Articles tagged with Academic Journals
A new review recommends combining enfortumab vedotin with pembrolizumab as the first-line therapy for advanced urothelial cancer, offering a more effective and better-tolerated alternative to traditional chemotherapy.
A new study found diverse genetic patterns and treatment gaps in HER2-mutated non-small cell lung cancer (NSCLC) in Northeastern Brazil. The research highlights the importance of comprehensive molecular profiling and expanded access to targeted therapies for underrepresented populations.
Knowledge Unlatched, a pioneering open access initiative, is moving to a new home within Annual Reviews organization. This transfer supports one of the most recognized initiatives in open access publishing, enabling thousands of titles to be freely available to readers worldwide.
A new study found that telomere shortening is not a shared characteristic of all progeroid syndromes, which cause individuals to display symptoms of aging far earlier than expected. The research suggests that the underlying biology of each syndrome plays a crucial role in determining whether telomere shortening occurs.
Top ten errors identified by Dr Dan Green include incorrect causal language, poorly formatted abstracts, and statistical analysis sections with inaccurate or incomplete details. The article provides recommendations for researchers to avoid these common mistakes and advance a transparent and reproducible research world.
A new precision oncology paper presents a case of a 62-year-old man with metastatic colorectal cancer who underwent multiple lines of therapy. The WIN International Molecular Tumor Board proposed personalized treatment plans based on the tumor's unique genetic mutations, highlighting the growing role of precision oncology in guiding th...
A new study found that moderate caloric restriction can preserve youthful ovarian follicles and reduce age-related tissue stiffness in rhesus macaques. This suggests that lifestyle-based strategies may help delay the decline in reproductive function associated with aging.
A new review identifies CHEK2 as a potential biomarker for predicting response to immunotherapy and suggests that combining CHEK2 inhibitors with existing therapies may enhance anti-tumor effects. This could lead to improved treatment outcomes in solid tumors.
Researchers found that low-cost genetic testing methods can effectively detect BRCA2 and HOXB13 mutations linked to increased prostate cancer risk. These findings support the adoption of precision medicine in prostate cancer care, enabling better diagnosis and personalized treatment plans.
A large-scale study identified early indicators of frailty decline in older adults, including health deficits such as sleep disturbances and muscle weakness. Early intervention programs addressing these modifiable health issues can contribute to disease control and slow frailty progression.
A new perspective challenges current epigenetic clocks, which use DNA methylation patterns to estimate biological age, by failing to distinguish between different types of methylation changes. This could lead to inaccurate conclusions and potentially slow down progress in anti-aging research.
Researchers found that cigarette smoke and reduced DNA repair capacity combine to increase cancer risk, with normal lung cells showing extensive damage after smoke exposure. The study's findings support a 'double hit' model, highlighting the critical role of XPC protein in preventing DNA damage.
The Longevity & Aging Series has been honored with a Silver Award for 'Excellence in Video/Film' at the inaugural EPIC Awards celebration. The series is praised for its impactful storytelling and production quality, making it a trusted resource for scientists, clinicians, and the broader public.
Researchers found that CBR3-AS1 and PCA3 were significantly overexpressed in gastric cancer tissues, suggesting their involvement in GC development. The study supports the use of these lncRNAs as diagnostic biomarkers.
Researchers identified a novel region in AR that binds to PCNA, and developed a small peptide to mimic this region, blocking the AR-PCNA connection. This approach reduced cancer cell growth, particularly in patients with limited treatment options.
A new editorial proposes a transformative shift in healthcare focus from reactive disease management to proactive healthspan extension. The approach targets the root causes of age-related diseases through aging biology, aiming to prevent diseases before they emerge.
Researchers found that aging increases the brain's vulnerability to low oxygen levels, disrupting the blood-brain barrier and leading to inflammation and cognitive decline. The study identified specific oxygen levels that trigger BBB disruption, with older mice showing increased sensitivity even at mild hypoxic levels.
Researchers discovered that blocking PRDX1 protein can make ovarian cancer cells more responsive to DNA-damaging platinum therapies. The study suggests targeting PRDX1 could be a viable strategy to improve chemotherapy efficacy.
A study investigated immune-related adverse events (irAEs) in Latin American patients with advanced liver cancer treated with atezolizumab and bevacizumab. Most irAEs were mild or moderate and resolved within a month, without impacting overall survival.
A new research paper published in Aging-US identified unintentional weight loss as the strongest predictor of fall risk among Taiwanese elderly. The study found that analyzing each frailty feature individually provided more accurate predictions of fall risk than using a broad frailty label.
