Researchers identified a specific subset of opioid receptors on interneurons in the prefrontal cortex that ketamine targets to relieve depressive symptoms. Combining small doses of three drugs targeting the same pathway may provide an effective alternative to ketamine with fewer side effects.
Researchers have developed a skin-conformal wearable healthcare system that measures electrocardiogram (ECG) signals without a battery. The system uses human body–coupled wireless power transfer to enable long-term health monitoring, overcoming the power supply challenge in wearable devices.
The Boyce Thompson Institute has received a multi-year award from the USDA's FANE program to expand access to biotechnology education for K-12 students. The P-BIOTEK initiative will create hands-on learning opportunities and community science programs to introduce students to plant biotechnology, bioengineering, and science communication.
A study by Penn State researchers found that trade secret policies restrict labor mobility, leading to early-career workers receiving higher starting wages but stunted wage growth later. Firms instead shifted toward greater use of capital, replacing human labor with automation equipment.
Historian Benjamin R. Siegel's book 'Markets of Pain' explores how opium was used as a commodity to wield power and control supply chains, contributing to the opioid epidemic. India's unique history with opium production, inherited from colonial era systems, is also examined.
Dr. Hannah Cabré has been appointed as an Assistant Professor and Director of the Aging, Gynecology, and Endocrinology Laboratory at Pennington Biomedical Research Center. Her research focuses on the role of female sex hormones in shaping nutrition, health, and performance across the lifespan.
The latest issues of APA journals feature new research on PTSD and substance use disorders. The American Journal of Psychiatry explores the understanding of these conditions, while Psychiatric Services discusses the future of the DSM. Focus journal delves into psychopharmacologic treatments with expert perspectives.
A study published in the Proceedings of the National Academy of Sciences found that over 70% of Leishmania parasite isolates showed evidence of genetic mixing, indicating sexual reproduction and hybridization play a major role in their evolution. This challenges longstanding assumptions about the reproduction mechanisms of these parasi...
Researchers found that reaction times are crucial in predator-prey interactions, allowing prey to evade faster predators through a 'head start' in turning. This contradicts the traditional theory of maneuverability, which suggests that smaller prey can turn more sharply and escape predators.
A cohort study found that poor housing affordability was associated with higher risks of frailty, disability, dementia, and mortality, while poor housing quality was linked to increased risks of frailty, disability, and mortality. Housing insecurity is identified as a clinically relevant social determinant of health among older persons.
A new study reveals significant variation in sickle cell disease hospitalizations and costs across New York State, with regional differences in access to specialized care and treatment impacting outcomes. Long Island and New York City show high costs and complex cases, while Central New York has the longest average length of stay.
Researchers at Tohoku University discovered that hollow nanoreactors can work more efficiently when transport into the reaction space is slightly restricted. This new insight allows for optimized reactions in confined spaces, potentially producing everyday products more efficiently and at a lower price.
Researchers predict that increased production will pose supply problems for certain raw materials like neodymium-praseodymium and carbon fibers. To mitigate these risks, they recommend piggybacking off existing capacity from industries like electric vehicles and designing robots with recyclable materials.
A study of children aged 8-12 found that only 40% of their relationships are positive or ambivalent, with half still including perpetrators in their networks. Children struggle to discuss traumatic experiences with parents and friends due to fear or lack of trust.
A study by Weill Cornell Medicine and others found that while cannabis arrests decreased by 62% for white individuals and 51% for Black individuals after legalization, racial disparities persisted. Legalization also led to a shift in law enforcement practices, with lower arrest rates for selling other illicit drugs.
A new international study suggests that people who feel less certain about themselves may look to celebrities for guidance and inspiration. The research found that celebrity worship can serve a compensatory role when people are struggling with their identity or autonomy.
Researchers developed a new tool called TRAnsmision Clustering of Strains (TRACS) to track the spread of disease-causing microbes using genomics. The tool distinguishes between closely related bacterial strains and can identify transmission networks and rule out events in ongoing public health applications.
A large-scale field experiment revealed that wild sulphur-crested cockatoos learn what foods are safe to eat by watching each other, with males more likely to follow other males. The study found that social relationships play a crucial role in shaping animal behavior, and that knowledge can spread rapidly through flocks.
A cohort study found that ultraexpensive drugs in Medicare Part D have limited international availability, highlighting their fiscal significance. Internationally unavailable products often result in higher spending per beneficiary.
Researchers at St. Jude Children's Research Hospital discovered that blood stem cells with aplastic anemia escape the immune system by acquiring different gene mutations independently. These mutations, such as HLA loss and CHIP gene changes, allow cells to hide from the immune system and provide long-term remission.
