A massive genomic survey reveals two distinct lineages of Arctic canids that originated in the northeastern Siberian Arctic generations earlier than thought. Approximately half of all Siberian huskies bred for racing have introgression with European breeds.
Researchers identified a natural pentacyclic triterpenoid as a PD-1 signaling inhibitor, blocking PD-1/PD-L1 interaction and restoring T cell function. The compound targets the phosphorylated ITSM recognition site of SHP-2.
Researchers have identified a promising method for extending the shelf life of perishable produce by using edible coatings made from chitosan and beeswax. The study found that these coatings significantly enhance the preservation of pointed gourds and green chillies, reducing weight loss and delaying visible decay.
Researchers from Tokyo Metropolitan University developed a new electrochemical cell that converts bicarbonate solution into formate ions with high selectivity and efficiency. The cell boasts unrivalled performances rivaling energy-hungry gas-fed methods, promising to have a significant impact on climate change technology.
Cholestasis leads to mitochondrial dysfunction, ER stress, inflammation, and autophagy impairment. Novel therapeutic agents modulate mitochondrial and bile acid metabolism pathways to improve liver function.
Researchers at NYU Abu Dhabi have developed nanoscale covalent organic frameworks (nCOFs) modified with peptides to treat triple-negative breast cancer. The COFs selectively release drug cargo within the acidic environment of tumors, improving treatment effectiveness and minimizing side effects.
The NIH has established a pandemic preparedness research network, ReVAMPP, to focus on high-priority pathogens with the potential to cause deadly diseases. The network will study viruses from families that have caused human disease for millennia and aim to develop safe and effective medical countermeasures.
A study at the University of Bonn has revealed that fly larvae have special sensors triggered by swallowing, releasing serotonin to continue eating. This control circuit may also exist in humans and could help understand eating disorders such as anorexia or binge eating.
Researchers found that metformin alleviates human cellular senescence, slowing down aging in primates. The study reveals that extended therapy yields geroprotective benefits, including cognitive improvements and rejuvenation of various tissues and organs.
Recent advancements in high-throughput proteomics have unveiled new insights into protein involvement in various cancers. The review explores four key techniques, including mass spectrometry and next-generation tissue microarrays, highlighting their strengths and limitations for large-scale molecular analyses.
The study assesses roadway damage from the 2020 wildfires in comparison to historical megafires in the region, finding significant increases in damage since the 2000s. The research emphasizes the critical need for targeted preventive measures and improved fire management strategies.
Researchers have successfully multiplied beta-carotene levels in lettuce leaves by up to 30 times using biotechnological techniques and high light intensity. The discovery represents a significant advance for improving nutrition through biofortification of leafy greens like lettuce, spinach, and chard.
Researchers at Osaka Metropolitan University used CRISPR/Cas9 to create a strain of Euglena that produces wax esters with shorter carbon chains, improving their cold flow and suitability as a biofuel feedstock. This breakthrough could potentially replace petroleum-based production of wax esters with biological sources.
A study published in Food Science of Animal Products found that replacing traditional fish meal with grasshopper meal resulted in enhanced libido, better sleep, and improved hair quality in rats. The findings highlight the potential of edible insects as sustainable and nutritionally superior alternative protein sources.
Scientists have developed new therapies that selectively remove aggregated tau proteins associated with Alzheimer's disease in mice. The approach utilises TRIM21 to target tau aggregates, leaving healthy tau intact, and demonstrates potential for other brain disorders driven by protein aggregation.
A new study by Boston University researchers found that the majority of social media posts from e-cigarette brands left out health warnings, despite a federal requirement to include them. The study used AI to analyze over 2,000 Instagram posts and discovered that only 13% complied with FDA health warning requirements.
A team of researchers discovered a class of materials that mimic the behavior of axons by spontaneously amplifying electrical pulses. These materials can harness internal instabilities to create spiking behavior and amplify signals, potentially leading to more efficient computing and artificial intelligence.
Scientists at Kyoto University's Institute for Integrated Cell-Material Sciences have discovered a protein complex that regulates phospholipid scrambling, a process important for blood clotting and unwanted cell removal. The finding could lead to new treatments for diseases like epilepsy and anemia.
A new study published in JAMA Health Forum found that machine learning can be more effective than traditional methods for distributing scarce treatments to patients most vulnerable during a public health crisis. The model reduces expected hospitalizations by about 27 percent compared to actual and observed care.
Researchers develop eco-friendly method to extract collagen from marine waste, reducing reliance on traditional processes that harm the environment. The study employs statistical modeling to optimize conditions, achieving high collagen yields and paving the way for more sustainable production practices.