UNAM and Taylor & Francis announce a three-year agreement to publish research articles in over 2,400 journals. This move aims to boost the global reach and impact of UNAM's research.
A 25-year review highlights the stomach cancer-fighting potential of Brazilian plant species, which contain bioactive compounds with potential anticancer properties. The studies suggest that regular consumption of fruits and vegetables rich in polyphenols and flavonoids may help lower the risk of stomach cancer.
Researchers review clinical and scientific advances combining radiation therapy with immunotherapy to strengthen the immune response and improve disease control. The approach may offer new treatment options for patients facing hard-to-treat forms of bladder cancer.
Researchers found that consuming foods high in methyl adaptogens, such as green tea and berries, can reduce markers of epigenetic aging. The study, which involved middle-aged men, suggests that targeted food choices may help slow the aging process.
New indicators have been introduced to Taylor & Francis journal articles to inform readers when cited research has been retracted or updated. These updates ensure researchers are fully informed about the status of the research and can make informed decisions.
A new DNA-based blood test using PhasED-Seq technology detects minimal residual disease (MRD) in B-cell malignancies, offering a powerful tool for early detection and monitoring treatment response. The assay demonstrates exceptional performance and high accuracy in detecting cancer cells in the bloodstream.
A nationwide cohort study found that immune checkpoint inhibitors significantly increase the risk of myocarditis in NSCLC patients, with a 7.4-fold increase in risk compared to non-users. Cardiac monitoring for at least six months following ICI initiation is recommended.
A University of Queensland study reveals that non-English language papers on bird, mammal, and amphibian protection have significantly fewer citations than their English-language counterparts. Providing an English abstract can boost citations by 1.5 times.
A systematic review and meta-analysis found that individuals with blood type A have a significantly higher risk of developing breast cancer compared to those with blood type O. The research, which pooled data from over 13,000 breast cancer patients and 717,000 controls, suggests an 18% increased risk associated with blood type A.
A new study found that patients using factor Xa inhibitors experienced significantly fewer cardiovascular problems than those on other anticoagulants. Researchers followed over 1,000 patients aged 80 and above for up to five years, revealing lower rates of heart failure, artery disease, and cardiovascular death.
A new study published in Aging (Aging-US) Volume 17, Issue 4 has found that the drug buthionine sulfoximine (BSO) produces similar reductions in fat mass and weight gain as the sulfur amino acid-restricted diet. BSO may offer a practical alternative to difficult-to-maintain diets for treating obesity.
Researchers discovered that METTL3, an oncogene, regulates the expression of SMAD4 via miR-146a-5p in OSCC. This pathway can potentially have therapeutic implications for treating oral squamous cell carcinoma.
GigaScience Press has won the first-ever Crossref Metadata Award, recognizing its efforts in providing high-quality metadata for its journal GigaByte. The award highlights the press's commitment to making research more discoverable and accessible through rich metadata standards.
The PEARL trial found that low-dose rapamycin improved lean muscle mass and reduced pain in women, while also showing improvements in emotional well-being. The study suggests rapamycin may offer measurable benefits for physical function and overall well-being in older adults.
Researchers found that fisetin reduces calcium buildup and protects blood vessels from hardening in vascular smooth muscle cells. Fisetin's anti-calcification activity depends on the phosphatase DUSP1, which inhibits p38 MAPK.
Impact Journals will exhibit its publications, including Aging-US, Oncotarget, and Genes & Cancer, at the SSP 47th Annual Meeting. The event aims to reimagine the future of scholarly publishing and aligns with Impact Journals' mission to foster open and impactful scientific communication.
Nicolas Hubert joins Zoosystematics and Evolution as Deputy Editor-in-Chief, bringing experience and expertise in ichthyology and genetics. He will drive further development and growth of the open-access journal.
Aging-US invites submissions for a Special Collection on cellular senescence, focusing on its mechanisms, physiological and pathological functions, and clinical applications. The collection honors Dr. Judith Campisi's groundbreaking work on senescence in aging, cancer, and tissue homeostasis.
Researchers discovered compromised NAD+ metabolism in WS cells and found that boosting NAD+ levels using nicotinamide riboside decreased senescence in both stem cells and primary fibroblasts. The study suggests targeting NAD+ metabolism for age-related and genetic diseases.
A harmful form of tau protein directly damages blood vessels in the brain, leading to inflammation and weakening the brain's protective shield. The discovery highlights the importance of focusing on early neurovascular changes mediated by tau to prevent or slow down damage to the blood-brain barrier.
