Researchers at Temple University hospital found that maternal-fetal mortality can be reduced to zero through patient-tailored management of right heart function prior to delivery. Women with pulmonary hypertension who received specialized care had excellent outcomes, with 100% survival for mothers and infants.
A third of COVID-19 patients experience neurological symptoms due to SARS-CoV-2's effect on the central nervous system. Researchers now investigate mechanisms of SARS-CoV-2 signaling in the CNS microvasculature with a new NIDA grant.
The new grant aims to address structural racism and discrimination affecting Asian-Americans with chronic hepatitis B virus infection and liver cancer. Researchers will examine factors such as socio-historical hardship, segregation, and mistrust of the health system to improve quality of care.
Researchers aim to understand how HIV affects cardiovascular health and the impact of substance use on this relationship. They plan to develop a human bone marrow chip model to study HIV pathogenesis and explore potential strategies for caring people with HIV who face cardiovascular disease.
Researchers at the Lewis Katz School of Medicine defined 11 subsets of cells found in esophageal tissue using single cell gene-expression profiling. This study could help clinicians diagnose or treat certain types of cancer by identifying functional cell types contributing to cancer progression.
The study found an increase in mass shootings and proportion of women and children shot, highlighting worsening structural inequalities. The researchers emphasize the need for investment in public education, employment, and social services to address gun violence.
Researchers at Temple University found that individuals with prior COVID-19 infection experienced rapid antibody production after the first vaccine dose, but showed little increase after the second dose. This contrasts with those without a history of infection, who exhibited massive responses after the second dose.
Researchers at Lewis Katz School of Medicine at Temple University discover a molecular pathway driving maladaptive processes in heart failure, revealing the importance of GRK5's catalytic activity and nuclear presence. The study opens doors to new therapeutic strategies for treating this devastating condition.
Researchers at Lewis Katz School of Medicine identify reduced efficiency of protein transport system as key factor in Alzheimer-like changes. The study suggests that targeting the retromer complex could lead to new treatments for Down syndrome-related dementia.
Researchers discovered YAP1 is a master regulator of Nodal signaling in human embryonic stem cells, crucial for human development. The study found that YAP1 regulates the allocation of germ layers and dictates the production of Nodal protein, essential for gastrulation.
Researchers found that nitrate triggers Salmonella bacteria to switch from a sessile, biofilm lifestyle to a motile, free-swimming lifestyle in the intestine. This switch enables the bacteria to cause active infection and establish transmission to a new host.
Scientists at Lewis Katz School of Medicine discovered that reintroducing the protein LIN28 into adult heart stem cells improves their chances of survival. This breakthrough could lead to new treatments for heart disease using stem cell therapy.
Scientists at Temple University will explore the therapeutic potential of KLS-13019, a CBD analog that shows promise as an opioid alternative. The Phase 2 SBIR grant aims to test the compound's effects on rat models of neuropathic pain, shedding light on its safety and efficacy.
Researchers at Temple University's Lewis Katz School of Medicine have been awarded a prestigious grant from the National Institutes of Health to develop novel treatments for individuals living with HIV using CRISPR technology. The $4.8M grant will fund four major research laboratories working towards eliminating HIV DNA from infected c...
Fels and Fox Chase researchers found specific TET2 and DNMT3A mutations in leukemia patients that affect DNA repair pathways. These mutations make leukemia cells sensitive to PARP inhibitors, a type of targeted therapy, while others are resistant. The study aims to develop personalized therapies for patients with these mutations.
Researchers aim to uncover a unifying molecular mechanism driving axon degeneration across multiple neurodegenerative diseases. They will investigate the role of palmitoylation in controlling axon survival factor destruction by DLK.
Researchers at Temple University are conducting a 5-year study to compare two approaches for reducing heart disease risk factors in Black birthing people. The study aims to eliminate disparities in heart disease among Black women and birthing people during and after pregnancy.
