Researchers found a 3% better survival rate for patients who received laryngeal tube (LT) devices on scene compared to traditional intubation breathing tube methods. The study showed that LT devices could potentially save over 10,000 lives annually.
Researchers used advanced cryo-EM technology to determine the structure of a molecular complex implicated in birth defects and several cancers. The study revealed that two Patched-1 molecules simultaneously engage a single Hedgehog molecule, forming a unique 2-to-1 ratio PTCH1-HH complex required for efficient Hedgehog signaling.
Researchers at UT Southwestern Medical Center have uncovered the means by which pediatric kidney cancer continues to grow, providing potential targets for more effective treatments. Impairment of miRNA function drives Wilms tumor formation through increased IGF2 production.
A new online tool, Astro-CHARM, has been developed to predict who is at the highest risk of suffering a heart attack or stroke in the next 10 years. The calculator combines coronary artery calcium measurement with traditional risk factors like blood pressure and cholesterol.
A new app-based intervention has shown promising results in reducing suicidal attempts among teenagers after hospital discharge. The BRITE app, part of a brief three-hour program, prompts daily mood ratings and offers personalized recovery strategies to equip teens with coping skills.
Researchers at UT Southwestern Medical Center have identified the body's microreactors for innate immunity, which could lead to novel treatments for infections and autoimmune diseases. The discovery involves a DNA-sensing enzyme that forms droplets that act as tiny bioreactors creating molecules to stimulate the immune system.
A new computational strategy using Bayesian analysis and CRISPR/Cas9 screening technology has identified 29 genetic changes contributing to rhabdomyosarcoma, a common childhood cancer. The study suggests potential treatments for the disease and provides a general approach for identifying oncogenic drivers in other cancers.
Small cell lung cancer researchers identified a key metabolic pathway that can be targeted with existing drugs, offering new treatment options. The study found that cancer cells become highly dependent on purine synthesis to grow and spread.
A new study found that middle-aged individuals with high fitness are 56% less likely to die from heart disease after a depression diagnosis. Dr. Madhukar Trivedi recommends steps to boost exercise success, including consistency, tracking progress, and varying exercises.
Researchers have solved the atomic structure of a brain receptor bound to GABA, a neurotransmitter that regulates calming signals in the brain. The high-resolution structures provide insights into how drugs like benzodiazepines act on the receptor, paving the way for better treatments for epilepsy and anxiety.
A new study from UT Southwestern researchers highlights the importance of diagnosing and treating stress urinary incontinence in men, who often wait years before seeking help. The study recommends a standing cough test as a routine part of male patients' physicals to accurately diagnose and treat this condition.
Researchers have identified a genetic variation associated with an increased risk of developing neuromyelitis optica (NMO), a potentially fatal disease that blinds and paralyzes patients. The study, published in Nature Communications, may help scientists develop targeted treatments for NMO.
Researchers discovered that Kapβ2, a nuclear localization signal, plays a crucial role in transporting the FUS protein into the nucleus. The study found that when this system fails, FUS proteins aggregate and form toxic droplets, contributing to neurodegenerative diseases like familial ALS.
An international study found that brain phosphorylation, a molecular process, is linked to sleep need. The researchers identified 80 proteins, or SNIPPs, that accumulate phosphate groups in the brain during wakefulness, and their levels decrease during sleep.
UT Southwestern investigators discovered a missing link in kidney cancer prognosis by analyzing neighboring cells. They found that tumors with an inflamed neighborhood were more likely to be associated with aggressive cancers and worse survival rates. However, these tumors may respond better to immunotherapy treatment.
A recent study by UT Southwestern researchers reveals that the NAD+ molecule plays a crucial role in controlling genes essential for fat cell differentiation and cancer growth. The findings suggest that compartmentalized synthesis of NAD+ integrates cellular information to control gene expression, maintaining metabolic health.
