A new use of an existing antibody cocktail has been confirmed to provide key information about tumor recurrence in head and neck cancer patients. The ProExC cocktail allows pathologists to differentiate between true pre-neoplasia and reactive biopsies, enabling surgeons to make informed decisions about therapeutic interventions.
A study of over 3,000 women in Michigan found that nearly 40% did not receive alternative treatment before their hysterectomy. Nearly two in five women under 40 had unsupportive pathology, suggesting that treatment guidelines are often not followed.
A new study published in the American Journal of Pathology suggests that HLA class I hyperexpression on pancreatic islet cells may not be a crucial step in developing type 1 diabetes. The study found discrepancies between results from immunohistochemistry and quantitative molecular techniques.
A pathology specialist, Dr. Glenn Palomaki, contributes to the debate on breast cancer gene screening, citing concerns about population characteristics and feasibility. He suggests pilot trials for high-risk populations like Ashkenazi Jewish women before considering widespread screening.
Schizophrenia and bipolar disorder are associated with dendritic spine loss, suggesting shared pathophysiological features. Individuals with these disorders have reduced average spine density and number of spines per dendrite compared to control group individuals.
A team of researchers from the University of Pennsylvania School of Medicine has developed new cell culture and mouse models to test immunotherapy for Parkinson's disease. By targeting distorted alpha-synuclein proteins, they prevented pathology development and reversed some effects of existing disease.
The clinical validation study showed ProMark correctly identified low-risk disease with a sensitivity of 90% or better. The test provided additional independent prediction relative to standard risk-stratification systems, improving personalized treatment decisions for prostate cancer patients.
The challenges in cancer molecular testing require effective communication between oncologists and pathologists. Close communication, systems approaches, and new institutional protocols can help ensure efficient testing and optimal patient outcomes.
Researchers investigated the connection between small-vessel disease and Alzheimer's disease pathology, revealing a possible correlation with cognitive impairment. The study found that small vessel disease may contribute to the development of Alzheimer's-like pathology in the brain.
The Association for Molecular Pathology (AMP) released a report recommending a molecular diagnostics curriculum for medical laboratory scientists, balancing accreditation, certification, and job market needs. The recommendations aim to prepare future scientists for high-complexity testing and support the growth of genomic technology.
Researchers found that higher cerebrospinal fluid alpha-synuclein levels predict faster cognitive loss in Parkinson's disease, but not motor symptoms. The study, published in the American Journal of Pathology, offers new insights into PD pathology and potential management strategies.
The new open access journal Pathogenesis will publish peer-reviewed original research and high-quality reviews in various areas of pathology. It aims to provide a platform for researchers and clinicians to share their work quickly and widely, promoting excellence in pathology.
The Association for Molecular Pathology proposes a new term, Laboratory Developed Procedure (LDPs), to describe service-oriented tests. LDPs rely on laboratory professionals for design, consultation, and interpretive reporting in clinical care.
Researchers at McMaster University have identified a protein called Xin that serves as a biomarker for muscle damage. Xin is only detectable after muscle injury and shows a strong correlation with the degree of damage, regardless of the cause.
A new study published in the American Journal of Pathology found that resveratrol actually worsened MS-like neuropathology and inflammation in mice. Resveratrol did not show anti-inflammatory or neuroprotective effects, contradicting previous claims about its benefits.
Researchers have discovered anti-tau antibodies that can prevent the accumulation of toxic tau proteins, improving cognitive function and reducing pathology in mouse models. The findings suggest a potential basis for treating Alzheimer's disease and other neurodegenerative disorders.
Researchers developed a test that can clearly distinguish early liver cancer cells from normal liver cells by giving them a distinctive red-brown hue. The test uses a probe to detect and stain a microRNA called mir-21, which is found in liver cancer but not healthy liver cells.
Researchers at Emory University have discovered a previously unrecognized type of pathology in Alzheimer's brains that sequesters proteins involved in RNA splicing. This finding could lead to new biomarkers, diagnostic approaches, and therapies by explaining how genes contribute their effects in the disease.
Researchers at Kansas State University have identified a PHS gene in wheat that prevents preharvest sprouting, a major cause of crop loss. The discovery provides a potential solution for the $1 billion annual industry losses associated with white wheat production.
A study found that decreased Aß42 and increased phosphorylated tau181 levels in spinal fluid are linked to reduced default mode network integrity. This association suggests that these biomarkers could be used to detect Alzheimer's disease pathology before symptoms appear.
The UNC-Malawi cancer pathology laboratory has provided invaluable service to patients and built capacity at a national teaching hospital. The lab, which assessed over 3,600 specimens, is now helping to relieve diagnostic delays and provide essential diagnostic services to Malawians suffering from cancer.
