A study found that individuals with chronic anxiety exhibited increased nerve activity in response to physiological and mental stressors, which can lead to high blood pressure and heart disease. The research team measured sympathetic nerve activity and blood pressure in volunteers with and without anxiety.
A recent study found that many academic institutions in the US are unprepared to comply with stricter requirements for clinical trial registration and reporting. The institutions face challenges in allocating staff time and resources to meet these new regulations. As a result, some organizations have not implemented policies to punish ...
Early intervention after completed clinical staging leads to increased survival rates in non-small cell lung cancer patients. Surgery within eight weeks from diagnosis significantly improves overall survival.
Ali Guermazi, the first radiologist to receive the award, has made significant contributions to identifying structural risk factors for osteoarthritis. His research and clinical trials have been published in top-tier journals and presented at international conferences.
A gene therapy treatment for cerebral adrenoleukodystrophy (ALD), a fatal degenerative brain disease, has been successfully tested in a clinical trial. The treatment halted the progression of the disease in 15 out of 17 boys who participated in the trial, leading to minimal or no symptoms and normal lives.
Scientists warn that human brains may be overlooking signs of extraterrestrial life due to cognitive biases. Researchers conducted an experiment where participants failed to detect artificial structures in images, mirroring the famous gorilla suit test.
The University of Minnesota's Clinical and Translational Science Institute has received $42.6 million in renewed NIH funding to accelerate discoveries that lead to treatments and cures for Minnesotans. The five-year award enables clinical and translational researchers across the UMN System and state to make important health discoveries.
Researchers at Lund University developed a new method to recode neural signals into computer language, enabling simultaneous communication with millions of nerve cells and analysis within milliseconds. This innovation has significant implications for brain research, clinical diagnosis, and treatment.
A study found that 16.2% of dual-registered clinical trials had discrepant completion statuses, with 33.9% listed as 'completed' on ClinicalTrials.gov despite being 'ongoing' on EUCTR. This discrepancy may affect publication bias and systematic reviews.
The Association for Molecular Pathology (AMP) has published consensus-based recommendations for clinical CYP2C19 genotyping allele selection. The guidelines aim to standardize testing across laboratories and improve concordance, enabling better patient care.
A study found that premature birth impacts brain function in infants, particularly in the frontal lobe, which is crucial for cognitive development. The research used EEG signals to measure functional networks in infant brains, revealing selective effects on cognitive functions.
Researchers recommend changes to international guidelines to collect more patient-reported outcomes, improving understanding of treatment impacts on patients' health and quality of life. The updated guidance aims to facilitate high-quality data analysis and reporting, ultimately enhancing patient-centered care.
The Clinical Pharmacogenetics Implementation Consortium has published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in women with early-stage estrogen receptor-positive breast cancer. The guidelines recommend alternative hormonal therapies based on CYP2D6 genotype, aiming to improve tre...
Researchers from the University of Tokyo have discovered a molecule called progranulin that plays a crucial role in strengthening and eliminating synapses in the brain. This process is essential for developing neural circuits, but genetic or environmental mutations can disrupt it, leading to disorders such as autism and dementia.
Researchers at Charité's NeuroCure Cluster of Excellence have identified a protein mechanism responsible for rapid signal transmission between nerve cells. The discovery, published in Nature Neuroscience, reveals that bridging by synaptotagmin allows high-speed transmission via synapse fusion.
New fMRI applications help researchers map verbal and visual memory in children with epilepsy, demonstrating the potential for non-invasive fMRI to assess and diagnose pediatric epilepsy. A second study showcases the ability of resting-state fMRI to assess language laterality, paving the way for expanded use as a clinical tool.
A UK study found that less than one per cent of children born with congenital heart disease participate in clinical trials, highlighting a need for improved treatment options. Researchers suggest establishing a congenital heart disease research network to conduct well-designed clinical trials and improve surgical outcomes.
Tufts Medical Center joins a new initiative to advance critical emergency medicine research with the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Network. The SIREN Network will conduct large-scale clinical trials to test new treatments in cardiology and neurology.
A University of Texas at Arlington bioengineering professor and her team will integrate a portable brain imaging system with an advanced signal-processing technique for newborns. This project aims to provide real-time analysis needed to treat encephalopathy or brain swelling more quickly, saving the lives of sick babies.
The SIREN network pools resources to boost patient numbers for emergency medicine clinical trials, targeting vulnerable populations and life-threatening emergencies like heart attacks, lung disease, trauma, and more. The network aims to improve treatments and outcomes for patients in critical care situations.
