Researchers discovered that a gene called ZNF750, active in skin cells, is essential for supporting Langerhans cells and building the body's first line of immune defense. The study found that ZNF750 controls the production of IL-34, a molecule released by skin cells that acts as a survival signal for Langerhans cells.
A review of 19 studies suggests healthier diets are associated with fewer depressive symptoms and greater psychological distress in adolescents. Whole-diet patterns and diet quality indices show more consistent associations with favourable mental health outcomes.
The International Telecommunication Union (ITU) has reaffirmed the need for critical cooperation on submarine cable resilience, with a focus on shortening repair times and supporting underserved regions. The Porto Summit Declaration and recommendations aim to bolster international cooperation across governments and industries.
Researchers identified DKK3 as a main cause of radiation-induced skin damage, leading to chronic inflammations and fibroses. Blocking DKK3 may help prevent or reduce long-term skin damage after radiotherapy, improving cancer patients' quality of life.
Researchers at the University of Cincinnati Cancer Center are developing a new treatment for glioblastoma, a highly aggressive brain cancer. The team is using 'glioblastoma-on-a-chip' technology and wafer delivery to stimulate the immune system and improve patient outcomes.
Researchers found that paid sick leave is linked to lower perceived infection risk, reduced job stress, and higher job satisfaction among home service workers. The study suggests that expanding paid sick leave can be a population-level prevention strategy during public health emergencies.
The vaginal microbiota is influenced by competition for specific nutritional resources, affecting health outcomes. A resource-based model identified key ecological mechanisms underlying microbiota composition and potential bacterial vaginosis interventions.
Researchers developed a single-use test strip detecting microRNAs in blood plasma, outperforming standard laboratory methods. The biosensor amplifies electrical signals to identify disease-indicative molecules at concentrations up to a trillion times lower than glucose.
A new hydrogel gel, inspired by nature's NETs, uses near-infrared light to kill bacteria and calm the immune system, promoting wound healing. Trials in mice and pigs show significant reduction in bacterial load and accelerated healing.
A team of physicists at UMass Amherst has proposed a new model for black holes, the 'dark charge' model, which explains high-energy neutrinos and solves cosmic mysteries. The model suggests that quasi-extremal primordial black holes, with a 'dark charge,' could be the missing link in explaining the universe's fundamental nature.
A new Concordia study finds that Montrealers face difficulties accessing fresh and healthy food due to inadequate public transportation and limited grocery store locations. The researchers recommend combining active transportation with public transit to increase accessibility to healthy food establishments.
The John Innes Centre has been awarded £21.5m in funding to support four precision breeding projects, aiming to reduce emissions and strengthen crop resilience. These projects will help protect two major agricultural crops from diseases, enhance the nutritional content of tomatoes, and develop sustainable sources of rubber.
A critically stressed fault has been identified in the Karoo Basin, which could be perturbed by potential shale gas exploration. The researchers used data from geophones and previously collected geophysical data to characterize and interpret the seismicity in the area.
The book argues that democratic systems must consider the interests of future people, promoting demographic vitality and egalitarian thinking. It also explores moral dilemmas surrounding unequal life chances and the tension between short-term security needs and long-term social investment.
A study published in Radiology found that photon-counting CT reduced radiation exposure by 66.34% and improved image quality compared to conventional CT in lung cancer patients. The technology also showed fewer adverse reactions, including contrast-induced acute kidney injury.
A novel viral vector, AAVT42, efficiently delivers therapeutic genes to the brain, restoring memory and protecting neuronal structures in multiple models of Alzheimer's disease. BDNF treatment achieves significant cognitive rescue, facilitating structural repair and suppressing harmful pathways.
A new study from the University of Notre Dame examines the prevalence, determinants and consequences of cheap stock options. The research found that firms granting more options, having larger public offerings and venture capital backing tend to have greater gaps between IPO prices and exercise prices.
The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) held its 12th plenary session in Manchester, UK, to agree on a landmark business and biodiversity report. The report provides evidence and options for action to measure and better manage business relationships with nature.
A three-year project utilizing GPS-enabled collars and mobile apps enables efficient rotational grazing, improving soil health and reducing farmer labor. Four Missouri producers have seen significant increases in cover crop utilization, with one producer reporting nearly double the value from the same acre of land.
Negotiations for a global plastics treaty stalled in August, hindering progress on addressing marine plastic pollution. Experts warn that current procedures lack prioritization and clear rules, jeopardizing efforts to tackle the crisis. The authors propose three key changes to revive talks and address the issue holistically.
