Researchers at Indiana University and Wuhan University developed a novel light-driven reaction to produce tetrahydroisoquinolines, a crucial group in medicinal chemistry. This approach enables the creation of new structural patterns in molecules, offering a more efficient way to make complex compounds.
A new study co-authored by Indiana University researchers finds that mountain formation directly influences the evolution of species. The study's findings suggest that as mountains rise, they create new habitats and isolate populations, leading to the emergence of new species through a process known as allopatric speciation.
The Indiana University School of Medicine is accepting nominations for the 2026 Watanabe Prize in Translational Research. The prize recognizes senior investigators focused on translating scientific discoveries into new therapies. Previous winners include notable researchers and scientists.
The study proposes a new framework for understanding complex higher-order networks, which could lead to breakthroughs in physics, neuroscience, computer science, and more. The framework integrates discrete topology and non-linear dynamics, offering insights into how topology shapes dynamics and evolves dynamically.
A team of scientists at Indiana University School of Medicine has identified a potential link between retinal changes and Alzheimer's disease. The study found that the APOE4 gene variant impairs retinal function in mice, suggesting a direct link to visual processing deficits associated with Alzheimer's disease.
An international team led by IU School of Medicine has discovered a novel gene associated with an ultrarare neurodevelopmental disorder. The breakthrough was made using cutting-edge genomic technologies and enabled the diagnosis of a patient at Riley Hospital for Children's Undiagnosed Rare Disease Clinic.
Brondizio's work highlights the vital role of Indigenous peoples in conservation and connects large-scale structural processes to local communities. His research has transformed knowledge of the Amazon region and its socio-ecological issues.
Children with severe malaria are at risk of serious health complications, higher mortality rates, and long-term cognitive impairment due to elevated uric acid levels. The study suggests that lowering uric acid may reduce hospital deaths and improve treatment strategies.
Researchers at Indiana University found that bacteria secrete molecules, like coelechelin, which weaken competitors' immune systems and increase their vulnerability to phage infection. This discovery highlights the potential of phage-chemical combinations in treating antibiotic-resistant infections.
A new study found that plant leaves are coated with diverse RNA molecules that may play a role in shaping microbial communities. The RNA present on the leaf surface can regulate gene expression in microbes, potentially impacting plant health and environmental interactions.
Researchers discovered a novel vulnerability in prostate cancer cells that starves them of critical nutrients called amino acids. By inhibiting two proteins, GCN2 and p53, the team found a way to effectively destroy prostate tumors.
Researchers found that children with primary ciliary dyskinesia (PCD) are 22 times more likely to have asthma compared to those without PCD characteristics. The study suggests that some children diagnosed with asthma may have undiagnosed PCD, particularly if they exhibit unique respiratory symptoms.
A study by Indiana University School of Medicine researchers reveals that Toxoplasma gondii parasites use cap-independent translation to make proteins for dormant stages, evading drug treatment. This unconventional method has been found in both the parasite and human cells, making it a potential target for new treatments.
New research from Indiana University finds that accepting funding from family and friends can lead entrepreneurs to make more conservative venture growth decisions. This 'funding-source-induced bias' can result in anticipated guilt, prompting founders to prioritize lower-risk strategies.
A new study found that AI-fact checking can lead to increased belief in false headlines, while decreasing faith in true ones. Human-generated fact checks, however, enhanced discernment of true headlines.
Neuro-oncology experts developed guidelines to standardize AI use in brain cancer diagnosis and treatment. The recommendations aim to ensure reliable clinical trial results and protect patients.
A study published in JAMA found evidence of partial resistance to artemisinin derivatives in young children with severe malaria, raising questions about the need for new treatments. The study also showed that 10% of children returned within 28 days with an infection from the same strain they had during their original admission.
Researchers have discovered a new phenomenon in quantum-driven superconductors that could lead to more precise control of driven quantum systems. The study, led by IU Professor Babak Seradjeh, explores the role of Floquet Majorana fermions in the Josephson effect and their potential for developing stable quantum computers.
A global research team, led by Indiana University's Linda Smith, will investigate how shape perception influences language acquisition in children with typical and atypical developmental trajectories. The project aims to develop a cross-disciplinary theory of the dynamic interaction between language and cognitive systems.
Researchers at Indiana University are developing next-generation ophthalmoscopes to spot early warning signs of diseases like Alzheimer's, diabetes, and heart disease with a simple eye scan. The technology uses machine learning and AI to reduce diagnosis time from days to minutes.
Researchers have made key insights into river avulsion phenomenon, shedding light on conditions that create sudden changes in river course. The study provides a novel framework for predicting avulsion hazards using satellite technology and topographic data.
Researchers will investigate the psychological influence of online communications developed with artificial intelligence, including misinformation and radicalizing messages. The team aims to develop a holistic model of multi-level belief resonance that can counter foreign influence on campaigns and radicalization.
A new study enables the reconfiguration of nanoparticles, a step toward smart materials and coatings. The approach combines electron microscopy, computer simulations, and microscopic channels, allowing researchers to watch how nanoparticles react to changes in their environment.
A study by Indiana University Kelley School of Business found that Black employees are more likely to attribute workplace mistreatment to racial prejudice and make a pessimistic attribution. This leads to higher rates of depression compared to white employees. Organisations must create an inclusive workplace to reduce workplace mistrea...
Pharmaceutical companies exploited a loophole in the DEA's monitoring system, leading to an oversupply of opioids in communities. The study highlights the impact on Black communities, where overdose deaths tripled from 2014 to 2020. High supply chain complexity played a key role in evading regulations.
