Researchers created a tiny 3D cell culture model that mimics the function of lymphatic vessels to explore how inflammatory substances affect the lymphatic system. They found that certain cytokines cause cells to tighten their junctions, leading to reduced fluid drainage and swelling. Inhibiting a protein called ROCK2 reversed lymphedem...
Researchers at Northwestern University developed Lattice, a device that simulates human disease in multiple organs to analyze interactions and test new drugs. The technology can replicate complex disease processes, allowing scientists to study the effects of obesity on endometrial cancer, for example.
Researchers at Northwestern University identified a new evolutionarily conserved RNAi-based form of cell death called Death Induced by Survival gene Elimination (DISE), which targets essential survival genes in cancer cells. This mechanism is ancient and effective against all cancers tested.
Cancer researchers at University of Cincinnati Cancer Center are exploring a new method called lattice therapy, which delivers higher doses to tumors and lower doses to surrounding tissues. The approach has shown promise in reducing treatment time and improving patient outcomes for head and neck, lung, and brain tumors.
Researchers propose analysis protocol to evaluate feasibility of silicon-containing batteries with reduced particle size and uniform dispersion. The study finds promising results from innovative synthesis technology and initial efficiencies exceeding 90% with improved lifespan characteristics.
Research highlights the challenges of rural hospital-based maternity unit closures and transportation barriers, leading to delays in care and adverse outcomes. The study suggests that telehealth services can provide a solution to address these disparities in maternal health outcomes.
The Human Brain Project has driven outstanding advances in brain research and medicine, producing over 3000 academic publications and 160 digital tools. The EBRAINS infrastructure will remain accessible to the scientific community after the project's end.
The University of Manchester will advance understanding of microbial communities and their impact on the world. The £5.4m project aims to engineer bespoke microbial communities for applications such as CO2 conversion, contributing to a more sustainable Net Zero future.
Researchers at the University of Illinois have successfully tuned graphene surface friction using external electric fields, allowing for dynamic control of friction. This breakthrough could lead to reduced energy consumption in nano- and micro-electromechanical systems and mitigate wear and corrosion of sliding surfaces.
A U of M Medical School professor has received a $3.5 million grant to develop a reproductive health curriculum for Tanzania that addresses the needs of people with disabilities. The project aims to improve healthcare services and build in-country capacity for comprehensive sexual and reproductive healthcare.
Researchers found differential activation patterns of the Default Mode Network nodes, with facial movement inducing an inverted positive BOLD pattern in certain areas. Facial recognition and movement uniquely impact brain activity, highlighting their importance in cognitive and social development.
Researchers found that etripamil nasal spray restored normal heart rhythms within 30 minutes in 54% of patients, making it a potential new option for self-treating paroxysmal supraventricular tachycardia. The study showed the medication to be safe and well-tolerated.
A Boston University-led study identified genetic signatures of TB-susceptible and TB-resistant macrophages, leading to a new approach to tweak the immune system to fight the disease. The research could lead to therapies targeting host immunity to tuberculosis.
The article discusses the need to reassess COVID-19 precautions in 2023, particularly for patients with hematologic malignancies. The researchers highlight the increased risk of poor response to vaccination and worse outcomes from COVID-19 infection among these patients.
A Michigan Medicine-led report found that adding a mobile health application to wearable devices did not significantly improve physical activity levels in patients enrolled in cardiac rehabilitation. However, some short-term outcomes showed an increase in walking distance over six minutes for Fitbit users.
A new study reveals that consanguinity may increase the risk of common diseases such as type 2 diabetes and post-traumatic stress disorder. The research analyzed genomic data from diverse groups to investigate the relationship between autozygosity, or genetic relatedness, and disease prevalence.
The 'Crystal Ribcage' technology enables scientists to study lung function at a cellular level while maintaining physiological processes. This innovation holds immense potential for understanding lung diseases and developing new treatments.
A study showed that yoga therapy can improve heart failure patients' endurance, strength, balance, symptom stability, and overall quality of life. Additionally, echocardiographic parameters revealed improved left ventricular systolic function in the yoga group compared to the non-interventional group.
Researchers aim to access ocean waters hidden beneath ice shelves, where critical information about climate change is stored. An intelligent mothership and coordinated marine robots will communicate data from under-ice cavities, optimizing sampling and configuration.
A new study found that living donor liver transplant access optimizes the timing of transplant for older, frail cirrhosis patients. Patients with moderate to severe frailty, short stature, and low MELD scores benefited from LDLT, reducing waitlist mortality and improving post-transplant outcomes.