The Lewis Katz School of Medicine at Temple University has received a $1 million T32 predoctoral training grant from the National Institute of General Medical Sciences. The grant aims to provide students with opportunities for training in cell signaling, epigenetics, and genome maintenance.
A new analysis by Temple University researchers found that endovascular stenting is highly effective in treating superior vena cava syndrome, with a success rate of nearly 99%. The therapy has also shown low restenosis and recurrence rates, making it the preferred option for patients with this condition.
Research led by Dr. Satya P. Kunapuli seeks to understand how platelets become activated to form clots that lead to cardiovascular diseases like stroke and heart attack. The study aims to identify molecular differences in platelet genes and proteins to facilitate the discovery of new signaling pathways relevant to cardiovascular disease.
Researchers will investigate potential mechanisms using mouse models and systems biology approach to identify new drug targets for Alzheimer's disease. The study aims to understand how altered mitochondrial calcium transport contributes to neurodegeneration and disease progression.
A novel CBD analog, KLS-13019, has been shown to effectively alleviate pain and reverse sensitivity in mice with chemotherapy-induced peripheral neuropathy. The study suggests that KLS-13019 may have an additional mechanism of action beyond pain relief, potentially disrupting opioid-seeking behavior.
Scientists at Temple University and Case Western Reserve University will explore the role of nitric oxide in controlling the beta-adrenergic receptor system, a key player in heart function. The insights gained could lead to new therapies for congestive heart failure.
Researchers at Temple University Health System discovered that blocking GRK5's nuclear activity can prevent cardiac hypertrophy and reduce maladaptive effects in the heart. The findings offer exciting avenues for developing therapies to prevent heart failure.
Researchers are investigating how sleep affects lung health and exercise tolerance in African Americans compared to Caucasian smokers, thanks to a $30,000 grant from the CHEST Foundation. The study aims to identify potential associations between sleep deficiency, smoking, and lung health disparities in high-risk African American adults.
A new study by scientists at Temple University identifies a promising novel therapeutic strategy targeting G protein-coupled receptor kinase 5 (GRK5) in the heart. Reducing GRK5 levels improves survival following heart attack in mice, suggesting that GRK5 inhibition may be a viable treatment option for human patients.
A Temple-led team found a significant and sustained increase in firearm violence in Philadelphia following COVID-19 containment policies, which exacerbated existing issues like poverty and structural racism. The study suggests that these measures had a strong association with increased gun violence.
Scientists at Temple University Health System have identified Kruppel-like factor 5 as a key protein driving both oxidative stress and toxic lipid accumulation in the heart. This discovery opens up new avenues for treating various types of cardiac disease, including diabetes and heart attack.
Researchers at Temple University Health System aim to break down race-related barriers to lung cancer screening and care among Blacks and African Americans. The two-year grant will support the expansion of a successful lung cancer screening program using a multi-specialty, integrated model.
Researchers at Temple University Health System develop improved models to predict 30-day readmission risk among patients with diabetes based on electronic health record data. The new tool, eDERRI TM, aims to accurately identify risk factors and improve care for vulnerable patients.
Researchers successfully edited SIV - a virus closely related to HIV - from the genomes of non-human primates using CRISPR gene-editing. The breakthrough demonstrates that the editing tool can reach infected cells and tissues, including viral reservoirs where the viruses integrate into host DNA.
A new study uses CLARITY technique to visualize opioid receptor distribution across the entire brain in 3D images, revealing previously unknown areas susceptible to opioids. The researchers identified extensive tracts related to pain and reward, as well as many neural tracts not previously known to express opioid receptors.
Researchers at Temple University Health System found that bacterial biofilms in the urinary tract can trigger autoimmune reactions in lupus patients. The study identified a link between chronic bacterial infections and increased frequency of lupus flares, suggesting a potential new approach to controlling flare-ups.
SARS-CoV-2 spike proteins can cause inflammation on endothelial cells forming the blood-brain barrier, making it 'leaky' and disrupting neural networks. This could lead to neuroinvasion and neurological manifestations in COVID-19 patients, especially those with pre-existing health conditions.
