A genetic clue has been uncovered for Parkinson's disease, a progressive movement disorder affecting millions worldwide. GIGYF2 mutations have been found to be directly linked to the development of Parkinson's in people with a family history of the disease.
Researchers have discovered that heart hormones can eliminate human pancreatic and breast cancers in mice, reducing tumors by up to 97%. The treatment has shown no side effects and has the potential to make cancer a chronic condition.
Researchers found a genetic link to cold sore susceptibility on chromosome 21, identifying six candidate genes. This discovery may lead to the development of new drugs to reduce the frequency of herpes outbreaks and improve treatment options for millions affected by the virus.
Researchers create a localized and controlled drug delivery system that is invisible to the immune system, providing a potential solution for cancer and other diseases. The system uses nanoscale polymer films to slowly release anti-inflammatory drugs, reducing side effects and enhancing treatment efficacy.
The journal has added several Asian researchers to its Editorial Board, including Professor Huan-Yao Lei as the first Asian Editor. An Asian office will open at NCKU Medical Center in Taiwan, increasing visibility of EBM and SEBM throughout Asia Pacific scientific communities.
A new study found that levo-thyroxine treatment did not lower weight or BMI in children with acquired hypothyroidism. Most subjects gained weight, while about a third experienced short-term weight loss due to extremely severe cases of the disease.
Researchers found that vitamin D2 is equally effective as vitamin D3 in maintaining 25-hydroxyvitamin D status, especially in people with vitamin D deficiency. The study showed similar increases in serum 25-hydroxyvitamin D levels for both vitamin D2 and D3.
Researchers at Vanderbilt University developed an RNA interference therapy that corrects a genetic disorder causing growth deficiency in mice. The therapy successfully restored normal growth and function to the pituitary gland, which produces growth hormone.
Researchers at Yale University found that an antibody used to treat certain cancers and rheumatoid arthritis delays type 1 diabetes in mice. The treatment works by depleting B cells, which can continue to suppress the inflammatory response even after the antibody is no longer administered.
Researchers found that activating a protein in muscle tissue increased average lifespan and prevented some age-related diseases in mice. The protein, uncoupling protein-1, converts energy from food into heat and mimics the effects of exercise.
Researchers at UC Davis Health System have identified a novel pathway that contributes to increased inflammation of blood vessels in type 1 diabetes patients. This finding may lead to the development of new treatments to reduce cardiovascular disease risk by controlling inflammation.
Researchers propose a broader approach to uncovering the causes and consequences of obesity, highlighting similarities in cell responses to excess nutrients. This understanding might reveal why overeating leads to various diseases and explain animal longevity on calorie-restricted diets.
Researchers at the University of Virginia Health System have identified a key enzyme involved in the development of Type 1 diabetes. The discovery, centered on the 12/15-lipoxygenase gene, has significant implications for understanding and treating the disease, with potential applications for preventing or reversing Type 1 diabetes.
A Northwestern University study found that a high-fat diet disrupts the body's internal clock, causing animals to eat during their natural rest periods. The study suggests that this disruption can lead to negative effects on metabolism and increase the risk of obesity and diabetes.
A large study found that adult height significantly impacts quality of life, with short individuals experiencing lower physical and mental well-being. Increasing height by a small amount can improve perceived health, equivalent to losing significant weight for obese individuals.
Scientists at Jefferson University have found a new molecular evidence of the role of prolactin in breast cancer. The hormone stimulates a signaling pathway that may regulate the growth and survival of breast cancer cells. Inhibiting the Jak1 protein could represent a new drug target for treating breast cancer.
New research supports the cardiovascular safety of ACTOS (pioglitazone HCI) and its benefits in improving blood glucose and lipid levels. The study found that therapies including pioglitazone are associated with significant reductions in the risk of stroke or myocardial infarction compared to non-thiazolidinedione therapies.
The Oregon Health & Science University School of Medicine is part of a national team researching ways to preserve or restore fertility in women with cancer. Researchers are studying methods to freeze and store ovary tissue and grow follicles in culture, aiming to help young cancer patients have children.
A study from the University of Pittsburgh Schools of the Health Sciences found that maternal vitamin D deficiency early in pregnancy is associated with a five-fold increased risk of preeclampsia. Low vitamin D levels also affect newborns, increasing their risk of mortality.
The university's Task Force for Obesity Research will tackle key molecular pathways, develop new approaches to prevent obesity and treat associated metabolic complications. Researchers will use data from the Dallas Heart Study and provide interdisciplinary training for postdoctoral fellows.