Researchers found that a specific pattern in tumor pathology is strongly associated with cancer recurrence. Patients with this pattern are more likely to benefit from lobectomy and have a 75% lower risk of recurrence. The study may lead to new technology to precisely identify tumors with this pattern before surgery.
Researchers found that women with atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) can avoid surgery if radiologist and pathologist findings are concordant. Yearly mammograms, MRI, or ultrasound as second-line screening tools may suffice.
A new study by Rush University Medical Center researchers found that a sudden decrease in testosterone levels may cause Parkinson's-like symptoms in male mice. Testosterone supplementation reversed the pathology in the mice. The study suggests that preserving testosterone levels may be important to prevent Parkinson's disease.
A recent study led by Loyola University Medical Center physician Matthew Kircher identified a simple way to reduce healthcare costs without compromising care. The researchers found that in 178 cases, there was virtually perfect agreement between otologists' findings and official diagnoses from the pathology lab, suggesting that these e...
Researchers have identified nine fungal lineages associated with ambrosia beetles threatening avocado production in the US and Israel. The unique fungi adaptability poses a threat to global farms and forests.
Researchers developed a staging system to track ALS disease progression, mapping out four distinct stages and identifying transmission patterns. The study's findings suggest a similar transmission process in other neurodegenerative diseases, such as Alzheimer's and Parkinson's, and may lead to new treatments like immunotherapies.
A study by McGill University researchers found that blocking the activity of a specific receptor can reverse memory pathology and improve cerebrovascular function in mice with advanced Alzheimer's disease. The treatment also reduced toxic amyloid-beta peptide levels, which contribute to neuronal and vascular dysfunction.
Researchers discovered that the p63 protein acts as a genetic modifier for EEC Syndrome, with TAp63 determining its manifestation. The study reveals that levels of TAp63 determine whether children inherit the syndrome, providing new insights into this rare condition.
Research suggests that early exposure to bisphenol A can damage the enamel of teeth in children, similar to a previously identified pathology known as MIH. The study found that low doses of BPA can cause mineral depletion and lead to hypomineralisation, making teeth more fragile and prone to cavities.
Scientists at USC have found a class of drugs, TSPO ligands, that can reduce measures of pathology and improve behavior in both young adult and aged mice with Alzheimer's Disease. The treatment showed promising results, including a significant decrease in symptoms and improvements in memory.
Researchers have discovered that innate lymphoid cells and T cells follow a similar development pathway, involving the Notch protein pathway. This finding has implications for understanding inflammatory diseases and could lead to new treatments.
Giant axonal neuropathy is caused by mutations in the gigaxonin gene, leading to accumulation of neurofilament proteins. The study shows that gigaxonin regulates neurofilament protein degradation, shedding light on the molecular pathology of GAN.
A new study found that average-risk screening adenoma detection rates are significantly higher than current guidelines suggest, with women having a 25.4% risk and men having a 41.2% risk. Overall advanced-pathology adenoma detection was also higher in men, highlighting the need for vigilance in identifying patients with adenomas to pre...
A new tau transmission model opens doors for potential treatments of Alzheimer's and Parkinson's diseases by inducing animal models to mimic the spread of tau pathology. The research demonstrates cell-to-cell transmission of neurodegenerative proteins, offering therapeutic opportunities.
A team at Vienna University of Veterinary Medicine found the same strain of Usutu virus in dead blackbirds in Italy in 1996 as in Austria's cases. This suggests the virus was present in Italy before reaching Europe, and forensic pathology can help unravel origins of emerging diseases.
Researchers at the University of Pennsylvania School of Medicine developed a new animal model that replicates the transmission of tau pathology, a hallmark of Alzheimer's disease. The study demonstrates that synthetic tau fibrils can induce authentic neurofibrillary tangles and initiate disease progression in mice.
A five-year NIH grant supports a program to develop resident genomic pathology curriculum, expanding pathologists' role in interpreting and acting on genomics data. The initiative aims to bridge the gap between genetic research and practical application in patient care.
The Association for Molecular Pathology report on next-generation sequencing technology addresses current technical, bioinformatic, and clinical implementation considerations. The report aims to improve patient care by exploring the clinical relevance and impact of NGS technologies.
Researchers at the University of Pennsylvania School of Medicine have found that surgery itself has a profound impact on brain pathology and cognition in mice with human Alzheimer disease genes. Surgery causes a lasting increase in Alzheimer's pathology and significant cognitive impairment, primarily through inflammation.
