Researchers created a novel platelet-based delivery system to target and penetrate tumors, combining photothermal therapy and immunotherapy. The biomimetic formulation demonstrated potent therapeutic effects against multiple types of cancer in murine models.
The study found that phospholipid PtdIns4P and cholesterol play a critical role in G-protein coupling and ligand recognition, stabilizing the receptor's basal activity. Water molecules also mimic polar functionalities of serotonin, sustaining basal activity.
The study optimized pegRNA designs to maximize plant prime editing efficiency, finding that the melting temperature of the PBS sequence is crucial for efficient editing. The introduction of dual pegRNAs resulted in significant improvements in editing efficiency, with a 3.0-fold increase compared to individual pegRNAs.
Researchers at the Chinese Academy of Sciences have developed a 'genome scalpel' to efficiently produce sustainable biofuels from sunlight and CO2 by removing non-essential genes from microalgae. This approach could lead to more efficient production of biomolecules like biofuels, with potential applications in renewable energy and redu...
Researchers using the New Vacuum Solar Telescope observed a significant acceleration of magnetic reconnection due to propagating disturbances caused by filament eruptions. The study, published in The Astrophysical Journal, found that these disturbances led to shorter and brighter current sheets with increased reconnection rates.
Researchers discovered three new FRBs with high dispersion measure from the Five-hundred-meter Aperture Spherical radio Telescope (FAST), indicating they happened billions of years ago. The findings suggest there could be as many as 120,000 detectable FRBs arriving on Earth every day.
A new modification strategy regulates pore size distribution and electronegativity in polyamide NF membranes, improving rejection rates for monosaccharides and monovalent salts. This results in better separation efficiency with only minor permeability loss.
Researchers have confirmed Noeggerathiales had fern-like spore propagation and seed plant vascular tissue, revealing a closer relationship to seed plants than previously thought. The study also shows that the ancestral lineage of seed plants diversified during the Devonian-Carboniferous-Permian periods.
A new study found that poor oral hygiene within 24-72 hours can lead to a steep decrease in good oral bacteria and an increase in bad bacteria associated with periodontitis. The researchers also discovered a sudden aging of the bacteria's microbiome, equivalent to about a year in less than a month.
The Tibet ASgamma experiment has discovered gamma rays beyond 100 TeV from a supernova remnant, suggesting that cosmic-ray nuclei are accelerated up to PeV energy and collide with a nearby molecular cloud. This discovery identifies the first candidate object in the Milky Way that can accelerate cosmic rays up to 1 PeV.
Direct ethanol fuel cells have high energy density, low toxicity, and easy operation, but lack robust electrocatalysts for anodic ethanol oxidation. The study proposes alloying effects with core-shell construction to optimize Pd shell surfaces, achieving highest mass activity and specific activity for catalyzing ethanol electro-oxidation
Researchers have developed novel Bi-BiVO4 Mott-Schottky heterostructure catalysts for efficient urea synthesis under ambient conditions. The spontaneous charge transfer at the heterointerfaces promotes targeted adsorption and activation of CO2 and N2 molecules, effectively suppressing CO poisoning.
Researchers developed a two-step amination strategy to enhance the intrinsic activity of M-N/C catalysts, leading to improved current density and Faraday efficiency. The new method enabled CO2 electrocatalytic reduction at an industrial level, with a remarkable current density of over 400 mA cm−2.
The latest observations from Insight-HXMT have discovered the origin of fast radio bursts (FRBs), revealing they come from soft-gamma repeater (SGR) J1935+2154, a magnetar in our Milky Way. This discovery resolves the longstanding puzzle concerning the origin of FRBs.
The stellar-mass black hole in the Cygnus X-1 binary system was found to have a mass 21 times that of the Sun and is rotating at a speed close to the speed of light. This discovery challenges astronomers' thoughts on how black holes formed.
The collapse of Aru glaciers has sent at least 7.1 million cubic meters of ice into downstream lakes, disrupting regional ecosystems. The volume increase of Memar Co Lake is 30% faster than the previous rate, and it may merge with Aru Co Lake within 7-11 years.
