Articles tagged with Academic Journals
Researchers found significant causal relationships between gut microbiome characteristics and age-related traits, including ApoM protein levels. The study suggests targeting the gut microbiota may help delay or reduce age-related inflammation and disease.
Adult fibrosarcoma is a rare and highly aggressive malignancy requiring precise diagnosis and multimodal treatment. The case report emphasizes the need for early detection, complete surgical removal, and tailored postoperative care to improve outcomes in patients with this type of tumor.
The UJI survey highlights issues with quantitative indicators, such as publication numbers and citations, that often overlook quality, social relevance, and working conditions. The university is addressing these concerns through its commitment to improving the scientific evaluation system.
A Taylor & Francis journal has found high levels of author satisfaction with the quality, speed, and decision-making under a transparent peer review model. Authors valued constructive feedback, and most reported they would submit or review again due to the journal's support for transparency.
Researchers propose idiopathic pulmonary fibrosis as a disease-specific treatment to test general geroprotector therapies, leveraging its high overlap with aging biology. This approach could accelerate drug development and reduce costs by targeting shared biological pathways.
Researchers associated with a fictitious network have collectively netted millions of dollars in funding from the US, Japan, Ireland, and other nations. The investigation highlights weaknesses in research and publishing systems that can be exploited for personal gain.
Researchers found that exosomes from senescent cells and circulatory exosomes carry molecular signatures associated with biological aging and cellular senescence. These signatures include proteins, lipids, and microRNAs linked to inflammation, oxidative stress, and tissue remodeling.
Researchers discovered that disrupting protein quality control slows tumor growth in rhabdomyosarcoma, a rare and aggressive cancer primarily affecting children. The treatment, which targets the proteostasis network, significantly slowed or stopped tumor growth in mice implanted with human RMS tumors.
A new AI tool has identified over 1,000 'questionable' scientific journals, including those that charge hundreds or thousands of dollars to publish research without proper vetting. The AI system uses six criteria to evaluate journals, including editorial board composition and website quality.
A study published in Oncoscience found that over 60% of oncology healthcare professionals in Morocco showed signs of severe burnout, with emotional exhaustion being the key factor. The study highlights the need for urgent institutional changes to support healthcare workers and improve work environments.
Researchers found that AUF1 helps prevent aging by breaking down enzymes involved in glucose metabolism. The study's findings improve our understanding of how metabolism affects the aging process.
Researchers found that faster biological aging is associated with lower scores on digital cognitive tests, particularly among older adults. DNA methylation patterns were used to estimate biological age acceleration, and protein markers PAI1 and ADM showed strong associations with lower cognitive scores.
The study found that EBV nuclear antigen 1 (EBNA1) significantly increases the expression of Derlin1 and PSMD10 genes in HeLa cells, both associated with enhanced cancer cell survival and proliferation. This suggests a potential mechanism by which EBV may contribute to cervical cancer progression.
The Journal of Applied Sports Sciences has transitioned to the ARPHA platform, enhancing accessibility and visibility of research in sports sciences. The journal operates under a Diamond Open Access model, allowing for free access to all research outputs without article processing charges.
The platform update enhances the visibility of video and audio content, doubling readership of associated research articles. Dedicated multimedia pages and journal homepage sections showcase all content in one place, making it easy to access and discover.
Researchers found that cancer does not typically affect forensic age estimation accuracy, except for very aggressive forms of cancer. In contrast, blood cancers led to large errors, with ages overestimated by up to 50 years.
A new study found a strong association between accelerated epigenetic aging and increased risk of colorectal cancer in postmenopausal women. Lifestyle factors like diet significantly influenced this risk, with healthy diets potentially reducing cancer risk associated with biological aging.
Researchers found that combining aramchol with regorafenib killed liver and colorectal cancer cells more effectively than either drug alone, triggering stress responses and disrupting survival pathways. The combination was especially effective in cells with a genetic variant called ATG16L1 T300.
A new paper warns that the world's reliance on submarine cables poses significant risks to global communication, commerce, and security. The study highlights growing vulnerabilities to natural disasters and deliberate sabotage, sparking calls for diversification of global communications infrastructure beyond the ocean floor. Experts pr...
A 36-year-old woman was diagnosed with non-gestational ovarian choriocarcinoma, a rare and aggressive tumor that shares symptoms with pregnancy. She received chemotherapy and showed complete response to treatment.