Dan M. Frangopol has been awarded the third ASCE Wellington Prize for his groundbreaking study on probabilistic connectivity assessment of road networks subjected to ground motion and tsunamis. The research provides a more realistic assessment of network performance under extreme conditions, helping engineers and planners identify vuln...
A single-center study demonstrates uterus transplant feasibility in multidisciplinary centers, supporting its use for women with absolute uterine factor infertility. Ongoing reporting and data sharing will refine risk estimates and optimize patient counseling.
The American Stroke Association honors seven Stroke Heroes for their efforts in supporting survivors and caregivers through connection, education, and shared experiences. The winners showcase how personal experience can become a source of strength for others, reducing isolation and helping fellow survivors find a path forward.
Two UVA scientists, Edward H. Egelman and James N. Galloway, were elected to the prestigious American Academy of Arts & Sciences for their outstanding contributions to biochemistry, environmental sciences, and research. The recognition acknowledges their collective breadth and depth of excellence in advancing public good.
The article warns that AI's rapid integration may stifle scientific creativity and innovation, diverting resources away from solving fundamental problems. Dr. Shim argues for preserving human-centered pathways for knowledge generation to ensure diverse thought necessary for breakthroughs.
An eye-tracking study reveals that attractive noses draw less attention than unattractive ones, highlighting the importance of holistic facial assessment in rhinoplasty. The study found that observers spent more time looking at unattractive noses and shifted their gaze to other areas.
Knowing stroke signs can help protect the brain, reduce long-term disability, and save a life, according to the American Stroke Association. Approximately 2 million brain cells die every minute when stroke goes untreated, making early recognition critical.
Researchers developed a new framework, 'Mollifier Layers,' to tackle challenging inverse PDEs. This advance could benefit fields such as genetics and weather forecasting by inferring hidden forces that produce observable patterns.
The Jack, Joseph and Morton Mandel Foundation has made a historic commitment of $125 million to Case Western Reserve University, the largest in their history. The investment will fund four focus areas: new humanities building, student scholarships, leadership initiatives, and ethical technological innovation.
Researchers have developed a novel method to generate diazo compounds without toxic precursors, enabling efficient synthesis of valuable intermediates for chemical and pharmaceutical applications. The phosphine-mediated Michael addition reaction produces β-heteroatom-substituted diazo esters under mild conditions.
Researchers subjected fruit flies to extreme gravitational forces and found they adapted and recovered, showing resilience in movement and energy use. The study suggests the brain makes energy trade-offs based on gravity levels, with moderate increases pushing for more movement and higher energy demands.
Researchers at Oxford have demonstrated a new type of quantum interaction called quadsqueezing, a fourth-order effect that was previously unreachable. By controlling complex forms of squeezing, the team has created stronger and more accessible quantum effects for applications in simulation, sensing, and computing.
Researchers found that oak trees delay leaf emergence to escape herbivores, reducing insect damage by an impressive 55%. This delay allows the tree to avoid being stripped bare and enables it to recover from infestations.
A new study finds that pregnant women with low levels of a specific fatty acid molecule are more likely to have children with childhood asthma. The researchers also found that children of these mothers are more prone to respiratory infections and altered lung microbiomes.
Researchers have discovered two thresholds for the behavior of charged water droplets on frictionless surfaces, enabling finer control over electrospray processes and opening up opportunities for nanofabrication. The study's findings may also lead to greener scientific techniques.
A recent study reveals that individuals with higher education or income are more aware of and use AI tools, exacerbating social inequalities. The researchers recommend increasing engagement with AI-related topics through outreach campaigns, educational programs, and community workshops to reduce this new digital divide.
Researchers found that eEF1A2 is significantly overexpressed in gallbladder cancer and correlates with advanced lymph node metastasis and poor patient survival. Targeting the EEF1AKMT4-eEF1A2 signaling axis may suppress translation-driven tumor growth and halt lymphatic spread.
Researchers at MIT discovered that gene circuits can reshape DNA folding and affect gene expression in human cells. The study found that rearranging genes along a DNA strand, or 'gene syntax,' can amplify or suppress the expression of neighboring genes.
The study reveals that decision-making occurs through nested feedback loops, not sequential stages, and can be emulated to create more intelligent AI. This finding has the potential to improve AI's power efficiency and effectiveness.
Researchers identify strong Brønsted acid site (BAS) in fluorinated γ-Al₂O₃ using advanced solid-state NMR techniques. The site is present only on fluorinated alumina and exhibits exceptional robustness, enhancing catalytic activity and aromatization performance.
