A new CRISPR-Cas3 tool allows for larger DNA edits, enabling researchers to study disease and normal function in humans and other organisms. This advancement will facilitate the development of new treatments and improve our understanding of the human microbiome.
Patients with anorexia nervosa who received higher-calorie diets recovered faster and had shorter hospital stays compared to those on lower-calorie diets. The study found that patients in the higher-calorie group reached medical stability three days earlier and gained weight faster.
An international team of researchers analyzed medical records and identified commonly hijacked cellular pathways in three lethal coronaviruses. The study revealed treatment regimens for current and potential future viral pandemics, providing real-world implications for COVID-19 treatment.
A national study found that COVID-19 symptoms in pregnant women can last two months or longer, impacting health and wellbeing. Researchers analyzed 594 women who tested positive for SARS-CoV-2 virus during pregnancy, discovering that half had symptoms after 3 weeks and 25 percent had symptoms persisting beyond 8 weeks.
A new study has discovered that accumulated DNA damage in skin cells can be used to estimate the risk of deadly skin cancer. Researchers sequenced DNA from individual melanocytes and found a significant number of mutations associated with melanoma, even in people without visible moles.
A new study by UCSF researchers uses exome sequencing to identify genetic diseases as the underlying cause in 37 cases of nonimmune hydrops fetalis, a life-threatening condition. The study finds that genetic diagnoses are critical for families and healthcare providers to guide prenatal management strategies.
A novel screening method could lead to earlier detection of life-threatening complications in babies born preterm and help reduce racial disparities in outcomes. The study identified a combination of six newborn characteristics and 19 metabolites that reliably predict preterm babies at increased risk for death and severe illness.
A UCSF study found parents are more likely to know their child is using e-cigarettes if they're older and male, but less aware of vaping compared to smoking. Parents setting strict household rules can help prevent tobacco use in children.
Researchers discovered that liver tumors can harness the liver's powers to retrain the immune system and exert its influence on distant cancer cells. Adding a second checkpoint inhibitor in combination therapy may overcome this resistance and increase immunotherapy effectiveness.
Researchers at UCSF create customizable antibiotic molecules to evade bacterial resistance mechanisms. By redesigning existing antibiotics, they've found promising variations with activity against dozens of strains of pathogenic bacteria.
According to a new study, infants born to mothers infected with COVID-19 generally do well six to eight weeks after birth. However, there was a higher rate of NICU admissions reported if the mothers had COVID-19 up to two weeks prior to delivery.
A new study published in Emotion journal found that older adults who took weekly 15-minute 'awe walks' for eight weeks reported increased positive emotions and less distress. Participants showed a visible shift in their selfies, featuring landscapes instead of themselves, and experienced significant boosts in daily prosocial emotions.
A team of researchers from the University of California, San Francisco, has made a significant breakthrough in developing a 'plug and play' brain prosthesis that enables individuals with paralysis to control devices using their brain activity. The device uses machine learning algorithms to match brain signals to desired movements, allo...
Women with Alzheimer's live longer and experience less severe symptoms due to the protective effects of their second X chromosome. The study found that women carrying a specific variant of the KDM6A gene have twice the dose of protective proteins, giving them greater protection against the disease.
A new study found that US adults' flu vaccination rates differ significantly by demographics such as age, insurance status, and chronic conditions. The researchers suggest that boosting vaccination rates requires a concerted public health campaign and proactive primary care outreach strategy.
A new UCSF study found that the prevalence of SARS-CoV-2 among asymptomatic children mirrors the number of confirmed cases in the general population. Researchers developed an equation to estimate the number of infected students in a classroom based on local data, revealing risks ranging from 11% to 79%.
Researchers at UCSF have developed a smartphone-based digital biomarker to detect Type 2 diabetes, providing a potential in-home alternative to blood draws and clinic-based screening tools. The algorithm correctly identified the presence of diabetes in up to 81% of patients, offering a promising solution for widespread disease screening.
