The Humanwide program at Stanford Medicine combines cutting-edge tools and a collaborative team-based method to provide proactive, personalized care. The pilot program successfully identified previously overlooked health conditions and future health risks in patients, setting them on a path to avoid serious medical problems.
A Stanford-led study tracked over 100 people for years, collecting genetic and molecular data to identify clinically actionable health discoveries. The research uncovered 67 health issues, including high blood pressure, arrhythmias, and early stage cancer detection.
Researchers at Stanford University School of Medicine have identified a specific set of brain cells that are particularly susceptible to harm from low oxygen exposure in early development. The discovery has implications for preventing brain injuries in premature babies, who often suffer from poor neurodevelopmental outcomes.
Researchers have developed CIBERSORTx, a technique that can analyze RNA from individual cells in whole-tissue samples, enabling insights into cell behavior and state. The tool has been shown to identify differences between cancer and normal cells, as well as changes in immune cells infiltrating tumors.
Researchers at Stanford University School of Medicine have developed a synthetic biology approach that targets cancer cells with customizable treatments. The RASER system uses two proteins to kill only overly active cancer cells while sparing healthy ones, promising a more targeted and effective treatment.
A Stanford-led study reveals that once Helicobacter pylori colonizes a pitlike gland in the stomach, it becomes difficult for other strains to dislodge it. The findings raise questions about the effectiveness of probiotic approaches and hint at potentially effective ways to deal with life-threatening H. pylori strains.
Researchers at Stanford University School of Medicine have created a blood test that can flag the disease, which currently lacks a standard diagnostic test. The test successfully identified participants in a study with chronic fatigue syndrome and is being used to screen for potential drugs that may help treat the condition.
Researchers discovered a link between filamentous phages and antibiotic-resistant Pseudomonas aeruginosa infections in cystic fibrosis patients. The viruses form biofilms that sequester antibiotics, allowing resistant bacteria to thrive.
A landmark clinical trial shows that canagliflozin lowers the risk of kidney failure by 30% in people with Type 2 diabetes and kidney disease. The study also found a significant reduction in cardiovascular events, providing a promising new treatment option for patients at high risk.
A new algorithm developed by Stanford researchers can accurately identify individuals at risk of familial hypercholesterolemia (FH), a cholesterol-raising genetic disease that increases the risk of early and fatal heart problems. The algorithm, trained on data from over 200 FH patients, correctly flagged 88% of cases in testing runs.
A recent study found that fewer than a quarter of breast cancer patients and a third of ovarian cancer patients underwent genetic testing for cancer-associated mutations. The research, which analyzed data from over 83,000 women diagnosed with breast or ovarian cancer in California and Georgia between 2013 and 2014, revealed substantial...
A Stanford University School of Medicine study found that blocking a specific protein's activity improved cognitive behavior in aging mice. The researchers identified a gene called CD22, which is involved in microglial phagocytosis and is upregulated with age.
Researchers found that brain network function and memory ability are key factors in determining PTSD patient response to behavioral therapy. A specific combination of reduced verbal memory and ventral attention network functioning leads to treatment resistance.
Starting colorectal cancer screening at age 45 rather than 50 would decrease U.S. cancer deaths by as much as 11,100 over five years and cases by up to 29,400. Screening a greater number of older adults would avert nearly three times as many diagnoses and deaths at a lower cost.
A Stanford study finds that a bacterial pathogen produces a virus that increases its ability to infect humans and causes the immune system to mount an antiviral response. The discovery could lead to new ways of preventing chronic infections by keeping antibiotic-resistant bacteria from getting a foothold in wounds.
A study from Stanford University School of Medicine found that rats' spatial maps change depending on their behavior and memories. The researchers suggest this process could play a role in addictive behavior in humans, as the brain's internal map is redrawn when rewards are associated with certain locations.
Researchers at Stanford University School of Medicine have discovered a method to forecast which breast cancer patients will experience heart problems from trastuzumab, a commonly used chemotherapy drug. A class of medications already approved by the FDA may mitigate these side effects.
A new study suggests that democracy is associated with improved public health outcomes in low- and middle-income countries, especially in areas such as cardiovascular disease and noncommunicable diseases. The researchers found that democratic institutions and processes can be a catalyst for improving population health.
Researchers found that adults born with mild congenital heart defects are 13 times more likely to develop heart failure or atrial fibrillation and five times more likely to have a stroke. A heart-healthy lifestyle can reduce this risk, but the exact reasons behind these increased risks remain unclear.
The US opioid epidemic has rapidly shifted to the Eastern states, with synthetic opioids accounting for most recent deaths. The study found that eight states have highest rates of opioid-related deaths, with Florida and Pennsylvania experiencing doubling mortality rates every two years.
The study found that burnout decreased and satisfaction with work-life integration improved among US physicians between 2014 and 2017. However, levels of burnout remain higher than in other fields, affecting around 44% of physicians.
A study led by Stanford researchers found that every 10 additional primary care physicians per 100,000 people was associated with a 51.5-day increase in life expectancy during the decade from 2005 to 2015. The researchers also found that an increase of 10 specialists per 100,000 corresponded to only a 19.2-day increase.
Researchers at Stanford University School of Medicine developed an antibody-based treatment that gently eliminates diseased blood-forming stem cells in the bone marrow. This could circumvent the need for harsh chemotherapy or radiation to prepare people for transplant, expanding the number of patients who can benefit from the procedure.
A Stanford University School of Medicine investigation discovered that common opioids are less effective for patients taking selective serotonin reuptake inhibitors (SSRIs) for depression. This interaction may lead to reduced pain relief and increased risk of opioid abuse.
A male mouse can quickly identify a stranger's sex without prior experience, thanks to hard-wired brain circuitry. This ability is likely to apply to humans, as we share similar brain structure and function for recognizing a stranger's sex.