Temple Lung Center enrolls first patient in RejuvenAir clinical trial to treat moderate to severe COPD with CB; aims to address daily symptom burden and hospitalization risk. The system delivers metered doses of liquid nitrogen spray to targeted airways, potentially allowing new cells to regrow.
Temple researchers developed and validated predictive criteria to identify COVID-19 patients at risk of developing a cytokine storm, which can lead to life-threatening organ damage. The six criteria relate to inflammation, cell death, tissue damage, and electrolyte imbalance, and were validated in two cohorts of patients.
A recent study aims to elucidate the link between B-type natriuretic peptide (BNP) and severe sepsis. Researchers found that BNP is increased in heart cells under stress, leading to lower cardiac output and promoting hypotension in septic patients.
Researchers at Temple University Health System discovered a mechanism behind drug resistance in leukemia cells and found that combining PARP inhibition with TGFBR kinase blockade can overcome resistance. This breakthrough could lead to a new treatment strategy for leukemia patients.
Researchers will investigate cardiovascular risk factors on Alzheimer's pathology and examine effects of hypertension, homocysteine, and other biomarkers on cognitive decline. The project aims to identify preventative strategies for Alzheimer's disease by maintaining cardiovascular health.
The new virtual echocardiography screening tool (VEST) uses initial screening data from echocardiography to accurately diagnose pulmonary hypertension. VEST enables physicians to quickly evaluate patients for the condition by searching for routine key measures in echocardiogram reports, facilitating early recognition and timely treatment.
Researchers at Temple University Health System have identified a new mechanism for promoting neuron regeneration after spinal cord injury, involving the metabolic switch associated with glucose metabolism in glial cells. The study found that upregulating glycolysis in glial cells can stimulate axon growth and improve functional recovery.
The Center for Substance Abuse Research at Temple University has received a $7.2M NIDA grant to continue critical research on drugs of abuse. The grant renewal will enable the continuation of high-quality, innovative research in addiction biology and the development of new treatments.
A study published in Circulation reveals that FoxO1 plays a crucial role in regulating abnormal heart growth, a condition characterized by cardiac hypertrophy. The research suggests that targeting FoxO1 could lead to the development of novel therapies for cardiac hypertrophy.
Researchers found that curli amyloid produced by Salmonella bacteria triggers autoimmune reactions in mice, leading to reactive arthritis. The study suggests that curli proteins may play a role in other autoimmune diseases and neurodegenerative processes.
Dr. Koch's work on G protein-coupled receptor kinases (GRKs) has led to breakthrough discoveries about heart function and their role in cardiac injury and heart failure. His ongoing research focuses on developing GRK inhibitors for potential gene therapy treatment.
Researchers at Temple University Health System will explore whether clavulanic acid can help patients recover from cocaine use disorder. The study uses functional magnetic resonance imaging (fMRI) to examine the brain and observe changes in glutamate levels.
Researchers at Temple University Health System have discovered that blocking the molecule Drp1 can prevent abdominal aortic aneurysms from developing in animals. The study suggests that maintaining mitochondrial fission-fusion balance may be fundamental to preventing AAA and other cardiovascular diseases.
Scientists at Temple University Health System discovered a novel mechanism between mitochondrial fission and endothelial cell inflammation. Salicylate reduces mitochondrial fragmentation, inflammation, and oxidative stress in the cardiovascular system.
Scientists at Temple University Health System are exploring the molecular mechanisms of heart injury and repair. They aim to identify new paths to developing innovative heart therapies. The study focuses on understanding the role of molecules known as G protein-coupled receptor kinases (GRKs) in heart function and disease.
Researchers at Temple University Health System use Lin28 to fuel axon regrowth in mice with spinal cord injury or optic nerve damage, enabling repair of the body's communication grid. The study shows significant improvements in coordination and sensation after Lin28 treatment.