A systematic review found that a difference of more than 10mmHg or 15mmHg in systolic blood pressure between arms is associated with increased risk of vascular disease and mortality. The study supports the need for two-arm blood pressure checks to become the norm.
The study will review evidence of practices used to support children with ADHD that do not involve drugs, such as classroom management programmes or psychological therapies. The research aims to identify which methods work best to reduce the symptoms of ADHD and provide best value for money.
Researchers have created a computer simulation to identify bottlenecks in the emergency stroke care process, allowing for earlier clot-busting treatment. The analysis of over 1400 episodes has led to a doubling of patients receiving treatment within three hours.
A new study reveals that South Asians living with coronary disease in Alberta experience a lower quality of life compared to Canadians of European descent. The study, published in American Heart Journal, found that they have more frequent and severe chest pains, and are less physically active.
A University of Alberta researcher is investigating the potential link between long-term exposure to disinfected water and an increased risk of bladder cancer. She will develop new tools to detect toxic DBPs in drinking water, with the goal of eliminating their formation.
Researchers at the University of Alberta have discovered a treatment that restores motor skills in lab models with Huntington disease by restoring normal levels of brain molecule GM1. The therapy has shown promise in improving cognitive symptoms as well, suggesting it could be effective for patients.
A NYU nursing-dental research team discovered that oral blood samples drawn from deep pockets of periodontal inflammation can measure hemoglobin A1c, a key indicator of diabetes status. The study found minimal false positive and negative results, making it a promising alternative to finger-stick samples.
Scientists at the University of Alberta have shed light on the structure and function of PNKP, a key DNA repair enzyme. By understanding how this enzyme repairs damaged DNA, researchers hope to develop new therapies that target cancer cells while leaving healthy cells intact.
Research reveals that cirrhosis patients losing muscle mass have a significantly shorter survival rate than those with normal muscle mass. The study's findings suggest that muscle mass should be considered alongside current scoring systems when assessing transplant list placement.
Researchers at Peninsula College of Medicine and Dentistry found that differences in systolic blood pressure between arms are associated with increased risk of vascular disease and mortality. A difference of 10mm Hg or more is linked to an increased risk of peripheral vascular disease, pre-existing cerebrovascular disease, and mortality.
Researchers discovered 13 new gene regions associated with menopause onset, providing insights into reproductive lifespan and conditions like breast cancer and heart disease. Early menopause is linked to increased risk of these diseases, while later menopause may provide protection.
Jan Potempa's discoveries on Porphyromonas gingivalis have led to a new understanding of the origin of gum tissue inflammation. His research may lead to the development of more effective medications to combat periodontal disease and reduce the risk of heart disease and arthritis.
A new study will assess the views and experiences of children with neurodisability and their families to measure the outcomes of NHS care. The CHUMS project aims to gather insights into patient-reported outcome measures for disabled children and young people.
Researchers from Jena University developed a new type of glass ceramic that can be used in dentistry due to its high strength and optical characteristics. The material, which is composed of nanocrystals, achieves a strength five times higher than comparable denture ceramics available today.
The 'plasma brush' uses chemical reactions to disinfect and clean out cavities, forming a better bond for cavity fillings. This technology could reduce costs by 75% and increase the lifespan of fillings by 60%, benefiting patients and dentists.
Researchers at the University of Alberta have discovered a new way to track the progression of multiple sclerosis by using powerful MRI to measure iron levels in brain tissue. The study found that high iron levels are associated with physical disabilities and may be an early marker of MS.
A rare genetic disorder has provided insight into pancreatic development, suggesting that GATA6 plays a crucial role in programming stem cells to become pancreatic cells. The study sheds light on the underlying causes of most cases of pancreatic agenesis and may help develop new treatments for type 1 diabetes.
Medical researchers created 'conversation cards' to facilitate open discussions between parents and health professionals about pediatric weight management. The deck of cards, piloted in January 2012, aims to reduce power differentials and promote a more supportive conversation.
Researchers discovered a mutation in the GATA6 gene linked to pancreatic agenesis, a rare condition where the pancreas fails to develop. This finding provides insight into how stem cells can be programmed to become pancreatic cells, potentially leading to new treatments for type 1 diabetes.
Medical researchers have discovered a hidden process that erases the shadoo protein in infected brains, up to seven months before physical symptoms of prion diseases like BSE or mad cow disease appear. This new understanding opens up research opportunities into attenuating the disease.
