Lauren Stern, a clinical associate professor of medicine at Boston University School of Medicine, has been recognized for her significant contributions to medical student education. She directs the Integrated Renal Physiology and Pathophysiology curriculum and serves as a field-specific advisor for fourth-year medical students.
Dr. Lisa M. Satlin, a renowned pediatrician-scientist, has been awarded the ASPN Founders' Award for her lifetime contributions to pediatric nephrology through research, education, and clinical care. She has advanced understanding of kidney function and development, with significant implications for hypertension and kidney disease.
AI models can analyze complex data to predict disease progression and identify early signs of kidney damage. This allows for earlier detection and better treatment planning, making a significant impact on patient outcomes.
The American Kidney Fund has awarded over $6 million in grants to researchers Dr. Sophie Claudel and Dr. Liz Kiernan, exploring the connection between kidney disease and cardiovascular health. Their studies aim to develop new treatments and improve diagnostics for patients with chronic kidney disease.
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
Vertebral fractures are a devastating complication of advanced kidney disease, associated with increased risk of further fractures and cardiovascular events. The first global consensus statement offers practical recommendations for clinicians to identify and manage vertebral fractures in patients with chronic kidney disease stages G4–G5D.
Researchers review current evidence on extracellular vesicles' interaction with renal tubular epithelial cells, showing protective effects against damaged tubular cells. However, challenges remain to overcome, such as biodistribution and targeting issues.
High-impact clinical trials are generating promising results for improving kidney health, according to recent studies. These trials are paving the way for innovative treatments and therapies to combat kidney diseases.
Recent clinical trials have demonstrated significant benefits in kidney health, including improved patient outcomes and reduced disease progression. These findings have the potential to revolutionize treatment approaches for patients with kidney disease.
High-impact clinical trials have generated promising results for improving kidney health, according to a recent study. The findings suggest that these trials may lead to better treatment options and improved patient outcomes.
A new study from the University of Cincinnati College of Medicine calls for more extensive nephrology fellowship training on reproductive health. Females with CKD face increased risks of high-risk pregnancies, preeclampsia, and preterm births, yet their contraceptive use remains relatively low.
The conference explores how generative AI is reshaping kidney medicine through AI-driven diagnostics, data integration, and omics analysis. Key findings include the use of LLMs to transform diagnostic precision, patient management, and research design.
A retrospective cohort study found system-based disparities in pre-dialysis nephrology care contribute to 1/3 of incident vascular access disparities among Hispanics. Targeted policies are needed to improve timely identification and referrals for equitable improvements in kidney failure outcomes.
Researchers discovered that immune hubs in the kidney create a unique metabolic environment, accumulating glutathione to counter oxidative stress. Blocking this process prevents TLS formation or causes existing structures to shrink. Urine glutathione levels can serve as a non-invasive biomarker for TLSs and disease progression.
Researchers have identified biomarkers that can predict and manage chronic kidney disease (CKD), offering a more nuanced understanding of patient disease progression and mortality risk. A combination of biomarkers, including sTNFR1 and hs-cTnT, were found to be comparable in predicting kidney failure and all-cause mortality.
Researchers at CRCHUM have discovered a crucial biomarker, miR-423-5p microRNA, to predict kidney function and diagnose chronic renal failure. The breakthrough could lead to early diagnosis, targeted approaches, and improved treatment options for millions of patients worldwide.
A new inpatient onconephrology service has been established to care for patients with cancer and kidney disease, resulting in improved kidney recovery rates. The study found that patients treated by the dedicated service were more likely to have kidney recovery at discharge compared to those treated by general nephrology services.
Researchers have developed a novel gene therapy called PS-002, which targets podocytes and blocks complement activation to treat IgA nephropathy. In mouse models, treatment with PS-002 reduced signs of kidney dysfunction and lowered complement deposition, while in pigs, it resulted in elevated gene expression without safety issues.
New phase 3 clinical trials show potential for improving kidney health outcomes with targeted therapies, such as pegcetacoplan and semaglutide. These studies have the potential to revolutionize kidney care and treatment.
A recent study found that GLP-1RA medications are not associated with an increased risk of acute kidney injury (AKI) in patients receiving anti-cancer therapies. Researchers analyzed medical records of 14,783 patients and discovered a lower incidence of AKI among those taking GLP-1RA compared to those without exposure.
