A global, multicentre phase III trial demonstrates the potential of Dato-DXd as an effective new treatment option for triple-negative breast cancer. The novel antibody-drug conjugate (ADC) nearly doubles overall survival and improves progression-free survival in patients with untreated, advanced TNBC.
Research from Lund University found a link between male infertility and an increased risk of developing colorectal and thyroid cancer. Men who underwent assisted reproduction techniques, such as ICSI, were more likely to develop these cancers.
A new study from Aarhus University identified nearly 200 proteins that change during the menstrual cycle, influencing conditions like endometriosis and bleeding disorders. The study provides a comprehensive picture of biological changes over a full cycle.
A new study from Aarhus University reveals that weight-loss drugs containing GLP-1 hormone may influence joint inflammation in arthritis patients. The study found that high doses of GLP-1 in medication could have a dual effect, both through weight loss and by increasing levels in the joints.
A study analyzing Neanderthal mitochondrial DNA sequences found evidence of a rapid decline in genetic diversity and geographic distribution around 65,000 years ago. This 'bottleneck' event is believed to have triggered the extinction of the species, with later populations emerging from refugia in southwestern France.
A large Nordic register-based study finds that high-dose folic acid supplementation before pregnancy reduces the risk of major congenital anomalies by 45% in women taking antiseizure medication. Starting folic acid after pregnancy onset has no protective effect.
Dorothee Haroske and Leszek Skrzypczak are awarded €200,000 for their joint research on function spaces, approximation theory, and Fourier analysis. Their work has given rise to numerous publications and specialist conferences.
Dr. André Biedenkapp's work on generalizability in reinforcement learning aims to make AIs more robust and adaptable, with potential applications in real-world scenarios
A study by the University of Bath found that elite MBA graduates hold top management positions and CEOs more frequently than those with non-elite MBAs or no MBA. The benefits of an elite MBA were not evenly spread between men, women, and minorities, and varied according to economic conditions.
Researchers developed mosaic mini-brains to study focal cortical dysplasia type II, a condition causing seizures in children. The findings support the two-hit model, suggesting that complete loss of DEPDC5 is necessary and sufficient to initiate the disease, with mosaicism determining lesion extent.
The research team successfully synthesized a novel single-crystalline 3D borate covalent organic framework, demonstrating exceptional performance as a solid-state electrolyte. The advancement promises safer and higher energy density solutions for electric vehicles and large-scale energy storage.
The UNITE project has selected three joint interregional projects to tackle health data sharing and personalized remote care. The selected projects will focus on heart failure, neonatal intensive care, and radiation exposure in medical imaging.
Researchers at Bar-Ilan University have developed a novel method to send, manipulate and measure quantum information across many frequency channels simultaneously, enabling faster and more efficient secure communication technologies.
Researchers at Tohoku University developed an AI-based method integrating physics-based modeling for rapid screening of material candidates. The approach significantly improves accuracy by evaluating basic properties before predicting complex ones.
The University of Tartu Institute of Family Medicine and Public Health has launched a new continuing education course on refugee and migrant health, based on the World Health Organization's global competency standards. The course aims to provide healthcare professionals with specific knowledge and skills to deliver high-quality care to...
The study found that non-Hispanic Black men experienced the highest absolute increase in opioid-only mortality rates, followed by non-Hispanic White men and Hispanic men. Structural factors such as unequal access to care and medical mistrust continue to drive these disparities.
Indiana University has expanded its free generative AI course, GenAI 101, to over 805,000 alumni worldwide. The course provides practical skills in prompt engineering, data storytelling, and ethical AI use, preparing learners for an AI-powered world.
Researchers developed Adaptive-SN2N, a risk-aware adaptive deep learning framework that resolves critical background artifact challenges. The framework integrates risk-aware adaptive normalization, self-inspired learning, and Gaussian-weighted overlap inference to suppress artifacts while improving photon efficiency.
The East Asian Subtropical Westerly Jet (EASWJ) and East Asian Summer Monsoon (EASM) relationship shows stable anti-phase changes across three climate periods. A significant mode shift is identified in the second MV-EOF mode, with varying relationships between EASWJ displacement and EASM intensity.
Researchers develop an event-based framework for functional biological imaging, capturing vascular and neuronal dynamics at high temporal resolution. An unsupervised reconstruction algorithm maps sparse event data into smooth functional images.
Researchers cloned novel BB resistance gene Xa48 in indica rice variety Shuangkezao, revealing molecular mechanism of BB resistance. The study provides foundation for breeding high-yielding disease-resistant rice varieties and improving crop disease resistance.