A new $4 million grant aims to test auricular point acupressure as a treatment for chronic pain in rural populations. The project, led by UTHealth Houston and USC, will use a smartphone app to guide patients through self-administered ear stimulation.
Researchers introduce a new mathematical model tailored for SOFCs using direct internal reforming of ethanol, validated against experimental data. The study reveals how operating conditions influence the reactions inside the SOFC, improving hydrogen yield and performance at increased current densities.
A recent study found that extreme melting episodes in Greenland have doubled in frequency since the 1950s, with significant consequences for the global climate. The increased risk of large ice blocks breaking off into the ocean is linked to global warming and is expected to continue, with potential impacts on Europe's climate.
Researchers have discovered dense, large-scale structures beneath a lost ocean on Mars, using gravity data from multiple missions. The findings suggest active processes in the martian mantle may be boosting the largest volcano, Olympus Mons.
A new study proposes that early dark energy could explain the formation of numerous bright galaxies in the early universe, resolving the 'Hubble tension' puzzle. The team modeled galaxy formation with a brief appearance of early dark energy, finding it fits observations and solves both puzzles.
Researchers observed accelerated presence of genetic variations increasing heat tolerance in European forest fly populations. The pace of new inversions is too slow to make up for the increase in temperatures, putting species with lower genetic variation at risk.
The BioRescue team evaluated ethical considerations for biobanking, including animal welfare, sample ownership, and good scientific practice. It introduced a modified ETHAS tool to provide a structured approach for biobank managers, enabling them to make wise decisions on conservation and research.
Researchers improve U-Net AI model for oceanographic research by enhancing its segmentation, forecasting, and super-resolution tasks. The upgraded model improves detection accuracy and prediction outcomes, showcasing its potential in ocean remote sensing.
A retrospective cohort study of 3,389 patients with obesity found that semaglutide and liraglutide were associated with significant weight reduction at 1 year. The study suggests that persistent medication coverage, dosage, treatment indication, and patient sex are important factors in determining weight loss outcomes.
Researchers analyzed 160,000 court decisions in Russia, finding men 3.25 times more likely to be involved in accidents that lead to criminal cases. Men drive faster, more aggressively, and are more likely to drive under the influence, contributing to a significant gap in road safety.
Researchers identified 339 fungal species, including 15 new species, from a field trip in southern Xizang, China. The discovery highlights the region's vast fungal diversity and underscores the need for further exploration.
A new study suggests that urban heating and cooling systems will significantly impact future energy demand due to climate change, with smaller-scale city-level waste heat contributing to local microclimates. The research emphasizes the need for comprehensive climate impact assessment and science-based policymaking to address this issue.
Researchers developed a system to effectively split transmissions from a single antenna array into multiple beams without additional hardware, allowing satellites to overcome the one-to-one user ratio. This enables significant reductions in cost and power consumption, potentially leading to fewer satellites, smaller satellites, or both.
Researchers used realistic numerical models to solve mysteries about Earth vibrations of unknown origin and discovered a 'seiche' phenomenon caused by a massive rockslide in the fjord. The event generated seismic waves detectable globally for nine days, highlighting the interrelations between climate change and geological processes.
A new study from the University of Leicester found that trees in logged tropical forests produce more carbon dioxide per unit area than those in unlogged forests. The researchers measured respiration in tree stems and estimated values for all trees in a one-hectare plot, showing higher carbon release levels in logged forests.
Researchers develop multifunctional material for adjustable color emission, enhancing white LED performance and paving way for visual thermometers. The phosphors' stability, repeatability, and thermochromism make them suitable for high-temperature safety markings.
A new study by Potsdam Institute for Climate Impact Research confirms that climate change poses significant economic risks to different income groups. The poorest worldwide are particularly vulnerable, but the risk for the wealthy is growing at an alarming rate.
Researchers at HUN-REN Centre for Ecological Research found that specific climate periods can shift by several months or even six months within a year, affecting species distribution. This shift poses significant challenges for distribution models, potentially leading to extinction or migration of species.
Scientists are investigating the basic biology of protein arginine methyltransferase 5 (PRMT5), an enzyme found in 15% of human cancers. The goal is to understand its normal functions and avoid potential side effects when targeting it for cancer treatment.
Researchers identified changes in the UBR4 gene as a key driver of fibromuscular dysplasia, a blood vessel disorder affecting up to five percent of adults. The discovery could lead to therapeutic approaches for the condition, particularly beneficial for women who account for 90% of cases.
