DNA content plays a crucial role in how aging cells function and respond to treatment.
JMIR Publications has launched a new 'News & Perspectives' section, providing in-depth analysis on the implications of increased political oversight in US research. The section aims to bring rigor and integrity to digital health news, empowering researchers, policymakers, and health professionals to stay ahead of the curve.
The Flat-Fee Unlimited Open Access Partnership between JMIR Publications and Jisc has expanded to cover 22 UK research institutions. Participating authors can publish in JMIR's Gold Open Access journals without APCs, simplifying the publication process.
Witten/Herdecke University has joined the Flat-Fee Unlimited Open Access Publishing Agreement, eliminating financial barriers to open access publishing in JMIR Publications journals. The partnership aims to increase international visibility of research and provide positive momentum for researchers.
Researchers discovered that FGF21, a muscle hormone released during exercise, is elevated in people with ALS and may play a protective role. Higher levels of FGF21 were associated with slower disease progression and longer survival in patients.
A study found that older adults with Parkinson's disease have a higher rate of brain amyloid positivity compared to younger patients, even without dementia. The researchers suggest this may indicate an accelerated transition from healthy cognition to dementia in PD patients.
These rare tumors often present with aggressive behavior, early metastasis, and resistance to chemotherapy and radiotherapy. Early detection and disease staging are key factors associated with improved survival.
Researchers used AI to identify shared biological features between aging and fibrosis, finding new potential targets for therapy. The study found that IPF is not simply accelerated aging, but a unique biological condition shaped by age-related dysfunction.
Problems of Dental Medicine joins Pensoft's ARPHA platform, streamlining publishing workflows and increasing accessibility for dental research. The journal will benefit from improved infrastructure, increased visibility, and new opportunities for advancing dental science.
Researchers found significant causal relationships between gut microbiome characteristics and age-related traits, including ApoM protein levels. The study suggests targeting the gut microbiota may help delay or reduce age-related inflammation and disease.
Adult fibrosarcoma is a rare and highly aggressive malignancy requiring precise diagnosis and multimodal treatment. The case report emphasizes the need for early detection, complete surgical removal, and tailored postoperative care to improve outcomes in patients with this type of tumor.
The UJI survey highlights issues with quantitative indicators, such as publication numbers and citations, that often overlook quality, social relevance, and working conditions. The university is addressing these concerns through its commitment to improving the scientific evaluation system.
A Taylor & Francis journal has found high levels of author satisfaction with the quality, speed, and decision-making under a transparent peer review model. Authors valued constructive feedback, and most reported they would submit or review again due to the journal's support for transparency.
Researchers propose idiopathic pulmonary fibrosis as a disease-specific treatment to test general geroprotector therapies, leveraging its high overlap with aging biology. This approach could accelerate drug development and reduce costs by targeting shared biological pathways.
Researchers associated with a fictitious network have collectively netted millions of dollars in funding from the US, Japan, Ireland, and other nations. The investigation highlights weaknesses in research and publishing systems that can be exploited for personal gain.
Researchers found that exosomes from senescent cells and circulatory exosomes carry molecular signatures associated with biological aging and cellular senescence. These signatures include proteins, lipids, and microRNAs linked to inflammation, oxidative stress, and tissue remodeling.
Researchers discovered that disrupting protein quality control slows tumor growth in rhabdomyosarcoma, a rare and aggressive cancer primarily affecting children. The treatment, which targets the proteostasis network, significantly slowed or stopped tumor growth in mice implanted with human RMS tumors.
A new AI tool has identified over 1,000 'questionable' scientific journals, including those that charge hundreds or thousands of dollars to publish research without proper vetting. The AI system uses six criteria to evaluate journals, including editorial board composition and website quality.
A study published in Oncoscience found that over 60% of oncology healthcare professionals in Morocco showed signs of severe burnout, with emotional exhaustion being the key factor. The study highlights the need for urgent institutional changes to support healthcare workers and improve work environments.
Researchers found that AUF1 helps prevent aging by breaking down enzymes involved in glucose metabolism. The study's findings improve our understanding of how metabolism affects the aging process.
Researchers found that faster biological aging is associated with lower scores on digital cognitive tests, particularly among older adults. DNA methylation patterns were used to estimate biological age acceleration, and protein markers PAI1 and ADM showed strong associations with lower cognitive scores.
The Journal of Applied Sports Sciences has transitioned to the ARPHA platform, enhancing accessibility and visibility of research in sports sciences. The journal operates under a Diamond Open Access model, allowing for free access to all research outputs without article processing charges.
The study found that EBV nuclear antigen 1 (EBNA1) significantly increases the expression of Derlin1 and PSMD10 genes in HeLa cells, both associated with enhanced cancer cell survival and proliferation. This suggests a potential mechanism by which EBV may contribute to cervical cancer progression.
The platform update enhances the visibility of video and audio content, doubling readership of associated research articles. Dedicated multimedia pages and journal homepage sections showcase all content in one place, making it easy to access and discover.
Researchers found that cancer does not typically affect forensic age estimation accuracy, except for very aggressive forms of cancer. In contrast, blood cancers led to large errors, with ages overestimated by up to 50 years.
Researchers found that combining aramchol with regorafenib killed liver and colorectal cancer cells more effectively than either drug alone, triggering stress responses and disrupting survival pathways. The combination was especially effective in cells with a genetic variant called ATG16L1 T300.
A new study found a strong association between accelerated epigenetic aging and increased risk of colorectal cancer in postmenopausal women. Lifestyle factors like diet significantly influenced this risk, with healthy diets potentially reducing cancer risk associated with biological aging.
A new paper warns that the world's reliance on submarine cables poses significant risks to global communication, commerce, and security. The study highlights growing vulnerabilities to natural disasters and deliberate sabotage, sparking calls for diversification of global communications infrastructure beyond the ocean floor. Experts pr...
A new study published in Aging-US found that frailty is associated with increased respiratory exacerbations and mortality in individuals with a history of cigarette smoking. Frail participants had a three- to five-fold higher chance of developing serious or frequent respiratory attacks, even if they had normal lung function.