Researchers have uncovered a vital mechanism for survival by studying the interaction between brain cells and fat cells in fruit flies. The study found that the immune system's discovery of pathogens leads to a change in behavior, triggering an avoidance response through the release of neurotransmitters octopamine and dopamine.
A new research paper proposes Wireless Environmental Information Theory (WEIT) as a novel theoretical foundation for 6G environment intelligence communication. WEIT validates the EIC architecture aided by wireless environmental information and discusses key challenges for its practical application.
Researchers at SKKU have successfully demonstrated the mass production of large-area visible metalenses using a fully automated roll-to-roll manufacturing platform. The platform achieves a record-high throughput of 300 metalenses per second, paving the way for the commercialization of flat optics.
Researchers at Indian Institute of Science have devised a method to grow high-quality 2D magnetic materials over centimetre-scale wafers, paving the way for their integration into next-generation electronics. The technique uses Physical Vapour Transport Deposition and enables scalable fabrication with minimal surface roughness.
A new genetic study found that Indigenous populations in Malaysia have well-preserved olfactory receptor genes, suggesting a strong evolutionary pressure to maintain them. The study suggests that the human sense of smell has played a bigger role in shaping evolution than previously thought, adapting alongside major cultural changes.
A nationwide study reveals that individuals with lower educational attainment are more likely to die from colorectal cancer at a younger age. The disparity in young-onset CRC mortality nearly doubled over the past three decades among those with 12 years or less education compared to those with 16 or more years of education.
Researchers at the University of Seville and Polytechnic University of Madrid demonstrate a new method to grow tomatoes beneath solar panels, reducing water consumption by 50% while generating clean energy. The agrovoltaic system improves irrigation management, increasing fruit productivity for every drop of invested water.
Researchers used a novel technique to analyze millions of individual particles in Antarctic ice cores, revealing common dust sources during the last Ice Age. The study highlights the importance of atmospheric circulation changes and provides insights into ancient climate systems and potential future environmental shifts.
A new mapping model uses geo-mapping and statistical analysis to identify areas with the greatest need for prehospital whole blood transfusions. The model can help hospital systems quickly deploy scarce blood resources and minimize waste, particularly in underserved communities.
Scientists at Karolinska Institutet have created a new method to produce insulin-producing cells from human stem cells, effectively regulating blood sugar levels in laboratory tests and reversing diabetes in mice. The optimized production process yields more mature and purer cells, demonstrating their potential for future treatments.
A study estimates annual mortality rates among US Immigration and Customs Enforcement (ICE) detainees between 2004 and 2026. The analysis reveals notable shifts in age and cause of death patterns over the two-decade period, providing valuable insights into the health risks faced by this population.
Researchers developed LightELF to detect phase singularities and encode information in optical topological knots. The system uses event-driven mechanism for high-speed detection and decoding of knot-based optical signals.
Neurobiologists have identified the brain circuitry responsible for placebo pain relief, revealing a site where endogenous opioid peptides drive pain relief. The study offers hope for using expectancy-driven placebo effects as a substitute for painkillers and developing protocols to produce placebo pain resilience in humans.
Research at the University of Vienna found a link between gut bacterial diversity and acute stress response in healthy adults. Higher microbial diversity was associated with stronger hormonal and subjective stress reactivity, suggesting the gut microbiome may play a role in regulating the acute stress response.
Researchers from Kumamoto University and partners discovered a method to enhance titanium alloys using high-density pulsed electric current, achieving improved strength and toughness. The technique harnesses an electron wind force to reorganize the internal crystal structure, producing nanoscale martensitic phases that disperse stress ...
A new study uses a human stem cell-derived model to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate. Glycyrrhizin significantly prevents intestinal cell death in both stem cell models and mice with IBD, reducing inflammation and cell death.
Researchers at Empa found that industrial chemicals, used in refrigerants and plastics, escape into the atmosphere at a rate of 3-4%, delaying ozone layer recovery by 7 years. These substances also emit significant greenhouse gases, posing a dual threat to the climate.
A team of researchers has identified a regulatory module centered on miR3699, MdMAN7, and eTM3699 that helps break down the cell wall of mature apple cells, promoting embryogenic cell formation and regeneration. Elevated MdMAN7 activity thins the cell wall, while miR3699 suppresses this process.
A new University of Kentucky Markey Cancer Center study identifies barriers to prescribing hormone therapy for cervical cancer patients who experience early menopause due to radiation treatment. Despite clinical guidelines supporting the use of hormonal therapy, research shows it remains underused. The study found that oncologists are ...