A physics-guided neural network called SGARNet is developed to address challenges in lensless multi-core fiber imaging. It reveals the frequency-domain characteristic of honeycomb artifacts and introduces a SpectralGate module to selectively suppress artifact-related components, preserving useful image details.
Researchers from Nagoya University developed a two-step synthetic method for dihydrodinapthopentalenes, conductive organic molecules with complex synthesis. The new mechanochemical method synthesizes DHDPs in 15 minutes with minimal solvent waste and structural constraints.
A research team has uncovered the atomic-scale understanding of how water drives structural reconstruction in oxide catalysts. The study reveals distinct hydroxylation pathways for different CoOx nanostructure initial structures in the presence of water.
A bimetallic NiFe catalyst was designed to overcome the activity-selectivity trade-off in furfural hydrogenation. The introduction of Fe creates synergistic active sites, boosting selectivity toward furfuryl alcohol from 38% to >90% at nearly full conversion.
Researchers examined two mechanisms of whole genome duplication in cells, finding that cytokinesis failure leads to more stable and viable cells, while mitotic slippage results in uneven chromosome distribution and reduced viability. The study suggests targeting chromosome separation could help limit survival of abnormal cells.
Researchers at UC Santa Cruz's Forest Fear Lab discovered that the dense upper story of the Amazon carries the cries of frightened birds to other animals, forming a shared information network. Small bird species are key drivers of this acoustic 'information highway,' with larger species also joining in.
A new rulebooks framework developed by Iowa State University researchers provides a principled way for autonomous systems to rank and reconcile competing goals. The framework avoids the issues of blending weighted trade-offs, allowing systems to clearly define which rules come first and choose the least harmful option.
A study at Saitama University found that subtle changes in molecular structure can significantly affect aggregation and interfacial behavior of sugar-based surfactants. The researchers demonstrated that the sulfur oxidation state alters the relationship between aggregation in water and surface tension.
A new review found that GLP-1 weight-loss drugs significantly reduced the risk of heart attacks, strokes, and premature death. The treatment also lowered rates of non-fatal heart attacks, hospital admissions for heart failure, and deaths from any cause.
A small trial found that once-weekly semaglutide injections reduced heavy drinking days by an average of 12 days in patients with alcohol use disorder and obesity. The study showed a 50% higher reduction than the placebo group, suggesting potential benefits for GLP-1s in treating alcohol use disorder.
The American Heart Association warns that healthcare affordability has reached crisis levels, with total spending approaching $5 trillion annually. The association proposes five guiding principles for action by lawmakers and policymakers to address the issue.
A growing gap in cervical cancer incidence rates between high- and low-income countries threatens to escalate unless prevention efforts are increased. Researchers urge universal vaccination for girls and boys, as well as catch-up campaigns, to close the gap and prevent nearly 37 million cases of cancer by the end of the century.
A study by Boston Children's Hospital researchers found that the US missed four out of seven measles elimination status indicators, with most at risk. The latest outbreak has spread continuously for over a year and affected 45 states since January 2025.
A new study published in the Journal of the American Heart Association found that methamphetamine use accounted for nearly 15% of heart attacks in a northern California study. People who suffered meth-related heart attacks were often young- to middle-aged men without traditional heart disease risk factors, highlighting the need for spe...
A recent study found an association between early-onset colorectal cancer and exposure to certain pesticides, particularly picloram. However, experts warn that further investigations are needed to confirm causality and establish a biological mechanism.
A new pretargeted radioimmunotherapy technique has been shown to be effective and safe in eradicating tumors from a preclinical colorectal cancer model. The multi-step theranostic approach delivers alpha-emitting radiation directly to tumors while limiting exposure to healthy tissues.
A new study reveals that impaired protein recycling is the key factor in T cell exhaustion, allowing researchers to develop a 'tag and sort' fix to restore normal proteostasis. This approach boosts the potency of cell therapy against cancer.
Researchers present findings on sociodemographic disparities in hypertensive disorders of pregnancy, highlighting the need for better characterization and management of these conditions. Dr. Basma S. Faris discusses reframing PCOS as a chronic disease requiring longitudinal care.
Research led by University of Utah biologists shows that host genetics and sex influence how influenza viruses evolve. Female mice from a specific strain exhibit accelerated virulence gains compared to male mice.
A new study by Lee Gettler of the University of Notre Dame found that COVID-19 lockdowns had a limited lasting effect on fathers' involvement in childcare, contrary to initial reports. The 15-year longitudinal data showed no significant change in fathering behaviors before and after the pandemic, with most dads resuming their pre-pande...