Scientists have discovered a new mechanism by which insulin-secreting cells regulate KATP channels, allowing for timely energy supply and storage of blood sugar. This discovery sheds light on how the human body maintains normal blood glucose levels and prevents diabetes.
Scientists have discovered that glucose-sensing neurons play an important role in regulating blood glucose levels in mice with obesity-induced Type 2 diabetes. The study found that defects in these neurons contribute to the disease's progression and may be targeted by novel therapies.
Researchers at Columbia University Medical Center have discovered that the skeleton acts as an endocrine organ, releasing osteocalcin to regulate blood sugar and fat deposition. This hormone boosts insulin sensitivity and enhances insulin-producing cells, preventing type 2 diabetes in mice.
A study published in Science found that maintaining a healthy lifestyle through diet and exercise can extend lifespan by reducing insulin-like signaling in the brain. The researchers discovered that mice with reduced insulin receptor substrates lived 18% longer, while also showing improved metabolic health.
A new study finds that reducing insulin signaling in the brain can lead to a longer lifespan, with genetically engineered mice living up to 18% longer. This breakthrough suggests that diet and exercise may be key to preventing age-related diseases.
A national study found that ICSI use for male-factor infertility has increased significantly, with a stable proportion of patients receiving treatment. States with mandated insurance coverage showed greater use of ICSI beyond male-factor infertility indications.
Researchers at McGill University Health Centre have identified a new gene involved in type 1 diabetes, bringing the total to five genes responsible for the disease. The discovery using high-density DNA microchip technology provides a promising step towards developing effective treatments and prevention methods.
A combination of calcium and vitamin D found in milk may offer protection against type 2 diabetes, with a 15% lower risk among individuals consuming the most dairy. Additionally, magnesium intake from milk products may also reduce type 2 diabetes risk by 15%.
A new study published in Annals of Internal Medicine found that dietary counseling results in significant weight loss, with 10-15 pounds lost after one year. Moderate weight loss reduces diabetes, cholesterol, and blood pressure risk, making a lasting impact on overall health.
Endurance exercise experts recommend limiting fluid intake during prolonged activities to prevent exercise-induced hyponatremia (EAH), a potentially lethal water intoxication. Excess drinking can lead to diluted sodium levels in the blood, posing risk to athletes engaging in 4-hour or longer endurance events.
Pediatricians now have a practical tool to help determine whether children with chronic diseases like Crohn's, juvenile arthritis and anorexia nervosa are at increased risk for bone mass deficiencies, fracture or osteoporosis as they get older. Researchers developed standardized data on bone mass categorized by sex, age, and race.
Researchers at Beth Israel Deaconess Medical Center have identified a key mechanism behind the turn of events when high-fat, low-carbohydrate diets cause demonstrable changes in metabolism and subsequent weight loss. FGF21, a liver hormone, is required to oxidize fatty acids and burn calories.
Cedars-Sinai researchers presented innovative insights into the pituitary gland's link to systemic illness, mental disorders, and aging. They also showcased advancements in subcellular mechanisms and treatment outcomes for patients with acromegaly, a growth hormone disorder.
Researchers at Jefferson Medical College found that a natural substance secreted by fat cells can protect blood vessels from inflammation, a factor in heart disease. Harnessing adiponectin's properties may someday help protect against blood vessel damage in patients with obesity and diabetes.
Researchers at Cedars-Sinai are studying a gene that may play a role in the development of polycystic ovary syndrome (PCOS), a condition characterized by insulin resistance, hirsutism, and other symptoms. The study aims to better understand the molecular mechanisms underlying PCOS and potential markers for risk.
Research shows that treating subclinical hypothyroidism with thyroid hormone improves symptoms, cholesterol levels, and reduces heart disease risk. Patients experience increased energy, weight loss, and improved quality of life.
Researchers have successfully engineered adult stem cells from human cord blood to produce insulin, a potential breakthrough in treating type 1 diabetes. The discovery uses complex signals produced by embryonic mouse pancreas to direct adult stem cells into islet-like cells, producing C-peptide and insulin.
Early onset type 2 diabetes in adolescents is associated with rapid progression of complications, including hypertension, nephropathy, retinopathy, and psychiatric disorders. The unborn children of pregnant young women are also at increased risk.
The University of Illinois at Chicago has received a $7 million grant from the National Institute of Child Health and Human Development to study endometriosis and its effects on fertility. The research aims to develop new therapies and better understand embryo implantation and pregnancy.