Researchers identified lithium hydride (LiH) as a dominant compound in anode breakdown during lithium metal batteries (LMBs), which can be reversed by increasing temperature. The discovery offers hope to enhance battery life without size increase or cost.
Researchers have discovered that non-teleost ray-finned fishes possess genetic traits similar to those of lobe- and ray-finned fishes, including limb development and respiratory systems. These findings provide crucial insights into the water-to-land transition during vertebrate evolution.
Researchers have discovered that pollinator host-switching and hybridization are common features of fig-wasp coevolution, contradicting the traditional view. The study analyzed genomes from 15 fig species and found widespread hybridization events with associated host-switches among pollinators.
Scientists used environmental transmission electron microscopy to visualize epitaxial rotation of gold nanoparticles on titanium dioxide surfaces during CO oxidation. Theoretical calculations showed that the epitaxial orientation could be induced by changing O2 adsorption coverage at the perimeter interface.
A high-resolution 3D chromatin structure map of the macaque fetal brain has been constructed, revealing human-specific chromatin structural changes. These changes include 499 human-specific TADs and 1266 human-specific loops, which are enriched with enhancer-enhancer interactions.
Researchers studied the brain and inner ear cavity of Brindabellaspis stensioi, discovering an ancient placoderm with features resembling modern jawed vertebrates. The fossil challenges existing theories on platyoderm relationships and sheds light on the evolution of jawed vertebrates.
A joint research team revealed that the growth of northern Tibet drastically altered climate and vegetation patterns in East Asia. The study found that increased rainfall allowed unique plants and animal species to evolve in vast numbers, creating a biodiversity hotspot.
A new algorithm called Meta-Apo reduces the need for expensive whole-genome sequencing to understand microbial function, improving consistency with 16S rRNA gene amplicon results. This approach enables accurate diagnoses like gingivitis improvement from 65% to 95% using low-cost 16S-amplicon sequencing.
The new search engine enables researchers to compare different samples with the same function in various microbiomes, aiding disease diagnosis and treatment. MSE 2 includes an extended database of over 260,000 samples, providing a bird's eye view of the microbiome data space
Researchers developed a stable graphene oxide nanofiltration membrane with uniform pore size to remove organic micropollutants. The study proposes combining signal amplification strategy and defect chemistry to reduce membrane pore size distribution, offering a promising method for preparing highly selective NF membranes.
A new method, D2O-CANST-R, allows for rapid and precise tracking of metabolic changes in cancer cells at the single-cell and single-organelle level. This approach has the potential to reveal the metabolism in a cancer cell with very fine details and distinguish between effective and ineffective drugs.
A giant 2D map of the universe, released by the Beijing-Arizona Sky Survey (BASS), will aid the upcoming DESI project's spectroscopic survey. The map covers half of the sky, spanning over 10 trillion pixels and containing about two billion objects.
A recent study found that Asian water towers will struggle to quench the thirst of downstream communities despite more river runoff brought on by a warmer climate. Rising water demands from the growing population will outweigh warming in determining water scarcity in the Indus and Brahmaputra basins.
A new study published in JAMA Network Open shows that deep learning can help predict occult peritoneal metastasis in stomach cancer. The researchers developed a deep learning model called Peritoneal Metastasis Network (PMetNet) to predict clinically occult peritoneal metastasis using preoperative computed tomography images.
Researchers found a key gene, OsTCP19, that helps rice adapt to low soil nitrogen levels. By introducing this gene into modern cultivars, farmers can improve crop yields while reducing fertilizer use, leading to more sustainable agricultural practices.
Scientists have developed a bioinspired material that enhances lithium-ion extraction by controlling interlayer spacing and achieving stable ordered nanostructures. The new membrane shows higher toughness and efficiently controls Li+ permeation rate, outperforming other materials.
Researchers from Chinese Academy of Sciences and University of Bristol solve the 'flea mystery' by classifying fleas as a group of highly modified scorpionflies. The study suggests that fleas evolved from small, nectar-feeding scorpionflies that later developed specialized blood-sucking mouthparts.