Cardiac injury leads to rapid morphological changes, including enlargement and fibrous growth tissue formation. Advanced stages of remodeling have begun by day seven following injury. This research provides insights into the coordinated events of cardiac pathology and possible intervention targets.
Researchers found that high baseline levels of neuronal activity in key brain regions may contribute to Alzheimer's development. The study suggests that brain dynamics could play a causal role in the disease.
A CSHL-led team has developed a new method to model human genetic diseases caused by errors in RNA splicing. The approach, called TSUNAMI, uses targeted 'negative ASOs' to cause missplicing and pathogenesis, offering a unique window into disease progression.
A new genetic analysis maps the Jewish Diasporas, focusing on North African Jews. The study supports historical records of Middle Eastern Jews settling in North Africa and forming distinct populations.
Scientists at Cold Spring Harbor Laboratory link gene mutations in Orc1 protein to extreme dwarfism and small brain size in Meier-Gorlin syndrome. The study reveals that centrosome reduplication and dysregulation of DNA replication contribute to severe manifestations of the rare condition.
A study published by researchers at Mount Sinai School of Medicine suggests that latrepirdine, a previously failed Alzheimer's drug, may be successful if tested on patients with earlier stages of the disease. The compound effectively stopped progression of memory deterioration and brain pathology in mouse models.
A study at Columbia University Irving Medical Center found that a specific gene fusion is responsible for the majority of glioblastomas, leading to dramatic slowing of tumor growth in mice. The discovery opens up new possibilities for personalized treatments using FGFR kinase inhibitors.
An anti-tau treatment called epithilone D (EpoD) has shown promise in preventing and intervening the progress of Alzheimer's disease in animal models by improving neuron function and cognition. The drug aims to stabilize microtubules, which support the transport of essential nutrients and information between cells.
Researchers found that aging mice's dendritic cells accumulated oxidation-damaged proteins, impairing their function. Administering antioxidants reversed some effects, suggesting a potential therapy to improve vaccine responses in the elderly.
Researchers have identified a process by which misfolded proteins, such as alpha-synuclein, travel from sick to healthy cells in the brain, leading to the progression of Parkinson's disease. The study provides new insights into the disease's pathology and offers potential targets for disease-modifying treatments.
Researchers at Emory University School of Medicine have identified a new class of anti-inflammatory compounds that inhibit the Nox2 enzyme, which produces reactive oxygen species. This approach may be more effective than traditional antioxidants in treating conditions like stroke, heart failure, and neurodegenerative diseases.
A new study demonstrates the potential of natural language processing (NLP) to measure performance on colonoscopy quality measures. The NLP-based computer software application efficiently analyzed a large sample of colonoscopy reports, revealing clear variation in performance even within a highly regarded academic health care system.
Researchers have found a key molecule, REG3A, highly expressed in skin cells during psoriasis and wound repair, causing abnormal cell proliferation. Blocking REG3A delays wound healing and clears up psoriasis-like pathology in mice, offering potential therapeutic targets.
A team of researchers identified a unique set of cells at the squamocolumnar junction that express biomarkers found in all forms of invasive cervical cancers linked to HPV. These cells do not regenerate when excised, which has significant implications for diagnosis, prevention, and treatment of cervical cancer.
Geoffrey L. Smith, a renowned virologist and leader in the field of microbiology, has been awarded the GlaxoSmithKline International Member of the Year Award. He is recognized for his numerous original contributions to virology and his role as a leader in various scientific institutions.
Bruce S. Rabin has made significant contributions to the understanding of the immune system's interaction with the nervous system, endocrine organs, and mental health. He has elucidated many dark corners of immunology and brought sound immunologic principles to the study of mental health and disease in humans.
L. Barth Reller, a renowned clinical microbiologist, has been recognized with the 2012 TREK Diagnostic ABMM/ABMLI Professional Recognition Award for his outstanding contributions to the field. He is also an accomplished mentor and trainer of medical microbiologists, having mentored 38 fellows who now hold leadership positions globally.
Researchers have successfully transplanted embryonic cells into adult mouse spinal cords to alleviate persistent pain. The study suggests that this approach may not only treat symptoms but also correct underlying disease pathology. This new therapy offers hope for patients with neuropathic pain, a condition with limited treatment options.
Weill Cornell Medical College researchers discovered that a chromosomal rearrangement in prostate cancer cells creates a new 'fusion' gene, warping DNA structure and triggering abnormal growth. The study suggests a model for how other chromosomal translocations contribute to cancer formation.
New research presents key insights into preventing and treating bowel diseases, which affect millions worldwide. Studies show that dietary additives, hormone replacement therapy, and even high-altitude travel may cause or exacerbate these diseases.