The MIT Press is expanding its shift+OPEN initiative with a $275,000 NSF grant to flip two high-impact subscription-based journals to diamond OA. The program aims to accelerate STEM and HSS research by providing barrier-free access to scholarly works.
The University of Minnesota Medical School has received a $16 million grant from the NIH BRAIN Initiative to create detailed maps of brain connections. This project aims to better understand how complex neural pathways generate human behaviors and develop treatments for brain disorders.
The National Science Foundation has added Worcester Polytechnic Institute to its Wildfire Interdisciplinary Research Center, a collaboration between universities and industry. WPI will leverage its expertise in fire protection to study new fire detection methods, robotics solutions for first responder safety, and fire suppression systems.
A recent study published in Journal of Advertising sheds light on the effects of in-stream video advertising on ad information encoding. The research found that mid-roll ads elicit negative emotions but do not affect viewers' purchase intention. In contrast, pre- and post-roll ads have a significant impact on memory formation, highligh...
Researchers at UMass Amherst have identified a small strand of microRNA called let-7 as crucial in governing the formation of cellular memories that enable T-cells to recognize and attack tumor cells. This discovery offers new insights into how vaccines work and could lead to improved cancer therapies by boosting cellular memory.
A cross-sectional survey of 294 primary care patients found leg cramps are a common symptom (51.7%) associated with age-related decline and poor sleep quality. Clinicians should review resting leg cramps as a marker for impaired health and aging, and address the issue to optimize healthy aging.
Researchers identified four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome, highlighting a major pathway involved in the increased EC risk in PCOS. The PI3K-AKT signaling pathway is consistent with a link between PCOS and EC.
Research found ginger consumption makes neutrophils more resistant to NETosis, a process that contributes to inflammation and autoimmune diseases. Ginger supplementation also boosted chemical levels in neutrophils, inhibiting NETosis in response to disease-relevant stimuli.
A comprehensive study found no evidence that e-cigarettes promote smoking and may even compete against cigarettes, potentially speeding up the decline in smoking rates. The study compared countries with different e-cigarette regulations and found a slower decline in smokers among those with stricter controls.
The team created a proof-of-concept nanocapsule capable of delivering specific payloads to targeted locations, with potential applications in drug delivery, nutrient transport, and other fields. By using calcium metal ions as building blocks, they can generate identical reservoirs for different substances.
A new study by researchers at the Complexity Science Hub found that Mexican cartels have between 160,000 and 185,000 members, making them the fifth largest employer in the country. Disrupting cartel recruitment is the only way to lower violence in Mexico, according to the research.
A recent study by the University of Toronto has found a significant link between food insecurity and muscle dysmorphia symptoms among adolescent and young adult Canadians. The research revealed that individuals experiencing food insecurity were more likely to suffer from symptoms of muscle dysmorphia, including functional impairment an...
Researchers warn that greenwashing poses a threat to achieving a 'nature positive' world, where environmental decline halts and biodiversity improves. The University of Queensland study emphasizes the need for standards and transparency to distinguish genuine efforts from misleading claims.
Researchers have developed a hybrid silicon photocatalyst that efficiently produces hydrogen and high-value compounds using solar power. The non-toxic catalyst achieves an impressive rate of 14.2 mmol gcat−1 h−1, significantly higher than conventional silicon photocatalysts.
A recent study published in the American Journal of Kidney Diseases found that lower uromodulin levels are associated with a higher risk of developing end-stage kidney disease. Participants who experienced steeper declines in uromodulin also showed an increased risk of kidney failure.
A Brown University team developed a hydrogel-based delivery system that balances tumor acidity and increases doxorubicin's effectiveness against cancer cells. Initial lab tests show promising results, paving the way for pre-clinical trials.
A new study co-authored by MIT economist Jonathan Gruber found that a New York City program helped arrange medical appointments for undocumented immigrants with limited incomes, leading to a substantial drop in emergency room use. The program resulted in a 21 percent decline in ER visits and a 42 percent decrease for individuals with h...
Researchers developed a reliable and reproducible real-time live tissue sensitivity assay (RT-LTSA) using fresh tumor samples to predict patients' clinical response to chemotherapy. The study showed improved disease-free survival and reduced recurrence rates in patients who received RT-LTSA sensitive adjuvant regimens.
The journal publishes articles promoting solution-based approaches at individual, hospital, and policy levels to address DEI. The themed edition aims to eliminate healthcare disparities by fostering meaningful change and progress.
