Researchers at Temple University Health System discover a protein called B-type natriuretic peptide (BNP) produced in sepsis, which lowers blood pressure. Inhibition of JNK and BNP activity reverses cardiovascular damage and improves survival rates in mice with sepsis.
Gimsilumab, targeting granulocyte macrophage-colony stimulating factor (GM-CSF), may help reduce lung hyper-inflammation in COVID-19 patients with ARDS. A multi-site clinical trial enrolls up to 270 patients to assess mortality and duration of mechanical ventilation.
Researchers at Temple University Health System aim to understand immunological synapse formation and its impact on T-cell activation. They will focus on the role of molecules like STIM1 and septins in shaping immune responses.
Researchers have found a way to halt and reverse muscle fibrosis caused by overuse injuries in animal studies. The discovery uses the drug FG-3019 to block protein CCN2, which promotes connective tissue growth, leading to significant improvements in muscle strength.
Researchers discovered EGR4 acts as a critical brake on immune activation, promoting killer T cell activation and boosting anticancer immunity. EGR4 knockout mice showed reduced lung tumor burden and fewer metastases, raising new possibilities for immunotherapy.
Researchers at Temple University Health System have developed a new monoclonal antibody that can break apart communities of harmful bacteria, allowing for more effective treatment of infections. The therapy has shown promise in eradicating biofilms on medical devices and reducing the risk of sepsis.
Dr. Silvia Fossati, a Temple University Health System researcher, has been awarded a $500,000 grant to develop an Alzheimer's-specific version of a carbonic anhydrase inhibitor drug family. The goal is to target mitochondrial dysfunction, amyloid protein build-up, and inflammation in the brain, which are hallmarks of Alzheimer's disease.
Researchers discover a drug already approved for cancer treatment can reverse symptoms of heart failure with preserved ejection fraction. The drug, SAHA, shows significant improvements in heart structure and function by reducing hypertrophy and increasing the heart's ability to pump blood.
A novel pharmacological chaperone has been shown to restore levels of the sorting molecule VPS35 and prevent the accumulation of abnormal proteins in mice with Alzheimer's disease. This treatment approach has been proven to improve memory and learning, reducing tau tangles and amyloid-beta plaques.
Researchers discovered that reactivating the PPP2R2A gene can slow or stop prostate cancer progression. The study found that patients with only one functional copy of the gene have shorter survival rates, and that reconstituting PP2A protein ultimately kills prostate cancer cells.
A new study by Temple University Health System scientists shows that extra virgin olive oil (EVOO) can defend against tauopathies, a type of mental decline linked to frontotemporal dementia. EVOO supplementation in mice with abnormal tau protein resulted in a 60% reduction in damaging deposits and improved brain function.
Researchers at Temple University Health System standardized the definition of neighborhood mass shootings and found 46 incidents in Philadelphia from 2006-2015. The majority of victims were black males under 25, and most events received limited media coverage.
Researchers at Temple University have discovered that an existing HIV drug can suppress Zika virus infection by targeting a common enzyme. The study opens the door to developing a broad-spectrum treatment strategy for multiple RNA virus infections using the same approach.
The Temple research team will investigate the mechanism by which HIV infection leads to greater sensitivity to pain and reduced effectiveness of opioid therapeutics. The study aims to understand how chronic inflammation promotes cross-desensitization of opioid receptors, resulting in elevated pain sensitivity.
A study by Temple-led researchers describes a unique mechanism for coordinating calcium entrance and exit 'doors' on T cells, which helps them carry out their jobs and ensure normal immune function. The research offers new insight into calcium signaling that could help scientists better understand autoimmune and immunodeficiency diseases.
Researchers at Temple University Health System have identified a novel signaling pathway that regulates fibrosis, a condition characterized by the formation of excessive scar tissue. By targeting this pathway, they hope to develop new treatments for fibrotic diseases, which can lead to serious health complications.
