Articles tagged with Laboratories
A new study found that E. coli K-12 has accumulated numerous genetic changes compared to its original isolated bacteria, making it less suitable as a model organism. This discovery highlights the rapid evolution of bacterial genomes and challenges the long-standing use of a single strain in research.
A team of biostatisticians created a framework to evaluate the congruence and discordance of laboratory animals with specific human diseases. The tool removes bias from scientific interpretation of animal data for human conditions, revealing that some models mimic biological mechanisms well while others poorly.
A study by OHSU researchers found that immunity from COVID-19 gathers strength over time, indicating that vaccination should not be delayed. The study suggests that vaccine boosters can be spaced no more frequently than a year apart among healthy individuals.
Researchers have identified the need for standardization of performance indices and a single frame for normalization methods to address concerns with bioelectrochemical systems. The study proposes strategies for up-scaling BES technologies, enabling resource recovery through on-site treatment of wastewater at an efficiency comparable t...
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.
Researchers found that abnormal methylation processes lead to disruption of gene expression essential for brain development in people with Williams syndrome. The study suggests targeting treatments to correct these disruptions.
Researchers discovered that ketamine increases background noise, impairing the function of thalamo-cortical neurons and affecting sensory perception. This finding may contribute to a better understanding of psychosis in schizophrenia.
Researchers have created a hydrogel-based material that can absorb up to three times more water-based liquid than traditional paper towels. The gel sheets also show promise in absorbing thick liquids, such as blood and syrup, with high efficiency and stability.
Researchers developed a new lidar technique using 3D flash lidar combined with super-resolution algorithm for hazard avoidance during landing. The technique improved the precision and safety of robotic vehicles on Mars, enabling them to navigate through challenging environments.
The NASA Deep Space Optical Communications project has successfully demonstrated a new type of laser system that can transmit large amounts of data, including high-definition images and video, through space. The system uses a combination of flight and ground-based lasers to establish an optical link between spacecraft and Earth.
A Rutgers study found that COVID-19 patients, especially those treated with antibiotics, experience significant disruptions in their gut microbiome balance. This imbalance may lead to the development of targeted probiotic supplements to improve treatment outcomes.
Researchers at the University Hospital Bonn have discovered a new function of CRISPR/Cas9 gene scissors, which produce small signal molecules that bind to proteins, activating an emergency response. This discovery opens up new possibilities for treating diseases using CRISPR technology.
A new study analyzed tumor biopsies from patients with newly-diagnosed germinal center B cell lymphoma and found that CREBBP mutations were associated with lower disease-free survival rates. The researchers identified CLMA as a practical tool to translate experimental findings into clinical applications.
Researchers at UCI have discovered that sound waves can disrupt the safe operation of negative pressure rooms, a space designed to protect against deadly pathogens. They found that manipulating airflow using a specific frequency can cause malfunction and leakage of microbes.
Researchers evaluated modified CEUS using perfluorobutane for diagnosing hepatocellular carcinoma in high-risk patients. The study found no significant difference in sensitivity, specificity, or accuracy between modified CEUS and CT/MRI LI-RADS v2018.
A handheld diagnostic lab developed by UCLA researchers can fully automate pooled testing and detect multiple diseases, reducing costs and usage of scarce supplies. The technology can be easily manufactured, deployed, and performed at a doctor's office or mass testing sites, helping authorities prepare for future pandemics.
The discovery pushes back the timeline of pre-Neanderthal hominins in Europe by 200,000 years, with the site yielding over 300 well-preserved footprints. The findings have significant implications for our understanding of human evolution and dispersal in the Middle Pleistocene.
A study by Children's Hospital of Philadelphia researchers found that COVID-19 vaccination results in higher antibody concentrations compared to natural infection, providing robust protection for mothers during pregnancy. The study also suggests optimal vaccine timing can maximize the transfer of antibodies to babies.
The West Texas Pharmacology Core laboratory at TTUHSC will focus on two primary areas: drug development and pediatric cancer. The core aims to address obstacles in drug development, including limited pharmacology expertise for small biotech companies and low profitability for pediatric cancer drugs.
Researchers have identified a new gene, NUCL-1, in the transparent roundworm C. elegans, which is linked to human neurodegenerative diseases such as ALS and Alzheimer's. The discovery challenges recent theories on the role of nuclear structures in these disorders.