A study found that cancer clinical trials lack appropriate representation of ethnic minorities and the elderly, resulting in findings that may not be generalizable to all patients. The study analyzed enrollment data from 2003 to 2016 and showed a decline in African-American and Hispanic representation over time.
A study found that a non-burdensome scientific reframing intervention improved patients' understanding of clinical research and its differences from clinical care. The 12-minute slideshow had no significant effect on participants' desire to enroll, but reduced therapeutic misconception scores by about 6 points.
A nationwide study in Ireland found that most oncology patients consider clinical trials important but struggle with central concepts like chance and randomization. The study aimed to understand factors influencing patients' decisions about participating in clinical trials.
A team from the Technical University of Munich developed tests to assess fine motor skills in patients with hemiparesis after a stroke. The new methods identified three decisive factors: grip force control, motor coordination, and movement speed, predicting 69% of everyday deficits.
Researchers have developed a new, ultra lightweight system for recording neural activity in mice, enabling the study of brain disorders like schizophrenia and Alzheimer's disease. The TaiNi device offers significant animal welfare benefits and high signal bandwidth, increasing information gathered from each mouse.
ASTRO has recognized 43 researchers and clinical teams for their top-rated research abstracts, showcasing innovative science in radiation oncology. The Resident Clinical/Basic Science Research Abstract Award and Annual Meeting Travel Award also support early-career scientists, with a total of $45,000 in honorariums awarded.
Researchers discover latrophilin/CIRL receptor's mechanism of action, using ion channels and intracellular messengers to trigger signal cascades. The study uses Drosophila larvae and super-resolution microscopy to visualize receptor location and signal transmission.
A study found a nearly 60% increase in exclusion criteria for lung cancer trials from 1986 to 2016, making it difficult to conduct clinical trials. The rise in exclusions is largely due to new medical concerns and complexities with targeted therapies, which are often given in pill form.
Lung cancer clinical trials have complex requirements that act as a barrier to development and patient enrollment. A retrospective study found an increase in eligibility criteria for medical therapy trials, particularly for cardiac, concurrent medications, and immunotherapy-related treatments.
The NIH is awarding $18.9 million to accelerate the use of genome sequencing in clinical care, focusing on diverse and underserved populations. The Clinical Sequencing Evidence-Generating Research (CSER2) Consortium will develop innovative approaches and best practices to integrate genomic medicine into healthcare settings.
Approval rates climbed steadily from 85% to 95% among privately insured patients, with fewer delays in clearance. The ACA provision required private insurers to cover clinical trial participation, benefiting those with insurance.
A study by Children's National Hospital found that doctors in the US have reached an unexpected consensus on prescribing medications for pediatric epilepsy patients, with levetiracetam being the most frequently chosen. The study highlights a need for real data on efficacy for each medication to inform evidence-based decision-making.
The Damon Runyon Cancer Research Foundation awarded $3.1M to five new Clinical Investigators and Continuation Grants to three existing recipients. The winners are conducting groundbreaking research in pancreatic cancer, glioblastoma, and leptomeningeal metastasis.
Researchers at Mount Sinai Hospital have developed a novel technique to continuously monitor laryngeal and vagus nerve function during otolaryngology and neurosurgery procedures. This non-invasive method uses a special breathing tube to stimulate and record nerve responses, allowing surgeons to adjust their approach in real-time.
The review provides a comprehensive understanding of NeuP etiology and pharmacological treatment options. It also discusses ongoing research efforts to develop new treatments for NeuP, aiming to improve diagnostic tools and patient outcomes.
Researchers found that current assessments are not keeping up with clinical trial advances, highlighting the need for improved treatment outcome measurement tools. Most outcome measures in FXS clinical trials received only a moderate rating due to limited information on reliability and validity.
The grants will support pre-clinical and clinical diagnostic and therapeutic research, including the development of new imaging agents and clinical trials on therapy safety and efficacy. The Brain SAFTIE initiative aims to identify gaps in existing knowledge and facilitate collaboration among experts.
Recent clinical trials using different gene transfer approaches have shown acceptable risk and potential for treating heart failure with reduced ejection fraction. Despite mixed results in terms of efficacy, the data support further clinical development of this therapeutic strategy.
The approved flash glucose monitoring system provides accurate data on demand, reducing the need for calibration, and offers a clinical benefit for individuals with type 1 diabetes. The technology has been shown to improve insulin dosing and overall glycemic control.
A study at Lund University reveals individual neurons can learn precise timed intervals, expanding the brain's learning capabilities and potential applications in AI research. This breakthrough may also shed light on autism, ADHD, and language disorders in children.
