Researchers have developed a new type of precise therapeutic vaccine against leukemia utilizing self-healing polylactic acid microcapsules. The vaccine co-encapsulates a new epitope peptide and PD-1 antibody, demonstrating superior performance over commercialized adjuvants in various models.
Researchers sequenced genomes of figs and pollinators to uncover dynamic karyotype variation associated with adaptive evolution. They also identified candidate genes for sex determination and a potential molecular mechanism of coevolution between fig species and their wasp pollinators.
A recent study from an international team led by Prof. ZHAO Gang, Prof. SHI Jianrong, and Dr. YAN Hongliang found that most lithium-rich stars are 'red clumps' rather than 'red giants'. The research provides new insights into the origin of the ancient element lithium.
A research team from Chinese Academy of Sciences proposes an innovative immune cocktail therapy combining ICT with other approaches to enhance cancer treatment. The therapy achieves anti-tumor effects by enhancing T cell priming, killing tumor cells, and generating immune memory T cells.
Chinese researchers discovered a link between liquid-liquid phase separation and human developmental disorders like Noonan syndrome. Gain-of-function mutations in the SHP2 protein lead to hyperactivation of downstream signaling pathways, providing a therapeutic strategy for targeting SHP2-associated disorders.
A study revealed that over 4,000 reptile species are in global trade, with 3/4 not covered by international regulations. Most traded species are endangered or range-restricted, especially from Asia.
A machine learning-based strategy developed by Prof. LI Xianfeng's team can predict VFB stack performance and cost with high accuracy. The strategy improves efficiency, reduces research time, and provides guidance for VFB development.
Researchers propose multifunctional liquid metal nanocapsules with tunable polylactone shells for improved thermal/photo-molding properties, electric conductivity, and notch-insensitive tearing. The powder of LM capsules combines exceptional properties of liquid metals and polylactone shells.
The satellite detected a low-frequency quasi-periodic oscillation (QPO) above 200 keV in a black hole binary, indicating the presence of a relativistic jet near the event horizon. The discovery resolves the long-running debate on the physical origin of low-frequency QPOs.
Fossilized ostracods found in 100-million-year-old amber reveal evidence of sexual intercourse, including male clasper, sperm pumps, hemipenes, eggs, and female seminal receptacles. This discovery provides insights into ancient ostracod autoecology and reproductive behavior.
A central neural circuit in the forebrain to the hypothalamus mediates chronic stress-induced bone loss via the peripheral sympathetic nervous system. Isolation significantly increases anxiety levels, inducing bone loss in human subjects.
A research team at Chinese Academy of Sciences has developed a new solvation strategy to enhance the oxidation stability of carbonate-based electrolytes in Zinc/Graphite batteries. This breakthrough could lead to high-voltage cells with low self-discharge and long shelf life, making them suitable for large-scale grid storage.
Researchers discovered that hollow multishelled structures can realize sequential drug release through unique temporal-spatial order property. This property enables burst, sustained, and stimulus-responsive release stages, providing a long sterility period in bacteria-rich environments.
Researchers have developed a novel approach to manipulate catalyst active centers at the subnanometer scale, using nano-confinement to host multiple Fe and Cu single atoms in graphitic carbon nitride. This strategy enhances electrocatalytic performance and efficiency, particularly for nitrogen reduction reactions.
A novel functional class of cortical neurons, known as holistic bursting cells, has been discovered to represent learned complex objects as wholes rather than parts. These cells exhibit a unique mode of high-rate, prolonged burst firing response to trained sounds, including chords consisting of multiple pure-tones.
A recent study published in Nature has zoomed in on dark matter haloes of varying masses, revealing a surprising similarity in their internal structure. The research team used supercomputers to simulate the evolution of the universe and found that even small haloes have dense centers and spread-out outer regions.
