Temple researchers discover that calorie restriction slows down epigenetic drift, which is associated with lifespan across species. The study reveals that the speed at which epigenome changes with age varies among species and that a slower rate of change is linked to longer lifespan.
Scientists at Temple University are exploring exosome-based treatments for heart disease using a $11.6 million NIH grant. Researchers aim to understand the regenerative capabilities of exosomes and develop novel therapies for patients with heart disease.
Scientists at Temple University Health System uncover the mechanism underlying energy loss from heart dysfunction in sepsis, proposing NOX2 inhibition as a potential treatment. The research builds on earlier findings and aims to provide extra time for anti-inflammatory treatments to work.
Temple University Hospital is introducing an endoscopic keyhole craniotomy approach for treating tegmen dehiscence and temporal encephalocele, two rare conditions affecting the skull. This innovative method reduces skin incision size, retraction on the temporal lobe, and risk of brain injury.
A Temple-led research team found a notable decrease in IVC filter usage following the FDA advisory, with implantation rates remaining high compared to European countries. The study also showed that VTE-related hospitalization rates remained steady despite the decline in IVC filter use.
Researchers at Temple University have identified a novel mechanism underlying the efficacy of common heart failure drug beta-blockers. The study reveals that dysfunctional beta-adrenergic receptor 3 and decreased levels of cardioprotective phospholipid sphingosine 1-phosphate contribute to treatment resistance in some patients.
Researchers at Temple University Health System found that extra-virgin olive oil reduces brain inflammation and activates autophagy, preserving synaptic integrity and reducing amyloid plaques and neurofibrillary tangles. This may provide a potential prevention or treatment strategy for Alzheimer's disease.
A Temple University Health System study analyzed the impact of combining baby boxes and personalized sleep education on reducing bed-sharing in infants. The research found that face-to-face postpartum education and providing a baby box with a firm mattress and fitted sheet reduced bed-sharing rates by 25% in the first eight days of life.
Scientists at Temple University have developed a gene editing strategy that can excise HIV DNA from the genomes of living animals, eliminating further infection. The CRISPR/Cas9 system was successfully tested in three animal models, including one with latent HIV-1 infection.
Researchers at Temple University Health System reveal that mitochondrial calcium efflux is essential for proper heart function and identifies a promising therapeutic target to limit heart disease. The study shows that augmenting NCLX expression can prevent cell death and protect against the progression of heart failure.
A Temple University Health System research team identified sex-based differences in the utilization and safety outcomes of catheter-directed thrombolysis (CDT) for treatment of deep vein thrombosis (DVT). Female patients were less likely to receive CDT, while males experienced more bleeding complications, but with similar mortality rates.
The study identifies a direct role for MCU complex in mitochondrial ROS-sensing, with oxidation-induced S-glutathionylation regulating activity during inflammation and cell survival. The findings could have implications for understanding metabolic disorders and neurological and cardiovascular diseases.
A new study by Temple University researchers links glucose deprivation in the brain to cognitive decline and memory impairment in Alzheimer's disease. The study identified p38 as a potential drug target, which could alleviate memory impairments caused by glucose deprivation.
The Temple Wedge Opioid (TWO) Treatment Program provides state-of-the-art care to pregnant women and their partners, addressing the growing issue of maternal opioid use. The Center of Excellence offers comprehensive treatment options, including medication-assisted treatment and psychiatric evaluation.
A new study by Temple researchers shows that the BAG3 protein helps protect the heart from damage caused by reperfusion injury. By increasing BAG3 expression, cells can clear out damaged components and prevent cell death pathways.
Researchers have made a breakthrough discovery on the structure of the mitochondrial Ca2+ uniporter (MCU), a membrane gateway that regulates calcium uptake. The study reveals that MCU activity is vital to calcium homeostasis and cell survival, and that it can be modulated through small molecule development.