A higher urine-to-plasma urea ratio is associated with faster decline in eGFR and development of kidney failure in patients with common forms of CKD. This biomarker may improve risk prediction, particularly in low-cost, easily measurable assays.
Researchers at Jacobs University have found that a compound in coffee, 5-caffeoylquinic acid, can inhibit the interaction between the SARS-CoV-2 spike protein and the ACE-2 receptor, potentially providing protection against COVID-19. The study's findings suggest that regular coffee drinkers may be less likely to contract the virus.
The SwRI experiment helped predict the effects of NASA's DART impact on asteroid Dimorphos. The study assessed ejecta momentum enhancement created by the space probe's collision, measuring a 3.4-fold increase in momentum transfer.
Research found a hospital code response team arrives at least one minute quicker and leads to better patient outcomes with smartphone emergency code notification systems. The study used a secure texting system that connected with electronic medical records, reducing conventional methods' average delay of 78 seconds.
A Tel Aviv University study reveals that the Israeli shoreline is contaminated with more than two million tons of microplastics, with Tel Aviv and Hadera beaches being the most polluted. The researchers warn that exposure to microplastic waste is unavoidable and poses a risk to human health.
A Tel Aviv University study shows that pressure chamber therapy can improve social skills and reduce neuroinflammation in the autistic brain. The treatment, which involves high-pressure chambers with oxygen enrichment, was found to increase blood and oxygen supply to the brain, leading to improved brain function and social behavior.
McCullough's research advances the field of cardiovascular science, with a primary focus on sex differences in stroke. Her work has led to significant discoveries about cell death pathways during ischemic insults.
Researchers found that centenarians have a lower epigenetic age than expected, suggesting slowed biological aging. The study used four epigenetic clocks based on small CpG sites to reveal these differences.
A new experimental device has been developed to generate temperature gradients on a microtiter plate, allowing for the simultaneous testing of different temperatures. This innovation solves a common challenge in biological studies of living cells, unlocking new possibilities for studying cellular growth and development.
Researchers discovered that plasmids can linger in the nose of lab workers for weeks, interfering with clinical diagnostic tests. The study highlights the importance of considering occupational exposure in diagnosis and treatment.
A recent poll reveals that 48% of people aged 50-80 have purchased at least one home health test, including COVID-19 and DNA tests. Notably, 82% of older adults express interest in future medical tests at home, while 90% agree to share results with their healthcare provider.
The USC COMPASS program aims to recruit and support students from historically underrepresented backgrounds to pursue careers in regenerative medicine. Scholars will receive a minor in Stem Cell Biology and Regenerative Medicine, as well as paid summer internships and mentorship opportunities.
A Cornell research team synthesized 16 types of rock surfaces that may form on exoplanets, providing a tool to decipher their composition. The study's findings offer clues to early planetary evolution and the chemical makeup of distant planets.
Researchers developed an electronic laboratory notebook that uses knowledge graphs to describe material properties and experimental processes. The platform enables automated analysis, lossless sharing, and discovery of new materials with potential applications in energy-related devices.
A new study finds that lab adaptation involves mutations to highly conserved proteins, but natural adaptation exhibits more complex patterns, including non-conservation within functional domains. Lab conditions differ significantly from natural environments with variable and changing selective pressures.
Researchers from Johns Hopkins Medicine and Dana Farber Cancer Institute found that irisin reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice. Irisin also speeds up the transport and degradation of alpha synuclein via fluid-filled sacs called lysosomes in brain cells.
Coronavirus levels in wastewater accurately predicted hospitalization peaks and healthcare pressure, enabling timely forecasting. The study's results demonstrate the value of virus surveillance in monitoring ongoing outbreaks.
Researchers have identified two effective antibodies that neutralize all known strains of COVID-19, including Delta and Omicron variants. These breakthrough antibodies could eliminate the need for repeated booster vaccinations and strengthen immune systems, especially in at-risk populations.
A Tel Aviv University study challenges the widely-held assumption that COVID-19 originated from bats, instead highlighting their highly effective immune system. The researchers found that many reported findings on bat-borne viruses are based on antibody presence or PCR tests rather than actual virus isolation.
The Association for Molecular Pathology has published consensus recommendations for clinical TPMT and NUDT15 genotyping assays, promoting standardization across laboratories. The report identifies a minimum set of alleles to include in clinical tests, enabling healthcare professionals to provide high-quality patient care.