Research monitored 30 Chinese lakes between 2008 and 2018, showing increases in total phosphorus and chlorophyll a across 47% and 70% of lakes, respectively. Climate change and internal loading from sediments also pose significant challenges to lake restoration efforts.
Researchers discovered dodder plants synchronize flowering with host plants by eavesdropping on their FT signaling protein. This unique behavior allows dodders to thrive by parasitizing diverse hosts without fixed flowering times.
A new manganese-based single-atom catalyst has been developed, exhibiting high Faradaic efficiency and current density in electrochemical CO2 reduction. The catalyst outperforms all reported Mn SACs, paving the way for low-cost and efficient conversion of CO2 into useful chemicals.
Scientists have developed a low-temperature resisting hybrid electrolyte for aqueous zinc-based batteries (ZBBs), exhibiting high zinc-ion conductivity at low temperature. The new electrolyte improved the performance of ZBBs, enabling high energy densities, power densities and long-cycle life at -20°C.
A recent study reveals the hierarchical representation of color in the brain, from cone-activation signals to isotropic hue representation. The study found that different areas of the cortex process color information in a progressive manner.
A new fossil discovery has provided critical evidence for the evolution of the mammalian middle ear, revealing the first unequivocal evidence of the five auditory bones from an extinct group. The findings have narrowed the morphological gap between ancient and modern mammals.
Researchers found SARS-CoV-2 can infect human brain organoids, targeting cortical neurons and NPCs. The study provides evidence for the pathogenesis of neurological complications in COVID-19 patients.
A research team has revealed that Ca2+ activities mediated by mechanosensitive Piezo1 channels regulate the pathfinding of growing brain vessels in larval zebrafish. This process is critical for proper patterning of the vasculature, but its underlying mechanism remained unknown.
Researchers found CAMSAP1 plays a crucial role in regulating axon/dendrite differentiation by creating an unbalanced distribution of microtubules among processes. The study resolves a long-standing question in neuroscience about the decisive factor for neuronal polarity establishment.
For the first time, researchers have measured the global magnetic field of the solar corona. By applying magneto-seismology to observations from Coronal Multi-channel Polarimeter (CoMP), they mapped the magnetic field in the global corona using wave propagation speed and density data.
Researchers developed a new method to synthesize unconventional nanoalloys composed of immiscible metals, which showed superior performances in electrocatalytic reactions. The approach uses vapor-source technology and allows for control over composition and size, enabling the creation of cost-effective, highly active, and durable elect...
Researchers have discovered that graphitic nitrogen (GN) dopants significantly improve the activity of adjacent carbon atoms for electrocatalytic CO2 reduction to CO. The study found a 95% Faradaic efficiency at -0.5 V versus reversible hydrogen electrode, outperforming other N-dopant types.
Chinese scientists introduce FlowRACS, a flow-mode Raman-activated cell sorter, to support high-throughput discovery of enzymes and their cell factories at the precision of just one microbial cell. The instrument can screen yeast for its TAG content and profile in real-time.
Researchers confirm special trap-jaw predation mechanism in ancient hell ants, providing new insights into their evolution. The study reveals an extinct early burst adaptive radiation triggered by innovation in mouthpart movement.
Researchers discovered evidence of ancient subduction in China and six other continents, revealing that plate tectonics went global 2 billion years ago. This finding provides the first global evidence for the operation of plate tectonics at this age.
Researchers have developed a catalytic system that directly installs the trifluoromethyl group onto arenes using trifluoroacetic acid. The new reaction offers a milder alternative to existing strategies and has been successfully applied to a diverse array of arenes and heteroarenes.
Researchers developed an optically induced electrokinetics (OEK) microfluidic method for label-free separation and characterization of gastric cancer cells. The new technique, published in Science Advances, achieved purity up to 71% in separating cancer cells from ascites and demonstrated rapid and non-destructive capabilities.
Researchers identified key drivers of secondary growth resumption in Northern Hemisphere conifers, including photoperiod and mean annual temperature. These factors interact with spring forcing and moisture availability to regulate wood formation.