The University of Texas at Arlington won the 2017 Brain Bowl competition, showcasing expertise in neurophysiology, neuroanatomy, and behavioral neuroscience. The team's victory reflects UTA's leadership in neuroscience research.
Two UChicago studies were recognized as among the top three clinical research papers of 2016 by the Clinical Research Forum. Geneticist Carole Ober and immunologist Anne Sperling led a study showing that house dust mites from Amish homes suppressed allergic asthma in young children. Another team, led by pulmonologist John P. Kress, fou...
New cells in retina found to directly affect biological clock by sending signals to brain region regulating daily rhythms. Disruption of circadian rhythms linked to health issues like gastrointestinal and cardiovascular disorders, depression, and cancer.
A new study found that combining nivolumab and bevacizumab resulted in a 53% complete or partial response rate for patients with metastatic renal cell carcinoma. The combination therapy showed promising clinical activities and measured immunological changes, suggesting potential for improved treatment outcomes.
A review paper suggests that clinical decision tools can influence pulmonary CTA use and yield, with physician nonadherence being a major obstacle. The study found that validated rules and integrated CDS systems can help appropriate use of CTAs, but further investigation is needed.
Dr. Tamanna Roshan Lal, a board-certified Pediatrician, received the $75,000 award to support her clinical genetics subspecialty training in biochemical genetics. The fellowship will provide advanced training in Clinical Biochemical Genetics and Lysosomal Storage Diseases.
The ACMG Foundation/Shire Laboratory Geneticist Fellowship Awards and Clinical Genetics Residency Program supports the training of future medical geneticists. The program provides funding for three specialties: Clinical Genetics Residencies, Clinical Laboratory Fellowships, and Medical Biochemical Genetics Subspecialty Fellowships.
Researchers at UC have found unique courtship behaviors in wolf spiders that contribute to their genetic isolation. The studies, conducted by graduate students Emily Pickett and Madeline Lallo, reveal varying strategies among species to woo females, including vibrations and visual signals.
A Phase 2 clinical trial of trofinetide in girls with Rett syndrome aged 5-15 showed statistically significant clinical benefits, including improvements in the Rett Syndrome Behavior Questionnaire and Clinical Global Impression of Improvement. The high dose of trofinetide was well-tolerated with no dose-limiting effects observed.
The NIH-funded Antibacterial Resistance Leadership Group has reviewed over 70 study proposals and initiated more than 30 clinical studies to address antibacterial resistance. The group's key accomplishments include the launch of the CRACKLE study, a prospective multicenter cohort study designed to characterize CRE infections.
The European Society of Cardiology calls for rewritten clinical trial rules to protect patients and ensure reliable results. The current ICH Good Clinical Practice guidelines need to be based on principles rather than operational details.
Researchers at KFU's bionanotechnology lab used atomic force microscopy (AFM) to create 3D images of nematode cuticles. The study revealed new insights into the surface anatomy of Caenorhabditis elegans, a widely used model organism in genetics and biology research.
A new clinical practice guideline provides comprehensive analysis of individual agents used in treating chronic insomnia disorder. The guideline recommends specific medications for sleep onset and maintenance insomnia, emphasizing the importance of sound clinical judgment in patient care.
A multidisciplinary team from UChicago is developing wireless brain implants that can convert camera input into electrical stimulations to produce useful visual perception in the brain. The technology could restore partial vision to people who have lost their sight, significantly improving their quality of life.
A Brown University study finds that overlearning visual perception tasks strengthens learning and prevents interference, while a longer break between tasks allows for similar performance on both. The study suggests that a temporary shift in neurotransmitter balance is key to the effect of overlearning.
The two organizations will collaborate on activities in strategic mutual interest, supporting intellectual exchange of expert consulting. Researchers at Baim Institute contributed to the landmark IMMEDIATE Trial, which significantly reduced composite endpoint of cardiac arrest or mortality.
Researchers developed a multiregional brain-on-a-chip to study how diseases impact different regions of the brain. The model characterized differences between neurons from distinct brain regions and mimicked system connectivity.
Researchers found that brain cells in specific columns cycle independently between active and inactive states during both sleep and wake. This cycling is linked to improved attention and response to external stimuli.
The JHU/Tufts MC/TUSM TIC will provide world-leading expertise in state-of-the-art trial design and execution of multi-site studies, particularly in neurology and cardiology. The center will lead innovative projects in clinical trial performance metrics and adaptive and integrated trial design to maximize trial performance.
A recent study reveals that men's brains require additional energy and resources when switching between tasks, unlike women whose brains appear to consume less power. This finding highlights the difference in brain activity between genders when performing complex tasks.