Recent phase 3 clinical trials have generated promising results for improving kidney health, including finerenone and semaglutide's effects on kidney parameters. These findings will be presented at ASN Kidney Week 2024.
The grant will create the Urinary Stone Disease Hub, combining medical expertise across adult and pediatric urology and nephrology, informatics, and AI to establish a novel data resource. The hub will include clinically important information from CT images, clinical notes, stone composition, and 24-hour urine labs.
A large-scale prospective cohort study found a positive association between regular mobile phone use and incident cardiovascular disease risk, particularly in smokers and individuals with diabetes. Poor sleep patterns, psychological distress, and neuroticism may be key mechanisms underlying this association.
Researchers analyzed 51,000 transplants and found rejection and graft failure rates were similar for toxoplasma-positive and negative donor kidneys. The study suggests it is safe to transplant toxoplasma-positive kidneys with additional monitoring, potentially increasing the supply of donor kidneys.
The DRIVE-RM consortium, led by UMC Utrecht, aims to develop smart materials that assist the body in healing and regenerate tissues and organs using regenerative medicine. The project focuses on treating chronic diseases such as heart failure, kidney failure, and worn joints.
A University of Cincinnati study developed a scoring model that uses key health indicators to predict kidney recovery in patients with acute kidney injury (AKI). The study found that around one-fourth of patients recover within 90 days and around one-third recover within 12 months.
A clinical trial found that an experimental drug, BI 690517, reduced albuminuria in 70% of patients when paired with a standard-care medication. The study also showed that the combination of the two drugs mitigated the risk of hyperkalemia.
A clinical study found that a ketogenic diet can improve kidney function in patients with hereditary polycystic kidney disease. After three months, positive changes were seen in key parameters, with no unexpected side effects.
Results from high-impact clinical trials will be presented at ASN Kidney Week 2023, offering potential improvements in kidney-related medical care. The trials bring together leading experts and professionals to exchange knowledge and discuss the latest advances.
Researchers analyzed 43 clinical trials and found that trial participants were less diverse than actual transplant recipients in the US. The study suggests that efforts are needed to improve participant diversity in clinical trials to better reflect real-world patients.
Researchers found a positive association between elevated urinary albumin and sub-clinical coronary artery pathology, including microcalcifications, in individuals with type 2 diabetes without symptoms of cardiovascular disease. Microcalcification activity was higher in those with albuminuria, indicating potential kidney damage.
Researchers have created a comprehensive atlas of human fetal kidney development, revealing transitions between different cell states. The study identifies key genes associated with rare genetic diseases and offers insights into the heritability of adult kidney traits.
A new study investigated the safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with diabetes who also have cancer. The research revealed a higher risk of diabetic ketoacidosis and fracture, but lower risks of acute kidney injury and urinary tract infection compared to another diabetes medication called GLP-1 RA.
Researchers found that vancomycin treatment reduced inflammation in the kidney and increased beneficial bacteria, while polymyxin B showed no significant effect. The study suggests modifying gut microbiota through antibiotic administration may help alleviate hypertensive organ damage.
A new Japanese ecological study found that prefecture-specific SHC participation rates significantly negatively affect treated ESKD incidence and CKD prevalence. Higher SHC participation rates are associated with lower ESKD incidence, suggesting the importance of regular health checkups at a population level.
A study by UC San Francisco researchers found that patients with acute kidney injury on outpatient dialysis may not need lifelong treatment if they have the potential to recover. The study tracked data from over 1,700 patients and showed that approximately three-quarters of those who recovered kidney function discontinued dialysis with...
A five-year, $6.15-million NIH grant has enabled six North Carolina institutions to collaborate on advancing the science of nephrology, hematology, and urology. The NC KUH TRIO Program aims to train the next generation of researchers and foster academic and professional development across disciplines and institutions.
A study of over 15,000 individuals with chronic kidney disease found that young age, Black race, and low education and income were linked to lower flu vaccine uptake. The study suggests that targeted vaccination efforts could improve uptake among those with kidney disease.
Researchers found that urine levels of adenine are predictive and causative biomarkers of looming progressive kidney failure in patients with diabetes. An oral therapeutic drug showed promise in mice by reducing kidney adenine levels and protecting against diabetic kidney disease.
Researchers analyzed electronic health record data from over 7.1 million children to identify risk factors associated with a faster decline in kidney function, including disease origin, proteinuria, hypertension, and younger age. The study found that certain attributes are linked to a more rapid decline in kidney function, providing va...
