African-American patients with chronic kidney disease have a faster decline in kidney function due to genetic variations, particularly the APOL1 gene variant. The study suggests that reducing the effect of this gene could lead to a significant decrease in progressive kidney and end-stage kidney disease in blacks.
A new study by Johns Hopkins Medicine found that young and middle-aged women with type 2 diabetes are at a significantly increased risk of coronary artery disease, comparable to men's risk. The study analyzed data from over 10,000 participants and suggests distinct genetic and hormonal factors may contribute to the higher risk.
Researchers say Chagas disease remains a leading cause of heart disease in impoverished North American communities, with inadequate healthcare and limited treatment options available. The editorial calls for increased medical awareness, scientific cooperation, and public-private partnerships to develop new tools and treatments.
A global collaboration of researchers has identified 11 new genetic areas of interest contributing to late onset Alzheimer's Disease. The study expands the scope of disease understanding to include new areas such as the immune system, where a genetic overlap with other neurodegenerative diseases was found.
Patients with moderate to severe psoriasis are at increased risk of developing chronic kidney disease, particularly those with severe disease. Closer monitoring and careful consideration of medications are recommended for this patient population.
Researchers identified 13 metabolites that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls. Twelve of the metabolites are linked to mitochondrial function, suggesting suppressed mitochondria as a fundamental characteristic of diabetic kidney disease.
Two studies published in BMJ Group found a significant association between aircraft noise exposure and cardiovascular disease hospital admissions. The research suggests that even low levels of daytime and night-time aircraft noise can increase the risk of heart disease, particularly among vulnerable populations.
A new MRI technique has been developed to detect Fabry disease, a genetic condition that affects the heart, brain, and nerves. The T1 mapping test can identify microscopic changes in the heart muscle structure that are not visible on regular images, allowing for early detection and treatment.
A new research chair will focus on developing innovative strategies for preventing and treating Alzheimer's disease, including early detection tools and less toxic therapeutic molecules. The goal is to improve patient quality of life and alleviate symptoms rather than control the disease.
A new analysis finds that patients with chronic kidney disease are being prescribed statins inappropriately, despite no proven benefit. The study recommends lower dosages for early-stage kidney disease to minimize risks such as muscle pain and diabetes.
Researchers have identified a promising avenue for early diagnosis of Alzheimer's disease through non-invasive brain wave analysis. The study found statistically significant differences in brain wave patterns between healthy individuals and those with mild to moderate Alzheimer's disease.
Researchers used PET scanning to map changes in brain metabolism in Huntington's disease gene carriers, identifying a characteristic network of abnormalities. This finding enables the tracking of disease progression and will aid in evaluating the effects of new drugs before symptoms appear.
Researchers at the University of Leicester have discovered a potential molecular defence against Huntington's disease, a fatal neurodegenerative disorder. Glutathione peroxidase activity was found to be robustly protective in models of the disease.
A Penn study found that psoriasis patients with more severe skin disease are at higher odds of having major medical diseases, including lung disease, heart problems, and kidney issues. The researchers identified a common pathway involving TH-1 cytokines promoting inflammation and insulin resistance.
A new definition of chronic kidney disease labels over 1 in 8 adults as having the disease, but low rates of kidney failure suggest many may never progress to severe disease. Experts argue that this is evidence of overdiagnosis and call for greater scrutiny and public awareness.
Researchers at McMaster University have developed a method to measure the shape of the huntingtin protein in living cells, revealing a key clue to solving Huntington's disease. The team discovered that the mutant huntingtin protein causing disease changes shape and can be corrected with chemicals.
A new study published in The Lancet found that calcium supplements may increase the risk of heart disease and death in patients with kidney disease. Patients who took non-calcium based treatments had a lower risk of death compared to those who took calcium supplements, highlighting the potential dangers of long-term use.
A recent study conducted at the University of Eastern Finland found that early diagnosis and treatment of Alzheimer's disease can significantly reduce psychological and behavioral symptoms. Persons with a very mild Alzheimer's disease diagnosed at an early stage are better able to manage their daily activities than those diagnosed at a...
A new study published in Hepatology reveals that higher body mass index (BMI) is associated with an increased risk of gallstone disease, especially in women. The research found a significant correlation between BMI and gallstone risk, with women facing a higher risk than men.
A large study found that people with Alzheimer's disease had a cut in half risk of developing cancer, and those with cancer had a reduced risk of developing Alzheimer's by 35%. The researchers controlled for life expectancy to confirm the findings.