Dome A's unique atmospheric properties make it an ideal location for optical and infrared astronomy, with measurements showing excellent seeing values of up to 0.13 arcseconds. The site's feasibility and cost-efficiency are enhanced by its lower boundary layer thickness compared to other Antarctic locations.
Scientists have developed a copper-catalyzed radical relay strategy for the asymmetric trifluoromethylation of secondary alkyl radicals, yielding optically pure CF3-containing organic molecules with good yields and excellent enantioselectivities.
The Hengduan Mountains have the most extensive alpine flora history, dating back to the early Oligocene. This was shaped by past geological and climatic events, including mountain building and climate change.
A new nanoreactor strategy has been proposed for synthesizing superior supported bimetallic catalysts, showing enhanced catalytic performance in formic acid dehydrogenation and recyclability. The synthesized PdAu BNPs exhibit uniform diameter and homogenous distribution, with a TOF value of 3684 h-1 at 333 K.
A research team led by Dr. Alida Bailleul has found that ovarian follicles can be preserved in fossils more than 120 million years old, confirming the function of a single functional ovary in birds. The study uses scanning electron microscopy and other methods to analyze fossilized tissues and compare them to extant bird follicles.
A recent study published in Nature Astronomy reveals the location of energy release in solar eruptions, finding that relativistic electrons are accelerated in a specific region known as the magnetic bottle. This breakthrough confirms a theoretical model and provides new insights into the complex process of solar flares.
Researchers have created two new cytosine base editors (CBEs) that induce fewer off-target mutations in rice, showcasing improved specificity and precision. The CBEs were designed using a truncated human APOBEC3 cytidine deaminase (A3Bctd) and underwent rigorous testing to validate their performance.
Researchers reconstructed natural runoff history for the middle reach of the Yellow River from 1492 to 2013 CE, finding reduced runoff and sediment load due to human activities. The study provides an important model for distinguishing anthropogenic influence from natural variability in global change studies.
A research team analyzed a 'gel-like' substance discovered by the Chang'e-4 rover, finding it to be an impact melt breccia. The surrounding regolith may have originated from a differentiated melt pool or igneous rocks.
A new study by YANG Jia and colleagues identified both task-specific and subject-invariant components of perceptual learning ability, revealing multifaceted nature of learning and strong evidence for consistent pattern of individual differences across multiple training tasks.
A team of scientists at the Chinese Academy of Sciences has discovered a new, very short-lived isotope of neptunium, confirming the existence of the N = 126 shell in Np isotopes. The study used alpha-decay spectroscopy to identify the new isotope, which was produced through fusion reactions.
A team of researchers developed an AI model to forecast complicated large-scale tropical instability waves in the Pacific Ocean. The model, which uses satellite data-driven deep learning, accurately predicted sea surface temperature evolution and captured TIW propagation's spatial and temporal variation.
A new study reveals that crop plants can absorb microplastics, contaminating edible plants and potentially entering the food chain. The research found that particles as small as 2 micrometers in size can be taken up by plant roots, raising concerns about human health and agricultural sustainability.
A comprehensive proteomic analysis of 103 Chinese patients with lung adenocarcinoma revealed molecular characteristics associated with clinical outcomes and potential prognostic biomarkers. The study identified 27 potential plasma biomarkers and several drug targets for LUAD, providing new insights into the disease.
Chinese researchers identify RNF126 as a key enzyme in the reubiquitination process, targeting misfolded membrane proteins for degradation. The study highlights the importance of this mechanism in maintaining normal cell physiology and potentially serving as a therapeutic target for cancer treatment.
Chinese researchers successfully integrated non-noble metal ions into semiconductor quantum dots, creating ultra-small nanocrystals with integrated light absorber, protecting layer and active site. The loading of metal ions enables the efficient evolution of hydrogen from water through photocatalysis.