A new analysis of two international clinical trials predicts that benralizumab may be effective for a subpopulation of patients with moderate to very severe COPD who have elevated blood eosinophil counts and a history of frequent exacerbations. The study found no significant efficacy in reducing annual COPD exacerbation rates for patie...
Researchers found that dual PPARα/γ agonists cause heart dysfunction in diabetes patients due to mitochondrial biogenesis and energy production issues. Activating SIRT1 with resveratrol reduced heart toxicity in mice treated with tesaglitazar, maintaining its therapeutic benefits.
A recent study published in Nature Communications found that a circular RNA called circFndc3b plays a critical role in tissue repair after a heart attack. The RNA acts like a 'sponge' to bind harmful molecules, preventing cell death and promoting vascular growth, which aids the repair process.
Researchers at Temple University Health System have identified a new target regulating mitochondria during stress, which could lead to a new approach to treating conditions such as heart failure, heart attack, stroke, and neurodegeneration. The discovery highlights the role of MCUB in mitigating calcium overload in injured heart tissue.
Researchers found that maladaptive changes in calcium transport by mitochondria contribute to the progression of Alzheimer's disease. Altering NCLX expression and mitochondrial calcium homeostasis restored cognitive function and reduced amyloid beta and tau pathology.
Researchers found that high maternal fat consumption during gestation improves offspring memory and learning skills by maintaining synaptic integrity. Offspring from mothers on a high-fat diet also have lower levels of amyloid-beta, an abnormal protein linked to Alzheimer's disease.
The All of Us Research Program aims to advance individualized prevention, treatment and care by enrolling more than 1 million participants from diverse backgrounds. Participants will share health information, participate in clinical trials and contribute to the development of precision medicine.
Researchers at Temple University Health System discovered that VPS35 clears the brain of a potentially harmful protein called tau, which accumulates in neurodegenerative disorders. The study found that altering VPS35 levels in individual neurons can directly control tau accumulation, implicating VPS35 in tauopathy.
Researchers at Temple University and UNMC eliminate HIV DNA from animal genomes using CRISPR-Cas9 technology, achieving a critical step towards a possible cure for human HIV infection. The study combines gene editing with LASER ART therapy to suppress HIV replication and eradicate the virus from cells.
A study published in JAMA Surgery found that inguinal hernia repair with mesh performed by medical doctors had similar outcomes to those performed by surgeons, with no statistically significant differences in recurrence rates or complications.
Researchers at Temple University Health System have discovered that a small RNA molecule can reactivate heart cell proliferation and improve heart function in mice with severe heart attacks. The study, published in Circulation Research, shows that miR-294 treatment reawakens an embryonic signaling program in adult heart cells.
Researchers found that IVC filter implantation prior to bariatric surgery is associated with higher rates of blood clots, pulmonary embolism, and prolonged hospital stays. Prophylactic IVC filters do not provide effective protection against post-surgical venous thromboembolism.
A recent study published in the New England Journal of Medicine found that benralizumab, an asthma drug, was ineffective in reducing exacerbations in patients with moderate to very severe COPD. The study involved over 3,000 patients and showed no significant decrease in COPD exacerbation rates among those receiving benralizumab.
Researchers at Temple University Health System found that the heart communicates with fat cells through a signaling enzyme, GRK2, regulating weight gain in patients with heart failure. The study's findings could lead to new ways to modulate weight gain.
Researchers analyzed firearm-injured patients arriving at Philadelphia-area hospitals within 15 minutes of each other, revealing 54 cluster events over 11 years. These clusters were more likely to occur at night and be female, with lower mortality rates than traditional mass shootings.
Dr. Feldman was awarded the Distinguished Scientist Award-Basic Domain by the American College of Cardiology in recognition of his major scientific contributions to cardiovascular disease research. He has made significant advancements in molecular biology of dilated cardiomyopathy and heart failure.
A synthetic compound derived from flaxseed has been shown to reverse cardiovascular dysfunction and improve heart function in mice with sepsis. Treatment with the antioxidant LGM2605 significantly reduced oxidative stress and restored energy production in heart cells.