A new IU study reveals that young infants' daily-life input is unique to their age, characterized by high-contrast edges and simple patterns, which serve as a foundation for human vision. This finding has implications for addressing lifelong visual deficiencies and improving AI visual systems.
Researchers at Indiana University Kelley School of Business found that AI-driven products with human-like features, such as eyes and speech, can influence consumers' perceptions and decision-making. The study suggests that complex products are more likely to trigger anthromorphism, leading to increased willingness to pay.
Indiana University researchers have found that nicotinamide nucleotide adenylyl transferase 2 (NMNAT2) plays a critical role in protecting the brain from aging and neurodegenerative diseases. The enzyme provides energy to axons, enabling them to carry out nerve impulses and maintain healthy function.
A recent study published in the journal Blood revealed that hydroxyurea treatment resulted in a 60% reduction in severe or invasive infections among Ugandan children with sickle cell anemia. The findings provide powerful justification for hydroxyurea's use as a standard of care in Africa, which could ultimately save countless lives.
A $2.8M NIH grant will help unravel the mysteries of disease-causing DNA folding errors, with researchers exploring the 'folding mechanisms' implicated in certain genetic disorders and cancers. The study aims to develop an artificial version of the DNA compaction system, also known as synthetic biology.
Researchers at Indiana University have completed the final gaps in the Arabidopsis genome sequence, revealing how ribosomal RNA genes are organized and regulated. The study found that one NOR is nearly completely silenced in growing plants, while the other accounts for almost all ribosomal RNA gene activity in its central region.
Researchers have long debated the cause of the Late Devonian mass extinction event, with some attributing it to large-scale volcanic eruptions and others to a mass deoxygenation event caused by land plants. A new study now posits that both factors played a role, highlighting the environmental tipping points the planet faces today.
Researchers at Indiana University discovered that pathogens can apply physical forces during entry into host cells, evading degradation and surviving intracellularly. This finding suggests targeting pathogen movement may be a new way to combat infection inside cells.
Researchers have identified a new therapeutic target for pulmonary hypertension treatment by discovering an epigenetic pathway mediated via the protein SPHK2 that can reduce and potentially reverse vascular remodeling. This discovery offers new hope for treating pulmonary hypertension, which is a complex and often fatal condition.
A study led by Indiana University researchers explores the potential of climate engineering to slow Antarctic ice loss through stratospheric aerosol injection. The approach could buy time to address climate change and avoid catastrophic sea-level rise.
A recent study presents exciting future possibilities for managing type 1 diabetes with the repurposed drug α-difluoromethylornithine (DFMO), which may reduce insulin dependency. The researchers have established preliminary safety of DFMO for individuals with type 1 diabetes, paving the way for innovative therapies.
Research identifies specific gut bacteria that increase risk of severe malaria in humans and mice, sparking new approaches targeting gut microbiota. The study's findings could lead to prevention strategies for severe malaria-related deaths.
The Canadian Cardiovascular Society has adopted a new classification system for heart attacks based on the extent of tissue damage, which aims to improve patient outcomes by guiding treatment and predicting disease progression. The four-stage classification outlines varying levels of injury following a heart attack.
A new study, funded by a $3 million grant, aims to investigate whether treating insomnia can lower the risk of cardiovascular disease. The SHADES trial will recruit 200 patients and compare those who receive modernized collaborative care with standard primary care for insomnia.
Using anonymized smartphone data, researchers found that police spend more time patrolling non-white neighborhoods, with disparities linked to socioeconomic and crime-driven demand for policing. The study reveals a strong correlation between racial composition of a neighborhood and police presence.
Researchers analyze relationship between agriculture, emergence of new diseases. They propose a holistic approach focusing on broader factors impacting disease transmission.
A team of scientists discovered evidence for sustained wet-dry cycling on early Mars, essential for prebiotic chemical evolution and the emergence of life. The findings suggest that ancient Martian mudstones may have hosted conditions conducive to complex organic molecule formation and pre-biotic chemistry.
The IU team has made significant contributions to the Human BioMolecular Atlas Program, including the development of Organ Mapping Antibody Panels and the creation of a Human Reference Atlas. The research papers cover various aspects of tissue mapping, organ imaging, and data visualization.
New IU research shows that a mutual connection to past changes an object's value, making sellers more willing to part with items. This connection also has implications for sustainability, as emphasizing heritage can lead to greater citizen value and environmental concern.
Researchers at Indiana University have identified a new method to reverse the effects of fentanyl, which is 50 to 100 times stronger than morphine. Cannabidiol, or CBD, was found to behave as a negative allosteric modulator at the binding site, successfully reversing fentanyl effects in in vitro tests.
A team of researchers at Indiana University created a synthetic cell with only 493 genes, essential for life. The cell evolved rapidly over 300 days, adapting to its environment and recovering fitness lost due to genome streamlining.
Researchers at IUPUI will lead two grants totaling $11.7 million to discover a drug treatment for hydrocephalus, a condition commonly associated with traumatic brain injury. The studies aim to test the effectiveness of treatments for three types of hydrocephalus and may lead to a new treatment option.
A team of researchers led by Indiana University's Chen Zhu aims to understand the chemical processes that trap CO2 in rocks. They will employ an isotope tracer method to investigate basalt-CO2-water interactions, which have shown potential for rapid carbon storage.
A study by Indiana University astronomer Songhu Wang reveals that at least a fraction of hot Jupiters cannot form through violent processes, suggesting a new understanding of their evolution. Researchers found 12% of hot Jupiters and 70% of warm Jupiters have nearby planetary companions.
New research from Indiana University suggests that Saturn's icy rings are no more than a few hundred million years old, much younger than the planet itself. The rings are expected to lose mass onto the planet at a prodigious rate, leading to their eventual disappearance in another few hundred million years.