A comprehensive assessment of genomic sequencing as a standalone newborn screening tool found it comes up short, missing about 160 cases and incorrectly identifying 8,000. However, sequencing can still be useful in suspicious cases not clearly identified by MS/MS.
A new drug, ofatumumab, has been shown to significantly reduce inflammation and clinical relapses in patients with relapsing multiple sclerosis. Nearly nine out of ten patients on the treatment showed no sign of disease activity after one year.
A study by UC San Francisco found that over a third of adults aged 65 and older face difficulties seeing their doctor via telemedicine due to various obstacles. The researchers highlight the need for innovation in devices, services, and policy to ensure older adults are not left behind during the shift to telehealth.
Researchers have identified 38 excipient molecules that interact with human enzymes and receptors, highlighting the potential for previously unappreciated effects on health. The study emphasizes the need for further investigation to establish whether these substances may contribute to unwanted side effects in human patients.
A new analysis of 426 emergency physicians found moderate to severe levels of anxiety at both work and home, with women reporting higher stress. The study identified key factors contributing to stress, including lack of PPE and inadequate rapid diagnostic testing.
A UCSF study found that older adults with retained senses of hearing, vision, and touch have half the risk of developing dementia compared to those with marked sensory decline. The study tracked over 1,800 participants in their seventies for up to 10 years, revealing a stronger association between olfaction and lower dementia risk.
A new UCSF study reveals that young adults with smoking habits are at a higher risk of severe COVID-19. The study found that medical vulnerability was 33% for males and 30% for females, with smoking surpassing other less common risks.
A new study has identified genes more frequently altered in prostate tumors from men of African ancestry compared to other racial groups. The research found no significant differences in frequencies of mutations in genes important for current prostate cancer therapies, but suggests that precision medicine approaches can be effective if...
A study found that exercising mice secretes a liver protein called Gpld1 into the blood, which correlates closely with improved cognitive function. Researchers believe this protein could be used to develop drugs that mimic the brain benefits of exercise, offering new hope for individuals unable to exercise due to physical limitations.
A new model of breast cancer's causes, called Paradigm II, illustrates the dynamic and sometimes unexpected interactions between biological, behavioral, social, and physical domains. The model, created by a multidisciplinary team, includes 96 potential interactions and is available online for further research and discussion.
Scientists have identified a role for microglia in clearing the extracellular matrix, allowing new synapses to form and improving memory. Disrupting this process can lead to memory problems, including those seen in Alzheimer's and anxiety disorders.
A new study by UCSF researchers found that weaker or irregular circadian rhythms in daily rest and activity cycles are associated with a greater likelihood of developing Parkinson's disease later on. Disruptions in the brain's internal clock may be an early warning sign of neurodegenerative disease processes.
A study of 3,000 independently living older men found that weak or irregular circadian rhythms are associated with a greater likelihood of developing Parkinson's disease years later. The researchers suggest that these disruptions may reflect neurodegenerative processes already affecting the brain's internal clock.
A new tool using 3D facial imaging and machine learning could help diagnose genetic syndromes more quickly and inexpensively. The prototype was created by a team of researchers from the University of California, San Francisco, and has been shown to accurately classify most subjects as either unaffected or having a syndrome.
A new study suggests that video visits may become a permanent feature of the patient-provider landscape due to the coronavirus pandemic. The study found that patients with eating disorders required significant workarounds to provide regular monitoring of weight and vital signs.
Researchers discover distinct effects of different tumor types on mouse immune system and human breast cancer patients, suggesting potential applications for cancer immunotherapy. Tumors cause widespread disruption of immune system, evolving over time, which can impact treatment efficacy.
A new UC San Francisco study found that precise synchronization of high-frequency brain waves is crucial for learning to let go of old rules and make way for new updates. Disrupting these synchronized waves can lead to perseverative behaviors, a common symptom in schizophrenia.