Researchers at Temple University Health System will investigate the combined impact of tobacco smoke and opiates on HIV-induced tissue damage in brain, lungs, and other organs. The study aims to better understand the pathology of HIV infection and develop new treatments for affected individuals.
Using gene editing technology, Temple researchers successfully excised large fragments of HIV-1 DNA from the genomes of living animals, including transgenic rats and mice. This breakthrough is a significant step towards developing a potentially curative strategy for HIV infection.
The study reveals that MCUR1 acts as a scaffold for the MCU complex, binding to both MCU and EMRE to protect cells from calcium overload. MCU complex assembly is disrupted by mutations in MCUR1/MCU binding regions, but small molecules may promote MCU complex assembly despite these mutations.
A recent Temple University Health System study analyzed over 600 reports and studies on elastic compression stockings, finding no significant reduction in post-thrombotic syndrome development. The results highlight the need for new and more effective therapies for this condition.
The Pincus Family Foundation Urban Health Fellowship will provide junior healthcare professionals with tools to implement community-driven health programs. Fellows will earn a Master's degree in Urban Bioethics and be offered Temple Faculty positions.
Researchers at Temple University Health System found that disturbances in circadian rhythm exacerbate motor and learning deficits in Parkinson's disease. Altering circadian rhythm through daily light exposure can accelerate cell death and worsen neuroinflammation, potentially speeding disease progression.
Temple researchers are investigating novel compounds that activate cannabinoid receptor type 2 (CB2) to prevent HIV-associated neurocognitive disorder (HAND). The study aims to test the safety and effectiveness of these compounds in cell models and mice with HIV infection.
Researchers at Temple University Health System have successfully eliminated HIV-1 from the DNA of human T-cells using a specialized gene editing system. The technology not only removes the virus but also protects infected cells against reinfection, holding promise for an eventual cure for patients with HIV.
Temple researchers have uncovered a new mechanism by which aldosterone triggers heart damage, involving GRK2 and GRK5 signaling molecules. The study found that inhibiting these kinases could provide a potential therapeutic solution for heart failure.
Cadavers are being used to advance genetics education in medical schools, providing real-world scenarios and insights into genetic variants. This approach connects anatomy to genomics, bridging the gap between clinical application and future clinicians' training.
A Temple University study found that an opioid prescribing guideline significantly decreased prescription rates for minor conditions and chronic noncancer pain in acute care settings. The guideline was implemented in January 2013 and resulted in a high degree of statistical significance across all age groups and complaint categories.
Temple researcher Arthur M. Feldman warns that the newly approved heart drug Entresto may increase patients' risk of Alzheimer's disease and macular degeneration. The drug was approved for heart failure via the FDA's fast-track program, but its cognitive risks have not been fully tested.
A study by Temple University researchers found a significant association between psychological stress and various skin symptoms, including itchiness, hair loss, and acne-like rashes. The study suggests that healthcare providers should ask patients about their stress levels to better understand skin conditions.
Researchers at Temple University Health System have discovered a small molecule inhibitor that selectively kills cancer cells with BRCA1 or BRCA2 gene mutations. The compound, 6-hydroxy-DL-dopa, works by blocking an alternative DNA repair pathway, providing a promising approach to precision medicine for various cancers.
Researchers investigated how hypoglycemia affects cardiovascular autonomic control, finding a clear change in the body's responses to cardiovascular stress. The study suggests that hypoglycemia may compromise the heart's function.
Researchers at Temple University Health System have identified a regulatory enzyme defect in Down syndrome that also malfunctions in Alzheimer's disease, leading to the formation of toxic amyloid plaques in the brain. This discovery could lead to the development of a targeted therapy to mitigate dementia in Down syndrome.
A recent study by Temple researchers found that a protein isolated from bacterial biofilms, known as curli, can effectively relieve intestinal inflammation in animals. The results suggest that curli could be a novel immunotherapy for inflammatory bowel disease, offering a new treatment option for patients.