Researchers at UT Southwestern found that mice with increased autophagy levels live longer, healthier lives, with a 10% extension in lifespan. The study also shows protection against age-related cancers and diseases.
A national analysis found treatment costs for drug-resistant MRSA infections are similar to those of susceptible MSSA infections. Researchers attribute the lower costs to factors such as price differences in drugs and possible misdiagnosis or coding errors.
A national trial has found that measuring electrical activity in the brain can predict a patient's response to an antidepressant, improving treatment accuracy. Researchers believe combining EEGs with blood and brain tests will lead to more effective treatments for depressed patients.
A study by UT Southwestern Medical Center found that financial strain is the primary factor influencing health care decisions for low-income patients. The researchers recommended that physicians take a proactive approach to recognize and address financial strain in their patients, rather than misinterpreting it as noncompliance.
A research team at UT Southwestern Medical Center has found that inhibiting glucose transport may be a safe and effective treatment for skin diseases like psoriasis. By targeting the metabolic requirements of hyperproliferative skin diseases, researchers were able to reduce disease-associated skin overgrowth and inflammation in mice.
UT Southwestern researchers have obtained atomic-scale blueprints of the most abundant class of brain nicotinic acetylcholine receptors. The study's findings suggest new ways to treat nicotine addiction and neurodegeneration by designing drugs that interact with the receptor in different ways.
Using UT Southwestern's largest lung cancer cell library, researchers identified 170 chemicals that could be developed into treatments for non-small cell lung cancer. The team also found biomarkers to predict patient responses and therapeutic targets, paving the way for personalized cancer care.
Researchers at UT Southwestern Medical Center identified a protein strongly linked to metastatic breast cancer and its growth. High levels of ZMYND8 correlate with poor survival rates in breast cancer patients.
The US FDA approved the combination of ipilimumab and nivolumab for metastatic kidney cancer patients. The treatment led to a 37% improvement in survival compared to sunitinib and durable responses in 42% of patients.
Researchers at UT Southwestern Medical Center identify a hormone that stimulates thirst in response to nutrient stresses, challenging traditional views on hydration. The study's findings suggest that FGF21 works through a novel pathway to increase water intake, potentially limiting alcohol consumption and protecting against its effects.
A combination of EGFR and TNF inhibitors effectively blocks cancer's escape route, making it sensitive to treatment. The two-drug strategy has the potential to work for all non-small cell lung cancers, offering a new hope for patients.
Larotrectinib, a new pediatric cancer drug targeting the TRK gene fusion, showed an unprecedented 93 percent response rate in patients tested. The drug has been effective in treating rare pediatric cancers such as infantile fibrosarcoma and papillary thyroid cancer.
The study reveals that the circulating form of soluble a-Klotho can act as a co-receptor for FGF23, making every cell a potential target. This breakthrough challenges the long-held belief that only cell-attached a-Klotho can receive FGF23 signals.
A recent UTSW study sheds light on the mechanisms underlying Sonic Hedgehog subtype medulloblastoma development, revealing a crucial role for the G protein-coupled receptor Gpr161. The research suggests that Gpr161 acts as a tumor suppressor by preventing excessive granule cell proliferation.
A new study in mice shows that turning on a gene called LZK can stimulate the healing process after spinal cord injuries, resulting in smaller scars. This trigger has implications for treating brain conditions through gene therapy targeting astrocytes.
A new study reveals that U.S. South Asians with Type 2 diabetes consumed fewer beneficial nutrients than healthy South Asians, including dietary fiber and essential vitamins. The research highlights the need for improved dietary habits to manage blood cholesterol and blood pressure levels.
Researchers found that beta-amyloid triggers calcineurin, leading to loss of dendritic spines and synapses in Alzheimer's disease. Rescuing synapses with extra Pin1 or FK506, an FDA-approved drug for transplant rejection, may slow disease progression.
Researchers use optogenetic methods to control songbird neurons, prompting birds to change specific syllables in their songs. The study provides insight into how the brain guides the learning of vocal behaviors in humans.