The Society for Cardiovascular Angiography & Interventions has released an expert opinion on the use of wire-free angiography-derived physiology (ADP) in coronary artery disease assessment. ADP uses computational modeling or AI to analyze standard coronary angiographic images, offering a potentially more efficient and effective approac...
Researchers developed a comprehensive framework for dynamic digital product passports to track lifecycle changes in perishable goods, enabling earlier interventions to prevent spoilage and reduce waste. The technology could support more circular supply chains and improve transparency across food and drink supply chains.
Researchers discover GPX3 plays a central role in limiting inflammation, oxidative damage, and renal dysfunction following ischemic insult. Restoring GPX3 expression improves renal functional indices, reduces histopathological injury, and alleviates tubular epithelial cell death.
Researchers at Pohang University of Science & Technology developed a secure hologram platform that stores information using the wavelength of light and spacing between metasurface layers. The technology enables information processing using light alone, without electrical power or electronic chips.
Couzin's research focuses on quantitative behavioural biology, using advanced technology to study collective motion and decision-making. He has challenged conventional views of collective motion and influenced fields like robotics and the social sciences with his widely cited publications.
Researchers from TU Wien have provided a surprising explanation for the long-standing relation between magnetism and superconductivity in quantum materials. Altermagnetism, an unusual form of magnetism, is found to be experimentally observable in certain materials when superconductivity sets in.
Researchers at the University of Konstanz found that fruit fly larvae detect peers through multiple senses and adjust their behavior accordingly. The team used a genetically tractable system to study how brains process social information, revealing fundamental principles of decision-making across species.
Researchers analyzed LiDAR data to identify growth patterns associated with defoliation processes and mortality in artificial pine forests. The study found a link between high temperatures and increased defoliation, and suggests forest management policies should focus on regulating tree density through thinning programs.
New insights from the University of Groningen reveal how the size and arrangement of building blocks affect the mechanical properties of metamaterials. This knowledge can be used to design safer, longer-lasting implants, robotic hands, and energy absorbers.
A recent study published in Cell Biology and Toxicology found that high concentrations of nanoplastics can cause damage to kidney cells, leading to changes in cell shape, survival, and function. The research highlights the need for more investigations into the long-term risks of nanoplastic exposure on human health.
A new study from Brown University finds that temperatures in parts of the tropics may increase by up to 4.8 degrees C due to rising CO2 levels. This is significantly higher than previously predicted, highlighting the importance of studying regional climate mechanisms.
New research from the University of Illinois has found that corn's wild ancestor genes can inhibit nitrifying and denitrifying bacteria, reducing nitrogen loss and greenhouse gas emissions. The study shows reductions in nitrification of up to 50% in field and greenhouse trials, with potential huge impacts on sustainable agriculture.
Researchers found GXYLT2 promotes malignant phenotypes in diffuse-type gastric cancer cells, driving tumor progression through Wnt/β-catenin signaling. Targeting GXYLT2 or its downstream axis may provide a novel strategy for improving molecular stratification and therapeutic intervention in gastric cancer.
A new study by IIASA researchers found that education has a stronger association with lower premature mortality than income or household wealth in India. Adults with higher levels of education are less likely to die prematurely, regardless of their economic status.
Researchers have uncovered new clues about the evolution of ancient fish, including primitive lungfishes that lived over 400 million years ago. The discoveries were made using advanced technologies such as CT scanning and provide insights into the development of tetrapods, backboned animals with limbs.
Researchers deciphered the ionome of chloroplasts in various plant species, revealing similar metal concentrations and a crucial role for iron storage proteins. This study provides a foundation for developing new biotech concepts to improve plant resilience and nutrient content.
The Cavendish Laboratory and FormationQ have launched an applied quantum program using IonQ's technology platform to translate advanced research into real-world solutions. The partnership aims to build the institutional ecosystem for sustained adoption of quantum technologies.
Researchers have identified a new class of one-dimensional particles, dubbed anyons, which exhibit properties between bosons and fermions. The discovery opens up new possibilities for investigating fundamental physics in realistic experimental settings.
A study published in PNAS successfully eliminated pancreatic tumours in mice completely and durably, with no significant side effects. The treatment, combining three molecular targets, induced robust regression of experimental PDACs without causing tumor resistance.
Researchers studied a 78-qubit superconducting quantum processor subjected to random multipolar driving. The system exhibited a long-lived prethermal regime before rapid heating, with the plateau's lifetime depending on driving frequency. Entanglement spread across the system, violating classical simulation methods.
Randy Davis, MBA, has been named President of Vanderbilt Clarksville Hospital, a 270-bed facility joining Vanderbilt Health's network. He aims to improve operating performance and add programs and services to enhance the region's healthcare.