A new study published in Aging-US found that frailty is associated with increased respiratory exacerbations and mortality in individuals with a history of cigarette smoking. Frail participants had a three- to five-fold higher chance of developing serious or frequent respiratory attacks, even if they had normal lung function.
A new study suggests that regular exercise can influence epigenetic aging and potentially reverse it, offering a promising way to extend healthspan. Physical fitness is closely associated with slower epigenetic aging, and sedentary behavior may have detrimental effects on the body's internal aging process.
Researchers found that RSPO2 amplification is associated with poor outcomes in PC patients and promotes genes and signaling pathways associated with aggressive PC. The study highlights RSPO2 as a key driver of disease progression and opens new possibilities for treatment strategies.
An analysis of article views in Taylor & Francis medical journals found that extenders can increase readership by 144%. Plain Language Summaries of Publications and Clinical Trial Protocols with extenders attracted more views than those without these supplemental resources.
A new analysis of data on scientists with exceptional early-career success identified common characteristics, including affiliation with institutions in less developed countries and work in specific fields. These findings could aid efforts to distinguish stellar talent from problematic behaviors.
Emerald Publishing has adopted Dimensions Author Check to improve research integrity and transparency. The platform provides a fast and reliable way for publishers to verify authors' publishing and collaboration histories, helping them spot unusual activities such as retractions or atypical collaboration patterns.
Researchers discovered that components in young human blood serum can restore youthful properties to skin when combined with bone marrow cells. This study highlights the role of bone marrow in supporting skin health and may lead to novel approaches to address age-related changes.
Researchers, particularly young scholars, feel anxiety about using statistical methods due to institutional demands. This pressure affects judgement and well-being, with some even justifying flawed analytical choices for significant outcomes.
A new research paper found that epigenetic aging is linked to cognitive decline in midlife, with twins experiencing a larger drop in IQ scores if they had grown up in families with lower socioeconomic status. This study provides new evidence for the impact of childhood adversity on brain aging.
Researchers analyzed data from over 10,000 solid tumor samples and found that more than 90 percent contained genetic changes that could guide treatment. The study identified biomarkers associated with approved therapies and rare mutations missed by simpler tests.
Researchers developed TraMA, an RNA-based measure of biological aging that predicts health risks and mortality. It captures distinct aspects of aging and health decline, including inflammation, immune function, and kidney and brain health.
A new case report describes the use of extracorporeal blood filtration to treat stage IV poorly differentiated pancreatic adenocarcinoma. The patient experienced clinical improvement, reduced pain, and no signs of new tumor growth over 12 months of follow-up.
A study reveals that epigenetic changes associated with aging in adults do not occur before sexual maturity. In fact, rDNA copy numbers and methylation increase during childhood and adolescence, suggesting cells actively maintain a youthful state to ensure efficient protein production.
The Digital Science relaunches its Scientometric Researcher Access to Data (SRAD) program, offering non-commercial scientometric studies free access to Altmetric and Dimensions data. The expanded program also provides access to Dimensions on BigQuery, enabling researchers to answer complex questions with big data.
Researchers discovered that statins selectively modulate key components of the Wnt/β-catenin signaling pathway, leading to lower levels of tumor-promoting proteins and cancer-suppressing cellular behaviors. Statins downregulate SATB1 while increasing SATB2, making cancer cells less able to grow and spread.
Researchers evaluated the Stem Cell Regenera treatment in 145 women with ovarian failure, showing nearly 70% oocyte activation and 14% conception through IVF after treatment. The therapy stimulates ovarian activity, increasing conception chances in selected patients.
A new case report documents a rare instance of lipoleiomyoma, a benign uterine tumor with characteristics similar to malignant liposarcoma. The diagnosis was confirmed through histopathological evaluation and imaging techniques, emphasizing the importance of careful assessment in elderly patients.
Researchers highlight microRNAs as crucial biomarkers for diagnosing and monitoring soft tissue sarcomas, with potential for precision medicine. MicroRNAs could help distinguish between tumor types and guide treatment decisions.
A new study introduces a novel muscular clock, MAA, which measures how quickly an individual's muscles are aging compared to their actual age. The research found that about 25% of healthy middle-aged and older adults experience accelerated muscle aging, increasing the risk of sarcopenia.
Sage has launched a new collection of peer-reviewed research on immigrant experiences, aiming to inform evidence-based policymaking and promote inclusive practices. The compilation offers a comprehensive perspective on the lives and challenges faced by migrants.