Researchers at the University of Minnesota have discovered how next-generation electronics, including memory components in computers, break down over time. By studying spintronic magnetic tunnel junctions, they found that continuous current causes layers to pinch, leading to device malfunction and degradation.
Aqueous zinc-ion batteries (AZIBs) have emerged as a promising alternative to lithium-ion batteries due to their inherent safety, cost-effectiveness, and environmental sustainability. The study reveals the potential of porous zinc anodes in overcoming the limitations of traditional planar zinc anodes, including dendrite growth.
Prescription volumes for stimulant and antidepressant medications rose, while opioid volumes decreased between 2019 and 2022. Telehealth prescriptions climbed across medications, with a notable increase in opioids.
This study investigates temperature fluctuations' impact on seafood quality, highlighting a need for stringent temperature control throughout the cold chain. The research identifies key indicators of spoilage and potential markers of quality deterioration.
A team of researchers developed a new, environmentally friendly battery binder using siloxane that surpasses EU regulations and provides over 1.4 times higher lifespan stability compared to conventional binders.
Researchers at Argonne National Laboratory have validated a cathode hydrogenation mechanism as the cause of self-discharge in lithium-ion batteries. This discovery could lead to the development of smaller, lighter and cheaper batteries with improved lifespan.
A new study reveals that soil pH sets the stage for microbial interactions and community composition, with bacteria cooperating to survive in acidic environments. The research sheds light on global nitrogen cycling and provides insights into reducing potent greenhouse gas emissions.
The Phase I/II trial of AZD8205, a topoisomerase 1 inhibitor ADC targeting B7-H4, demonstrated partial responses in ovarian, breast, and endometrial cancers. Notably, only two patients experienced severe toxicities, indicating a favorable safety profile.
Researchers at the University of Cambridge found that flowers like hibiscus use an invisible blueprint to dictate the size of their bullseyes, which can significantly impact their ability to attract pollinating bees. Larger bullseyes are preferred by bees and can potentially boost efficiency for both bees and blossoms.
Researchers have developed a novel multi-step facet engineering approach for growing wurtzite-based InGaAs/InP MQW NWs with controlled size, morphology and high crystal quality. This enables the design of controllable nanowire optical cavities, allowing for tunable lasing peaks across the telecommunication O and C bands.
A team of researchers discovered a universal inequality between energy transfer rate, information transfer rate, and Hilbert space size, showing that both require sufficient states to transmit. This breakthrough sheds new light on the challenging problem of calculating these quantities.
Researchers developed a novel approach to map planted and natural forests globally at 30-m spatial resolution, enabling accurate tracking of forest changes. By analyzing frequency of disturbance on satellite images, the team distinguished between established natural forests and planted forests.
Researchers developed health-focused food technologies using non-thermal processing methods to regulate postprandial blood glucose levels. The study demonstrates the significant impact of non-thermal techniques on starch digestibility, offering a promising dietary strategy to mitigate obesity and type 2 diabetes.
Researchers discovered that disrupting plant microbiomes can compromise a plant's immune system, leading to autoimmunity. Prebiotics could potentially support or reset the microbiome to maintain balance, reducing losses in food crops.
Astronomers have discovered a massive exoplanet, the Super-Jupiter, orbiting its parent star every 14 years. The planet has a mass eleven times that of Jupiter and is located six astronomical units away from its star.
A cross-sectional study found that 87% of Instagram posts from synthetic nicotine brand accounts failed to comply with FDA health warning requirements. This non-compliance may contribute to increased youth engagement with tobacco marketing.
Researchers have gained insights into clouds in Antarctica using a new platform, discovering warm air intrusions and sulphate aerosol at high altitudes. The study, conducted over 12 months, was the first to investigate vertical distribution of aerosol particles and clouds above the German Neumayer Station III.
Researchers identified protein kinase N as a key regulator of heart fibrosis, which threatens heart function. Deleting this enzyme reduced cardiac dysfunction, suggesting anti-PKN treatments may protect against heart failure.
A study reveals discrepancies between preferred and actual sources of contraceptive information among adolescents and young adults. Clinicians are the most commonly preferred source, yet they also pose the largest discrepancy between preference and use. This highlights the importance of clinicians in supporting informed contraceptive d...
A drug that delivers chemotherapy directly to tumors has shown substantial and durable activity in treating brain metastases of HER2-positive breast cancer. The treatment, trastuzumab deruxtecan, has improved progression-free survival and objective response rates in patients with advanced disease.