A recent Penn study found a significant association between cerebrovascular disease and dementia, particularly in younger patients with Alzheimer's disease. The researchers suggest that early management of vascular risk factors and healthy lifestyles may delay or prevent the onset of dementia due to Alzheimer's and Parkinson's disease.
Researchers successfully mobilize brain's native stem cells to replenish neurons lost in Huntington's disease. The study demonstrates the feasibility of a completely new concept to treat the disease by recruiting endogenous neural stem cells to regenerate cells, significantly extending survival of treated mice.
A new study found that increased serum iron levels are associated with a 3% relative reduction in the risk of developing Parkinson's disease. The research used a Mendelian randomization approach to investigate the link between iron levels and Parkinson's disease risk.
Research published in The Journal of Nuclear Medicine found that highly educated pre-Alzheimer's patients exhibit increased neural reserve and compensation, leading to better coping mechanisms. This suggests that education level plays a crucial role in determining cognitive reserve against the disease.
Defects in cellular trash removal processes lead to toxic protein build-up and neuronal damage in Gaucher disease, mirroring Parkinson's disease pathology. Researchers suggest targeting mitochondrial function to develop treatment strategies for both diseases.
A nationwide study reveals that heredity plays a significant role in common forms of atherosclerotic disease, with risk highest for individuals with family history. The study found a strong correlation between early-onset aortic atherosclerosis and increased risk of developing the same type of disease.
A study published in the Journal of the American Society of Nephrology found that LDL cholesterol is not a reliable indicator of heart disease risk in patients with kidney disease. Patients with very low kidney function were more likely to have a heart attack, regardless of their LDL levels.
A national study estimates 2.9 million Canadian adults have chronic kidney disease, a risk factor for death and significant healthcare burden. High blood pressure and diabetes are more common among those with chronic kidney disease.
A research team led by Nalini Santanam is investigating the epigenetics of pain in endometriosis, with preliminary findings suggesting that epigenetic markers may play a role in the disease's development. The team hopes to find new biomarkers for diagnostics and personalized treatment approaches.
A large-scale genetic study has associated nine new genetic regions with primary sclerosing cholangitis (PSC), a rare autoimmune liver disease. The study definitively proves PSC is a distinct disease, despite its genetic relationship to inflammatory bowel disease (IBD).
A recent study found that African Americans with kidney disease who experience large fluctuations in blood pressure are nearly three times more likely to die prematurely. Monitoring and addressing these day-to-day changes may improve health outcomes.
Researchers found that participants with preclinical Alzheimer's disease had poorer sleep efficiency and spent less time asleep than those without markers of the disease. Early evidence suggests a possible connection between sleep loss and brain plaques, a hallmark of Alzheimer's disease.
Researchers at the University of Alberta have made a breakthrough in understanding how prion diseases spread between different types of animals. By studying the adaptation process, they aim to determine why certain strains can infect one type of animal but not another.
A psychiatrist proposes a new subspecialty to address the link between depression and heart disease. Interleukin-6 levels were found to be higher in depressed patients than healthy controls.
A genetic mutation causing Pompe disease has been found in both humans and dogs. A genetic test can now diagnose canine Pompe disease, allowing for the identification of affected individuals and their breeding lines. This breakthrough could lead to improved treatment options and disease management.
Researchers found that cured Cushing's disease patients who had depression when symptoms started were at elevated risk of mortality and cardiovascular disease. Men were more susceptible than women due to a lack of follow-up care, while patients with diabetes were also at higher risk of developing cardiovascular disease.
A new enzyme therapy has significantly delayed the onset and progression of symptoms in dogs with Batten disease, a rare genetic disorder affecting children. The treatment, developed by MU and BioMarin researchers, replaces the deficient enzyme and is administered into the spinal fluid, slowing brain degeneration and extending survival.
A study at the University of Liverpool found that disease risk in ladybirds cannot be predicted without understanding disease dynamics at a small geographical scale. The researchers discovered that differences in mating rates across habitats, driven by food supply, contributed to varying disease outbreak sites.
Chagas disease infects an estimated 10 million people worldwide, causing significant economic burden, including USD $6.7 billion in future healthcare costs in the United States.
Research suggests that being overweight is a risk factor for gum disease, which can lead to chronic inflammation and other health issues. Daily brushing, flossing, and professional cleanings are essential for preventing gum disease and maintaining good oral health.
A major new study has found that men with erectile dysfunction are at higher risk of hospital admission for heart disease and premature death. The research, which examined data from over 95,000 men, also showed a direct link between the severity of erection problems and the risk of cardiovascular events.