The South West Ambulance Service will introduce TXA for civilian trauma patients, which has shown a 30% reduction in death from bleeding when used within three hours of trauma. The cost of the drug is estimated to be £2,560 in year one, with potential savings of many lives and reduced trauma-related disability.
Research into Polycystic Ovary Syndrome (PCOS) and diabetes aims to improve the health of thousands of women in Cornwall. The study will investigate factors that increase the risk of diabetes in women with PCOS.
A new study suggests a possible link between radon exposure and non-melanoma skin cancer in the southwest region of England. The research found a correlation between areas with high radon concentrations and squamous cell carcinoma cases.
Dr. David Llewellyn has been awarded a two-year grant to investigate the link between low vitamin D levels and increased risk of dementia. His research aims to identify vitamin D as a potential biomarker and therapeutic target for preventing and treating the disease.
A new study finds weak evidence supporting exercise referral schemes as a means of increasing physical activity and improving health outcomes in sedentary individuals. Despite the importance of physical activity, the study highlights the need for targeted and effective schemes to address the growing public health issue.
Researchers discovered that crocin in saffron exerts protective effects on brain cells and prevented damage in models of MS. The study also found a link between an ancient virus and cell stress leading to inflammation in the disease.
A potential new drug target has been discovered to stop debilitating effects of MS by preventing brain cell death caused by granzyme B. The target is the M6PR receptor, which allows granzyme B to enter neurons and wreak havoc.
The NCBRSI will bring together scientists, clinicians, and clinical trial specialists to develop groundbreaking surgical ideas, carry out clinical trials, and disseminate knowledge and techniques to hospitals across the UK. The centre aims to improve quality of life for millions of people affected by bowel disorders in the UK.
A study found that an exercise program improved balance and reduced fear of falling in people with Parkinson's disease who had a history of falls. The research team tracked significant improvements in physical recreational activity, supporting the effectiveness of physiotherapy and exercise in managing Parkinson's disease.
Researchers from the University of Alberta and Cambridge have discovered a fifth adaptin protein complex involved in membrane trafficking, which has been present for billions of years. This finding opens up new avenues for understanding neurodegenerative diseases such as Alzheimer's, Huntington's disease, and ALS.
Research by biologists at the University of York has revealed that under stressful conditions, synapses can grow excessively, potentially contributing to dysfunction. This finding has strong implications for neuronal function as brains age and adds significantly to our understanding of neurodegenerative diseases.
A literature review suggests that some stroke patients can receive treatment beyond the standard 3-hour window, with brain cells remaining structurally intact and potentially revivable if normal blood flow is restored. This finding could enable doctors to provide better patient care by considering the 'tissue window' rather than just time
Researchers at the University of Alberta have developed a multi-cellular model of Zellweger's syndrome, a rare and deadly genetic disease, using fruit flies. The model mimics the human phenotype and is ideal for medical research due to its rapid development and low cost.
Researchers have found that brain wiring continues to develop well into our 20s, with structural changes in the white matter being detected in healthy adults using magnetic resonance imaging. This challenges the long-held belief that brain development stops at adolescence.
Recent studies by Sanjay Kalra demonstrate that ALS damages neurons in cognitive and behavioral areas of the brain, contradicting previous assumptions. MRI scans reveal decreased levels of neural markers NAA and increased mIns, indicating biological changes responsible for behavioral symptoms.
The IADR/AADR published the proceedings of the 3rd AADR Fall Focused Symposium on Salivary Diagnostics, featuring scientific posters and invited speakers from leading institutions. The symposium explored cutting-edge technology and techniques in salivary diagnostics research.
A $23.2 million grant has been awarded to Rutgers University and the University of Medicine and Dentistry of New Jersey (UMDNJ) to continue research on developing drug products to treat individuals exposed to mustard gas, a deadly chemical agent used in chemical warfare.
Researchers at the University of Alberta found that resveratrol prevents a metabolic syndrome in offspring born growth-restricted, characterized by glucose intolerance and insulin resistance. The study suggests resveratrol may be a potential pharmacological treatment to prevent future metabolic problems.
Researchers have developed a method to create perfect-fit prosthetic dentistry using 3D printing technology. The approach combines medical imaging with computer-aided design to produce complex shapes like teeth and crowns. This technique has the potential to reduce production time and improve fit, making dental care more efficient.
Researchers from Peninsula College of Medicine and Dentistry discovered a potential therapeutic strategy for managing heart failure by modulating the interaction between hydrogen sulphide (H2S) and nitric oxide. The study found that this 'cross talk' can have positive effects on heart health and may lead to new drug therapies.