A Stanford study has identified a set of 20 genes that predict the severity of dengue fever, allowing for more accurate diagnosis and treatment. The researchers used gene expression data from hundreds of patients to develop a predictive model that can identify patients at risk of severe disease.
A team of researchers at Stanford University has discovered a signaling molecule that promotes the growth of small arteries leading into oxygen-starved heart tissues, offering hope for new treatments. The protein, CXCL12, is activated in response to low oxygen levels and helps heal damaged heart tissue.
Gun injury hospitalizations averaged $911 million from 2010 to 2015, with Medicaid and Medicare covering most of the costs. The study highlights the chronic nature of firearm injuries, with 93% of patients surviving their initial hospital stay and 15.6% readmitted within six months.
A team of scientists at Stanford University has identified a bundle of brain cells in mice responsible for the negative emotions associated with pain. The amygdala region is key to processing painful stimuli and conveying emotional responses.
Researchers have engineered immune cells to target different types of pediatric solid tumors, including brain tumors, with promising results. The treatment uses a surface marker called B7-H3, which is expressed on most pediatric cancer cells, and has been shown to eradicate tumors in mice.
Researchers at Stanford University discovered that activating social brain circuits can suppress feeding behavior in mice. The study used optogenetics to target specific neurons in the orbitofrontal cortex and found that stimulating fewer than two dozen nerve cells linked to social interaction was enough to inhibit feeding behavior.
A new study by Stanford Medicine and Duke University finds that early physical therapy can reduce the risk of long-term opioid use by 7-16% for patients with musculoskeletal pain. Physical therapy is also associated with a 5-10% reduction in opioid dosage for those who do use them.
A Stanford study found that methotrexate damages brain cells, leading to cognitive impairment. Researchers identified a potential remedy and hope to improve treatment for cancer survivors struggling with debilitating side effects.
Researchers at Stanford University have developed a zinc-based regenerative drug that selectively targets insulin-producing cells in the pancreas, potentially paving the way for more appealing alternatives to insulin injections. The method uses chelation to deliver a drug to beta cells, which have a strong affinity for zinc.
Researchers have found that Botryllus schlosseri, a marine invertebrate, has a blood-forming system with uncanny similarities to humans. This discovery may provide a way to improve immune function and find new tools for biological discovery. The study also reveals parallels between the blood systems in Botryllus and mammals.
A Stanford University School of Medicine study found that teens and young adults who receive their initial opioid prescriptions from dentists are at increased risk for opioid addiction in the following year. The study, which examined nearly 15,000 patients, found that those who received dental opioid prescriptions were more likely to c...
Researchers identified a cell type responsible for initial steps of adhesion formation and developed an antibody-based therapy to treat and prevent adhesions. The treatment showed promise in mouse models and expressed similar genes as human tissue, suggesting potential translation into the clinic.
A new study from Stanford University School of Medicine has developed a method to diagnose autism in children using short home videos, expanding on previous feasibility studies. The researchers employed machine learning to determine relevant behavioral features and devised an algorithm to provide an overall diagnostic score.
A study by Stanford University researchers found that four Himalayan populations with different dietary histories have distinct gut microbiome compositions. The findings suggest that changes in human lifestyle can occur within a lifetime and may be driven by dietary factors.
A study by Stanford University researchers found that surgery remains the best treatment option for appendicitis, despite being more expensive upfront. Patients treated with antibiotics alone had higher rates of hospital readmissions and abdominal abscesses, highlighting the risks of this alternative approach.
Researchers developed a method to release drugs from nanoparticle cages in small areas of the brain, reducing neural activity. The technique uses focused ultrasound to jiggle drug molecules loose and has potential for treating various conditions, including cancer.
A Stanford study found that lax state gun laws are associated with higher rates of firearm-related fatalities among children and teenagers. States with stricter gun control legislation have lower rates of firearm-related suicides among youth.
The study aims to determine the accuracy of irregular-pulse detection by the watch and compare it with simultaneous ECG patch recordings. Researchers hope this study will help better understand how wearable technologies can inform precision health.
Babies born to fathers over 35 have higher risks of adverse birth outcomes, such as low birth weight and seizures. The study used data from 40 million births to show that every year a man ages increases the risk by two new DNA mutations in his sperm.
A novel immunotherapy combining Hu5F9-G4 and rituximab has shown safety and promise in a phase-1 clinical trial for non-Hodgkin's lymphoma. Half of the 22 patients enrolled experienced a positive response, with eight going into complete remission.
A Stanford-led study identifies uhrf1 and s100a10 as key genes driving rapid deer antler growth, a process that could inform new approaches for treating human bone conditions like osteoporosis. The researchers hope to apply the underlying biology of deer antlers to develop more efficient therapies.
Researchers identified a link between chromatin, transcription factors, and gene activation patterns in cancer. They found that specific mutations in chromatin can lead to changes in gene activity, driving cancer growth and development. The study provides new insights into cancer biology and potential treatments.
Researchers at Stanford University discovered that adult mouse skeletal stem cells revert to an earlier developmental stage when tasked with regenerating large portions of bone and tissue. This process, called de-differentiation, allows the cells to become more primitive and express genes typically found in early embryonic development.
A Stanford University School of Medicine study found that teens and young adults who use Juul e-cigarettes fail to recognize the product's addictive potential, with some reporting addiction despite infrequent smoking. The study emphasizes the need for clear public-health messages about the risks of new types of e-cigarettes.
A new treatment for lymphedema symptoms has been found to be effective in restoring skin health and reducing swelling. Ketoprofen, an anti-inflammatory drug, has shown promising results in two clinical trials, with participants experiencing significant improvements in skin thickness and appearance.