A multi-institutional study found that mandatory flu vaccines for health care workers increase participation by up to 30% and reduce absenteeism during critical patient surges. Vaccinated health care workers had a 30% reduction in absenteeism compared to non-vaccinated workers.
A new study from UT Southwestern Medical Center found a correlation between traumatic brain injury and early-onset Alzheimer's disease. People who sustained concussions were diagnosed with dementia on average 2 1/2 years earlier than those without TBI.
A study by UT Southwestern researchers found that only half of older adults are transferred to long-term acute care (LTAC) facilities due to illness severity or complexity. Many others are sent based on hospital preferences and regional trends, potentially leaving them eligible for less expensive post-acute care settings.
A UTSW study found that inhibiting glucagon action has potent anti-diabetic effects, reducing negative fat tissue impacts and improving cardiac function. The research may advance understanding of diabetes drugs' benefits for heart health.
Researchers discovered that polyploid liver cells can protect the liver against cancer by carrying extra copies of tumor suppressor genes. This finding challenges the notion that polyploidy is a pro-cancer state and suggests it could be an adaptive response within normal liver cells.
Combining a blood test for high alpha fetoprotein (AFP) levels with ultrasound imaging improves liver cancer detection by 40 percent, according to researchers at UT Southwestern Medical Center. Early detection is crucial for improving survival rates in patients with liver cancer, which is on the rise in the US.
Scientists developed a CRISPR gene-editing technique that can correct most DMD mutations by making a single cut at strategic points along the patient's DNA. The new strategy enhances genome editing accuracy and offers an efficient alternative to individualized molecular treatments.
New research emphasizes the significance of hospitals adhering to treatment guidelines for heart failure patients over comparing patient volumes. Lower-volume hospitals have been found to have worse adherence to essential processes, such as prescribing beta-blockers and running tests to check heart function.
Researchers at UT Southwestern's Simmons Cancer Center have made a historic breakthrough in CAR-T therapy for acute lymphoblastic leukemia (ALL) in children and young adults. Eighty-one percent of patients treated with CAR-T therapy went into remission, offering new hope for those previously untreatable.
RAS molecules act in pairs, known as dimers, to cause cancer and transmit signals that tell a cell to grow and divide. The study provides a foundation for further studies on RAS biology and could potentially pave the way to develop new cancer drugs.
A new study found that exercising four to five times a week can improve maximum oxygen intake during exercise by 18% and elasticity of the left ventricular muscle of the heart by over 25%. The research suggests that beginning exercise in late middle age can help reverse damage to sedentary hearts.
Researchers at UT Southwestern Medical Center used precision editing to target metabolic pathways in the gut, reducing inflammation in mouse models of colitis. The strategy, which targets specific bacterial species, prevented or reduced inflammation without affecting healthy gut bacteria.
A study published in Nature Communications reveals that African trypanosomiasis, also known as sleeping sickness, is a circadian rhythm disorder caused by the acceleration of biological clocks. This understanding could lead to the development of new therapeutic alternatives to toxic treatments.
Researchers at UT Southwestern Medical Center have developed a new Magnetic Resonance Imaging (MRI) technology that can accurately diagnose the nature and aggressiveness of kidney cancer without the need for invasive biopsies. This breakthrough technology, known as multiparametric MRI, uses multiple types of images to evaluate the chem...
Researchers found that the FDA-approved drug hydralazine extended the life span of roundworms by 25% by activating the NRF2/SKN-1 signaling pathway, which may mimic caloric restriction. The treatment also showed neuroprotection and reduced tau toxicity in a model of Alzheimer's disease.
A new class of medicines called HIF-2a inhibitors, including PT2385, have shown promise in treating metastatic kidney cancer. The drug blocked tumor growth for at least 4 months in 40% of patients and stopped cancer growth for over a year in 25% of patients with minimal side effects.