Researchers have discovered that inhibiting the metalloprotease ADAM19 can reduce gut inflammation and cell aging markers across species. The study found that blocking ADAM19 reduced gut damage and inflammation in fruit flies, mice, and human cells, offering a promising path for creating treatments to maintain healthy tissues.
Two Taylor & Francis journals will be converted to open access for 2025, thanks to funding from collective OA agreements and read access. The Collective Pathway to Open Publishing model combines multiple funding sources to support the conversion of HSS journals.
A new study reports on five patients with Canavan disease who have a novel variant identified through targeted long-read sequencing, revealing an SVA_E retrotransposable element that disrupts gene function. The findings enhance genetic diagnostics and enable improved guidance for families.
A study on captive olive baboons found that about a quarter exhibited accelerated aging, while another quarter showed signs of slower aging. The researchers investigated physical indicators such as walking speed and fine motor skills, but found that these changes were more closely related to chronological age than epigenetic age.
A University of Cincinnati study explores the link between health literacy and fear surrounding cataract surgery, revealing no correlation between the two. The research emphasizes the importance of open communication and building relationships to overcome fear.
A single dose of a psychedelic compound can enhance cognitive flexibility for weeks after administration, according to a groundbreaking study. Mice treated with the compound showed improved performance in reversal learning tasks compared to control groups when tested weeks later.
The American Physical Society has received the leading score among publishers participating in SCOAP3 for its investment in open science practices. The Society earned high marks in elements like data availability, article metadata, and persistent identifiers.
A new machine learning model accurately predicts the fitness of AAV capsids based on their amino acid sequence, enabling more efficient and cost-effective gene therapies. The model's robustness and generalizability have been demonstrated through tests on independent datasets, offering a promising tool for capsid engineering.
Dr. Rhonda Winegar investigates the effectiveness of music therapy in supporting neurological care, including its ability to reduce anxiety and depression in Alzheimer's patients. Her research also highlights its potential to regulate heart rate and blood pressure, as well as improve motor function in individuals with Parkinson's disease.
Researchers developed a new method to measure changes in DNA that can help predict a person's age, focusing on how random chemical tags become over time. The study found that methylation entropy predicted age as accurately as traditional methods, with an average error of just five years.
A new study finds that a specific genetic variation in the PTGS2 gene is associated with an increased risk of benign prostate hyperplasia (BPH) in Lebanese men. Men carrying the C version of this gene were more than twice as likely to have BPH compared to those without it.
Researchers evaluated different types of Glasgow Outcome Scale Extended (GOSE) scores among US trauma center patients. They found that GOSE-All scores capture the combined effect of brain and extracranial injuries, while GOSE-TBI scores exclude extracranial injury effects.
A new study found that both employed people with obesity and employer representatives acknowledge the impact of obesity on future health problems and perceive lifestyle change alongside anti-obesity medications as the most effective approach for maintaining weight-loss reduction. Cost of medication coverage remains a significant barrie...
A study found that smaller embryos already hatching are more likely to be chromosomally normal. This insight helps fertility clinics select better embryos during IVF, particularly for women over 35 or those undergoing PGT-A.
A new study found that mesenchymal stem cell-derived extracellular vesicles significantly enhance survival and facilitate substantial peripheral blood recovery in mice exposed to high-dose irradiation. The treatment promoted hematopoietic recovery, with increases in red blood cell, platelet, white blood cell, and hemoglobin levels.
A new study by the University of Surrey found that restricting carbohydrates can lead to improvements in metabolic markers and better handling of high-fat meals. This approach may be more sustainable than extreme calorie restriction, reducing hunger and increasing energy burning.
The STAR initiative has benefitted over six thousand researchers worldwide by providing access to top-tier articles and enabling them to update references and enrich their findings. This support has helped scholars from under-resourced regions contribute to global knowledge, transforming their careers and advancing academic discourse.
Researchers investigated why bones become less responsive to exercise with age, finding increased mtROS or decreased Atg7-dependent autophagy in osteoblastic cells do not contribute to reduced mechanoresponsiveness. Damage to the bone's osteocyte network also does not prevent a healthy bone-building response.
Researchers found that NSD2 helps maintain MM cell identity by reorganizing DNA and influencing gene activity. This discovery could shape future treatment approaches for patients with t(4;14) myeloma.
Three Taylor & Francis journals will be published open access in 2025 volumes with no cost to authors. Institutional support has reached the required threshold for the Subscribe to Open pilot, enabling OA publishing.