A study found that among individuals with diabetes, those with both diabetes and kidney disease have a mortality rate of 31.1%, compared to 11.5% for those with diabetes but without kidney disease. Preventing and treating kidney disease in diabetics may be crucial to reducing mortality risk.
A study published in the Canadian Medical Association Journal found that women with hypertensive disorders during pregnancy are at higher risk of chronic kidney disease and end-stage renal disease. The study analyzed data from over 26,000 women in Taiwan and found an increased risk of end-stage renal disease among those with preeclamps...
Researchers at UCSF and Kaiser Permanente have found that atrial fibrillation significantly increases the risk of end-stage renal disease among patients with chronic kidney disease. The study involved over 206,000 adults and showed that those who developed atrial fibrillation were 67% more likely to progress to kidney failure.
Researchers found no correlation between Parkinson's disease itself and impulse control symptoms, contradicting previous studies. The study suggests that dopamine-related medications may be the primary cause of these disorders.
Researchers have identified four new regions on the human genome linked to Behcet's disease, which is characterized by inflammation of blood vessels and potential blindness. The study provides insights into genetic factors contributing to the disease and suggests new therapies for treatment.
A new urine test using protein biomarkers may enable early diagnosis and treatment of Kawasaki disease, a rare but increasingly prevalent condition that can cause inflammation of blood vessels and lead to heart attacks. The test has shown promising results in distinguishing children with Kawasaki disease from those with other conditions.
Infants with severe RSV disease may have a dysfunctional innate immune response that relates to the severity of their disease. Immune monitoring could help identify children at high-risk for severe disease, and may lead to the use of immune stimulant drugs to reverse innate immune suppression.
Scientists from VIB and KU Leuven discovered a new target molecule to develop a treatment against Alzheimer's disease. β-arrestin 2 plays a role in regulating the γ-secretase complex function and development of the disease. This research opens a new avenue for treating the disease at an early stage.
A study found that exercise programs on stationary bicycles improve Parkinson's disease symptoms, with faster pedaling leading to greater brain connectivity and motor ability improvements. The therapy is low-cost and effective, even for patients who don't need forced-rate exercise.
Current risk models have modest-to-acceptable discriminatory performance but require better calibration and external validation to inform clinical guidelines. Few studies tested the models in diverse populations, highlighting the need for further research.
A new factor of genetic susceptibility to Alzheimer's disease has been identified through a large-scale international study. Mutations in the TREM2 gene on chromosome 6 are associated with a five times greater risk of developing late-onset Alzheimer's disease, according to researchers.
A new study published in JAMA found that chronic kidney disease and its complications are associated with a higher risk of death regardless of age. Both low kidney function and high albuminuria were independently linked to mortality and end-stage renal disease, according to the findings.
Researchers developed a method to differentiate patients with Alzheimer's disease from those with other types of dementia using biomarkers in cerebrospinal fluid. The study analyzed five proteins and found that they could accurately diagnose Alzheimer's disease, as well as distinguish it from Parkinson's disease and Lewy body dementia.
A study published in JAMA found that high plasma levels of proneurotensin are associated with an increased risk of developing diabetes, cardiovascular disease, and breast cancer in women. The study also found a significant interaction between sex and proneurotensin on the risk of cardiovascular disease.
The American Academy of Neurology has released a new guideline to help doctors diagnose Creutzfeldt-Jakob disease, a rare and always fatal brain disorder. The guideline suggests that the 14-3-3 protein test can be useful in reducing uncertainty when the probability of the disease is between 20% and 90%.
The study found that women with heart disease can safely go through pregnancy if adequately evaluated, counseled, and receive high-quality care. However, developing countries have poorer outcomes due to limited access to better care, while cardiomyopathy patients face higher mortality rates.
Researchers found reducing copper in mice with prion disease delays onset by 20 days, with less abnormal protein in brains. However, study does not advocate for copper depletion as therapy and aims to learn more about copper function and prion disease biochemical workings.
A study found that rheumatoid arthritis patients are four times more likely to develop gum disease, with severe cases associated with increased inflammatory markers and antibodies. Gum disease in these patients may contribute to the development and maintenance of systemic inflammation.
A Mayo Clinic-led analysis found that approximately 1.8 million Americans suffer from undiagnosed celiac disease, while 1.6 million use a gluten-free diet without medical confirmation. The study highlights the need for increased awareness and testing to accurately diagnose and treat this common condition.