Research in rats found that an enriched environment leads to better maternal behavior and higher-quality breastmilk. Mothers in enriching environments had more efficient parenting, resulting in larger offspring with increased body weights and improved social behavior.
A study published in the American Journal of Roentgenology found that combining deep-learning reconstruction with a subtraction technique yielded optimal diagnostic performance for detecting in-stent restenosis by coronary CT angiography. This approach reduced radiation exposure while maintaining high image quality.
Researchers have created and observed novel vortices in an ultracold gas, exhibiting unexpected properties due to hidden discrete symmetries. The discovery may lead to breakthroughs in quantum computing and information processing.
Researchers developed a small molecule that effectively controls tumor growth by inhibiting PD-1/PD-L1 binding, overcoming accessibility and cost issues of existing antibody treatments. The new molecule has advantages in terms of affordability and oral administration, making immunotherapy more accessible to all cancer patients.
A recent study from University of East Anglia compared 13 face shield styles in laboratory settings and surveyed over 600 people in Nigeria and Brazil about their views on face shields as PPE. The results showed that all face shields provided some protection, but none gave high levels against external droplets.
CoVaRR-Net is investing $6.9 million in 15 research projects focused on understanding Omicron subvariants and finding solutions to curb their spread. The studies will explore various aspects of variants, including viral transmission between animals and people, new variant mutations, and the impact of social factors on Indigenous Peoples.
A study by Goethe University Frankfurt found that antibodies against Omicron variants BA.1 and BA.2 decline rapidly, even after a second vaccination or booster shot, offering limited protection against infection.
A Tel Aviv University study reveals that corals' fluorescence serves as a lure for plankton, which are then consumed by predators like corals. The researchers found that green-fluorescent corals were 25% more preyed upon than yellow-fluorescent ones.
Researchers at UBC Okanagan have created wearable human motion devices that can track a multitude of activities, including breathing and muscle contractions. The devices use a two-dimensional inorganic nanomaterial called MXene alongside a conductive polymer for electromagnetic interference shielding.
A new processing technique could make potatoes healthier by slowing starch digestion and reducing blood sugar spikes. The approach blocks certain digestive enzymes from reaching potato starch as quickly, leading to a more controlled release of dietary glucose.
Researchers from the University of Illinois at Urbana-Champaign created a remote laboratory activity to teach undergraduate students about enzyme kinetics. The at-home kit included basic equipment and protocols that allowed students to conduct experiments and collect data, providing an alternative to traditional lab techniques.
A new platform mimics live cellular environment to guide stem cell differentiation outside the body. Researchers from Chung-Ang University developed a novel platform based on metal-organic frameworks, which offers advantages over conventional methods for in vitro stem cell differentiation.
CHOP researchers developed CancerVar, an artificial intelligence-empowered platform for interpreting somatic cancer mutations. The tool provides standardized procedures for assessing the clinical impacts of over 13 million somatic cancer mutations.
The new COBRE grant will help WVU recruit researchers and clinician-scientists to develop innovative solutions for preventing and treating incurable vision problems. The project aims to reduce visual disparities in West Virginia by understanding the complex combination of factors that contribute to these problems.
Researchers have designed simpler magnets for twisty stellarator facilities, which could aid the development of a stellarator power plant. The new magnets have straighter sections than before while preserving their strength and accuracy.
The Lustgarten Foundation has awarded a $5 million grant to Break Through Cancer to target KRAS in pancreatic cancer. The Conquering KRAS in Pancreatic Cancer Team will integrate clinical and laboratory approaches to understand why patients respond to new therapies.
Tel Aviv University researchers develop innovative model that explains wave formation, tested in complex experiments. The model takes into account all unstable harmonics and limitations of previous models, providing high reliability for describing physical situation.
A new strain of algae has been identified that can produce green hydrogen gas via photosynthesis on an industrial scale. This breakthrough could accelerate the transition to environmentally friendly green hydrogen and reduce pollution. The researchers also plan to develop methods to increase production rates and reduce costs.
Three Brookhaven scientists, Simerjeet Gill, James Dunlop, and Sanjaya Senanayake, were selected as Oppenheimer Science and Energy Leadership Program fellows. They engage in virtual visits to other national labs, distilling their experiences into think-pieces on organizational, policy, and scientific challenges.
A new study introduces a commercially available test that enables laboratories with real-time PCR capabilities to detect known SARS-CoV-2 variants. The assay is faster and more cost-effective than traditional sequencing methods, allowing for more widespread tracking of circulating variants.