Researchers discovered a new monoclonal antibody, 2B010, that selectively targets regulatory T cells (Tregs) in tumors, boosting the activity of CD8+ T cells and improving anti-tumor immune responses. This unique mechanism could complement existing cancer therapies and lead to more effective treatments.
Researchers found that telomerase inactivation in immune cells or connective tissue cells slows tumor growth, but creates conditions for aggressiveness. In contrast, endothelial cell preservation suppresses metastasis.
Researchers found that prostate cancer cells store fats in lipid droplets under low oxygen conditions, making them less vulnerable to ferroptosis. This adaptation allows cancer cells to evade therapies designed to trigger cell death.
The Cambridge Elements series has reached a major milestone with the publication of over 2000 formats, offering original and peer-reviewed research from leading scholars. The series provides comprehensive coverage of key topics in various disciplines, filling the gap between journal articles and monographs.
Researchers found that spermidine supplementation improves memory and preserves physical activity, while reducing protein intake boosts mitochondrial activity and extends lifespan. Combining the two interventions offers additive benefits, suggesting potential for synergistic effects.
Researchers identified RTK dependent and independent mechanisms of resistance to EGFR targeted therapies in breast and head and neck cancers, highlighting opportunities for combination therapies and biomarker identification.
Researchers found that waist-to-hip and waist-to-height ratios are strong predictors of physical performance in older adults. Individuals with higher abdominal fat tend to have poorer physical function, which can impair independence as people age.
This special collection aims to bring together cutting-edge research on cognitive aging, exploring its cellular and molecular underpinnings, as well as psychosocial and environmental factors. The collection seeks to foster a holistic understanding of how cognitive function changes with age.
LMD delegation visits Italy to deepen international cooperation, promoting joint scientific research projects, talent exchange, and high-quality manuscript sources. The journal aims to establish a structured mechanism for cross-border research talent training.
A recent study discovered that the mutational landscape of blastic plasmacytoid dendritic cell neoplasm (BPDCN) is similar to other myeloid neoplasms. The researchers identified CCDC50 as a potential biomarker for this disease, which showed promising results in tracking disease activity and monitoring treatment success.
The International Society for Stem Cell Research has selected five distinguished early career scientists to serve as Early Career Editors for Stem Cell Reports. The new editors bring expertise in cell differentiation, tissue engineering, and precision therapies to the journal.
A new perspective on Peto's paradox highlights the importance of studying species that resist cancer naturally, which may offer insights into understanding cancer and aging. Understanding how cells interact with their environment could provide deeper insight into how cancer develops or is prevented.
A new research paper introduces DoliClock, a biological aging clock based on lipid profiles in the human brain, showing accelerated brain aging in individuals with autism, schizophrenia, and Down syndrome. The study found that dolichol levels serve as reliable biomarkers of aging.
A new review recommends combining enfortumab vedotin with pembrolizumab as the first-line therapy for advanced urothelial cancer, offering a more effective and better-tolerated alternative to traditional chemotherapy.
A new study found diverse genetic patterns and treatment gaps in HER2-mutated non-small cell lung cancer (NSCLC) in Northeastern Brazil. The research highlights the importance of comprehensive molecular profiling and expanded access to targeted therapies for underrepresented populations.
Knowledge Unlatched, a pioneering open access initiative, is moving to a new home within Annual Reviews organization. This transfer supports one of the most recognized initiatives in open access publishing, enabling thousands of titles to be freely available to readers worldwide.
A new study found that telomere shortening is not a shared characteristic of all progeroid syndromes, which cause individuals to display symptoms of aging far earlier than expected. The research suggests that the underlying biology of each syndrome plays a crucial role in determining whether telomere shortening occurs.
Top ten errors identified by Dr Dan Green include incorrect causal language, poorly formatted abstracts, and statistical analysis sections with inaccurate or incomplete details. The article provides recommendations for researchers to avoid these common mistakes and advance a transparent and reproducible research world.
A new precision oncology paper presents a case of a 62-year-old man with metastatic colorectal cancer who underwent multiple lines of therapy. The WIN International Molecular Tumor Board proposed personalized treatment plans based on the tumor's unique genetic mutations, highlighting the growing role of precision oncology in guiding th...
A new study found that moderate caloric restriction can preserve youthful ovarian follicles and reduce age-related tissue stiffness in rhesus macaques. This suggests that lifestyle-based strategies may help delay the decline in reproductive function associated with aging.