A digital health application facilitated early detection and treatment of COPD exacerbation symptoms, with patient adherence exceeding 90% and response times to worsening COPD symptoms in less than 11 hours. The app uses a symptom score system to generate alerts and provide evidence-based treatment recommendations.
A post-hoc analysis of the ACCORD study found that higher doses of insulin were not associated with increased cardiovascular death. The study's findings provide reassurance for physicians and patients with diabetes, but underscore the need for further research to clarify the potential risks of insulin use.
Researchers at Temple University School of Medicine are testing the effectiveness of mirror therapy in reducing pain and improving mobility in combat veterans with complex orthopedic injuries or nerve damage. The study aims to assess whether this technique can help alleviate symptoms and improve quality of life for these individuals.
Researchers at Temple University School of Medicine have identified a protein that opens the door to cell death, causing severe power failures in mitochondria. Blocking this protein with a small molecule inhibitor could aid in the treatment of cardiovascular diseases such as heart attack and stroke.
COPD patients who used a digital health application experienced fewer and less severe exacerbation symptoms, improving daily symptom control, lung function, and activity status. The application allowed for same-day treatment recommendations from healthcare providers.
Researchers tested the novel next-generation small molecule drug SGI-110 in MDS and AML patients, revealing it is well-tolerated and biologically active. The study found potent dose-related DNA demethylation associated with clinical response, showing promise for treating leukemia patients.
A study led by Temple University researchers found that hospitals performing more catheter-directed thrombolysis (CDT) procedures per year had lower mortality rates and bleeding complications. The research, published in the Circulation journal, suggests standardizing CDT protocols can minimize risks at low-volume centers.
A recent study by Temple researchers reveals a potential molecular link between excess fat in the blood and the recovery of damaged blood vessels. The study shows that inhibiting a specific molecule called caspase-1 could enhance blood vessel growth and restore oxygen supply to tissues.
A Temple-led research team has discovered that bacterial biofilms found in the gut can provoke the onset of systemic lupus erythematosus (SLE) in lupus-prone mice. The researchers found that curli amyloid and DNA complexes in biofilms lead to inflammation, self-attacking antibodies, and autoimmune disease symptoms.
A recent weight loss study showed significant improvements with liraglutide treatment, resulting in an average weight loss of 8.4 kg. The Temple doctors emphasized that modest weight loss can be considerable and improve medical issues, but more research is needed for longer-term results.
Researchers at Temple University School of Medicine discovered that calcium uptake by mitochondria is essential for the heart to beat faster and harder during stress. The study found that during a heart attack, increased calcium uptake leads to cell death, but in normal conditions, it has little impact on metabolic function.
A team of Temple researchers led by Dr. Raj Kishore used stem cell exosomes to induce the repair of damaged mouse hearts, improving heart function and reducing scar tissue. The study's findings suggest a unique way to regenerate the heart without using stem cells.
Researchers at Temple University Health System used fMRI imaging to study brain activity in chronic itch patients and healthy subjects. The study found that areas of the brain involved in motor control and reward processing were overactivated in chronic itch patients, explaining their addictive scratching behavior.
Academic medical centers face pressure to transition from 'sickness' care to 'healthcare', emphasizing preventive and therapeutic services. AMCs must redesign delivery mechanisms, position themselves as tertiary hubs, or create new specialties like observation medicine to survive.
New models of medical education with minimal research focus could lead to a two-tiered system, decreasing the physician-scientist pipeline and diminishing patient care advancements. Experts argue that research exposure is crucial for all students, regardless of primary care or specialty pursuit.
Researchers found that paroxetine, a commonly prescribed antidepressant, restored heart function in mice with heart failure by inhibiting the GRK2 enzyme. The study's findings suggest that physicians may consider prescribing paroxetine to heart failure patients with clinical depression to improve their heart function.
Researchers at Temple University will examine how cocaine and HIV-1 interact to cause brain impairment in patients infected with HIV-1. The study aims to determine where to focus potential treatments to disrupt this damaging pathway.