Temple researchers discover that choline functions as an endogenous ligand for sigma-1 receptors, triggering intracellular signaling pathways and potentially treating conditions like substance abuse. The findings provide a long-sought activation mechanism for these receptors, which interact with various psychoactive drugs.
Researchers at Temple University Health System will test whether inhibiting a specific protein can stimulate new neuron growth. The goal is to understand the significance of reduced adult neurogenesis in Alzheimer's disease and potentially develop novel therapies.
A Temple-led research team finds blocking GRK2 localization to mitochondria protects heart cells from ischemic injury and death. The study also reveals that mitochondrial GRK2 pooling is associated with impaired cardiac metabolism and increased heart cell death.
Scientists at Temple University Health System have identified LKB1 as a critical regulator of axon regeneration in mature neurons, leading to significant gains in functional recovery in mice with spinal cord injuries. Targeted upregulation of LKB1 protein stimulated long-distance neuron regeneration and improved locomotor function.
The partnership aims to reduce cancer health disparities among African-American, Asian-Pacific-American, and Hispanic-American communities in the NYC-Philadelphia corridor. It will focus on multidisciplinary research, community outreach, and education to improve quality of life and health outcomes.
Researchers discovered that inhibiting CDK9, a DNA transcription regulator, reactivates genes silenced by cancer. This leads to restored tumor suppressor gene expression and enhanced anti-cancer immunity. The new epigenetic drug strategy shows broad effectiveness against cancer in both in vitro and in vivo studies.
The EMPROVE study shows significant improvements in lung function, shortness of breath, and quality-of-life parameters for patients treated with the Spiration Valve System. After 12 months, patients experienced a mean reduction of 974 milliliters in targeted lobe volume.
Researchers at Temple University Health System have identified four BAG3 gene variants linked to poor outcomes in African American patients with dilated cardiomyopathy. The variants facilitate programmed cell death and reduce autophagy, leading to worsening heart failure.
The Temple Lung Center has become the first US site to perform bronchoscopic lung volume reduction using implantation of the Zephyr Endobronchial Valve, treating severe emphysema. The procedure improved lung function and quality of life for patients with severe emphysema.
Researchers have developed a tool that analyzes protein phosphorylation patterns in the brain, revealing changes associated with desired and undesired opioid effects. This study aims to identify potential non-addictive opioids and reduce side effects by interfering with signal cascades.
Researchers at Temple University Health System discover a dual synthetic lethality approach to eradicate cancer cells by inhibiting two backup repair pathways simultaneously. The strategy effectively narrows down the number of secondary repair pathways available, helping to ensure cancer cell eradication.
Researchers at Temple University Health System have discovered a way to reverse memory deficits and tau pathology in mice with dementia. By administering a drug that blocks leukotriene formation, they were able to improve spatial learning and working memory in treated animals.
The Zephyr Endobronchial Valve successfully reduced shortness of breath and improved lung function in patients with severe emphysema, with benefits lasting at least one year after treatment. Proper patient selection was key to the trial's success.
Researchers found that high homocysteine levels in mice lead to increased tau tangles, nerve cell death, and impaired learning and memory. The study suggests a potential link between hyperhomocysteinemia and neurodegenerative diseases, highlighting the need for further investigation into the role of 5-lipoxygenase in disease progression.
A study by Temple University researchers found that mice fed canola oil daily suffered impaired working memory and increased amyloid plaques, indicative of neuronal damage. The findings suggest that long-term consumption of canola oil may be detrimental to brain health.
A study published in Laryngoscope found that certain genetic variations are linked to acquired laryngotracheal stenosis (ALTS), with African Americans being more susceptible. The researchers hope to use genetic testing to prevent ALTS through alternative breathing tube options.
Dr. Walter J. Koch, a renowned researcher at Temple University Health System, has been awarded the American Heart Association's Basic Research Prize for his groundbreaking work on molecular signaling of cardiac injury and repair. His research has identified novel molecular targets for treating heart failure.