Developed by Chinese scientists, this lateral flow immunoassay can detect SARS-CoV-2 RNA in under an hour with a limit of detection of 500 copies/mL. The test kit has been commercialized and received regulatory approval for its use as an on-site diagnostic tool.
New research challenges previous understanding, finding Third Pole grew at a much slower pace than thought. The findings shed light on regional and global climate processes.
Fossil discovery provides insights into ancient Tibetan biota and land surface height in the middle Eocene. The study reveals a diverse and humid subtropical forest ecosystem at an elevation of 1,500 meters under a monsoonal climate.
Researchers identified coral GSDME as a pyroptosis-inducing protein in reef-building corals, revealing its role in pathogen-induced coral death. Activation of coral GSDME triggers rapid cell swelling and cytoplasmic content release, leading to necrotic tissue damage.
Researchers found unprecedented magnitude of summer heatwaves and droughts in inner East Asia, tightly coupled by anthropogenic climate change. Tree-ring data suggests abrupt shift to hotter and drier climate over the past two decades.
Researchers designed a catapult-like hydrogel that can store and release elastic energy, achieving high contractile force and ultrahigh work density. The material overcomes mechanical weakness in traditional hydrogels, enabling controllable multistable deformation and programmable elasticity.
A new agglutinate, reprogrammable, and disintegrable magnetic spray has been developed to transform inanimate objects into millirobots with high adaptivity for various biomedical applications. The spray can be repurposed by adjusting its magnetization direction, allowing the creation of diverse locomotion modes.
Researchers observed two distinct seismic discontinuities in the mantle transition zone, representing the upper and lower boundaries of a subducted Pacific high-velocity slab. The study suggests a compositionally layered slab with high-water contents beneath the slab, challenging existing knowledge on slab interfaces.
The Five-hundred-meter Aperture Spherical radio Telescope (FAST) detected a weak correlation between fast radio bursts and soft gamma-ray repeater J1935+2154, suggesting a magnetar origin for FRBs. The study provides crucial clues to the generation of FRBs.
A team of researchers used the FAST telescope to detect over 15 fast radio bursts, revealing a galaxy 3 billion light years away as the source. The bursts' polarization signals showed diverse swings, indicating production in compact star magnetospheres and disfavoring shock models.
The discovery of Kylinxia, a shrimp-like fossil with five eyes, has provided crucial insights into the early evolution of arthropods. The study suggests that Kylinxia represents a transitional form between Anomalocaris and true arthropods, bridging the evolutionary gap between these two groups.
Researchers discovered Denisovan DNA in sediments from the Baishiya Karst Cave on the Tibetan Plateau, revealing that Denisovans occupied the region for a long time and had adapted to the high-altitude environment. The findings support the idea that Denisovans had a wide geographic distribution beyond Siberia.
Researchers have identified five cubic isomers in a tiny ice cube, including two with chirality, using a novel infrared spectroscopy technique. The study provides crucial information for understanding the formation processes of cloud, aerosol, and ice.
The NanDeSyn Database collects and integrates functional genomics data for industrial microalgae, including genome sequences, gene annotations, and transcriptomes. This will facilitate research cooperation among the global Nannochloropsis community to develop the microalgae as a chassis for photosynthetic production of oils.
Researchers at Chinese Academy of Sciences HQ found a pH-dependent switch in the interaction between protein molecules dockerin and cohesin, allowing for more complex biological switches. This discovery has potential applications in biofuel production, biotechnology and synthetic biology.
Researchers developed a near-infrared/pH dual-responsive drug delivery system using graphitic carbon nitride quantum dots and carbon nanosheets for improved chemotherapy response. The system exhibits light-to-heat conversion and singlet oxygen generation capabilities under single NIR excitation.
Researchers propose that volatile outgassing led to the flattening shape of Arrokoth, a small Kuiper Belt object. The study suggests sublimation mass loss could be a ubiquitous process shaping KBOs' structures.