A new study published in Circulation: Cardiovascular Quality and Outcomes journal reveals that men who experience job strain combined with high efforts and low reward have doubled the risk of heart disease. The research highlights the pressing need to proactively address stressful working conditions to create healthier work environments.
A new study calls for stronger regulation of pharmaceutical industry marketing practices to enhance patient health and safety. Healthcare professionals and organisations need to distance themselves from offending companies and demand tougher action.
A study of five case studies reveals the benefits of incorporating ecological connectivity into environmental assessments. The research emphasizes the need for guidance on conducting connectivity analyses and monitoring project impacts.
The project aims to assess the operational resilience of microgrids on DoD installations and ships, using new operational resilience indexes developed by Lehigh University researcher Javad Khazaei. The team will develop a dashboard to monitor resilience indexes in real-time, providing recommendations for improving the systems.
A study by Cornell University and Microsoft found that remote workers can have a lower carbon footprint compared to onsite workers, with hybrid workers reducing their footprint by 11-29%. Lifestyle choices and work arrangements play a crucial role in determining the environmental benefits of remote and hybrid work.
The University of Colorado Anschutz Medical Campus has received a $54 million grant from the National Institutes of Health to advance clinical and translational science. The grant will enable the Colorado Clinical and Translational Sciences Institute (CCTSI) to translate discoveries into better health and patient care across the state.
The September issue of the CHEST journal features research on long COVID, including a review on exercise pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2. Original studies also explore asthma treatment with albuterol-budesonide inhalers and sleep therapy using oronasal masks.
Researchers found that preschoolers from low-income families had poorer health outcomes and improved less in healthy lifestyle habits compared to their peers from more affluent backgrounds. The intervention program showed significant improvements in knowledge, attitudes, and behaviors among children with higher socioeconomic status, bu...
By 2070, 44.61% of koala habitats in Australia will be highly susceptible to bushfires, up from 39.56% today. Koalas may struggle to survive due to habitat fragmentation and food source vulnerability.
Philip Low, a Purdue University researcher, is working on validating a previously successful malaria treatment by reducing the number of days required for therapy. His goal is to prevent drug-resistant strains from proliferating and save lives in developing countries.
Researchers use genomic surveillance to identify distinct sexual networks for syphilis transmission in England, highlighting the presence of drug resistance. The study reveals information beyond standard epidemiological surveillance data, aiding public health strategies to break transmission chains.
A UH research team is developing innovative chemical processes to transform plastic waste into useful materials, aiming to create new ways to reuse and recycle polyolefins. The project seeks to produce durable thermoset materials that can be recycled multiple times, reducing environmental impact and promoting a circular plastics economy.
A recent study published in the Journal of Diabetes Science and Technology found that HbA1c levels are markedly higher in young black youth compared to whites with type 1 diabetes. This disparity can lead to increased risk of hypoglycemia and long-term complications if primarily used for insulin management.
A study of 805,000 patients found that receiving physical therapy after dizziness was associated with a significant reduction in fall risk over the next 12 months. The findings suggest that timely physical therapy referral for dizziness may be beneficial for these patients.
A study across three countries found that individuals who prioritize achievement over enjoyment experience lower happiness the next day. In contrast, those who value freedom report a 13% increase in well-being, including better sleep quality and life satisfaction. Relaxation and hobbies also lead to a significant boost in well-being.
A new study led by Dr. Armen Saghatelyan uncovered the migratory mechanisms of neuronal cells in a neurodevelopmental disorder. The team found that modulating autophagy with FDA-approved drug metformin restored the cells' migratory properties.
A study published by the American Academy of Neurology found that nearly one in five people on Medicare travel 50 or more miles to see a neurologist, indicating significant access barriers for individuals with chronic neurologic conditions. The research also revealed that people living in areas with fewer neurologists and rural residen...
Researchers identified distinct genomic characteristics that impact prognosis for patients with triple negative apocrine carcinoma. The study confirmed a five-year disease-free survival rate of 92.2% for these patients, significantly higher than those diagnosed with other types of TNBC.
Researchers discuss new drugs available for HER2-positive breast cancer patients with brain metastasis, showing improved outcomes and quality of life. The development of targeted therapies has led to better survival rates among these patients.
The Human Brain Project has achieved major breakthroughs in understanding the complex structure and function of the brain, enabling novel medical and technological applications. The project's digital atlas and personalized virtual models have provided unprecedented insights into brain conditions such as epilepsy and Parkinson's disease.
The Fralin Biomedical Research Institute at VTC will accelerate health sciences research with a focus on cancer and brain disorders. The institute will recruit 14 researchers and support six major projects.