A new study found that ketogenic diets significantly changed the proportions of common gut microbial phyla in human participants, with a particular decrease in Bifidobacteria. In mouse experiments, ketone bodies directly impacted the gut microbiome, reducing Th17 immune cells and promoting anti-inflammatory effects.
Researchers found that LACTIN-V, a product containing healthy vaginal bacteria, significantly reduced the recurrence of bacterial vaginosis (BV) in women. The study also suggests that LACTIN-V may have the potential to prevent HIV infection and preterm birth.
A research team has identified a powerful self-corrective mechanism within synapses that slows down disease progression in animal models of ALS. This mechanism is activated by neurodegeneration and acts to keep the synapse between nerve and muscle working correctly, even though the disease process has already begun to nibble away at it.
Researchers have developed a new oral polio vaccine that uses genetic wizardry to prevent the virus from evolving into a deadly form. The vaccine showed promise in a Phase 1 clinical trial, with participants generating plentiful antibodies against the poliovirus and no paralysis in mice.
A blood test measuring phosphorylated tau 181 (pTau181) shows promise in detecting Alzheimer's disease and mild cognitive impairment. The test's accuracy surpasses existing methods, offering a potential solution for early diagnosis and treatment.
Researchers at UCSF successfully transplanted stem cells into fetal mice carrying a genetic mutation that causes MPS7, a disorder affecting enzyme production. The treatment improved survival rates and helped sustain the fetus through birth, with potential benefits for related metabolic disorders.
A computational study identified lansoprazole and 12 other FDA-approved drugs that reduce inflammation and may prevent preterm birth. The drugs act on biological pathways affecting the immune response, which is implicated in preterm birth. Further testing is needed to confirm their effectiveness.
A study in mice reveals that new nerve insulation, myelin, plays a critical role in laying down long-lasting emotional memories. Increased myelin formation is necessary for the consolidation and maintenance of fear memories, which could lead to new treatments for post-traumatic stress disorder.
A retrospective study by researchers at UC San Francisco found that removing the non-contrast-enhancing tumor increases survival for adults with glioblastoma. Patients with IDH-mutant tumors who underwent resections of both contrast-enhancing and non-contrast-enhancing tumor had a significantly longer average survival time, around 37.3...
Researchers at University of California - San Francisco discovered how the brain generates imagined future scenarios, providing new insights into neurobiology of decision-making. Place cells in the hippocampus rapidly switch between present and possible paths, generating a 'menu' for other parts of the brain to make decisions.
A new study published in Nature found that widely used cerebral organoids are 'confused' and 'disorganized' compared to the developing human brain. The researchers measured gene expression in over 235,000 cells from 37 different organoids and compared it to normal brain tissue, revealing a lack of development into distinctive cell type...
A low-cost test screening for excess protein in the urine accurately identifies patients at higher risk for progressive kidney disease after being hospitalized for acute kidney injury. Targeting treatment to these high-risk patients could reduce future need for dialysis or kidney transplants and save billions of dollars.
Researchers found that modifying default settings for opioid prescriptions resulted in lower quantities prescribed. The study's findings suggest that reducing default settings can help improve prescription practices and protect patients from developing opioid addictions.
A UC San Francisco-led research team has discovered the first conclusive evidence that natural selection may also occur at the level of the epigenome for tens of millions of years. The study found a particular epigenetic mark on the DNA sequence of Cryptococcus neoformans, which should have disappeared during the age of the dinosaurs.
A single payer system would replace private insurance and simplify billing, leading to savings through lower drug costs and efficiencies. The study found that 19 of 22 models predicted net savings in the first year, averaging 3.5% of total healthcare spending.
A landmark study published in Social Science & Medicine found that over 95% of women who had an abortion said it was the right decision for them five years later. The study also showed that negative emotions such as sadness and guilt decreased dramatically over time, while relief remained a dominant emotion.