A recent analysis of COVID-19 cases in four waves found that individuals with chronic kidney disease were more likely to develop severe forms of COVID-19 and experience complications. Pre-existing conditions, including CKD, were consistent clinical predictors of COVID-19 severity across multiple pandemic waves.
The COVID-19 pandemic has significantly increased the mortality risk of hemodialysis patients, with risks persisting at higher levels for those with confirmed infections. Other patients on dialysis experienced slightly elevated mortality risk during peak pandemic periods.
The American Society of Nephrology presents results from high-impact clinical trials that could transform kidney-related medical care. The trials will focus on improving patient outcomes and advancing the treatment of kidney diseases.
Research analyzed 350,994 participants and found that higher air pollution concentrations increased the risk of developing chronic kidney disease. Individuals with high air pollution exposure and low genetic risk faced a significantly higher risk of developing CKD compared to those with high genetic risk.
Researchers developed an AI-based algorithm to predict major adverse kidney events within 90 days of discharge. The algorithm accurately predicted 19.7% of patients' development of acute kidney injury or chronic disease.
An AI-based model has been developed to predict patients' risk of acute kidney injury (AKI), which is common in intensive care units. The model was validated in four medical centers and showed accuracy in predicting AKI 24 hours ahead of time.
Dr. Susan E. Quaggin, a leading expert in kidney health, has been recognized as one of seven Distinguished Scientists by the American Heart Association. Her groundbreaking research on transcription factor action and vascular endothelial growth factor has led to new insights into pre-eclampsia and kidney disease.
A study published in the New England Journal of Medicine found that new onset CKD rates are higher among Native Hawaiian/Pacific Islander, Black, American Indian/Alaska Native, and Hispanic/Latino populations compared to white persons with diabetes. The rate declined from 8% in 2015-2016 to 6.4% in 2019-2020.
A study published in the American Society of Nephrology found that one-third of patients with chronic kidney disease experienced worsening symptoms over time, leading to a higher risk of needing dialysis and death. The study identified two profiles of symptom trajectories: those with worsening symptoms and those with stable symptoms.
Experts recognize obesity as a prime inducer of CKD and related adverse outcomes, emphasizing the need for bridging common ground between nephrology and obesity medicine. Strategies include recognizing obesity as a chronic disease with targeted treatments and trained clinical extenders to promote effective care.
Researchers at UT Southwestern have identified a gene therapy target for polycystic kidney disease (PKD), which could lead to the arrest or cure of the condition. By blocking the inhibition of PKD1 and PKD2 gene expression, the researchers found that kidney cyst growth was hindered in ADPKD models.
Researchers at Washington University have developed a hydrogel system that preserves biochemistry and mechanical environments of cultured podocyte cells. This allows researchers to identify new ways to control mechanisms used by cells to heal themselves, potentially leading to therapies for currently incurable diseases.
A new study published in Pediatric Transplantation found that pediatric kidney transplant patients have better long-term outcomes when their kidney comes from a living donor. The study analyzed data from the Organ Procurement and Transplant Network database and compared the rates of graft failure and death among children who received k...
A new study at Stellenbosch University identified significant knowledge gaps among medical specialists regarding the emergency management of hyperkalaemia. The researchers recommend starting therapy when potassium levels reach 6 mmol/L or higher, performing an ECG on all patients, and monitoring for hypoglycaemia.
Contraceptive use is low among women with kidney transplants in the US, with an overall rate of 9.5%. Younger age and certain racial/ethnic groups are associated with higher likelihoods of contraceptive use, while socioeconomic status and donor type do not impact rates.
A new study reveals that in many countries, there are significant gaps in care related to the importance of nutrition for maintaining kidney health. Nutritional interventions can slow kidney function decline and reduce symptoms.
Despite receiving three vaccinations, kidney transplant patients have inadequate cellular and humoral protection against SARS-CoV-2, with around 90% showing little to no protection. Researchers are now investigating the efficacy and safety of a human antibody cocktail in these patients.
A study surveyed AKI survivors to reveal its physical, social, and emotional effects. The results show the need for interventions to improve health-related quality-of-life for AKI patients.
A survey of US transplant centers found a consensus to remove race-based adjustments from kidney function calculations, but also acknowledged potential harms of dropping the adjustment. The study aims to reduce healthcare disparities and improve patient care.