Researchers are conducting a clinical trial called MANTICORE to detect and treat cardiovascular disease in breast cancer patients before treatment begins. The study aims to use special blood tests and imaging scans to identify potential cardiac risk factors.
A study by Peninsula College of Medicine and Dentistry found that acupuncture significantly improved the overall health status of patients with unexplained symptoms. The treatment also led to reduced medication use and improved wellbeing, without affecting GP visits or clinical outcomes. Patients reported positive experiences with the ...
Researchers at the European Centre for the Environment and Human Health found that virtual environments can promote improved human health and wellbeing. The development of accurate simulations has been shown to be beneficial for individuals with infirmity or other limitations, but not a substitute for real-world nature interaction.
A pan-Canadian clinical trial led by UBC researchers aims to revolutionize oral cancer surgery with a new fluorescence visualization technique, potentially reducing recurrence rates and improving patient outcomes.
Scientists at the University of Alberta discovered the first step in a bacterial immune response, where RNA is cut into pieces to target invading viruses. This finding has implications for controlling bacterial growth and fighting human infections.
Researchers have discovered that a specific type of T-cell can kill neurons, raising concerns about the potential effectiveness of an MS therapy. The study found that these protective T-cells, which are meant to regulate the immune system, can instead cause autoimmune diseases like MS.
Researchers at the University of Alberta have discovered a critical molecule that, when absent in T-cells, can cause autoimmunity. This finding has significant implications for stem-cell transplantation treatments used for autoimmune diseases and cancer.
The FASEB MARC Program has announced 37 travel award recipients for the 98th Annual Meeting of The American Association of Immunologists. These awards aim to promote diversity in biomedical research by supporting junior faculty and students from underrepresented minority groups.
Scientists mimic the body's natural mechanism of fighting inflammation by using natural human microparticles to deliver anti-inflammatory therapeutics. This new approach could have application for various inflammatory diseases, including arthritis and temporomandibular disorders.
A recent study published in PubMed found that swiping contaminated plates three times significantly reduced bacterial counts. The mechanical removal of bacteria, not the disinfectant itself, was key to this effect. Saline wipes were found to be as effective as disinfectant wipes when swiped multiple times.
A large randomized control trial found no evidence that osteopathic therapy improves movement, quality of life, or pain in children with cerebral palsy. However, parents whose children received osteopathy reported a slightly better overall wellbeing for their child compared to those who did not receive treatment.
Research found that used woodwind and brass instruments are heavily contaminated with bacteria and fungi, including species of Staphylococcus and molds. Proper sanitation and regular cleaning are crucial to prevent the spread of illness and infection in children who play these instruments.
A worldwide problem, zinc deficiency can cause health issues; proper denture care and regular dental check-ups are essential for safe use of zinc-based adhesives.
UBE4B is a molecule that binds to p53 and MDM2, allowing them to degrade the tumor-suppressing protein p53 in cancer cells. This discovery could lead to novel anti-cancer therapies and improve prognosis for cancer patients.
Professor Alan Stitt has received a Royal Society Wolfson Research Merit Award to support his ground-breaking research on vascular stem cells and eye disease treatment at Queen's University. The award aims to retain top researchers in the UK and reflects the excellence of the School of Medicine, Dentistry and Biomedical Science.
A systematic review by the Peninsula College of Medicine and Dentistry has found that exercising outdoors improves mental well-being, with participants reporting greater feelings of revitalisation and positive engagement. However, further research is needed to fully understand the effects of outdoor exercise on physical well-being.
Research found that folic acid lowers homocysteine in the blood, which should reduce heart attack risk. However, clinical trials showed no extra benefit due to high aspirin use by participants. The study suggests folic acid may still be beneficial for those not taking aspirin.
A new report by Indiana University School of Dentistry calls for quick and creative solutions to address the decline in US dental faculty. The report cites widening pay gaps between private practice dentists and clinical professors as a factor in fewer dentists committing to careers in teaching. To reverse the trend, the report recomme...
The European Diabetes Research Network, funded by the EU, will investigate the possible role of virus infection in causing type 1 diabetes. The network aims to develop a vaccine to prevent diabetes in children and improve diagnosis and patient care.
A U of Alberta researcher is working towards developing a pharmacological target for cholera by understanding the bacteria's mechanism of infection and survival. He has discovered how Vibrio cholerae uses molecular nano-syringes to infect host cells, providing a potential vaccine target.