Researchers at Duke University have created a programmable Lego-like material that can change its stiffness and damping in response to temperature changes. The material, made from gallium and iron, can be programmed to mimic various commercially available soft materials.
A UC Irvine-led study suggests that high estrogen levels in the brain may increase women's risk of stress-related memory issues, such as post-traumatic stress disorder and dementia. Women are more likely to develop PTSD and face higher dementia risk due to hormonal fluctuations during stressful events.
A new axis-based data model resolves long-standing issues in Earth data grids, enabling more accurate, flexible, and interoperable data across science, policy, and industry. The framework clarifies grid structure, coordinate handling, and value interpretation, allowing for efficient querying of massive multidimensional datasets.
Researchers investigate real-world blockchain security incidents to extract representative attack patterns and categorize them into six classes based on standard blockchain architecture layers. The study also evaluates current detection and defense strategies, highlighting their strengths and limitations.
A new study using Victorian recordings from Lancaster University's archive found strong links between industrial growth and accent evolution in northern England. The Barrow-in-Furness accent developed due to intense population change and mixing, leading to distinct social histories and settlement patterns.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center developed a new zinc oxide formulation that significantly reduces the white, chalky cast associated with traditional mineral sunscreens. The tetrapod-shaped particles provide strong protection against UV radiation while staying evenly distributed in the sunscreen.
Research found that widespread contaminants like mercury and certain PFAS compounds affect the function of mitochondria in wild seabirds, potentially undermining fitness. The study measured pollutant levels and mitochondrial function in Scopoli's shearwaters and connected diet to exposure through stable isotopes.
George Coukos directs the Ludwig Laboratory for Cell Therapy at Weill Cornell Medicine's Sandra and Edward Meyer Cancer Center. The lab focuses on developing personalized cellular immunotherapies to optimize cancer treatment strategies.
MIT engineers have designed a 3D-printed floor truss system made from recycled plastic, which exceeds building standards set by the US Department of Housing and Urban Development. The printed flooring can hold over 4,000 pounds and weighs about 13 pounds per truss, making it a lighter alternative to traditional wood-based trusses.
A University of Calgary-led international research team has identified the runt-related transcription factor 1 (RUNX1) as a genetic factor influencing opioid responses. People carrying the RUNX1 variant require higher doses for pain relief and experience more intense withdrawal symptoms.
A nationwide study found that trazodone reduces the risk of death and rehospitalization among older adults with delirium. Trazodone may offer a safer alternative to antipsychotic drugs, particularly when medication use cannot be avoided.
A clinical prediction model called the Goliat score can estimate the risk of acute complications in patients with minor and moderate traumatic brain injuries. The model, developed by researchers at UOC and IRBLleida, uses easily accessible variables to predict neurological or cardiorespiratory complications and mortality within 48 hours.
Researchers at Monash University have discovered a way to permanently switch off cancer-causing genes, potentially leading to shorter treatment periods and reduced side effects. The breakthrough uses epigenetic therapy, targeting specific proteins that keep cancer-promoting genes switched on.
Researchers found that warmer waters and commercial fishing lead to smaller meals for predators, resulting in reduced energy intake. This can weaken predators and make marine ecosystems more fragile. The study suggests managing climate change and fisheries together is essential to protect marine food webs.
Researchers found OXCT1 to be a key regulator of colorectal cancer liver metastasis, with low expression linked to increased metastasis. OXCT1 suppression promotes oncogenic signaling through the CDK8/beta-catenin complex, highlighting its potential as a novel therapeutic target and prognostic biomarker.
Researchers found molecules such as syringic acid that protect neurons from aging, while others like resveratrol promote neurodegeneration. An AI-powered approach identified potential therapeutic substances to preserve brain function and prevent neurodegenerative diseases.
A study by the University of Córdoba reveals that olive pomace oil extraction is the most sustainable alternative for managing olive oil industry byproducts. The methodology considers economic, environmental, and social indicators, concluding that this option is economically attractive while also offering significant environmental bene...
The ESMT Berlin DEEP Institute and Creative Destruction Lab will be launched in Doha to support technology transfer and innovation. The initiative aims to connect the innovation ecosystems of Germany and Qatar, fostering entrepreneurial growth and driving economic growth.
NTU Singapore has unveiled its first locally designed and built full-sized eVTOL aircraft technology demonstrator, combining aerodynamic efficiency with hovering capability. The aircraft was developed over three years by researchers and engineers, powered by NTU-designed electric motors and featuring eight lift rotors.