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Washington University in St. Louis


A sodium surprise

Biomedical engineers found that different beta subunits attach to the main protein in a unique way, affecting the channel's control over the heartbeat. This discovery could lead to precision medicine and therapies tailored to individual needs.

SourceWashington University in St. Louis·JournalJournal of General Physiology·DateJul 20, 2017

The glass transition caught in the act

Researchers at Washington University in St. Louis used a new experimental setup to measure the atomic properties of liquid materials, resolving some long-standing debates about the glass transition. The team found that fragility is related to atomic interactions and structural changes during the transition.

SourceWashington University in St. Louis·JournalNature Materials·DateJul 17, 2017

Engineers examine chemo-mechanics of heart defect

Scientists discovered that changes in mechanical behavior and gene signaling play a crucial role in the development of heart defects, with LOX-deficient mice exhibiting protection against aneurysms. The research provides new insights into the chemo-mechanics of heart defects and its potential applications for disease prevention.

SourceWashington University in St. Louis·JournalAJP Heart and Circulatory Physiology·DateJun 28, 2017

A little place for my stuff

A new study published in Current Biology found that bacterial cells are limited by their ability to produce fat, which affects their growth and size. The research, conducted at Washington University in St. Louis, used a novel approach to understand the role of biosynthesis in cell-size regulation.

SourceWashington University in St. Louis·JournalCurrent Biology·DateJun 26, 2017

Shaking Schroedinger's cat

Researchers at Washington University in St. Louis have discovered that quasimeasurements, a new type of measurement interaction, cause the quantum Zeno effect and anti-Zeno effect. The disturbance from these measurements shifts the energy levels of the atom, leading to faster or slower decay rates.

SourceWashington University in St. Louis·JournalPhysical Review Letters·DateJun 16, 2017

The next enchanted ring?

Researchers at Washington University in St. Louis have developed a method to synthesize ß-lactone peptides, a new class of antibiotics, by copying bacterial enzymes. These peptides inhibit serine hydrolases and may be useful in treating cancer, obesity, and infectious diseases.

SourceWashington University in St. Louis·JournalNature Chemical Biology·DateMay 30, 2017

Death by volcano?

A team of scientists found that massive volcanic eruptions may have caused the end-Ordovician extinction, which wiped out 85% of marine animal species. The eruptions released sulfur dioxide and carbon dioxide, interacting in complex ways to affect the climate.

A simple sniff

Researchers developed a non-invasive nanoparticle delivery method that can target the brain via the nasal cavity, reaching it within minutes. The approach uses aerosol science and engineering principles to generate monodisperse nanoparticles that pass through the brain-blood barrier.

SourceWashington University in St. Louis·JournalScientific Reports·DateApr 12, 2017

Domesticated rice goes rogue

A recent study has discovered the ancestry of Asian rice and its weedy cousins, revealing that rice has a natural tendency towards becoming weeds. The research found that both strains evolved from different crop varieties, with relatively few changes needed to turn the crop plant into a weed.

SourceWashington University in St. Louis·JournalNature Genetics·DateApr 3, 2017

The fed's bank bailout

New research from Washington University in St. Louis shows that the Fed's actions were effective in encouraging banks to lend, benefiting the economy. The study found that a total of 62% of bigger US banks used the Discount Window or Term Auction Facility during the crisis, leading to increased lending of almost all types.

SourceWashington University in St. Louis·JournalJournal of Financial Intermediation·DateMar 16, 2017

Secrets of the calcerous ooze revealed

Researchers have developed a new method to analyze the carbon content of ancient coccolithophore shells, providing insights into past CO2 levels and climate sensitivity. The study uses mathematical modeling and laboratory experiments to understand the biology of ancient creatures and their impact on the environment.

SourceWashington University in St. Louis·JournalNature Communications·DateFeb 28, 2017

The power of tea

Researchers found that a green tea compound may prevent light chain amyloidosis, a condition where parts of the body's own antibodies become misshapen and accumulate in organs, by transforming the protein into a non-toxic form. The study suggests potential lifesaving benefits for patients with multiple myeloma and amyloidosis.

SourceWashington University in St. Louis·JournalJournal of Biological Chemistry·DateFeb 6, 2017

Why big brains are rare

Researchers found that the largest-brained species of electric fish have the highest demand for oxygen, while the smallest-brained species have the lowest. This suggests that large brains can only evolve if constraints on energy intake are lifted or alternative solutions are found to accommodate the increased energy demands.

What's up with Madagascar?

Researchers found three areas of hot rock within the mantle beneath three separate volcanic provinces, indicating that Madagascar's volcanoes are not related to nearby tectonic activity. The study suggests that the island's unique geology, with a delaminated lithosphere and a mantle plume, led to the formation of these hot regions.

SourceWashington University in St. Louis·JournalEarth and Planetary Science Letters·DateNov 28, 2016

Single enzyme controls 2 plant hormones

Researchers at Washington University in St. Louis isolated an enzyme GH3.5 that regulates the levels of two plant hormones, auxin and salicylic acid, simultaneously. The study reveals how this single enzyme controls distinct classes of hormones, providing new insights into the molecular pathways for growth and defense.

SourceWashington University in St. Louis·JournalProceedings of the National Academy of Sciences·DateNov 22, 2016

Engineering a better biofuel

A team from Washington University in St. Louis has developed a new method to produce biofuels in E. coli bacteria, boosting BCFA manufacture to 80 percent of all fuel products, and opening up potential applications for pharmaceuticals and other useful products.

SourceWashington University in St. Louis·JournalMetabolic Engineering·DateAug 10, 2016

Big trash pickup

Cells have two disposal systems: proteasomes, which handle smaller proteins, and autophagy, a process that removes larger complexes. Researchers discovered a smart bin liner-like system in autophagy, involving Cue5 receptors and Hsp42 chaperones.

SourceWashington University in St. Louis·JournalCell Reports·DateAug 1, 2016

Dirty to drinkable

Researchers at Washington University in St. Louis have created a new approach to purify water using graphene oxide and bacteria-produced cellulose. The bi-layered biofoam is light, strong, and flexible, allowing for efficient evaporation of contaminated water.

SourceWashington University in St. Louis·JournalAdvanced Materials·DateJul 26, 2016