The Immune Tolerance Network, a seven-year-old international consortium, has secured significant NIAID funding to develop new therapies for autoimmune diseases. The network's focus on immune tolerance and biological markers aims to create individually targeted treatments.
Researchers found HIV-infected patients had a higher incidence of heart attacks and major cardiovascular risk factors compared to noninfected patients. The study's findings indicate that HIV-infected individuals should be assessed for cardiovascular risks and that strategies to modify those risks are urgently needed.
Researchers found that cortisol production is cyclic in nature, involving rhythmic binding and unbinding of a protein essential to its production. This process starts with a signal from the hypothalamus, causing adrenal cells to increase cAMP production.
The completed Rhesus macaque DNA sequence has advanced understanding of primate evolution and will enhance medical research in various fields. The analysis revealed examples of duplicated segments, expanded gene families, and individual genes influenced by natural selection.
The rhesus macaque genome sequence comparison with the chimpanzee and human genomes revealed significant genetic differences, including genes involved in hair formation, immune response, and membrane proteins. The study also identified nearly 200 key player genes that may contribute to differences among primate species.
The study found that Crestor arrested the progression of thickened carotid arteries in participants with moderately elevated cholesterol levels. The therapy also lowered low-density lipoprotein and increased high-density lipoprotein, as well as reduced triglycerides.
Researchers developed a new ultrasound-based test that can accurately predict ovarian response and IVF success. The antral follicle count was found to be an effective predictor of egg production, providing a less costly and invasive alternative to current hormone-based tests.
Researchers found that acute colitis was associated with decreased body weight, food intake, and fat content, while chronic colitis led to reduced bone mineral density and lower energy expenditure. Chronic inflammation also altered metabolism, reducing the use of nutrients as an energy source.
A new study found that a natural family planning method called symptothermal method (STM) is as effective as the contraceptive pill in preventing unplanned pregnancies when used correctly. The STM method uses two indicators to identify the fertile phase in a woman's menstrual cycle and has an unintended pregnancy rate of 0.4% per year.
Researchers are investigating the causes of bone loss in astronauts due to prolonged weightlessness. The study focuses on the role of integrins, which may be key to decreasing bone cell production and preventing fractures.
Research finds standard therapy more effective in helping women with PCOS achieve pregnancy compared to diabetes drug metformin, which was initially thought to have great promise. Clomiphene fosters ovulation by stimulating hormone release, increasing pregnancy chances two times over metformin.
Researchers found that surgically removing the vagus nerve in mice prevented or reversed insulin resistance and high blood pressure. The study suggests altering vagal nerve activity could provide a novel treatment approach for diabetes and hypertension.
Most fertility clinics fail to adhere to advertising guidelines, leading to potential misinformation for patients. Private clinics were more likely to publish success rates and use comparative marketing, but often failed to provide accurate information.
A review found that growth hormone had minimal effects on body composition but increased rates of unhealthy side effects, diabetes, and adverse events. The use of GH for anti-aging in healthy adults is not recommended due to the lack of evidence and potential risks.
A Stanford study systematically reviewed medical literature on growth hormone therapy for the elderly, concluding that it has minimal to no benefit and potential adverse side effects. The research found modest effects on body composition but no impact on clinically important outcomes such as bone density or cholesterol levels.
Researchers found kisspeptin levels decrease in male Siberian hamsters as winter approaches, indicating a decline in libido and reproduction. Kisspeptin is believed to play an integral role in coordinating seasonal reproduction in animals.
Acromegaly, a condition caused by pituitary gland disorders, has seen improvements in diagnosis and treatment due to advances in medical technology and medication. Effective control of the disorder is now possible for many patients, reducing negative implications such as tissue damage and hormone imbalance.
A new study found a genetic link between the 'diabetes gene' (calpain-10) and polycystic ovary syndrome (PCOS), which affects up to five percent of females. The study suggests that specific variants of the CAPN10 gene may contribute to PCOS susceptibility, providing hope for diagnosis and treatment.
The increasing prevalence of metabolic syndrome, a state characterized by cardiovascular risk factors such as obesity and high blood pressure, is a growing concern. Physicians emphasize the need for aggressive treatment and lifestyle modifications to prevent serious health problems.
Women's long-term weight training programs increase biologically active growth hormone, a key factor in muscle development and bone strength. The study found that heavy loading cycles or workouts with moderate to heavy intensity regimens stimulate growth hormone production.
A new study from the University of Michigan Health System suggests that hormone therapy may help retain certain memory functions in postmenopausal women. The research found increased brain activity in the prefrontal cortex of participants taking combined estrogen-progestin hormone therapy, compared to those on placebo.