Researchers developed a powerful model to understand charge separation at the interface, influencing catalytic activity. The model provides insights into the formation of electric double layers and local electric potential variations.
A new single-chip camera captures ultraviolet, near-infrared and visible images using a compact design inspired by the multiwavelength vision capability of the mantis shrimp. The camera helps surgeons identify cancer-linked lymph nodes during surgery, making cancer treatment safer and less invasive.
Researchers have identified six key elements - meaning and purpose, life satisfaction, self-acceptance, strong relationships, autonomy, and happiness - as crucial for positive mental wellbeing. Experts say these factors can help policymakers better understand where to intervene in promoting mental health.
Researchers at City of Hope present findings on early-onset colorectal cancer, highlighting the role of gut microbiome differences and a new molecular pathway in immune resistance. The study uses AI tools to analyze complex relationships between data types, shedding light on potential strategies for earlier detection and treatment.
A new study has identified the WWOX protein as a molecular guardian that prevents common skin tumors from undergoing a dangerous metamorphosis and spreading to other parts of the body. The loss of this protein allows cancer cells to transform into more aggressive, invasive forms.
The newly discovered Bicharracosaurus dionidei is a 20-meter-long sauropod that shares characteristics of both Brachiosauridae and Diplodocids. Its fossil discovery in Patagonia provides valuable comparative material for understanding the evolutionary history of these animals in the Southern Hemisphere.
A recent study found that strengthening one's sense of belonging to natural environments has a protective effect against loneliness. The study investigated the impact of outdoor activities on loneliness and discovered that noticing details in nature, such as sounds and patterns, can be beneficial for mental well-being.
Research finds that the rounded shape of natural tips is due to random mechanical wear, not just evolutionary optimization. The experiment with pencils demonstrates how collisions can lead to a universal parabolic shape across different structures.
A new study from Florida Atlantic University challenges the narrative that rising temperatures will drive Americans away, finding that heat alone isn't driving large-scale out-migration. Instead, population shifts are shaped more by economic opportunity, housing affordability and local quality of life than climate conditions.
A specific protein, PKC-eta, has been identified as a central driver of aggressive breast cancer cell migration and metastasis. Reducing PKC-eta activity significantly slows tumor growth and reduces metastatic spread in laboratory and animal models.
A recent study published by the American Psychological Association found that people who rely heavily on AI programs for work tasks experience reduced confidence in their own independent reasoning. In contrast, those who actively challenge or modify AI suggestions report greater confidence and a stronger sense of authorship.
The 2026 cohort of Leon Levy Scholars in Neuroscience will pursue research projects addressing neurological disorders and developing new treatments. The program provides scientific and professional career development opportunities, including mentorship and networking.
A new remote psychological therapy program has been shown to improve symptoms and quality of life in young lupus patients. The six-session Treatment and Education Approach for Childhood-onset Lupus (TEACH) program incorporates cognitive behavioral therapy and mindfulness meditation to help kids manage depression, fatigue, and pain.
A new Washington State University study shows that recurring inflammation linked to endometriosis can sensitize the nervous system, driving lasting pain. This finding helps explain why pain persists even after lesions are removed.
A new coaching tool helps users identify biases in their prompts and generate more inclusive content. The study found that the intervention increased users' awareness of algorithmic bias and boosted confidence, but led to a less satisfactory user experience.
A recent study reveals that MLKL activation causes direct damage to mitochondria, impairing energy production and leading to functional decline in hematopoietic stem cells. In contrast, deletion or inhibition of MLKL significantly alleviates these defects, suggesting a post-transcriptional mechanism driving HSC aging.
A new study finds that warmer winters will lead to faster water transit times in the western United States, negatively impacting summer water levels and quality. The research focuses on the Naches River basin, where snowpack declines have already resulted in earlier spring discharges.
The device exhibits outstanding performance across a broad optical spectrum, with high responsivity and specific detectivity. Its polarization-sensitive detection capability enables the direct deciphering of light's polarization state without external filters.
A new study published in The Journal of Nutrition suggests that the widely cited 'adiposity rebound' may reflect lean muscle growth, not increased body fat. Waist-to-height ratio, a measure that better reflects body fat, continues to drop despite BMI increases after an initial decline.
Researchers at Chiba University have found that a balance between photocatalytic and photothermal processes is necessary for efficient CO2 conversion. The team achieved high rates of CO2-to-methane conversion by controlling temperature and light intensity, providing a pathway toward designing more efficient catalysts.