Researchers have developed a promising strategy using multivalent combinations of antibodies to prevent and treat HIV. These broadly neutralizing antibodies offer increased efficacy against various strains of the virus, including those at mucosal surfaces.
Researchers at UNC School of Medicine have created a new drug-like compound that activates only the kappa opioid receptor, a key step in developing better pain medications. This breakthrough could lead to safer and more effective opioids with reduced side effects.
Researchers at UNC School of Medicine discovered that the minichromosome maintenance (MCM) complex plays a crucial role in keeping stem cells in their immature state. The study suggests that rapid MCM loading rate is essential for maintaining stem cell identity.
Researchers found that certain bacterial strains can produce factors that increase or decrease the susceptibility of another bacterium to antibiotics. The study identified three specific factors: LasA, rhamnolipids, and HQNO, which could be used to create new antibiotics or develop genetic tests to detect antibiotic resistance
Researchers developed a simple, minimally-invasive test to predict which CFTR drug works best for each patient. Nasospheroids, grown from nasal samples, are exposed to drugs and their reactions measured, offering a quick alternative to rectal biopsy.
A new lab model was developed to test new therapeutics for cystic fibrosis. The model uses primary bronchial epithelial cells from CF patients and infectious/inflammatory factors normally found in the CF airways.
A study published in the American Journal of Pathology found that higher levels of the protein CXCL5 are associated with clearer heart arteries and lower risk of coronary artery disease. Researchers believe that mimicking or increasing CXCL5 production could lead to new prevention and treatment strategies for CAD.
Researchers have discovered a long-distance brain circuit that controls the production of new neurons in the hippocampus, a critical area for learning and memory. The circuit, involving the medial septum and PV interneurons, regulates stem cell activity and maintains healthy neurogenesis.
Researchers at UNC and Auckland University propose a new 'peptide-RNA' theory, suggesting genetic instructions (nucleic acids) and small proteins (peptides) interacted to form life. The theory contradicts the widely-held 'RNA-world' hypothesis, which states nucleic acids gave rise to life.
UNC researchers discovered that high-intensity shear shock waves amplify deep inside the brain, delivering a tenfold increase in tissue-ripping acceleration. This phenomenon may explain why some head knocks cause more harm than others.
Artificial beta cells mimic the body's natural glucose-controllers and can be subcutaneously inserted into patients or delivered via a painless skin patch. In lab experiments and animal models, they demonstrated rapid responsiveness to excess glucose levels and normalized blood glucose levels in diabetic mice.
Researchers at UNC School of Medicine have made a breakthrough in understanding the molecular changes that occur during cell fate conversion from fibroblast to cardiomyocyte. They used single-cell RNA sequencing technology, mathematical modeling, and genetic approaches to identify key regulators and pathways involved in the process.
A new study published in the American Journal of Respiratory and Critical Care Medicine found that e-cigarettes trigger both unique and familiar immune responses in the lungs. Researchers compared sputum samples from e-cigarette users, cigarette smokers, and non-smokers, revealing significant increases in inflammatory biomarkers, oxida...
Researchers at UNC-Chapel Hill and UCSF have solved the crystal structure of a specific dopamine receptor called D4 at an incredibly high resolution, allowing them to design a new compound that tightly binds only to D4. This breakthrough could lead to more precise psychiatric drugs with fewer side effects.
A study published in Clinical Infectious Diseases defines the burden of hepatitis C virus infection in the Democratic Republic of Congo (DRC). Researchers developed a simple test using existing HIV testing equipment, identifying 1% of adults living in the DRC as potentially infected.
Scientists have discovered that axon damage leads to shrinking dendritic spines and rising excitability in neurons, but also found that blocking gene activity with netrin-1 can reverse these changes. This breakthrough could lead to improved treatments for brain injury patients.
The UNC School of Medicine will use the grant to develop a new protocol for Afib patients, allowing them to receive care in outpatient settings. The goal is to reduce hospitalizations and improve patient engagement in their own health.
Scientists at UNC School of Medicine compare two reprogramming techniques to generate patient-specific cardiomyocytes, finding that one method produces cells with embryonic cell signatures while the other yields cells with adult characteristics. This knowledge is crucial for developing new therapies and understanding cardiac disease.
UNC School of Medicine researchers found that faulty cell signaling in progenitor cells can derail cerebral cortex development, potentially leading to autism. The study suggests that disruptions in the Wnt protein pathway may play a crucial role in brain development and autism symptoms.
A recent study published in the New England Journal of Medicine describes how airway dehydration leads to thick mucus accumulation, a hallmark of chronic bronchitis. The research found a strong association between mucin concentrations and disease severity in people with chronic bronchitis.
Researchers at UNC School of Medicine have discovered a damaging cascade of events inside brain cells that contribute to Alzheimer's disease. The study shows that amyloid beta protein can trigger an inflammatory response in immune cells, leading to the formation of bead-like structures filled with abnormal tau protein.
A new rapid diagnostic test has been shown to effectively distinguish between severe and uncomplicated malaria in children in Sub-Saharan Africa. The test was tested on 2,678 children with fever, resulting in a sensitivity and specificity of 97.6% for detecting severe malaria.
Researchers at UNC School of Medicine have developed a new imaging technique using nuclear magnetic resonance (NMR) to visualize RNA structure and motion over time. This discovery opens up new avenues for developing drugs that target RNA, crucial for understanding health and disease.
Researchers found that defects in primary cilium structure impaired brain development, resembling those seen in autism and schizophrenia. Restoring signaling through primary cilia resolved wiring defects in the brain.
Researchers develop a potential stem cell treatment for idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and cystic fibrosis by harvesting lung stem cells noninvasively and multiplying them in the lab. The therapy has shown promising results in treating IPF in rodent models.
Researchers at the University of North Carolina Health Care found that Ebola virus RNA can persist in the semen of survivors for more than two years after infection. This persistence has important implications for transmission and may require an update to World Health Organization guidelines.
Researchers at UNC Health Care have developed an assay to detect antigen production and immune effectors capable of clearing infected cells. Vorinostat reverses latent HIV infection, making it vulnerable to clearance and potentially paving the way for a cure for the millions living with the virus.
Researchers at UNC are testing a therapeutic vaccine to target HIV reservoirs and boost the immune system's response. The goal is to potentially pair the vaccine with latency-reversing agents to clear the virus.
Researchers at UNC and NC State found that acetylation promotes TDP-43 clumping in animals, leading to muscle degeneration. In mouse models, reversing protein clumping prevented sIBM-related muscle weakness, offering potential therapy reversal.
Research from the UNC School of Medicine found an association between certain microbial communities and higher levels of cognitive development. Infants with high levels of Bacteroides had better cognitive scores, while those with diverse gut microbiomes performed worse.
Researchers at UNC have shown that interval dosing of Vorinostat can reverse latent HIV and improve detection, paving the way for further research into clearing infection. The study's findings suggest that pairing a latency reversing agent with an antiviral immune therapy may be necessary to achieve a cure.
UNC Health Care was honored as a national leader in health IT by the American Hospital Association (AHA) for leveraging technology to enhance patient care. The system has fully integrated its electronic health record (EHR) across all hospital entities and outpatient clinics.
The UNC School of Medicine, UNC Eshelman School of Pharmacy, and other health professions schools will establish clinical experiences for students in rural areas of North Carolina, launching the UNC Rural Interprofessional Health Initiative (RIPHI). The program aims to improve health disparities and develop a health workforce prepared ...
UNC researchers discovered that Set2 enzyme is essential for maintaining proper transcription during cellular stress, preventing mis-expression of genes and promoting cancer initiation. The study's findings have implications for understanding cancer development and potential therapeutic strategies.
A new technique developed by UNC School of Medicine scientists has mapped DNA damage caused by cigarette smoking at high resolution across the genome. The study provides a genome-wide map of the damage caused by benzo[α]pyrene, a chemical that accounts for about 30 percent of cancer deaths in the United States.
A phase 2 double-blind study found that brexanolone reduced HAM-D scores by 21 points in women with severe PPD, compared to an 8.8-point reduction in the placebo group. The medication was generally well-tolerated and showed sustained effects beyond a 30-day follow-up period.
A large pragmatic trial found that checking finger-stick blood sugars did not offer significant advantages in blood sugar control or quality of life for non-insulin treated type 2 diabetes patients. The study suggests that the costs of home blood glucose monitoring may outweigh its benefits for this population.
Researchers at the University of North Carolina have identified how NS5A inhibitors block Hepatitis C virus replication, revealing a difference in the speed of decline depending on the strain of HCV. This understanding may lead to more effective therapies against a broader range of viruses.
Researchers used MRIs to analyze infant brain connectivity and synchronize brain regions. The study found that differences in these connections at six months could predict autism diagnoses at two years old, with the machine learning classifier correctly identifying 81% of babies who developed autism.
Scientists at UNC discovered a cascade of molecular signals that program gene activity to drive fruit fly maturation, involving alterations to DNA packaging and chromatin accessibility. This basic biology finding may hold significance for understanding how cancers arise in humans.
Researchers found that exercising burns fat in bone marrow, leading to improved bone health. The study suggests that exercise is beneficial even more so for obese individuals, who may experience greater bone formation and strength.
A special issue of the Journal of Infectious Diseases focuses on HIV eradication, exploring scientific thinking behind cure strategies. Researchers from UNC and other institutions discuss challenges and priorities in key areas of HIV cure research.
Researchers identified a genetic locus on chromosome 12 associated with anorexia nervosa, which also shows correlations with neuroticism and schizophrenia. The study suggests that anorexia may have both psychiatric and metabolic roots, potentially leading to new treatment opportunities.
Researchers used virtual reality to identify balance impairments and train people to improve their balance. The study found that virtual reality can reveal balance deficits that are not apparent during normal walking, providing an important roadmap for detecting balance impairments.
Researchers at UNC School of Medicine have found that HIV persists in macrophage cells, a type of white blood cell, which has significant implications for HIV cure research. This discovery demonstrates that two types of cells may be targets for therapeutic intervention to eradicate the virus.
UNC School of Medicine scientists pinpoint MRGRPX2, a receptor protein on mast cells, as the key to understanding opioid-induced itching. The researchers created a chemical probe to interact with this receptor, potentially leading to the development of an antagonist to reduce itching side effects.
Researchers at UNC are developing an injectable drug delivery system that forms a long-lasting implant to steadily release anti-HIV medication. The goal is to provide durable, sustained protection from HIV transmission while improving adherence and allowing for easy removal.
Researchers found that mucin proteins fail to unfold normally in CF airways due to dehydration, leading to thick and sticky mucus. This understanding could lead to therapies targeting the abnormal compact form of mucin proteins, such as rehydrating the airway lining with hypertonic saline.
A study published in the Journal of the American Geriatrics Society found that poor oral health and food scarcity are major contributors to malnutrition in older adults. The research suggests that linking patients in need to existing food assistance programs, such as Meals on Wheels, can help address this issue.
A study found that many toddlers diagnosed with autism at two years of age had a substantially greater amount of extra-axial cerebrospinal fluid at six and 12 months of age, before diagnosis was possible. The more CSF at six months, the more severe the autism symptoms were at two years of age.